Article
Rheumatology
S. Retamozo, N. Acar-Denizli, I. F. Horvath, W-F Ng, A. Rasmussen, X. Dong, X. Li, C. Baldini, P. Olsson, R. Priori, R. Seror, J-E Gottenberg, A. A. Kruize, G. Hernandez-Molina, A. Vissink, P. Sandhya, B. Armagan, L. Quartuccio, A. Sebastian, S. Praprotnik, E. Bartoloni, S-K Kwok, M. Kvarnstrom, M. Rischmueller, R. Solans-Laque, D. Sene, S. G. Pasoto, Y. Suzuki, D. A. Isenberg, V. Valim, G. Nordmark, H. Nakamura, V Fernandes Moca Trevisani, B. Hofauer, A. Siso-Almirall, R. Giacomelli, V Devauchelle-Pensec, M. Bombardieri, F. Atzeni, D. Hammenfors, B. Maure, S. E. Carsons, T. Gheita, I Sanchez-Berna, M. Lopez-Dupla, J. Morel, N. Inanc, E. Fonseca-Aizpuru, C. Morcillo, C. Vollenweider, S. Melchor, M. Vazquez, E. Diaz-Cuiza, S. Consani-Fernandez, B. de-Miguel-Campo, A. Szanto, S. Bombardieri, A. Gattamelata, A. Hinrichs, J. Sanchez-Guerrero, D. Danda, L. Kilic, S. de Vita, P. Wiland, R. Gerli, S-H Park, M. Wahren-Herlenius, H. Bootsma, X. Mariette, M. Ramos-Casals, P. Brito-Zeron
Summary: This study analyzed the impact of age at diagnosis on the phenotypic features of primary Sjogren's syndrome. The results showed that older patients had a higher frequency of oral dryness symptoms, while autoantibodies and immunological markers decreased with age. The study concluded that age at diagnosis plays a critical role in disease expression and should be considered in diagnostic and treatment approaches.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Manuel Ramos-Casals, Nihan Acar-Denizli, Arjan Vissink, Pilar Brito-Zeron, Xiaomei Li, Francesco Carubbi, Roberta Priori, Natasa Toplak, Chiara Baldini, Enrique Faugier-Fuentes, Aike A. Kruize, Thomas Mandl, Minako Tomiita, Saviana Gandolfo, Kunio Hashimoto, Gabriela Hernandez-Molina, Benedikt Hofauer, Samara Mendieta-Zeron, Astrid Rasmussen, Pulukool Sandhya, Damien Sene, Virginia Fernandes Moca Trevisani, David Isenberg, Erik Sundberg, Sandra G. Pasoto, Agata Sebastian, Yasunori Suzuki, Soledad Retamozo, Bei Xu, Roberto Giacomelli, Angelica Gattamelata, Masa Bizjak, Stefano Bombardieri, Richard-Eduardo Loor-Chavez, Anneline Hinrichs, Peter Olsson, Hendrika Bootsma, Scott M. Lieberman
Summary: Childhood-onset primary Sjogren's syndrome is characterized by sicca features, parotid enlargement, and systemic disease, with age at diagnosis influencing the phenotypic expression of the disease. Symptom presentation includes dry mouth, dry eyes, positive ANA, anti-Ro/La antibodies, and positive RF, among others.
Article
Rheumatology
Paolo Delvino, Federica Sardanelli, Sara Monti, Pascal Cohen, Xavier Puechal, Luc Mouthon, Carlomaurizio Montecucco, Loic Guillevin, Benjamin Terrier
Summary: This study assessed the prevalence and impact of different levels of disease activity on damage accrual in patients with GPA and MPA. The results showed that more than 60% of patients achieved prolonged remission, which was associated with better long-term outcomes.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Michael Hughes, Suiyuan Huang, Juan Jose Alegre-Sancho, Patricia E. Carreira, Merete Engelhart, Eric Hachulla, Joerg Henes, Eduardo Kerzberg, Maria Rosa Pozzi, Gabriela Riemekasten, Vanessa Smith, Gabriella Szucs, Marie Vanthuyne, Elisabetta Zanatta, Oliver Distler, Armando G. Gabrielli, Anna-Maria Hoffmann-Vold, Virginia D. Steen, Dinesh Khanna
Summary: This study aimed to investigate the prevalence and characteristics of late skin fibrosis in systemic sclerosis (SSc). The study found that late skin fibrosis is not uncommon in SSc, and different patterns of development exist among patients. Patients with lower baseline mRSS and lcSSc are more likely to develop late skin fibrosis. Anti-Scl-70 is associated with progression from lcSSc to dcSSc, while anticentromere antibodies have a protective effect.
