Review
Oncology
Laura Evangelista, Francesco Fiz, Riccardo Laudicella, Francesco Bianconi, Angelo Castello, Priscilla Guglielmo, Virginia Liberini, Luigi Manco, Viviana Frantellizzi, Alessia Giordano, Luca Urso, Stefano Panareo, Barbara Palumbo, Luca Filippi
Summary: The aim of this review is to provide a comprehensive overview of the existing literature concerning the applications of positron emission tomography (PET) radiomics in lung cancer patient candidates or those undergoing immunotherapy. Fifteen papers were included, thirteen were qualified as using conventional radiomics approaches, and two used deep learning radiomics. Radiomics is promising for the evaluation of TME and for the prediction of response to immunotherapy, but some limitations should be overcome.
Article
Oncology
Laura Evangelista, Andrea Bianchi, Alessio Annovazzi, Rosa Sciuto, Silvia Di Traglia, Matteo Bauckneht, Francesco Lanfranchi, Silvia Morbelli, Anna Giulia Nappi, Cristina Ferrari, Giuseppe Rubini, Stefano Panareo, Luca Urso, Mirco Bartolomei, Davide D'Arienzo, Tullio Valente, Virginia Rossetti, Paola Caroli, Federica Matteucci, Demetrio Arico, Michelangelo Bombaci, Domenica Caponnetto, Francesco Bertagna, Domenico Albano, Francesco Dondi, Sara Gusella, Alessandro Spimpolo, Cinzia Carriere, Michele Balma, Ambra Buschiazzo, Rosj Gallicchio, Giovanni Storto, Livia Ruffini, Veronica Cervati, Roberta Eufrasia Ledda, Anna Rita Cervino, Lea Cuppari, Marta Burei, Giuseppe Trifiro, Elisabetta Brugola, Carolina Arianna Zanini, Alessandra Alessi, Valentina Fuoco, Ettore Seregni, Desiree Deandreis, Virginia Liberini, Antonino Maria Moreci, Salvatore Ialuna, Sabina Pulizzi, Maria Luisa De Rimini
Summary: A study conducted in 17 Italian centers found that serial [18F]FDG PET/CT scans can be useful in evaluating the response to immunotherapy in patients with some solid tumors, such as lung cancer and malignant melanoma. This assessment can be done soon after 3 and 6 months from the start of immunotherapy. However, larger prospective trials are needed to confirm these findings.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna-Larissa N. Niemeijer, Daniela E. Oprea-Lager, Marc C. Huisman, Otto S. Hoekstra, Ronald Boellaard, Berlinda J. de Wit-van der Veen, Idris Bahce, Danielle J. Vugts, Guus A. M. S. van Dongen, Erik Thunnissen, Egbert F. Smit, Adrianus J. de Langen
Summary: This study investigated the response of NSCLC patients to pembrolizumab monotherapy and the uptake of Zr-89-pembrolizumab in tumors, finding that patients with higher uptake had better responses to treatment. Although no significant correlation was found with PD-L1 or PD-1 immunohistochemistry, the injection of Zr-89-pembrolizumab was deemed safe in the study.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Qian Lin, Hai Jun Wu, Qi Shi Song, Yu Kai Tang
Summary: In this study, the predictive ability of CT-based radiomics features, clinical features, and deep learning features for a good pathological response (GPR) in NSCLC patients receiving immunotherapy-based neoadjuvant therapy (NAT) was evaluated. The results showed that the entire model had the highest prediction accuracy among the combined radiomics features, clinical characteristics, and deep learning features.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhi-Yong Chen, Rui Fu, Xiao-Yue Tan, Li-Xu Yan, Wen-Fang Tang, Zhen-Bin Qiu, Yi-Fan Qi, Yu-Fa Li, Qing-Yi Hou, Yi-Long Wu, Wen-Zhao Zhong, Ben-Yuan Jiang
Summary: This study aimed to investigate the association between dynamic changes in SUVmax on F-18-FDG PET/CT scans and MPR in patients with NSCLC. The results showed a significant correlation between SUVmax decrease and MPR, with a decrease of over 60% in SUVmax more likely to result in MPR.
Article
Oncology
Kazuhiro Kitajima, Mitsunari Maruyama, Hiroyuki Yokoyama, Toshiyuki Minami, Takashi Yokoi, Akifumi Nakamura, Masaki Hashimoto, Nobuyuki Kondo, Kozo Kuribayashi, Takashi Kijima, Seiki Hasegawa, Koichiro Yamakado
Summary: This study compared three FDG-PET criteria (EORTC, PERCIST, imPERCIST) with CT criteria (combined modified RECIST and RECIST 1.1) for response evaluation and prognosis prediction in recurrent MPM patients treated with ICI therapy. The results showed that both FDG-PET and CT criteria are accurate for evaluating tumor response and predicting prognosis, with FDG-PET criteria identifying a greater percentage of patients as having complete metabolic response compared to CT criteria.
