Article
Medicine, General & Internal
Yulika Yoshida-Montezuma, Branavan Sivapathasundaram, Hilary K. Brown, Charles Keown-Stoneman, Russell J. de Souza, Teresa To, Cornelia M. Borkhoff, Catherine S. Birken, Jonathon L. Maguire, Laura N. Anderson
Summary: Children born late preterm and moderately preterm have higher cardiometabolic risk, suggesting that screening and early-life interventions for these children may prevent cardiometabolic outcomes.
Article
Acoustics
Jose R. Duncan, Linda Odibo, Elizabeth A. Hoover, Anthony O. Odibo
Summary: The NICHD and FMF standards may increase the detection rate of LGA compared to the Hadlock chart. However, they are poor predictors for adverse neonatal outcomes.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ewa Skarzynska, Klaudia Mularczyk, Tadeusz Issat, Artur Jakimiuk, Barbara Lisowska-Myjak
Summary: This study investigated the concentrations of transferrin and ferritin in meconium and found a negative correlation between birth weight and ferritin concentration, as well as a positive correlation between transferrin and ferritin concentrations in neonates with higher birth weight. Moreover, the study discovered correlations between transferrin and ferritin based on different transferrin concentration levels, as well as correlations between birth weight and transferrin-ferritin concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Laura Tarancon-Diez, Miguel Genebat, Manuela Roman-Enry, Elena Vazquez-Alejo, Maria de la Sierra Espinar-Buitrago, Manuel Leal, Ma Angeles Munoz-Fernandez
Summary: This study aimed to determine a clinically relevant ferritin threshold to define absolute iron deficiency. The findings suggest that serum ferritin levels below 50 ng/mL are indicative of early iron deficiency.
Article
Nutrition & Dietetics
Sixtus Aguree, Arthur Owora, Misty Hawkins, Manju B. Reddy
Summary: Obesity is associated with health and nutritional problems, including impaired iron metabolism leading to anemia. We conducted a study to determine the prevalence of anemia, iron deficiency (ID), and iron deficiency anemia (IDA) in women aged 20-49 years based on body mass index (BMI). Analysis of data from the National Health and Nutrition Examination Survey (NHANES) showed higher levels of certain iron measures and lower levels of others in obese women compared to those with normal weight. The prevalence rates of ID and anemia (and IDA) were generally higher in obese women, but the choice of iron indices impacted the estimates.
Article
Obstetrics & Gynecology
Duna Trobo, Cecilia Garcia, Marta Martinez, Ines Rodriguez, Maria Rojo, Sonsoles Moreno, Gonzalo Nozaleda, Ana Solis, Laura Perez, Miguel Caballero, Elena Ceballos, Maria T. Navarro, Federico Mariano Perez-Milan
Summary: The transfer of frozen-thawed embryos is associated with an increased risk of large for gestational age (LGA), regardless of other factors.
REPRODUCTIVE SCIENCES
(2023)
Article
Pediatrics
Giulia Vizzari, Daniela Morniroli, Valentina Tiraferri, Marta Macchi, Silvana Gangi, Alessandra Consales, Federica Ceroni, Jacopo Cerasani, Fabio Mosca, Maria Lorella Gianni
Summary: This study examined the growth outcomes of late preterm infants and identified factors associated with failure to recover growth. The results showed that 34% of children did not regain weight at 36 months. Infants who did not regain weight at 12 months were at a higher risk of not regaining weight at 36 months. The same risk factor was also associated with length catch-up growth. Additionally, infants fed any human milk at discharge were protected from failure to achieve weight and length catch-up growth at 36 months.
PEDIATRIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Arash Derakhshan, Tuija Mannisto, Liangmiao Chen, Joris A. J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fang-Biao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena A. Vasukova, Abel Lopez-Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernandez-Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt-Rasmussen, Elena N. Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Monica Guxens, Eila Suvanto, Kypros H. Nicolaides, Tim I. M. Korevaar
Summary: This study explores the association between gestational FT3 and TT3 levels and adverse obstetric outcomes. The findings suggest that FT3 and TT3 levels have different associations with various adverse obstetric outcomes, with high TT3 associated with an increased risk of gestational hypertension and low TT3 associated with a higher risk of very preterm birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Laura Tarancon-Diez, Marianela Iriarte-Gahete, Pilar Sanchez-Mingo, Guillermo Perez-Cabeza, Fernando Romero-Candau, Yolanda M. Pacheco, Manuel Leal, Maria Angeles Munoz-Fernandez
Summary: The study evaluated the safety and effectiveness of a generic intravenous iron treatment in Spanish patients with absolute iron deficiency. The results showed improvements in iron-related biomarkers, anemia, and ferritin levels. The recurrence of iron deficiency was associated with baseline iron stores depletion and sTfR/hepcidin ratio.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Lan-Wan Wang, Hung-Chih Lin, Ming-Luen Tsai, Yu-Tzu Chang, Yu-Chia Chang
Summary: This study investigated the relationship between hypertensive disorders of pregnancy (HDP) and the risk of autism spectrum disorder (ASD) in children. It found that children born to mothers with HDP had higher rates of preterm-birth and small-for-gestational-age, both of which are risk factors for ASD. The study also suggested that HDP may not be a major contributor to ASD, but rather preterm-birth and SGA play a moderating role in increasing ASD risks.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Rensheng Wan, Shaina L. Rosenblum, Giancarlo E. Denaroso, Christina G. Angeliu, Zachary Smith, Congying Wang, Pablo M. Paez
Summary: By disrupting the expression of the Tf receptor gene in oligodendrocyte progenitor cells, researchers found that the Tf cycle is uniquely important for the development and function of oligodendrocytes. Deleting the Tfr gene resulted in impaired iron absorption and hypomyelination in mice. The Tf cycle plays a crucial role in iron homeostasis and energy production in oligodendrocyte progenitor cells.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: There is a significant association between vitamin D and iron deficiency in African children. The risk of iron deficiency is increased in children with vitamin D deficiency, and vitamin D concentration variably influences iron status. Therefore, the link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies.