Article
Virology
Fernando Cava, Jesus San Roman, Pablo Barreiro, Francisco Javier Candel, Francisco Javier Alvarez-Timon, David Melero, Nerea Coya, Raquel Guillen, David Cantarero-Prieto, Javier Lera-Torres, Noelia Cobo-Ortiz, Jesus Canora, Francisco Javier Martinez-Peromingo, Raquel Barba, Maria del Mar Carretero, Juan Emilio Losa, Antonio Zapatero
Summary: Prediction tools can help guide public health decisions by forecasting COVID-19 case surges and hospitalizations. Low cycle threshold (CT) counts can indicate a higher concentration of SARS-CoV-2 in the respiratory tract, serving as a marker for increased viral transmission. This study validated CT counts as an epidemiological marker for predicting pandemic waves, showing a temporal association between CT counts and COVID-19 cases and hospital admissions.
Article
Respiratory System
A. Franco-Moreno, D. Brown-Lavalle, M. Campos-Arenas, N. Rodriguez-Ramirez, C. Munoz-Roldan, A. I. Rubio-Aguilera, N. Munoz-Rivas, J. Bascunana-Morejon De Giron, E. Fernandez-Vidal, E. Palma-Huerta, S. Estevez-Alonso, B. Rodriguez-Gomez, S. Manzano-Valera, R. Pedrero-Tome, M. Casado-Suela, C. Bibiano-Guillen, M. Mir-Montero, J. Torres-Macho, A. Bustamante-Fermosel
Summary: This study compared the severity of pulmonary embolism (PE) and the long-term complications between COVID-19 patients and non-COVID-19 patients, and investigated the validity of risk stratification tools for PE in this population. The results showed that COVID-19 patients had fewer traditional risk factors for PE and a lower incidence of deep vein thrombosis. COVID-19 patients also had smaller PE size, less right ventricular dysfunction, and lower incidence of long-term complications.
BMC PULMONARY MEDICINE
(2023)
Article
Immunology
Cloe Comarmond, Elodie Drumez, Julien Labreuche, Eric Hachulla, Thierry Thomas, Rene-Marc Flipo, Raphaelle Seror, Jerome Avouac, Nathalie Balandraud, Renaud Desbarbieux, Renaud Felten, Melanie Gilson, Marie-Hlene Guyot, Ambre Hittinger-Roux, Thao Pham, Myriam Renard, Nicolas Roux, Vincent Sobanski, Anne Tournadre, Christophe Richez, Patrice Cacoub
Summary: This study investigated whether RMD patients receiving anti-IL6 therapy have less severe forms of COVID-19 and better outcomes. Retrospective analysis of the French RMD COVID-19 cohort data showed that the severity of COVID-19 was lower in the anti-IL6 group, but there were no significant differences in the evolution of COVID-19 between the groups.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Editorial Material
Rheumatology
Xavier Puechal, Laure Delaval, Philippe Blanche
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Respiratory System
Luis Gonzalez-de Paz, Laura Valdesoiro-Navarrete, Josep Roma, Esther Blat-Guimera, Jaume Benavent-Areu, Joan Bartra, Antoni Siso-Almirall
Summary: This study investigated the prevalence of asthma and allergies in children under 14 years old in Spain and their impact on health-related quality of life, activities, healthcare utilization, and environmental and household exposure risk factors. The results showed that asthma and allergies have a significant impact on children's daily life and healthcare utilization.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Review
Immunology
Antoine Hankard, Xavier Puechal, Nicolas Martin Silva, Samuel Deshayes, Nolwenn Lorcy, Thomas Le Gallou, Pierre-Louis Carron, Eric Daugas, Gilles Kaplanski, Jonathan Boutemy, Gwenola Maigne, Caroline Galimard, Benjamin Terrier, Achille Aouba, Hubert de Boysson
Summary: This study investigated the phenotypic characteristics of patients with ANCA-associated vasculitis (AAV) associated with aneurysms. It found that aneurysms were more frequently observed in granulomatosis with polyangiitis (GPA) patients and predominantly affected medium-sized vessels, especially the renal arteries. Aneurysmal rupture occurred in 43% of patients, with those experiencing rupture having higher baseline pulmonary infiltrates and creatinine levels compared to those without rupture.
AUTOIMMUNITY REVIEWS
(2023)
Article
Respiratory System
Astrid Rasmussen, Bryan A. Dawkins, Chuang Li, Nathan Pezant, Albert M. Levin, Benjamin A. Rybicki, Michael C. Iannuzzi, Courtney G. Montgomery
Summary: Sarcoidosis is a systemic granulomatous disease with heterogeneous manifestations. African Americans have higher morbidity and mortality. Multiple Correspondence Analysis revealed different patterns of organ involvement between African American and European American patients, suggesting ancestry-specific risk profiles. Understanding these profiles will help achieve personalized medicine for this complex disease.
