Fundamental limit of detection of photonic biosensors with coherent phase read-out

Photonic biosensors offer label-free detection of biomolecules for applications ranging from clinical diagnosis to food quality monitoring. Both sensors based on Mach-Zehnder interferometers and ring resonators are widely used, but are usually read-out using different schemes, making a direct comparison of their fundamental limit of detection challenging. A coherent detection scheme, adapted from optical communication systems, has been recently shown to achieve excellent detection limits, using a simple fixed-wavelength source. Here we present, for the first time, a theoretical model to determine the fundamental limit of detection of such a coherent read-out system, for both interferometric and resonant sensors. Based on this analysis, we provide guidelines for sensor optimization in the presence of optical losses and show that interferometric sensors are preferable over resonant structures when the sensor size is not limited by the available sample volume. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement