Review
Oncology
Jen-Hao Yeh, Yung-Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Tsung-Kun Chang, Wei-Chih Su, Jaw-Yuan Wang
Summary: For locally advanced gastric cancer (LAGC), a multimodal approach, including neoadjuvant chemoradiotherapy (NCRT), leads to better long-term prognosis compared to mere surgical resection. NCRT has shown superior disease control and reduced local recurrence, but optimal chemotherapy regimen, patient selection, technical consideration, and potential biomarkers are still under investigation. The comparison of NCRT with neoadjuvant/perioperative chemotherapy is also an important issue to be answered.
Article
Multidisciplinary Sciences
Song Li, Wenbin Yu, Fei Xie, Haitao Luo, Zhimin Liu, Weiwei Lv, Duanbo Shi, Dexin Yu, Peng Gao, Cheng Chen, Meng Wei, Wenhao Zhou, Jiaqian Wang, Zhikun Zhao, Xin Dai, Qian Xu, Xue Zhang, Miao Huang, Kai Huang, Jian Wang, Jisheng Li, Lei Sheng, Lian Liu
Summary: The combination of immune checkpoint inhibitors, antiangiogenesis agents, and chemotherapy showed activity in the neoadjuvant/conversion treatment of cT4a/bN+ gastric cancer. Pathological responses correlated with microsatellite instability status, PD-L1 expression, and tumor mutational burden. Further validation in large randomized trials is warranted.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Zining Liu, Yinkui Wang, Fei Shan, Xiangji Ying, Yan Zhang, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Ziyu Li, Jiafu Ji
Summary: The study found that adjusting treatment based solely on postoperative pathological evaluation may not be enough to effectively treat poor responders among locally advanced gastric cancer patients. Treatment changes require a more careful clinical track and multifaceted assessment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yilin Tong, Yan Zhao, Zexing Shan, Jianjun Zhang
Summary: This study found that CA724 is an independent prognostic factor in locally advanced GC patients undergoing NCT and curative resection, and can be used to predict lymph node metastasis and TNM stage, while AFU, AFP, and CEA showed no association with survival.
Review
Oncology
Anna S. Koerner, Ryan H. Moy, Sandra W. Ryeom, Sam S. Yoon
Summary: Gastric cancer is a common and deadly disease worldwide. Many patients are diagnosed with unresectable advanced disease due to the ambiguous symptoms. However, some patients have locally advanced gastric cancer (LAGC), which can be treated with surgical resection and perioperative chemotherapy. The optimal treatment for LAGC varies for different subtypes, but promising treatments based on molecular subtypes and biomarkers of LAGC are on the horizon.
Review
Biochemistry & Molecular Biology
Yasushi Sato, Koichi Okamoto, Tomoyuki Kawaguchi, Fumika Nakamura, Hiroshi Miyamoto, Tetsuji Takayama
Summary: Neoadjuvant chemotherapy (NAC) is an effective therapeutic option for locally advanced gastric cancer (LAGC), but its therapeutic effect is unpredictable due to tumor heterogeneity and a lack of predictive biomarkers. Researchers are focusing on biomarkers such as metabolic enzymes, nucleotide excision repair, and microsatellite instability, as well as noninvasive liquid biopsy detection methods such as miRNA and exosome detection, to guide the choice of preoperative treatment.
Article
Oncology
Jiayi Zhang, Yanfen Cui, Kaikai Wei, Zhenhui Li, Dandan Li, Ruirui Song, Jialiang Ren, Xin Gao, Xiaotang Yang
Summary: This study developed a model using deep learning algorithm and computed tomography (CT) images to predict neoadjuvant chemotherapy (NACT) resistance in patients with locally advanced gastric cancer (LAGC). The model showed promising performance in both internal and external validation cohorts, outperforming the clinical model.
Article
Oncology
Xin Wang, Dong-Bing Zhao, Lin Yang, Yihebali Chi, Hong Zhao, Li-Ming Jiang, Jun Jiang, Yuan Tang, Ning Li, Wen-Yang Liu, Li-Zhou Dou, Shuang-Mei Zou, Li-Yan Xue, Jian-Song Ren, Yan-Tao Tian, Xu Che, Chun-Guang Guo, Xiao-Feng Bai, Yue-Min Sun, Shu-Lian Wang, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Ye-Xiong Li, Jing Jin
Summary: This study compared the efficacy and safety of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced gastric cancer. The results showed that neoadjuvant chemoradiotherapy resulted in better tumor regression but did not improve the R0 resection rate. There was no significant difference in postoperative complications between the two groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhihao Zhou, Yong Ren, Zhimei Zhang, Tianpei Guan, Zhixiong Wang, Wei Chen, Tedong Luo, Guanghua Li
Summary: This study evaluated a deep learning (DL)-based biomarker derived from histopathological images to predict the pathological response to neoadjuvant chemotherapy in patients with gastric cancer.