Editorial Material
Biochemistry & Molecular Biology
Joshua R. Veatch, Sylvain Simon, Stanley R. Riddell
Summary: Preliminary results from a phase 1 trial suggest promising anti-tumor activity of tumor-infiltrating-lymphocyte therapy in patients with advanced non-small-cell lung cancer.
Article
Oncology
Sarah Boughdad, Sofiya Latifyan, Craig Fenwick, Hasna Bouchaab, Madeleine Suffiotti, Javid J. Moslehi, Joe-Elie Salem, Niklaus Schaefer, Marie Nicod-Lalonde, Julien Costes, Matthieu Perreau, Olivier Michielin, Solange Peters, John O. Prior, Michel Obeid
Summary: This study aimed to evaluate the value of Ga-68-DOTATOC PET/CT for the early detection and diagnosis of ICI-related myocarditis. The research found that Ga-68-DOTATOC PET/CT is a highly sensitive method that can effectively detect early myocardial inflammation, especially useful for patients with concomitant myositis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Chang Liu, Jing Gong, Hui Yu, Quan Liu, Shengping Wang, Jialei Wang
Summary: The study developed a CT-based radiomics model to predict clinical outcomes of advanced NSCLC patients treated with nivolumab. The model showed promising results in accurately predicting the risk of PFS and OS, as well as effectively stratifying patients into high and low risk subgroups.
FRONTIERS IN ONCOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Charles Marcus, Shahein H. Tajmir, Steven P. Rowe, Sara Sheikhbahaei, Lilja B. Solnes
Summary: Treatment response assessment plays a crucial role in the management and prognosis of lung cancer patients. 18F-FDG PET/CT provides early and specific assessment of treatment response. Familiarity with different assessment algorithms and criteria is essential for accurate response assessment by physicians and nuclear radiologists. Artificial Intelligence is being explored to assist in providing timely and accurate treatment response assessments.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
You Cheng, Zhi-yong Chen, Jian-jiang Huang, Dan Shao
Summary: This study analyzed the changes in PET/CT metabolic parameters and CT size before and after neoadjuvant immunotherapy plus chemotherapy in 67 patients with resectable stage II/IIIA non-small-cell lung cancer (NSCLC), and correlated them with postoperative pathology. The results showed that PET/CT assessment had high consistency with postoperative pathological evaluation, while CT assessment had low consistency. The PERCIST criteria were more sensitive and accurate than (i)RECIST criteria. PET/CT has high accuracy in predicting postoperative pathological response and plays an important role in evaluating the efficacy, predicting prognosis, and guiding postoperative treatment of NSCLC patients undergoing neoadjuvant immunotherapy plus chemotherapy.
EUROPEAN RADIOLOGY
(2023)
Article
Immunology
Ander Puyalto, Maria Rodriguez-Remirez, Ines Lopez, Fabiola Iribarren, Jon Ander Simon, Marga Ecay, Maria Collantes, Anna Vilalta-Lacarra, Alejandro Francisco-Cruz, Jose Luis Solorzano, Sergio Sandiego, Ivan Penuelas, Alfonso Calvo, Daniel Ajona, Ignacio Gil-Bazo
Summary: This study demonstrates the use of [Zr-89]-anti-PD-1 immuno-PET as a safe and feasible imaging modality to accurately assess the response to PD-1/PD-L1 blockade in NSCLC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Daniel J. Hughes, Manil Subesinghe, Benjamin Taylor, Andrea Bille, James Spicer, Sophie Papa, Vicky Goh, Gary J. R. Cook
Summary: Immunotherapy has greatly improved the treatment of many cancers, but patient selection and the accuracy of predictive biomarkers remain challenges. Molecular imaging shows potential in assessing treatment response, guiding personalized therapy, and monitoring immune-related toxicities.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christos Sachpekidis, Annette Kopp-Schneider, Leyun Pan, Dimitrios Papamichail, Uwe Haberkorn, Jessica C. Hassel, Antonia Dimitrakopoulou-Strauss
Summary: This study aimed to investigate the prognostic role of [F-18]FDG PET/CT in predicting long-term outcomes to immunotherapy in metastatic melanoma. The results showed that PET/CT-based response to PD-1 blockade is significantly correlated with progression-free survival (PFS), highlighting its potential for early stratification of response to anti-PD-1 agents.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Immunology
Liangliang Wu, Shengzhi Xie, Lingxiong Wang, Jinfeng Li, Lu Han, Boyu Qin, Guoqing Zhang, Qiyan Wu, Wenjuan Gao, Lijun Zhang, Huafeng Wei, Tianyi Liu, Shunchang Jiao
