Article
Endocrinology & Metabolism
Ilse Wieland, Ina Schanze, Ina Marianti Felgendreher, Winfried Barthlen, Silke Vogelgesang, Klaus Mohnike, Martin Zenker
Summary: This study found that paternal UPD on the short arm of chromosome 11 is the major second genetic event specifically within focal lesions of CHI, leading to LOH and monoallelic expression of the mutated ABCC8/KCNJ11 alleles. Additionally, upregulation of growth promoting gene ASCL2 and downregulation of growth suppressing genes CDKN1C and H19 were observed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Na Zhang, Jie Zhang, Zhihong Liu, Tushuai Li
Summary: This study utilized ChIP-seq data to analyze the gene transcription regulation network of ASCL1 in GBM and identified EGFR, SPTAN1, and CTNN1B as potential downstream genes in GBM development.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Kazuma Iida, Kensuke Suga, Kotaro Suzuki, Shunjiro Kurihara, Yoko Yabe, Takahiro Kageyama, Kazuyuki Meguro, Shigeru Tanaka, Arifumi Iwata, Akira Suto, Hiroshi Nakajima
Summary: The study found that Achaete-scute complex homolog 2 (Ascl2) is highly and preferentially expressed in CD25+ and CD25- T follicular regulatory (Tfr) cells. The absence of Ascl2 impairs the differentiation from CD25+ Tfr cells to CD25- Tfr cells. Additionally, forced expression of Ascl2 in regulatory T (Treg) cells downregulates CD25 expression and suppresses IL-2-induced phosphorylation of STAT5, which inhibits the development of CD25- Tfr cells. These findings suggest that Ascl2 plays a vital role in Tfr cell development by downregulating CD25 expression in a Bach2-independent mechanism.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Yuko Iida, Yoko Nakanishi, Tetsuo Shimizu, Masayuki Nomoto, Yoshiko Nakagawa, Reiko Ito, Noriaki Takahashi, Shinobu Masuda, Yasuhiro Gon
Summary: This study aimed to investigate the relationship between genetic alterations and histological components in combined small-cell lung cancer (cSCLC) and metachronously transformed small-cell lung cancer (mtSCLC). The study found that the most common somatic mutations in both SCLC and NSCLC components were TP53, RB1, and EGFR. Additionally, gene expression analysis revealed significantly lower expression of ASCL1 in the NSCLC component.
Article
Oncology
Greta Ali, Iose Di Stefano, Anello Marcello Poma, Stefano Ricci, Agnese Proietti, Federico Davini, Marco Lucchi, Franca Melfi, Gabriella Fontanini
Summary: Research showed high prevalence of DLL3 expression in high-grade lung NET patients, associated with aggressive clinicopathological features, suggesting its potential as a useful biomarker for target therapy in high-grade tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiawei Nie, Peng Zhang, Chaoqi Liang, Ying Yu, Xinghuan Wang
Summary: Neuroendocrine prostate cancer (NEPC) is a highly resistant variant of prostate cancer that often develops in castration-resistant prostate cancer. The mechanisms underlying the trans-differentiation from CRPC to NEPC have not been clarified.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Justyna A. Janas, Lichao Zhang, Jacklyn H. Luu, Janos Demeter, Lingjun Meng, Samuele G. Marro, Moritz Mall, Nancie A. Mooney, Katie Schaukowitch, Yi Han Ng, Nan Yang, Yuhao Huang, Gernot Neumayer, Or Gozani, Joshua E. Elias, Peter K. Jackson, Marius Wernig
Summary: This study reveals the role of Tip60 acetyltransferase in inducing neuronal cell fate. The researchers found that Tip60 acetyltransferase establishes neuronal cell identity partly through acetylation of the histone variant H2A.Z. Additionally, they discovered that H2A.Z acetylation regulates epigenetic competence for bivalent gene activation and cell lineage transition.
Article
Multidisciplinary Sciences
Jun W. Kim, Julie H. Ko, Julien Sage
Summary: This study investigates the role of tumor heterogeneity in small-cell lung cancer (SCLC) and identifies DLL3 as a biomarker of neuroendocrine state and a regulator of cell-cell interactions in SCLC.