Article
Oncology
Yilin Tong, Yanmei Zhu, Yan Zhao, Chengyao Jiang, Wentao Wang, Zexing Shan, Fan Sun, Dong Liu, Jianjun Zhang
Summary: The study found that CA724 is an independent prognostic factor for overall survival (OS) and can be used to predict pathological response. Pre-CA724 and post-CA199 were related to OS, whereas changes in all tumor markers were not associated with OS.
Article
Medicine, General & Internal
Jian-Xian Lin, Yi-Hui Tang, Guan-Jie Lin, Yu-Bin Ma, Jacopo Desiderio, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Amilcare Parisi, Mark J. Truty, Chang-Ming Huang
Summary: This cohort study compares the survival rates of patients with locally advanced gastric cancer who received adjuvant chemotherapy (AC) and those who did not after neoadjuvant chemotherapy followed by surgery. The study found that AC was associated with improved survival in patients with a lymph node ratio of at least 9%. These findings suggest that the lymph node ratio could be useful in AC selection for locally advanced gastric cancer in future decision-making processes.
Article
Oncology
Jing Shen, Xin Lian, Qiu Guan, Lei He, Fuquan Zhang, Jie Shen
Summary: This study investigated the effectiveness and safety of neoadjuvant chemoradiation with image-guided IMRT in patients with locally advanced resectable gastric cancer. The results showed high rates of pathological downstaging, overall survival, and local recurrence-free survival. The method was well-tolerated with acceptable side effects.
Article
Oncology
Jia Wei, Xiaofeng Lu, Qin Liu, Lin Li, Song Liu, Fangcen Liu, Yao Fu, Xiangshan Fan, Yang Yang, Chuang Qi, Yangyang Yu, Wenxian Guan, Baorui Liu
Summary: The combination of PD-1 blockade and chemoradiotherapy as neoadjuvant therapy shows promising results in patients with unresectable locally advanced gastric cancer, with acceptable side effects.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Youqi Zhu, Jiuzhou Chen, Xueqing Sun, Yufei Lou, Miao Fang, Fengjuan Zhou, Lei Zhang, Yong Xin
Summary: This meta-analysis evaluates the efficacy and safety of neoadjuvant chemoradiotherapy compared to neoadjuvant chemotherapy in the treatment of locally advanced gastric cancer. The results show that neoadjuvant chemoradiotherapy significantly improves response rates, pathologic complete response rate, R0 resection rate, and 3-year overall survival rate compared to neoadjuvant chemotherapy. It also has a lower stable disease rate and similar rates of postoperative complications and adverse reactions.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hao Zhong, Tongyu Wang, Mingyu Hou, Xiaodong Liu, Yulong Tian, Shougen Cao, Zequn Li, Zhenlong Han, Gan Liu, Yuqi Sun, Cheng Meng, Yujun Li, Yanxia Jiang, Qinglian Ji, Dapeng Hao, Zimin Liu, Yanbing Zhou
Summary: We aimed to construct and validate a deep learning radiomics nomogram using baseline and restage enhanced computed tomography images and clinical characteristics to predict the response of metastatic lymph nodes to neoadjuvant chemotherapy in locally advanced gastric cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Jen-Hao Yeh, Yung-Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Tsung-Kun Chang, Wei-Chih Su, Jaw-Yuan Wang
Summary: For locally advanced gastric cancer (LAGC), a multimodal approach, including neoadjuvant chemoradiotherapy (NCRT), leads to better long-term prognosis compared to mere surgical resection. NCRT has shown superior disease control and reduced local recurrence, but optimal chemotherapy regimen, patient selection, technical consideration, and potential biomarkers are still under investigation. The comparison of NCRT with neoadjuvant/perioperative chemotherapy is also an important issue to be answered.
