Journal
ORGANIC LETTERS
Volume 21, Issue 9, Pages 3276-3280Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01002
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Funding
- Ministere de l'Education Nationale, de l'Enseignement Superieur et de la Recherche (MENESR)
- Centre National de la Recherche Scientifique (CNRS)
- China Scholarship Council (CSC)
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Enantioenriched cis-3-(hydroxymethyl)-chroman-4-ol derivatives were conveniently prepared by rhodium-catalyzed asymmetric transfer hydrogenation of 3-formylchromones through a dynamic kinetic resolution process. The reaction proceeded under mild conditions using a low catalyst loading and HCO2H/Et3N (5:2) as the hydrogen source, delivering the reduced compounds in good yields, high diastereomeric ratio (up to 98:2 dr), and excellent enantioselectivities (up to >99% ee).
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