Review
Oncology
Weichang Yang, Wenjun Wang, Zhouhua Li, Juan Wu, Xiaotian Huang, Jinbo Li, Xinyi Zhang, Xiaoqun Ye
Summary: Small cell lung cancer is a highly invasive and aggressive type of lung cancer with limited treatment options. Delta-like ligand 3 (DLL3) is overexpressed on the surface of SCLC cells and is considered a potential target for SCLC treatment. Several drug trials targeting DLL3 are currently underway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Medicine, General & Internal
Christiane Kuempers, Tobias Jagomast, Rosemarie Krupar, Finn-Ole Paulsen, Carsten Heidel, Julika Ribbat-Idel, Christian Idel, Bruno Maerkl, Martin Anlauf, Sabina Berezowska, Markus Tiemann, Hans Boesmueller, Falko Fend, Barbara Kalsdorf, Sabine Bohnet, Eva Dreyer, Verena Sailer, Jutta Kirfel, Sven Perner
Summary: Rovalpituzumab tesirine (Rova-T), an antibody-drug conjugate targeting DLL3, is being developed for SCLC. DLL3 expression was found in the majority of chemonaive and chemorelapsed SCLC samples, with variations in expression levels. Although DLL3 expression did not correlate significantly with clinicopathological data, high DLL3 expression in chemorelapsed samples showed a trend towards better prognosis.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Benjamin J. Drapkin, Charles M. Rudin
Summary: In recent years, there has been a renewed interest in the biology and therapeutic vulnerabilities of small-cell lung cancer (SCLC), leading to the development of diverse models and translational research avenues. These offer new hope for patients with SCLC by combining mechanism-based preclinical and clinical research.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Developmental Biology
Georg Brenneis, Martin Schwentner, Gonzalo Giribet, Barbara S. Beltz
Summary: The study focused on the embryonic expression patterns in the crayfish Procambarus virginalis, revealing similarities in neurogenesis with insects and other crustaceans. Interestingly, the research suggested a neuroblast-independent phase of brain neurogenesis in the crayfish head region. The findings provide a promising starting point for further embryonic studies and molecular genetic characterization of subregions and cell types in the adult crayfish brain.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Review
Oncology
Charles M. M. Rudin, Martin Reck, Melissa L. L. Johnson, Fiona Blackhall, Christine L. L. Hann, James Chih-Hsin Yang, Julie M. M. Bailis, Gwyn Bebb, Amanda Goldrick, John Umejiego, Luis Paz-Ares
Summary: Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine carcinoma with limited treatment options. DLL3, a Notch inhibitory ligand, is overexpressed on SCLC cells, making it an attractive therapeutic target. This article discusses the clinical experience with a DLL3-targeting antibody-drug conjugate called Rova-T, as well as other DLL3-targeting agents currently in development, including T-cell engager molecules and CAR T-cell therapy. The challenges and opportunities for DLL3-targeting therapies, such as using DLL3 as a biomarker and exploring combinatorial approaches, are also discussed.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Kathryn M. Tully, Salomon Tendler, Lukas M. Carter, Sai Kiran Sharma, Zachary Samuels, Komal Mandleywala, Joshua A. Korsen, Avelyn Mae Delos Reyes, Alessandra Piersigilli, William D. Travis, Triparna Sen, Nagavarakishore Pillarsetty, John T. Poirier, Charles M. Rudin, Jason S. Lewis
Summary: In the treatment of small cell lung cancer, [Lu-177]Lu-DTPA-CHX-A-SC16 showed good targeting and antitumor efficacy, with mild and transient toxicity.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Kota Ishioka, Hiroyuki Yasuda, Junko Hamamoto, Hideki Terai, Katsura Emoto, Tae-Jung Kim, Shigemichi Hirose, Takashi Kamatani, Sachiyo Mimaki, Daisuke Arai, Keiko Ohgino, Tetsuo Tani, Keita Masuzawa, Tadashi Manabe, Taro Shinozaki, Akifumi Mitsuishi, Toshiki Ebisudani, Takahiro Fukushima, Mari Ozaki, Shinnosuke Ikemura, Ichiro Kawada, Katsuhiko Naoki, Morio Nakamura, Takashi Ohtsuka, Hisao Asamura, Katsuya Tsuchihara, Yuichiro Hayashi, Ahmed E. Hegab, Susumu S. Kobayashi, Takashi Kohno, Hideo Watanabe, David M. Ornitz, Tomoko Betsuyaku, Kenzo Soejima, Koichi Fukunaga
Summary: In this study, FGF9 was found to play a crucial role in the transdifferentiation of lung adenocarcinoma to small cell lung cancer. The upregulation of FGF9 was confirmed to induce neuroendocrine differentiation in established human lung adenocarcinoma cells, providing direct evidence for FGF9-mediated SCLC transdifferentiation and proposing the FGF9-FGFR axis as a therapeutic target for transdifferentiated SCLC.