Article
Multidisciplinary Sciences
Yi-Ting Chen, Pei-Yu Huang, Jaw-Yuan Wang, Yao-Chang Lee, Chee-Yin Chai
Summary: This study utilized WPK-FTIR imaging to explore the glycosylation differences between neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) in different anatomical locations of the gastrointestinal tract. The results showed that beeswax had greater physisorption than paraplast, indicating higher population of elongated glycans in NETs than adjacent benign mucosa. Moreover, the WPK results of gastric NEN tissue sections demonstrated a higher population of elongated glycans in gastric NET compared to gastric NEC. These findings suggest that WPK-FTIR imaging has potential as an alternative diagnostic method for gastrointestinal NENs.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yi-Jung Huang, Ming-Yii Huang, Tian-Lu Cheng, Shih-Hsun Kuo, Chien-Chih Ke, Yi-Ting Chen, Yuan-Chin Hsieh, Jaw-Yuan Wang, Chiu-Min Cheng, Chih-Hung Chuang
Summary: This study investigated the functionality and stability of ERCC1 using the Tet-on gene expression system. The results showed that overexpression of ERCC1 increased radioresistance in colorectal cancer cells and was highly correlated with radiotherapeutic efficiency. Furthermore, ERCC1 overexpression also promoted cell migration under radiation exposure. Additional experiments confirmed the increased cancer radiation resistance associated with ERCC1 overexpression. Therefore, ERCC1 overexpression may serve as a prognostic marker for colorectal cancer patients undergoing concurrent chemoradiotherapy.
Article
Oncology
Ching-Wen Huang, Po-Li Wei, Chien-Chih Chen, Li-Jen Kuo, Jaw-Yuan Wang
Summary: This retrospective observational study evaluated the perioperative and short-term oncological outcomes of robotic-assisted rectal surgery (RRS) in hospitals with a high-volume of robotic-assisted surgeries. The results showed equivalent or superior perioperative and short-term oncological outcomes compared to other studies, indicating that RRS is an effective, safe, and feasible technique for patients with rectal cancers in high-volume hospitals.
Review
Cell Biology
Jen-Pin Chuang, Hsiang-Lin Tsai, Po-Jung Chen, Tsung-Kun Chang, Wei-Chih Su, Yung-Sung Yeh, Ching-Wen Huang, Jaw-Yuan Wang
Summary: Despite global screening programs, colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide. Locally advanced colon cancer (LACC) presents surgical challenges, and the advantages and disadvantages of preoperative radiotherapy for LACC are still undetermined. While several reliable biomarkers have been proposed for CRC prediction and prognosis, few studies have focused on the treatment of LACC. This comprehensive review highlights the role of predictive biomarkers in the treatment and postoperative oncological outcomes of LACC, as well as discusses the emerging needs and approaches for the discovery of biomarkers to facilitate the development of new therapeutic targets and surveillance of LACC patients.
Review
Pathology
Yung-Sung Yeh, Hsiang-Lin Tsai, Po-Jung Chen, Yen-Cheng Chen, Wei-Chih Su, Tsung-Kun Chang, Ching-Wen Huang, Jaw-Yuan Wang
Summary: Colorectal cancer is a leading cause of death, and chemotherapy with or without targeted therapy is the standard treatment. Immune checkpoint inhibitors can be effective in a small portion of microsatellite instability-high colorectal cancer cases, but this represents only 5% of metastatic cases. Research on immunotherapy is uncovering mechanisms of immune resistance in colorectal cancer patients and discovering new biomarkers.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Biotechnology & Applied Microbiology
Ching-Wen Huang, Huang-Ming Hu, Wen-Hung Hsu, Chiao-Yun Chen, Ming-Yii Huang, Chou-Pin Chen, Po-Li Wei, Bor-Nian Shen, Jaw-Yuan Wang
Summary: This study aims to investigate the safety profile, dose-limiting toxicity, and antitumor activity of PEP503 (NBTXR3) nanoparticles with radiotherapy and chemotherapy in patients with locally advanced or unresectable rectal cancer. Patients will receive a single intratumoral injection of the nanoparticles, followed by radiotherapy and concurrent intravenous infusion of fluorouracil or oral capecitabine. The study design includes an escalation phase and an expansion phase to determine the efficacy and safety of this treatment approach.
Review
Oncology
Jen-Hao Yeh, Cheng-Hao Tseng, Wen-Lun Wang, Chih- Chen, Yu-Peng Liu, Yi-Chia Lee, Jaw-Yuan Wang, Yu-Ching Lin
Summary: The incidence of early-onset colorectal cancer (CRC) is increasing, and current guidelines recommend starting screening at age 45. This study examined the use of fecal immunochemical tests (FITs) to detect advanced colorectal neoplasms (ACRNs) in individuals aged 40-49. The results showed that FIT can effectively identify high-risk individuals with advanced colorectal lesions, suggesting it may be a suitable first-line screening tool for this age group.
