Article
Environmental Sciences
Lingyun Zhu, Pingping Cao, Suisui Yang, Fan Lin, Jing Wang
Summary: This study reveals the molecular mechanisms of MC-LR-induced brain damage, highlighting the activation of the Erk/MAPK signaling pathway and ferroptosis. These findings provide valuable insights into the neurotoxicity of MC-LR and potential strategies for prevention of MC-induced neurodegenerative diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Zhengqiang Hu, Guanmin Meng, Lejun Zhang, Meng Zhang, Huashun Cui, Huifang Tang
Summary: This study investigated the potential of Huanglianjiedu Decoction (HLJD) in counteracting the neurotoxic effects induced by MC-LR. Results showed that HLJD effectively reversed the cytotoxicity caused by MC-LR in PC 12 cells and attenuated MC-LR-induced neuronal damage while improving learning ability in mice. These findings highlight HLJD as a promising protective strategy against MC-LR-induced neurological injury.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Xiaodong Ling, Junli Zuo, Meiqi Pan, Hongyan Nie, Jianzhong Shen, Qing Yang, Tien-Chieh Hung, Guangyu Li
Summary: The accumulation of nanoplastics exacerbates the toxic effects of microcystin on the liver of zebrafish, leading to cellular damage and oxidative stress. The presence of nanoplastics enhances the bioavailability of microcystin in the liver and alters the levels of reactive oxygen species, malondialdehyde, glutathione, and catalase, exacerbating the oxidative stress response.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Yu Zhang, Zheyu Li, Xing Tian, Pianpian Xu, Kai Sun, Nanqi Ren
Summary: This study investigates the toxic effects of MC-LR on crayfish. The results show that MC-LR can effectively accumulate in the hepatopancreas, gills, and intestines of crayfish. Antioxidant-related genes show different expressions in response to MC-LR-induced oxidative stress. MC-LR also leads to histological changes and disruptions in the intestinal flora of crayfish. These findings provide new insights into the toxic impacts of microcystins on aquatic crustaceans.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Joshua D. Breidenbach, Benjamin W. French, Tamiya T. Gordon, Andrew L. Kleinhenz, Fatimah K. Khalaf, James C. Willey, Jeffrey R. Hammersley, R. Mark Wooten, Erin L. Crawford, Nikolai N. Modyanov, Deepak Malhotra, Justin G. Teeguarden, Steven T. Haller, David J. Kennedy
Summary: This study found that exposure of human airway epithelium to MC-LR-containing aerosols can induce an inflammatory response that may worsen acute or chronic diseases.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Eun-Ji Won, Dokyun Kim, Je-Won Yoo, Soyeon In, Kyung-Hoon Shin, Young -Mi Lee
Summary: The experimental results showed that the brackish water flea exposed to the cyanobacteria toxin MC exhibited antioxidant responses at the molecular and enzyme levels, but no acute toxicity. The brackish water flea exposed to algal blooms could absorb and accumulate MC, with a significant increase in MC content in the body after exposure.
MARINE POLLUTION BULLETIN
(2021)
Article
Toxicology
F. Shahid, Z. Farooqui, T. Alam, S. Abidi, I Parwez, F. Khan
Summary: The study demonstrates that TQ has a protective effect against CP-induced hepatotoxicity and can alleviate the adverse effects of CP on liver function in rats.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Yue Yang, Shuilin Zheng, Hanyu Chu, Can Du, Mengshi Chen, Mohammed Y. Emran, Jihua Chen, Fei Yang, Li Tian
Summary: The objective of this study was to determine the effect and the mechanism of subchronic MC-LR toxicity on preexisting diet-induced colorectal damage. The results showed that MC-LR may cause colorectal inflammation and barrier disruption by stimulating the Raf/ERK signaling pathway. The study suggests that MC-LR treatment may exacerbate the colorectal toxicity caused by an HFD.
Article
Engineering, Environmental
Shaofeng Xu, Lingyue Zhang, Kaizong Lin, Miao Bai, Yue Wang, Mengyao Xu, Minglu Zhang, Can Zhang, Yun Shi, He Zhou
Summary: The study found that light intensity and water disturbance have significant effects on the growth of Microcystis aeruginosa and the release of algal toxins. High light intensity and water disturbance inhibit algal growth, but optimal conditions for algal growth may not be conducive to toxin release. Enzyme indicators are correlated with both the release of algal toxins and the growth of algal cells.