Article
Medicine, General & Internal
Yoo Hyun Chung, In Sun Hwang, Gyul Jung, Hyun Sun Ko
Summary: This study aimed to investigate the association between parental age and the risks of term low birth weight and macrosomia. The results suggest that both maternal and paternal age are significantly associated with these risks. Additionally, parental education levels are also correlated with term low birth weight and macrosomia.
Article
Medicine, General & Internal
Andrew W. Manigault, Stephen J. Sheinkopf, Brian S. Carter, Jennifer Check, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Michael O'Shea, Steven Pastyrnak, Lynne M. Smith, Todd M. Everson, Carmen J. Marsit, Lynne M. Dansereau, Sheri A. DellaGrotta, Barry M. Lester
Summary: This study examined the association between acoustic cry characteristics at neonatal intensive care unit discharge and behavioral and developmental outcomes at age 2 years in very preterm infants. The findings suggest that acoustic cry characteristics are associated with developmental and behavioral outcomes at age 2 years. Therefore, acoustic cry characteristics may be used for early identification of risk for long-term developmental and behavioral deficits in children.
Article
Pediatrics
Chang-Fa Sun, Han Liu, Yan-Hui Hao, Hong-Tao Hu, Zhi-Yang Zhou, Ke-Xin Zou, Xin-Mei Liu, Jian-Zhong Sheng, Guo-Lian Ding, He-Feng Huang
Summary: This study investigated the relationship between anemia in different trimesters and neonatal outcomes, revealing that gestational anemia is a public health issue in China with only about a quarter of women able to be corrected. Anemia occurring in the first trimester, whether corrected or not, still led to lower birth weight, highlighting the importance of preventing anemia before pregnancy.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Ying Zhou, Xueqin Mao, Hua Zhou, Zhiqiang Qin, Li Wang, Zhengmao Cai, Bin Yu
Summary: The prevalence of birth defects (BDs) in perinatal infants in Changzhou has significantly increased from 2014 to 2018. The leading BDs include polydactyly, congenital heart defects, and syndactyly. Male perinatal infants have a higher risk of BDs compared to female infants. Collecting information on BDs, improving awareness and education, enhancing monitoring capabilities, and utilizing new diagnostic technologies are important measures to reduce the prevalence of BDs in perinatal infants.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Genetics & Heredity
Fengying Lu, Peng Xue, Bin Zhang, Jing Wang, Bin Yu, Jianbin Liu
Summary: This cohort study aimed to assess the prevalence of chromosomal abnormalities in Chinese foetuses with different types of CHD and found that 21.5% of the foetuses had clinically significant chromosomal abnormalities. CMA is recommended as the initial examination for cases of CHD, with follow-up WES offering additional detection of clinical significance for cases with negative CMA results.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Endocrinology & Metabolism
Bin Yu, Fang Guo, Yuqi Yang, Wei Long, Jun Zhou
Summary: This study discovered the profiles of different steroid hormones at the maternal-fetal interface and revealed the change characteristics in pregnant women at advanced maternal age (AMA). High androgen levels in AMA women have a positive relationship with adverse pregnancy complications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Xiaosong Yuan, Xiaoya Han, Chenbo Jia, Huiyan Wang, Bin Yu
Summary: This study explores the associations between serum uric acid (UA) and cystatin C (CysC) levels in late pregnancy and major adverse birth outcomes. The findings suggest that higher UA levels are associated with an increased risk of low birth weight and small for gestational age babies, but a decreased risk of preterm birth. Additionally, higher CysC levels are associated with an increased risk of macrosomia and large for gestational age babies, while the risk of preterm birth and small for gestational age babies is decreased. Routine determination of maternal UA and CysC levels in late pregnancy may help assess the risks of these birth outcomes.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Obstetrics & Gynecology
Wenbo Zhou, Pingping Xue, Yuqi Yang, Lin Xia, Bin Yu
Summary: This study examines the role of N6-methyladenosine (m6A) in placenta-related diseases and summarizes the current research on m6A modification in the placenta. The study also briefly describes the role of m6A in placenta-related diseases such as recurrent miscarriage, preeclampsia, and gestational diabetes mellitus. Despite being in the preliminary stage with inconsistent results, studies on m6A modification provide new insights and a basis for the diagnosis, treatment, prognosis, and monitoring of reproductive diseases.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Developmental Biology
Wenqiang Fan, Wenbo Zhou, Qiang Yan, Yue Peng, Huiyan Wang, Chengcai Kong, Bin Zhang, Bin Yu, Li Chen, Pingping Xue
Summary: This study found that the levels of global RNA m(6)A methylation and the expression of METTL14 were significantly increased in placental tissues of patients with preeclampsia. In vitro experiments showed that overexpression of METTL14 inhibited trophoblast proliferation and invasion, but induced autophagy and apoptosis. Further research revealed that METTL14 epigenetically elevated FOXO3a expression through an m(6)A-dependent mechanism.