Editorial Material
Medicine, General & Internal
Nozomu Matsuda, Hiroyuki Minemura, Shunsuke Kobayashi, Kazuaki Kanai
Article
Respiratory System
Yuki Sato, Yoshinori Tanino, Takefumi Nikaido, Ryuichi Togawa, Takaya Kawamata, Xintao Wang, Naoko Fukuhara, Hikaru Tomita, Mikako Saito, Natsumi Watanabe, Mami Rikimaru, Takashi Umeda, Julia Morimoto, Tatsuhiko Koizumi, Yasuhito Suzuki, Kenichiro Hirai, Manabu Uematsu, Hiroyuki Minemura, Atsuro Fukuhara, Suguru Sato, Junpei Saito, Kenya Kanazawa, Yoko Shibata
JOURNAL OF THORACIC DISEASE
(2020)
Article
Oncology
Hiroyuki Minemura, Hiroshi Moriya, Hisao Imai, Tomohide Sugiyama, Yutaka Yamada, Mitsunori Higuchi, Kyoichi Kaira, Yuki Ozaki, Kenya Kanazawa, Hiroshi Yokouchi, Takashi Kasai, Takayuki Kaburagi, Hiroyuki Suzuki, Koichi Minato, Yoko Shibata
Article
Oncology
Hisao Imai, Hiroyuki Minemura, Takayuki Kishikawa, Yutaka Yamada, Kensuke Suzuki, Yukihiro Umeda, Satoshi Wasamoto, Norimitsu Kasahara, Shinichi Ishihara, Ou Yamaguchi, Ichiro Naruse, Junji Uchino, Keita Mori, Kenya Kanazawa, Yoko Shibata, Takashi Kasai, Takayuki Kaburagi, Kyoichi Kaira, Koichi Minato
Article
Medicine, General & Internal
Yasuhito Suzuki, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Takashi Umeda, Mami Rikimaru, Takumi Onuma, Shotaro Naito, Yoshinori Takiguchi, Hikaru Tomita, Takaya Kawamata, Ryuichi Togawa, Yuki Sato, Manabu Uematsu, Julia Morimoto, Kadzuhiro Kitakawa, Yasuhiko Tsukada, Kiwamu Nakamura, Keiji Kanemitsu, Ken Iseki, Yoko Shibata
Summary: In this case, clinical and radiological deterioration occurred despite a decrease in viral load, suggesting that deterioration was caused by reactivation of proinflammatory factors rather than direct viral effects. IVIg treatment not only provides immunosuppressive effects but also inhibits proinflammatory cytokines.
Article
Oncology
Hironori Takagi, Songji Zhao, Satoshi Muto, Hiroshi Yokouchi, Hiroshi Nishihara, Toshiyuki Harada, Hikaru Yamaguchi, Hayato Mine, Masayuki Watanabe, Yuki Ozaki, Takuya Inoue, Takumi Yamaura, Mitsuro Fukuhara, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Ryuzo Kanno, Miho Aoki, Chengbo Tan, Saki Shimoyama, Shigeo Yamazaki, Hajime Kikuchi, Jun Sakakibara-Konishi, Satoshi Oizumi, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Kei Takamura, Tetsuya Kojima, Osamu Honjo, Yoshinori Minami, Masaharu Nishimura, Hirotoshi Dosaka-Akita, Koji Nakamura, Akihiro Inano, Hiroshi Isobe, Hiroyuki Suzuki
Summary: This study confirmed the expression of DLK1 in SCLC and NSCLC, suggesting a potentially different clinical significance in the two lung cancer types. The results also indicated the possibility of DLK1 as a new therapeutic target, including RIT, in SCLC, as demonstrated in cell and animal experiments.