Article
Rheumatology
Adrien Cottu, Matthieu Groh, Charlene Desaintjean, Sylvain Marchand-Adam, Loic Guillevin, Xavier Puechal, Stacy Beaumesnil, Estibaliz Lazaro, Maxime Samson, Camille Taille, Cecile-Audrey Durel, Elizabeth Diot, Sarah Nicolas, Laurent Guilleminault, Mikael Ebbo, Pascal Cathebras, Clairelyne Dupin, Halil Yildiz, Nabil Belfeki, Gregory Pugnet, Pierre Chauvin, Stephane Jouneau, Francois Lifermann, Jean-Philippe Martellosio, Vincent Cottin, Benjamin Terrier, French Vasculitis Study Grp
Summary: This retrospective study investigated the use of benralizumab in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA), and found that benralizumab is effective for refractory asthma and ENT manifestations, and reduces the use of glucocorticoids. However, its efficacy is lower in patients who have previously failed mepolizumab treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Substance Abuse
Ignacio Novo-Veleiro, Ana-M. Mateos-Diaz, Beatriz Roson-Hernandez, Jose-A. Medina-Garcia, Roberto Muga, Joaquim Fernandez-Sola, M. -Candelaria Martin-Gonzalez, Elena Seco-Hernandez, Carlos Suarez-Cuervo, Rafael Monte-Secades, Begona Machado-Prieto, Ruben Puerta-Louro, Cristina Prada-Gonzalez, Alvaro Fernandez-Rial, Patricia Sabio-Repiso, Rocio Vazquez-Vigo, Ana-C. Antoli-Royo, Aina Gomila-Grange, Nieves-C. Felipe-Perez, Arantza Sanvisens-Berge, Emilia Antunez-Jorge, Camino-M. Fernandez-Rodriguez, Lucia Alvela-Suarez, Alba Fidalgo-Navarro, Joaquin Castro, Maria-A. Polvorosa-Gomez, Mario Del Valle-Sanchez, Jose Lopez-Castro, Antonio-J. Chamorro, Miguel Marcos
Summary: This retrospective study analyzed data from a large sample of patients with Wernicke's encephalopathy (WE) to examine the variability in thiamine dosages and routes used in the treatment, as well as the factors associated with this variability. The study found a high level of variability in WE treatment, with a low rate of high-dose intravenous thiamine administration. Factors such as delayed diagnosis, Caine criteria fulfillment, mental status alterations, folic acid deficiency, malnutrition, reduced consciousness, and lack of timely thiamine treatment were associated with poor outcomes.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Endocrinology & Metabolism
Marie Doussiere, Claire Jesson, Laetitia Diep, Jimmy Menis, Corinne Fauvet, Patrice Fardellone, Vincent Goeb
Summary: This study describes the characteristics of 337 patients seen by the fracture liaison service of the Amiens University Hospital for at least two osteoporotic fractures between 2009 and 2019. Results showed that recurrent fracture occurs rapidly after the index fracture. Rheumatological and therapeutic managements are not sufficient, mainly because of cognitive disorders or patients' refusal.
OSTEOPOROSIS INTERNATIONAL
(2023)
Meeting Abstract
Rheumatology
Louai Zaidan, Noemie Le Gouellec, Eric Hachulla, Luc Mouthon, Francois Jerome Authier
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
T. Rabin, G. De Marco, S. R. Dubash, F. Shuweihdi, H. Marzo-Ortega, P. Emery, F. Ponchel, V. Goeb
Summary: This pilot study analyzed the abnormalities in circulating lymphocyte subsets in axial spondyloarthritis (axSpA) and investigated their potential association with the response to biologic disease-modifying anti-rheumatic drugs (b-DMARDs). The results showed dysregulation of lymphocyte subsets in axSpA and different associations with clinical response to IL17i and TNFi.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
C. Tolosa-Vilella, M. del Mar Rodero-Roldan, A. Guillen-del-Castillo, A. Marin Ballve, R. Boldova-Aguar, B. Mari-Alfonso, C. Feijoo-Masso, D. Colunga-Argueelles, M. Rubio-Rivas, L. Trapiella-Martinez, N. Iniesta-Arandia, E. Callejas-Moraga, F. J. Garcia-Hernandez, L. Saez-Comet, C. Gonzalez-Echavarri, N. Ortego-Centeno, M. Freire, J. A. Vargas-Hitos, J. J. Rios-Blanco, J. A. Todoli-Parra, I. Rodriguez-Pinto, A. -J. Chamorro, X. Pla-Salas, A. B. Madronero-Vuelta, M. Ruiz-Munoz, V. Fonollosa-Pla, C. P. Simeon-Aznar
Summary: Late scleroderma pattern identified by NVC is associated with severe disease features and poor prognosis in patients with SSc.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)