WATER ENVIRONMENT RESEARCH
(2021)
Article
Chemistry, Medicinal
Mohamed Aboubakr, Said M. Elshafae, Ehab Y. Abdelhiee, Sabreen E. Fadl, Ahmed Soliman, Afaf Abdelkader, Mohamed M. Abdel-Daim, Khaled A. Bayoumi, Roua S. Baty, Enas Elgendy, Amira Elalfy, Bodour Baioumy, Samah F. Ibrahim, Ahmed Abdeen
Summary: The study demonstrated that thymoquinone and/or lycopene showed significant protective effects against chlorpyrifos-induced neurotoxicity, likely through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
Article
Pharmacology & Pharmacy
Leila Ait Abderrahim, Khaled Taibi, Mohamed Boussaid, Baker Al-Shara, Nawel Ait Abderrahim, Sabrina Ait Abderrahim
Summary: The study demonstrated the effectiveness of garlic extract as an antioxidant against oxidative damages induced by MC-LR, supporting garlic as a potential remedy against pathologies related to toxic agents.
Article
Integrative & Complementary Medicine
Gholam-Hassan Danaei, Arian Amali, Mohammad Karami, Mohammad-Bagher Khorrami, Bamdad Riahi-Zanjani, Mahmood Sadeghi
Summary: This study aimed to evaluate the protective effects of thymoquinone (TQ) against diazinon (DZN)-induced hepatotoxicity and found that the antioxidant and free radical scavenging properties of TQ may be associated with its ability to alleviate oxidative stress and enhance cholinesterase enzyme activity. In addition, it was observed that TQ could improve DZN-induced liver pathological alterations, increase the activity of acetylcholinesterase, butyrylcholinesterase, and superoxide dismutase enzymes, and reduce malondialdehyde levels.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Abdullah M. Alnuqaydan, Abdulmajeed G. Almutary, Mohammed A. Alsahli, Sulaiman Alnasser, Bilal Rah
Summary: This study evaluates the hepatoprotective activity of a Tamarix articulata extract against carbon tetrachloride-mediated hepatotoxicity in Wistar rats. The results demonstrate that the extract restores liver enzyme and antioxidant levels, reduces hepatic fibrosis and necrosis of hepatocytes, and restores pro-inflammatory markers to normal levels. These findings suggest that Tamarix articulata extract prevents liver fibrosis and decreases hepatocyte necrosis induced by carbon tetrachloride.
Article
Environmental Sciences
Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min Hu
Summary: Neurotoxicity caused by environmental lead (Pb) pollution is a global concern. In this study, the role of TREM2 in Pb-induced neuroinflammation was investigated using cell culture experiments and animal models. It was found that TREM2 regulates the anti-inflammatory functions of microglia and alleviates Pb-induced neuroinflammation. The activation of TREM2 may represent a potential therapeutic strategy against environmental Pb-induced neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Fisheries
Yong Shi, Lei Zhong, Yuding Fan, Junzhi Zhang, Jihong Dai, Huan Zhong, Guihong Fu, Yi Hu
Summary: The study demonstrated that taurine can alleviate oxidative stress, inflammation, apoptosis, and autophagy in rice field eel induced by hydrogen peroxide. The addition of taurine has a better effect on reducing liver damage.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Correction
Chemistry, Physical
G. Gnanamoorthy, P. Priya, Daoud Ali, M. Lakshmi, Virendra Kumar Yadav
CHEMICAL PHYSICS LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Saad Alkahtani, Norah S. S. AL-Johani, Saud Alarifi
Summary: Neurodegenerative diseases (NDs) are a major cause of disability and are related to brain development. The neurological signs of brain lesions can vary from mild clinical shortfalls to more delicate and severe neurological/behavioral symptoms and learning disabilities, which are progressive. In this paper, we have tried to summarize a collective view of various NDs and their possible therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Evolutionary Biology
Hafiz Ishfaq Ahmad, Laraib Jameel, Quratulain Zahra, Jiabin Zhou, Linmiao Li, Xiujuan Zhang, Shakeel Ahmed, Daoud Ali, Gokhlesh Kumar, Aleena Safdar, Farhan Abbas, Jinping Chen
Summary: This study examines the molecular evolution of the IFN epsilon pseudogene in Manis javanica and its role in modulating the innate and specific antiviral immunity in this species. It finds evidence of positive selection in the human and primate IFN epsilon genes, suggesting their importance in the evolution of the immune system. Comparative genomic analysis reveals that the IFN epsilon pseudogene in pangolins originated from a gene duplication event and has lost its protein-coding function, but it may still play a regulatory role in antiviral immunity.
JOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH
(2023)
Article
Environmental Sciences
Kumar Pandion, Kantha Deivi Arunachalam, Rajinikanth Rajagopal, Daoud Ali, Saud Alarifi, Soon Woong Chang, Balasubramani Ravindran
Summary: The distribution of heavy metals in seafood intake was studied in the Kalpakkam coastal region. The average concentrations of heavy metals in 40 different fish species were determined. Zinc and copper were found to have higher bioaccumulation index and metal pollution index. Risk assessment calculations showed high values for different age groups. However, the cancer risk did not exceed recommended limits in the region.