Article
Oncology
Daichi Fujimoto, Satoru Miura, Kenichi Yoshimura, Kazushige Wakuda, Yuko Oya, Toshihide Yokoyama, Takashi Yokoi, Tetsuhiko Asao, Motohiro Tamiya, Atsushi Nakamura, Hiroshige Yoshioka, Koji Haratani, Shunsuke Teraoka, Takaaki Tokito, Shuji Murakami, Akihiro Tamiya, Shoichi Itoh, Hiroshi Yokouchi, Satoshi Watanabe, Ou Yamaguchi, Keisuke Tomii, Nobuyuki Yamamoto
Summary: This retrospective cohort study examined the incidence and characteristics of pneumonitis caused by the combination of cytotoxic chemotherapy and programmed cell death protein 1/programmed death-ligand 1 checkpoint inhibitors in patients with chemo-naive advanced non-squamous non-small cell lung cancer. The study found that treatment-related pneumonitis occurred at a higher rate in the real-world population and led to worse survival outcomes, emphasizing the need for further attention and research to improve the safety of this combination therapy.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Hisashi Tanaka, Yukihiro Hasegawa, Yuka Fujita, Atsushi Nakamura, Eiki Kikuchi, Yasutaka Kawai, Toshiyuki Harada, Naomi Watanabe, Hiroshi Yokouchi, Kazuhiro Usui, Ryota Saito, Hiroshi Watanabe, Tomomi Masuda, Tatsuro Fukuhara, Keita Kudo, Ryoichi Honda, Satoshi Oizimi, Makoto Maemondo, Akira Inoue, Naoto Morikawa
Summary: Maintenance therapy with CPT-11 or AMR after induction therapy may be effective for some patients with extensive disease small cell lung cancer, but further validation is needed due to the premature termination of the study and the small number of patients included.
Article
Medicine, General & Internal
Yutaka Yamada, Hisao Imai, Tomohide Sugiyama, Hiroyuki Minemura, Kenya Kanazawa, Takashi Kasai, Koichi Minato, Kyoichi Kaira, Takayuki Kaburagi
Summary: This study investigated the effectiveness and safety of EGFR-TKI rechallenge after first-line treatment in elderly patients with NSCLC harboring drug-sensitive EGFR mutations. The results showed that EGFR-TKI rechallenge treatment was a limited, safe, and effective treatment option for elderly EGFR-positive lung cancer patients after first-line treatment.
MEDICINA-LITHUANIA
(2021)
Meeting Abstract
Critical Care Medicine
T. Kawamata, Y. Tanino, T. Nikaido, Y. Sato, R. Togawa, H. Tomita, N. Watanabe, M. Rikimaru, T. Umeda, T. Koizumi, Y. Suzuki, M. Uematsu, J. Morimoto, H. Minemura, F. Naoko, A. Fukuhara, J. Saito, K. Kanazawa, Y. Shibata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Tatsuro Sugaya, Takuto Hikichi, Jun Nakamura, Minami Hashimoto, Mika Takasumi, Tsunetaka Kato, Ryoichiro Kobashi, Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Yuki Sato, Hiroki Irie, Mami Rikimaru, Manabu Uematsu, Hiroyuki Minemura, Masao Kobayakawa, Hiromasa Ohira
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2020)
Meeting Abstract
Critical Care Medicine
R. Togawa, Y. Tanino, T. Nikaido, Y. Sato, T. Kawamata, N. Fukuhara, H. Tomita, N. Watanabe, T. Umeda, M. Rikimaru, J. Morimoto, T. Koizumi, T. Koizumi, Y. Suzuki, M. Uematsu, H. Minemura, A. Fukuhara, J. Saito, K. Kanazawa, Y. Shibata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Meeting Abstract
Critical Care Medicine
T. Nikaido, Y. Tanino, Y. Sato, R. Togawa, T. Kawamata, N. Fukuhara, H. Tomita, N. Watanabe, T. Umeda, M. Rikimaru, J. Morimoto, T. Koizumi, Y. Suzuki, M. Uematsu, H. Minemura, A. Fukuhara, J. Saito, K. Kanazawa, Y. Shibata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Meeting Abstract
Critical Care Medicine
Y. Sato, Y. Tanino, T. Nikaido, R. Togawa, T. Kawamata, N. Fukuhara, H. Tomita, N. Watanabe, M. Rikimaru, T. Umeda, J. Morimoto, T. Koizumi, Y. Suzuki, M. Uematsu, H. Minemura, A. Fukuhara, J. Saito, K. Kanazawa, Y. Shibata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Oncology
Hiroshi Yokouchi, Hiroshi Nishihara, Toshiyuki Harada, Toraji Amano, Takayuki Ohkuri, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Kei Takamura, Tetsuya Kojima, Mitsunori Higuchi, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Masaharu Nishimura, Hiroyuki Suzuki, Hirotoshi Dosaka-Akita, Hiroshi Isobe
Summary: In small-cell lung cancer (SCLC), high infiltration of OX40(+) lymphocytes in tumor stroma is associated with better survival outcomes compared to low infiltration, suggesting a potential role for OX40(+) lymphocytes in regulating relapse. Coordinating the recruitment of OX40(+) lymphocytes with CD4(+) and CD8(+) T cells in tumor stroma may be a promising immunotherapeutic strategy for SCLC patients.