Article
Biophysics
Yamini Bobde, Tarun Patel, Milan Paul, Swati Biswas, Balaram Ghosh
Summary: Polymeric micelles composed of mPEG-b-HPMA copolymer were studied for delivering DOX effectively. The optimized micelle P6-M1 showed small particle size, high drug loading, and promising anticancer effects in breast cancer cell lines. This study demonstrated the potential of mPEG-b-HPMA micelles as a nanomedicine for breast cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Sarita Rani, Umesh Gupta
Summary: The study successfully synthesized three conjugates of HPMA and PCL using a simple and robust synthetic strategy. The results indicate potential applications in the preparation of blends, fibers, etc., and suggest that the explored synthetic scheme could be a suitable approach for the synthesis of HPMA and PCL conjugates in the future.
Article
Biochemistry & Molecular Biology
Ceren Cokca, Franz J. Hack, Daniel Costabel, Kira Herwig, Juliana Huelsmann, Patrick Then, Rainer Heintzmann, Dagmar Fischer, Kalina Peneva
Summary: This study describes the shielding of a high performing terpolymer using block copolymerization with various molecular weights of P(MEO(9)MA) and investigates its influence on cytotoxicity, pDNA binding, and transfection efficiency. The results show that higher molecular weight P(MEO(9)MA) blocks exhibit excellent biocompatibility and efficient transfection efficiency.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Instruments & Instrumentation
Yi Wen, Zhimei Song, Hongmei Xu, Sijia Feng, Li Zhu, Fangfang Teng, Runliang Feng
Summary: The study prepared new polymeric micelles loaded with azithromycin to enhance its solubility and evaluate its antibacterial activity against Staphylococcus aureus. The micelles showed good in vitro and in vivo antibacterial effects, demonstrating their potential as a candidate for treating Staphylococcus aureus infections.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Polymer Science
Gabriela S. Garcia-Briones, Richard Laga, Zulfiya Cernochova, Carely Arjona-Ruiz, Olga Janouskova, Miroslav Slouf, Ognen Pop-Georgievski, Dana Kubies
Summary: Polyelectrolyte nanoparticles (NPs) have been investigated as carriers for protein delivery. The formation of these NPs was studied using a newly synthesized polycationic diblock copolymer and heparin without the use of additives. The encapsulation of heparin-binding proteins achieved high entrapment efficiency and increased protein stability. The released proteins exhibited sustained release and preserved bioactivity. The NPs showed noncytotoxic performance, making them promising candidates for controlled delivery of bioactive proteins in biomedical applications.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Chemistry, Physical
Daniel Horak, Karolina Turnovcova, Zdenek Plichta, Dana Marekova, Vladimir Proks, Radek Kaiser, David Netuka, Pavla Jendelova
Summary: In this study, a block copolymer consisting of PHP and PMAH was synthesized and conjugated with Dox and/or RGDS targeting peptide to create nanoparticles that can reduce glioblastoma tumor growth. The nanoparticles were found to effectively decrease tumor size and induce more apoptosis in treated cells compared to untreated cells.
COLLOID AND POLYMER SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yamini Bobde, Milan Paul, Tarun Patel, Swati Biswas, Balaram Ghosh
Summary: Delivery of combination chemotherapeutic agents to tumors using nanovesicles shows promise for enhanced tumor suppression and reduced toxicity. These novel micelles exhibit improved anti-tumor efficacy and cytotoxicity, with higher induction of apoptosis and cellular arrest in G2 and S phase compared to traditional drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Zemin Hou, Wencheng Zhou, Xi Guo, Rui Zhong, Ao Wang, Jiehua Li, Ying Cen, Chao You, Hong Tan, Meng Tian
Summary: This study investigates the drug delivery system of clinically relevant micelles composed of methoxypolyethylene glycol (MPEG) with identical chain length and poly(epsilon-caprolactone) (PCL) with tunable chain length. The results show that the micelles have negligible effects on blood components, phagocytosis, and biodistribution. The stability of the micelles plays an important role in biodistribution.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Polymer Science
Russul Mamdooh Al-Nakashli, Cheng Cao, Radhika Raveendran, Hongxu Lu, Martina H. Stenzel
Summary: Polymeric micelles with different drug loading contents were studied to investigate their cellular uptake, penetration, and effects on biological activities. The results showed that micelles with high drug loading content exhibited higher cellular uptake and toxicity.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Pharmacology & Pharmacy
Xiangjun Meng, Zhi Zhang, Jin Tong, Hui Sun, John Paul Fawcett, Jingkai Gu
Summary: The in vivo fate of PEG-PLA was investigated in rats, showing that PEG-PLA is mainly excreted in urine as its PEG metabolite. This will help facilitate the scientific design and safety evaluation of PEG-PLA-based nanocarrier drug delivery systems.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Materials Science, Multidisciplinary
Kohei Sano, Koki Umemoto, Haruka Miura, Satoshi Ohno, Kyohei Iwata, Rin Kawakami, Masayuki Munekane, Toshihide Yamasaki, Daniel Citterio, Yuki Hiruta, Takahiro Mukai
Summary: Poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) was investigated as a potential drug carrier for tumor diagnosis. Different derivatives of POEGMA with varying molecular weights and side chain lengths were synthesized and labeled with radioisotopes or fluorescence dyes. The results showed that the POEGMA derivatives were efficiently taken up by tumor cells and exhibited high accumulation in tumor tissues. In vivo fluorescence imaging using optimized POEGMA derivatives confirmed their suitability as drug carriers for sensitive tumor diagnosis.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Biomaterials
Anna Adler, Yuuki Inoue, Yuya Sato, Kazuhiko Ishihara, Kristina N. Ekdahl, Bo Nilsson, Yuji Teramura
Summary: The study demonstrates that PMPC-lipids can be used for liposomal coating, suppressing the adsorption of albumin, C3, and fibrinogen, and potentially serving as an alternative to PEG.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ozlem Gokce Kocabay, Osman Ismail
Summary: In this study, doxorubicin (DOX) loaded polymeric micelles (PMs) with high drug-loading encapsulation efficiency and pH-dependent drug release were successfully synthesized. The co-encapsulation of two agents led to enhanced solubility compared to DOX loaded formulations (DOX-PMs).
Article
Biochemistry & Molecular Biology
Irina M. Le-Deygen, Oxana E. Musatova, Victor N. Orlov, Nikolay S. Melik-Nubarov, Irina D. Grozdova
Summary: This study provides the first evidence of the interaction between PEG and HA in aqueous solutions. The binding of PEG to HA requires multiple free primary hydroxyls regularly distributed along the polysaccharide chain. Additionally, PEG-induced compaction of HA may be related to changes in plasma membrane properties and resealing of mechanical injuries.
