Article
Biochemistry & Molecular Biology
Alejandro Tejada-Arranz, Rute G. Matos, Yves Quentin, Maxime Bouilloux-Lafont, Eloise Galtier, Valerie Briolat, Etienne Kornobis, Thibaut Douche, Mariette Matondo, Cecilia M. Arraiano, Bertrand Raynal, Hilde De Reuse
Summary: Research revealed that the RNase R protein from Helicobacter pylori lacks helicase activity, but can degrade double stranded RNA in interaction with the sole DEAD-box RNA helicase RhpA in H. pylori.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Food Science & Technology
Fei Gao, Lin Sui, Guangqing Mu, Fang Qian, Xuemei Zhu
Summary: This study isolated and identified two potential probiotic Lactobacillus strains from healthy infant feces, which showed inhibitory effects on Helicobacter pylori. These strains significantly reduced the viable count of H. pylori when co-cultured with live cells or cell-free supernatants.
Article
Cell Biology
Ruiting Guo, Xixi Cui, Xue Li, Wen Zang, Mingjie Chang, Zenghui Sun, Zhifang Liu, Yundong Sun, Jihui Jia, Wenjuan Li
Summary: This study found that Helicobacter pylori can induce the upregulation of circMAN1A2 in gastric cancer cells, and the downregulation of circMAN1A2 can inhibit the growth and invasion of gastric cancer cells. Furthermore, circMAN1A2 promotes the progression of H. pylori-induced gastric cancer by regulating the expression of MTA2. This study suggests that circMAN1A2 may be a potential diagnostic marker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2022)
Review
Gastroenterology & Hepatology
Evariste Tshibangu-Kabamba, Yoshio Yamaoka
Summary: Helicobacter pylori is a major human pathogen with increasing antibiotic resistance posing a serious threat to human health. The resistance mechanisms include single drug resistance, multidrug resistance, and heteroresistance, primarily related to mutational changes and target-mediated mechanisms. Further research is needed to explore additional biological attributes driving drug resistance in H. pylori for better treatment outcomes.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joyeeta Chakraborty, Raghunath Chatterjee
Summary: Bacterial virulence factors, including enterotoxins, toxin-antitoxin systems, and collagenase, located in genomic islands of Helicobacter pylori have been found to play important roles in disease progression. These factors can enhance toxin release, worsen ulcers, inhibit immune response, and promote biofilm formation, leading to chronic infection and poor disease prognosis.
BIOSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ji Yeong Yang, Jong-Bae Kim, Pyeongjae Lee, Sa-Hyun Kim
Summary: Evodiamine inhibits the growth of H. pylori by downregulating gene expressions related to replication and transcription machineries of the bacteria. Moreover, evodiamine also suppresses urease expression, leading to reduced translocation of CagA and VacA proteins into AGS cells. Additionally, evodiamine inhibits the activation of signaling proteins induced by H. pylori infection, contributing to reduction of IL-8 production in AGS cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chao Wang, Yiyang Hu, Huan Yang, Sumin Wang, Bo Zhou, Yulu Bao, Yu Huang, Qiang Luo, Chuan Yang, Xia Xie, Shiming Yang
Summary: Gastric cancer, a common malignant tumor of the digestive system, is influenced by genetic, environmental, and microbial factors. Infection of Helicobacter pylori is closely related to the occurrence of gastric cancer, while non-coding RNA plays a crucial role in tumor progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lei Qi, Huan Liu, Jian Gao, Kai Deng, Xiaoyan Wang, Xiuzhu Dong, Jie Li
Summary: This study investigates the pathways of rRNA maturation in Methanococcus maripaludis, a representative archaeon lacking known 3'-5' exonucleases. The results demonstrate that endonucleolytic processing, particularly at the 10-nt A/U-rich motifs, plays an essential role in the pre-rRNA maturation of M. maripaludis, indicating diverse pathways of rRNA maturation in archaeal species.
Review
Biochemistry & Molecular Biology
Rosanna Capparelli, Domenico Iannelli
Summary: Epigenetics plays a role in regulating gene expression, cell differentiation, and response to environmental stimuli. Helicobacter pylori (Hp) uses DNA methylation to silence genes in human gastric mucosa, which is a primary cause of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Peter Malfertheiner, M. Constanza Camargo, Emad El-Omar, Jyh-Ming Liou, Richard Peek, Christian Schulz, Stella I. Smith, Sebastian Suerbaum
Summary: Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer summarizes the epidemiology, pathophysiology, diagnosis and management of this infection, and discusses patient quality of life and open research questions.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Review
Infectious Diseases
Julie Nguyen, Kallirroi Kotilea, Patrick Bontems, Veronique Yvette Miendje Deyi
Summary: In the context of epidemiology, the manifestation of Helicobacter pylori (H. pylori) infection varies between children and adults. The prevalence of H. pylori infection is decreasing globally, including in many developing countries. However, pediatric H. pylori infection and its consequences remain a concern in some areas. Most infected children do not show symptoms, and there is no evidence supporting the link between H. pylori and functional disorders like recurrent abdominal pain. The pathophysiology of H. pylori infection depends on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors. Various gastritis phenotypes can develop, potentially leading to different gastroduodenal pathologies. The diagnosis of H. pylori infection in children requires upper gastrointestinal endoscopy with mucosal biopsy samples for histology and culture, or at least Polymerase Chain Reaction (PCR). Eradication treatment should be given when necessary and compliance is expected, with treatment choice based on antimicrobial susceptibility. Vigilant surveillance of resistance patterns and strategic antibiotic management are crucial for combating multidrug resistance.