MARINE POLLUTION BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Partha Biswas, Shabana Bibi, Qudsia Yousafi, Asim Mehmood, Shahzad Saleem, Awais Ihsan, Dipta Dey, M. D. Nazmul Hasan Zilani, M. D. Nazmul Hasan, Rasha Saleem, Aeshah A. Awaji, Usama A. Fahmy, Mohamed M. Abdel-Daim
Summary: An onco-informatics-based evaluation was conducted to assess the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer. The study analyzed the differential expression of MDM2 and searched for mutations and copy number variations. Several transcriptome servers and bioinformatics tools were used to determine the survival rate and protein interactions related to the MDM2 gene in LGG cancer patients.
Article
Environmental Sciences
Nisha Choudhary, Virendra Kumar Yadav, Huma Ali, Daoud Ali, Bader O. O. Almutairi, Simona Cavalu, Ashish Patel
Summary: The authors developed a halloysite clay/zinc oxide nanocomposite with photocatalytic activity and high surface area, and demonstrated its efficient removal of methylene blue from aqueous solutions.
Article
Plant Sciences
Anil Patani, Dharmendra Prajapati, Daoud Ali, Haresh Kalasariya, Virendra Kumar Yadav, Jigna Tank, Snehal Bagatharia, Madhvi Joshi, Ashish Patel
Summary: The aim of this research was to isolate halotolerant plant growth promoting Bacillus sp. to promote tomato growth and salt stress resistance. Five selected bacterial strains showed plant growth promoting abilities and improved tomato germination, seedling growth, plant height, dry weight, leaf area, as well as enhanced tolerance to salt stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Energy & Fuels
Mahwash Mahar Gul, Khuram Shahzad Ahmad, Andrew Guy Thomas, Daoud Ali
Summary: Spin coating with a single source precursor was used to produce a transparent conductive electrode for a photoelectrochemical cell. Yb2S3:Cu2S:ZnS composite with a crystallite size of 44 nm was discovered using X-ray diffraction analysis. The composite was found to have an optical bandgap of 2.49 eV and comprised Yb, Cu, Zn, and S. Electrical investigations in a photoelectrochemical cell showed that the photocurrent density of the electrode was higher under light and the specific capacitance increased at all scan rates under illumination. The study introduced a useful photoelectrode for renewable energy systems.
Editorial Material
Neurosciences
Dragica Selakovic, Daoud Ali, Aziz Eftekhari, Nemanja Jovicic, Gvozden Luka Rosic
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Md. Abdul Mannan, Amir Yasmin, Umakanta Sarker, Nasimul Bari, Dipanjoli Baral Dola, Hirokazu Higuchi, Sezai Ercisli, Daoud Ali, Saud Alarifi
Summary: Using water extracts of the red seaweed Gracilaria tenuistipitata var. liui as a biostimulant can improve soybean growth and yield, and alleviate the adverse effect of drought stress.
Article
Biochemistry & Molecular Biology
Muhammad Zahid Khan, Abul Kalam Azad, Saleem Jan, Muhammad Safdar, Shabana Bibi, Amin Malik Shah Abdul Majid, Ghadeer M. Albadrani, Nehal Ahmed Talaat Nouh, Jawaher A. Abdulhakim, Mohamed M. Abdel-Daim
Summary: The essential oil of Urtica dioica L. whole plant was evaluated for its antioxidant, phytotoxic, and antibacterial activities using GC-MS technique. The analysis identified various constituents and demonstrated potential antioxidant effects and antibacterial activity against selected pathogens. Protein-ligand docking study further correlated docking results with experimental analysis and provided insight for further investigation.
Article
Environmental Sciences
Ali B. Jebur, Raghda A. El-Sayed, Mohamed M. Abdel-Daim, Fatma M. El-Demerdash
Summary: The study aimed to investigate the protective effects of pomegranate peel extract (PGPE) against testicular toxicity and oxidative stress induced by fenpropathrin (FNP). The results showed that PGPE exerted significant protective effects against oxidative stress and toxicity in the testes of rats, indicating its potential antioxidant activity.
Editorial Material
Multidisciplinary Sciences
Nikita Maruti Gaikwad, Pravin Digambar Chaudhari, Karimunnisa Sameer Shaikh, Somdatta Yashwant Chaudhari, Rasha Mohammed Saleem, Mohammad Algahtani, Ahmed E. Altyar, Ghadeer M. Albadrani, Mohamed Kamel, Mohamed M. Abdel-Daim
Summary: Drug repurposing is the process of discovering new activity for existing drugs. This study investigates the interaction of Albendazole, a well-known antihelmintic drug, with the tyrosine kinase protein receptor VEGFR-2. The findings suggest that Albendazole has potential as a potent angiogenesis inhibitor and could aid in the development of anticancer therapies.
Correction
Environmental Sciences
Eman A. Alwaleed, Mostafa El-Sheekh, Mohamed M. Abdel-Daim, Hani Saber
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)