Review
Oncology
I-Ping Yang, Kwan-Ling Yip, Yu-Tang Chang, Yen-Cheng Chen, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Jaw-Yuan Wang
Summary: It takes nearly two decades for a cancer lesion to develop from normal colon mucosa, but most colorectal cancer patients are at advanced stages at diagnosis. Chemotherapy, targeted therapy, and radiotherapy can improve the prognosis, but therapy resistance is common, and survival rates remain poor for patients with locally advanced or metastatic colorectal cancer. MicroRNAs (miRs) can regulate cancer pathways and serve as predictive biomarkers for detecting cancer or resistance to treatment. MiRNA-based therapeutics may reach clinical stages.
Article
Oncology
Hsiang-Lin Tsai, Chun-Chi Lin, Yung-Chung Sung, Shang-Hung Chen, Li-Tzong Chen, Jeng-Kai Jiang, Jaw-Yuan Wang
Summary: This study aimed to investigate the prevalence of RAS mutations detected in ctDNA and examine the role of RAS ctDNA status in detecting tumor response and predicting the benefit of anti-EGFR therapy. The detection rate of RAS mutations during treatment was found to be 9.3%, occurring a median of 3 months prior to radiologic documentation. Patients with RAS mutations had significantly inferior progression-free survival and overall survival.
BRITISH JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Yu-Tang Chang, Chou-Chen Chen, Shih-Ching Chang, Yu-Yao Chang, Bo-Wen Lin, Hong-Hwa Chen, Yao-Yu Hsieh, Hung-Chih Hsu, Meng-Che Hsieh, Feng-Che Kuan, Chih-Chien Wu, Wei-Chen Lu, Yu-Li Su, Yi-Hsin Liang, Joe-Bin Chen, Shuan-Yuan Huang, Ching-Wen Huang, Jaw-Yuan Wang
Summary: This study investigated the efficacy and safety of a supplemental home parenteral nutrition (HPN) program for patients with RAS wild-type metastatic colorectal cancer (mCRC) receiving cetuximab plus chemotherapy. The HPN program group showed higher metastasectomy rate, longer duration of treatment and response, and improved progression-free survival (PFS) and overall survival (OS) compared to the non-HPN program group. These findings suggest that supplemental HPN programs may improve oncological outcomes in select patients with mCRC receiving targeted therapy plus chemotherapy.
Article
Oncology
Huei-Jen Chen, Yi-An Cheng, Yu-Tung Chen, Chia-Ching Li, Bo-Cheng Huang, Shih-Ting Hong, I. -Ju Chen, Kai-Wen Ho, Chiao-Yun Chen, Fang-Ming Chen, Jaw-Yuan Wang, Steve R. Roffler, Tian-Lu Cheng, Dung-Ho Wu
Summary: Modification of PLD with CD20-specific mPEG x CD20 enhances the internalization and anti-cancer efficacy of PEG-NPs, improving therapeutic efficacy.
CANCER NANOTECHNOLOGY
(2023)
Article
Oncology
Hsiang-Lin Tsai, Yung-Sung Yeh, Po-Jung Chen, Yu-Tang Chang, Yen-Cheng Chen, Wei-Chih Su, Tsung-Kun Chang, Ching-Wen Huang, Jaw-Yuan Wang
Summary: Patients with LARC taking LMF as a supplement to neoadjuvant CCRT showed improved quality of life, reduced skin rash and itching, fatigue, and improved gut microbiota composition.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Surgery
A. C. Lynch, J. Ngu, S. S. M. Ng, S. Tsukamoto, A. Shiomi, X. Lai, J. Y. Wang, T. Scoble
Summary: This study examines the opinions of colorectal surgeons in the Asia-Pacific region on robotic surgery. The survey identified consensus statements related to patient positioning, docking, and table placement, and developed five recommendations based on the responses. The results demonstrate the recognition and acceptance of robotic surgery technology among colorectal surgeons in the Asia-Pacific region, highlighting the potential for further improvements in surgical outcomes.
JOURNAL OF ROBOTIC SURGERY
(2023)
Article
Cell Biology
Chia-Hui Lo, Deng-Chyang Wu, Shu-Wen Jao, Chang-Chieh Wu, Chung-Yen Lin, Chia-Hsien Chuang, Ya-Bo Lin, Chien-Hsiun Chen, Ying-Ting Chen, Jiann-Hwa Chen, Koung-Hung Hsiao, Ying-Ju Chen, Yuan-Tsong Chen, Jaw-Yuan Wang, Ling-Hui Li
Summary: This study identified the overrepresentation of Prevotella intermedia in colorectal adenocarcinoma tissues and its role in enhancing migration and invasion abilities of CRC cells. The co-abundance of P. intermedia and F. nucleatum in tumor tissues was associated with lymph node involvement and distant metastasis, with additive effects on CRC cell migration and invasion. These findings could help identify patients at high risk for malignant transformation of colorectal adenomas or metastasis of CRC for optimal clinical management.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)