Article
Obstetrics & Gynecology
Fang Guo, Pei Yuan, Wei Long, Yuqi Yang, Bin Yu, Peng Xue
Summary: This study evaluated the levels of amino acids in newborns of women with and without pre-eclampsia. The findings show significant differences in the amino acid levels between the two groups, suggesting the need for further research on the metabolic status and future disease risk in these newborns.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Pediatrics
Xian Wu, Yuqi Yang, Lingna Zhou, Wei Long, Bin Yu
Summary: Most healthcare professionals working in newborn screening centers in southeast China are interested in and consider newborn genetic screening necessary. However, they also have concerns about the inability to provide genetic counseling and ethical issues. The level of education, institution level, and engagement in tandem mass spectrometry screening are important factors influencing their interest and perspectives.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Xiaosong Yuan, Xiaoya Han, Wenbo Zhou, Wei Long, Huiyan Wang, Bin Yu, Bin Zhang
Summary: This study found that an imbalance between folate and vitamin B12 before delivery is associated with adverse pregnancy outcomes, such as intrahepatic cholestasis of pregnancy (ICP), pre-eclampsia (PE), and large-for-gestational-age (LGA) newborns.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Bin Zhang, Feng Zhang, Fengying Lu, Jing Wang, Wenbai Zhou, Huihui Wang, Bin Yu
Summary: This study analyzed the cellular signature and transcriptomes of human placentas in advanced maternal age women, revealing that impaired cell invasion may underlie the increased risk of pregnancy complications in these women.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Obstetrics & Gynecology
Beiyi Lu, Lizhong Yin, Jing Wang, Bin Yu, Bin Zhang
Summary: This study discusses the residual risk of noninvasive prenatal screening (NIPS) in mothers with fetal ultrasound abnormalities. The results show that the overall residual risk of NIPS in fetuses with ultrasound anomalies is approximately 2.0%, with higher risks in echogenic bowel, multiple systems of structural anomalies, and nervous system anomalies.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2023)
Article
Medicine, Research & Experimental
Yishan Dong, Ming Zhang, Jun Ouyang, Wenbai Zhou, Bin Yu
Summary: The study reveals the increased presence of tumor-derived endothelial cells and the important role of EFNB2 in endometriosis, which is associated with the risk of recurrence.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Genetics & Heredity
Jing Wang, Wei Wang, Wenbo Zhou, Yan Zhou, Linna Zhou, Xinyue Wang, Bin Yu, Bin Zhang
Summary: This study aimed to establish a cell-free fetal DNA (cffDNA) assay using multiplex digital PCR (dPCR) for identifying fetuses at increased risk of 22q11.2 deletion/duplication syndrome. The established assay showed high sensitivity and specificity in detecting the condition in plasma samples from pregnant women.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Obstetrics & Gynecology
Xiaosong Yuan, Xiaoya Han, Chenbo Jia, Wenbo Zhou, Bin Yu
Summary: This study found an association between low fetal fraction of cell-free DNA at non-invasive prenatal screening and the risk of preterm birth in uncomplicated singleton pregnancy, particularly early preterm birth.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Wenbo Zhou, Huiyan Wang, Yuqi Yang, Fang Guo, Bin Yu, Zhaoliang Su
Summary: This study revealed different transcriptional profiles and regulatory modules in trophoblasts between placentas from patients with preeclampsia (PE) and healthy controls at the single-cell level, suggesting a potential molecular basis for preeclamptic trophoblast dysfunction.
MOLECULES AND CELLS
(2022)