Editorial Material
Microbiology
Daniel Falush
Summary: The genome of Helicobacter pylori undergoes extensive mixing through homologous recombination, resulting in significant free recombination within populations. A recent study reveals that the UvrC gene in H. pylori has evolved an additional function, allowing very short DNA tracts to be imported into the genome during natural transformation.
Article
Oncology
Ken Namikawa, Norio Tanaka, Yuki Ota, Manabu Takamatsu, Mayuko Kosugi, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Sayuri Amino, Rie Furuya, Osamu Gotoh, Tomoko Kaneyasu, Izuma Nakayama, Yu Imamura, Tetsuo Noda, Junko Fujisaki, Seiichi Mori
Summary: This study compared the genomic differences between HP-exposed and HP-naive diffuse-type gastric cancer (DGC) and found that they develop along different molecular pathways. This finding provides a basis for early detection strategies in high incidence settings.
JOURNAL OF PATHOLOGY
(2022)
Article
Immunology
Wei Zheng, Jing Miao, Lingling Luo, Gao Long, Bo Chen, Xiaoli Shu, Weizhong Gu, Kerong Peng, Fubang Li, Hong Zhao, Benson O. A. Botchway, Marong Fang, Mizu Jiang
Summary: Presence of Helicobacter pylori significantly influences gastric microbiota and results in lower abundance of multiple taxonomic levels in children. Meanwhile, it affects gastric immune environment and promotes the occurrence of gastritis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hidehiko Takigawa, Ryo Yuge, Satoshi Masaki, Rina Otani, Hiroki Kadota, Toshikatsu Naito, Ryohei Hayashi, Yuji Urabe, Shiro Oka, Shinji Tanaka, Kazuaki Chayama, Yasuhiko Kitadai
Summary: For gastric MALT lymphoma cases that are Helicobacter pylori-negative and API2-MALT1-negative, a high rate of non-Helicobacter pylori Helicobacter infections was observed, which may have contributed to the success of eradication therapy. Therefore, eradication therapy is recommended as a first-line treatment for non-Helicobacter pylori Helicobacter-positive gastric MALT lymphoma.
Article
Biochemistry & Molecular Biology
Helene Arnion, Dursun Nizam Korkut, Sara Masachis Gelo, Sandrine Chabas, Jeremy Reignier, Isabelle Iost, Fabien Darfeuille
NUCLEIC ACIDS RESEARCH
(2017)
Review
Biochemistry & Molecular Biology
Isabelle Iost, Thierry Bizebard, Marc Dreyfus
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2013)
Article
Biochemistry & Molecular Biology
Florence Proux, Marc Dreyfus, Isabelle Iost
MOLECULAR MICROBIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Dmitrii Trubetskoy, Florence Proux, Frederic Allemand, Marc Dreyfus, Isabelle Iost
NUCLEIC ACIDS RESEARCH
(2009)
Article
Biochemistry & Molecular Biology
Isabelle Iost, Chaitanya Jain
NUCLEIC ACIDS RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Anais Le Rhun, Nicolas J. Tourasse, Simon Bonabal, Isabelle Iost, Fanny Boissier, Fabien Darfeuille
Summary: This study adapted and improved a method to investigate T1TAs in Escherichia coli, revealing the death-inducing phenotype of the Hok toxin when expressed from the chromosome in the absence of the antitoxin. They identified essential nucleotides for the transcription, translation, and activity of Hok and discovered single-nucleotide substitutions leading to structural changes affecting the translation or stability of hok mRNA.
NUCLEIC ACIDS RESEARCH
(2023)
Biographical-Item
Biochemistry & Molecular Biology
Isabelle Iost, Ciaran Condon
MOLECULAR MICROBIOLOGY
(2023)
Article
Biology
Sara Masachis, Nicolas J. Tourasse, Claire Lays, Marion Faucher, Sandrine Chabas, Isabelle Iost, Fabien Darfeuille
Article
Biochemistry & Molecular Biology
Isabelle Iost, Marc Dreyfus
NUCLEIC ACIDS RESEARCH
(2006)
Article
Biochemistry & Molecular Biology
A Prud'homme-Généreux, RK Beran, I Iost, CS Ramey, GA Mackie, RW Simons
MOLECULAR MICROBIOLOGY
(2004)
Article
Biochemistry & Molecular Biology
T Bizebard, I Ferlenghi, I Iost, M Dreyfus
Article
Biochemistry & Molecular Biology
J Charollais, M Dreyfus, I Iost
NUCLEIC ACIDS RESEARCH
(2004)
Article
Biochemistry & Molecular Biology
J Charollais, D Pflieger, J Vinh, M Dreyfus, I Iost
MOLECULAR MICROBIOLOGY
(2003)