Editorial Material
Rheumatology
Juergen Braun, Dietmar Krause, Uta Kiltz
Summary: This editorial discusses the impact evaluation of a nurse-led program for patient self-assessment and self-management in axial spondyloarthritis, presented in a prospective, multicenter, randomized, controlled trial (COMEDSPA) conducted by Anna Molto et al.
Article
Rheumatology
Walter Reinisch, Wayne Hellstrom, Radboud J. E. M. Dolhain, Suresh Sikka, Rene Westhovens, Rajiv Mehta, Timothy Ritter, Ursula Seidler, Oleksandr Golovchenko, Vladimir Simanenkov, Olena Garmish, Slawomir Jeka, Radka Moravcova, Vijay Rajendran, Franck-Olivier Le Brun, Sarah Arterburn, Timothy R. Watkins, Robin Besuyen, Dirk Vanderschueren
Summary: The phase 2 MANTA and MANTA-RAy studies aimed to determine the impact of the oral Janus kinase 1 inhibitor filgotinib on semen parameters and sex hormones in men with inflammatory diseases. Results showed that once daily filgotinib 200 mg for 13 weeks had no measurable impact on semen parameters or sex hormones.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Luis Fernando Perez-Garcia, Esther Roder, Robbert J. Goekoop, Johanna M. W. Hazes, Marc R. Kok, Hieronymus T. W. Smeele, Ilja Tchetverikov, Annette H. M. Van der Helm-van Mil, Jos H. van der Kaap, Petra Kok, Bouwe P. Krijthe, Radboud J. E. M. Dolhain
Summary: This study is the first to demonstrate that inflammatory arthritis can impact male fertility. Men diagnosed with IA before and during the peak reproductive years have lower fertility rates, higher rates of childlessness, and more fertility problems.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Yuanyuan Zhang, Bo Feng, Jing Dong, Yanyan Zhong, Liqin Wang, Lei Zhao
Summary: This study retrospectively reviewed the clinical features and delayed diagnosis of 22 patients with coexisting RA and AS, finding that middle-aged women were the most common subgroup and often presented with systemic, symmetric, peripheral, and axial arthritis. Misdiagnosis due to lack of recognition of RA and AS together is a common reason for delayed diagnosis in these patients.
Article
Rheumatology
Matthias Dreher, Torsten Witte, Kirsten Hoeper, Gunter Assmann, Fabian Proft, Denis Poddubnyy, Niels Murawski, Konstantinos Triantafyllias, Marlon Grodd, Erika Graf, Urs A. Fichtner, Harald Binder, Jan Zeidler, Juliana Rachel Hoeper, Johanna Callhoff, Kirsten Karberg, Anna Trautwein, Dativa Tibyampansha, Leszek Wojnowski, Reinhold E. Schmidt, Andreas Schwarting
Summary: The Rheuma-VOR study aimed to improve the time to diagnosis of patients with early arthritis by coordinating cooperation between primary care physicians, specialists, and patients in Germany. The study showed a significant improvement in the time to diagnosis and other secondary endpoints, and also demonstrated cost savings compared to standard care.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Bogunia-Kubik, Wojciech Wojtowicz, Jerzy Swierkot, Karolina Anna Mielko, Badr Qasem, Joanna Wielinska, Renata Sokolik, Lukasz Pruss, Piotr Mlynarz
Summary: RA, AS, and PsA are comprehensive immunological disorders with treatment focused on symptom relief. Metabolite changes were most significant in AS, with the shortest time to remission, potentially influenced by ethanol as a common metabolite negatively correlated with healing processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kai Du, Chen-Yu Zhang, Ao Li, Jia-Ze Hu, Ren Guo, Shu-Ming Li
Summary: This study found no direct causal relationship between specific occupational exposures and RA or AS through Mendelian randomization analysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Christina Charles-Schoeman, Ernest Choy, Iain B. McInnes, Eduardo Mysler, Peter Nash, Kunihiro Yamaoka, Ralph Lippe, Nasser Khan, Anna K. Shmagel, Hannah Palac, Jessica Suboticki, Jeffrey R. Curtis
Summary: This study provides an integrated analysis of major adverse cardiovascular events (MACEs) and venous thromboembolism (VTE) events in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) patients treated with upadacitinib. The results show that the rates of MACEs and VTE events with upadacitinib are similar to those reported for conventional synthetic and biologic disease-modifying drugs, and comparable to adalimumab and methotrexate.
Article
Rheumatology
Anton Jonatan Landgren, Mats Dehlin, Lennart Jacobsson, Ulrika Bergsten, Eva Klingberg
Summary: The study aimed to compare traditional cardiovascular risk factors among patients with different rheumatic diseases, and found that hypertension was the most common comorbidity, with patients with gout having the highest prevalence of traditional CVRFs. Significant differences in occurrence of CVRFs by sex were also observed among patients with PsA, RA and AS.
Article
Rheumatology
Mark D. Russell, Christopher Stovin, Edward Alveyn, Olukemi Adeyemi, Chun Kit David Chan, Vishit Patel, Maryam A. Adas, Fabiola Atzeni, Kenrick K. H. Ng, Andrew Rutherford, Sam Norton, Andrew P. Cope, James B. Galloway
Summary: This study aimed to evaluate the association between Janus kinase inhibitors (JAKi) and the incidence of malignancy. The results showed that JAKi were associated with a higher incidence of malignancy compared with TNFi.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Alberto Di Martino, Francesco Ursini, Barbara Bordini, Cristina Ancarani, Jacopo Ciaffi, Matteo Brunello, Claudio D'Agostino, Cesare Faldini
Summary: This study investigated the impact of perioperative exposure to TNF inhibitors (TNFi) on the long-term survival of total hip arthroplasty (THA) in patients with inflammatory arthritis. The results showed that perioperative use of TNFi did not increase the risk of revision surgery or postoperative infection, indicating the long-term safety of TNFi in this population.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Endocrinology & Metabolism
Xinlin Nie, Zhaoliang Liu, Dongheng Xie, Yang Sun
Summary: This study provides genetic evidence for causal associations between rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis with eye diseases, and identifies an increased risk of juvenile idiopathic arthritis associated with disorders of sclera, cornea, iris, and ciliary body.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Rheumatology
Sanjana Tarannum, Jessica Widdifield, C. Fangyun Wu, Sindhu R. Johnson, Paula Rochon, Lihi Eder
Summary: This study compared patterns of healthcare utilization between male and female patients with inflammatory arthritis (IA). The findings showed that female patients had higher healthcare utilization than male patients before and after diagnosis, possibly indicating biological differences in disease course or sociocultural differences in healthcare-seeking behavior.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Samantha S. R. Crossfield, Helena Marzo-Ortega, Sarah R. Kingsbury, Mar Pujades-Rodriguez, Philip G. Conaghan
Summary: This study found that the incidence of ankylosing spondylitis decreased between 1998 and 2007, then increased from 2007 to 2017. The rising prevalence may indicate improved patient survival. However, there is a persisting delay in rheumatology referral and diagnosis, particularly in women.
Article
Rheumatology
Reinder Raadsen, Romy Hansildaar, Lianne C. Pouw, Femke Hooijberg, Laura Boekel, Gerrit Jan Wolbink, Arno W. R. van Kuijk, Michael T. Nurmohamed
Summary: This study evaluates the cardiovascular disease risk and prevalence of risk factors in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (SpA). The results show that the traditional cardiovascular risk factors are significantly elevated in these patients compared to healthy controls. However, after adjusting for traditional risk factors, the cardiovascular risk was not increased in these patients.