Summary: The ratio of IP-10 to IL-8 in peripheral blood can serve as a biomarker for predicting treatment response and survival in patients receiving immune-combined chemotherapy for lung cancer and multiple cancers. The combination of IL-8 and IP-10 as predictors shows improved specificity and sensitivity compared to using them alone, with potential broad clinical applications in treating intractable neoplasms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Laura Evangelista, Andrea Bianchi, Alessio Annovazzi, Rosa Sciuto, Silvia Di Traglia, Matteo Bauckneht, Francesco Lanfranchi, Silvia Morbelli, Anna Giulia Nappi, Cristina Ferrari, Giuseppe Rubini, Stefano Panareo, Luca Urso, Mirco Bartolomei, Davide D'Arienzo, Tullio Valente, Virginia Rossetti, Paola Caroli, Federica Matteucci, Demetrio Arico, Michelangelo Bombaci, Domenica Caponnetto, Francesco Bertagna, Domenico Albano, Francesco Dondi, Sara Gusella, Alessandro Spimpolo, Cinzia Carriere, Michele Balma, Ambra Buschiazzo, Rosj Gallicchio, Giovanni Storto, Livia Ruffini, Veronica Cervati, Roberta Eufrasia Ledda, Anna Rita Cervino, Lea Cuppari, Marta Burei, Giuseppe Trifiro, Elisabetta Brugola, Carolina Arianna Zanini, Alessandra Alessi, Valentina Fuoco, Ettore Seregni, Desiree Deandreis, Virginia Liberini, Antonino Maria Moreci, Salvatore Ialuna, Sabina Pulizzi, Maria Luisa De Rimini
Summary: A study conducted in 17 Italian centers found that serial [18F]FDG PET/CT scans can be useful in evaluating the response to immunotherapy in patients with some solid tumors, such as lung cancer and malignant melanoma. This assessment can be done soon after 3 and 6 months from the start of immunotherapy. However, larger prospective trials are needed to confirm these findings.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marco Spadafora, Pasqualina Sannino, Luigi Mansi, Ciro Mainolfi, Rosario Capasso, Eugenio Di Giorgio, Salvatore Fiordoro, Serena Imbimbo, Filomena Masone, Laura Evangelista
Summary: This study aims to reduce the overall biological detriment associated with PET/CT by using a simple algorithm based on patient's age. The results show that the implementation of this algorithm can significantly reduce the additional cancer risk, especially in young and female patients.
NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Laura Evangelista, Luca Filippi, Orazio Schillaci
Summary: This study provides an overview of the current data on FAPI PET in breast cancer patients. The results show that FAPI PET has potential advantages in breast cancer diagnosis compared to the current available 2-[18F]FDG. However, further clinical trials are needed to evaluate its diagnostic utility.
ANNALS OF NUCLEAR MEDICINE
(2023)
Review
Pathology
Luca Filippi, Luca Urso, Francesco Bianconi, Barbara Palumbo, Maria Cristina Marzola, Laura Evangelista, Orazio Schillaci
Summary: In the past decade, two new radionuclide-based therapies, (223)Radichloride and radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA), have been approved for the management of castrate-resistant prostate cancer (PCa). This article illustrates the basic principles of PCa molecular imaging, with a focus on the combined use of diagnosis and therapy for response prediction and assessment. Radiomics, an emerging discipline based on quantitative features extracted from medical images, is also discussed for its potential in this field.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Oncology
Natale Quartuccio, Pierpaolo Alongi, Luca Urso, Naima Ortolan, Francesca Borgia, Mirco Bartolomei, Gaspare Arnone, Laura Evangelista
Summary: We investigated the predictive value of baseline F-18-FDG PET-derived semiquantitative parameters on disease-free survival (DFS) in patients with grade III breast cancer of different molecular subtypes. Volume-based parameters (such as WB_MTV and WB_TLG) showed promise in predicting recurrence in patients with grade III luminal B and luminal B-HER2 breast cancer undergoing neoadjuvant chemotherapy.
Review
Oncology
Laura Evangelista, Francesco Fiz, Riccardo Laudicella, Francesco Bianconi, Angelo Castello, Priscilla Guglielmo, Virginia Liberini, Luigi Manco, Viviana Frantellizzi, Alessia Giordano, Luca Urso, Stefano Panareo, Barbara Palumbo, Luca Filippi
Summary: The aim of this review is to provide a comprehensive overview of the existing literature concerning the applications of positron emission tomography (PET) radiomics in lung cancer patient candidates or those undergoing immunotherapy. Fifteen papers were included, thirteen were qualified as using conventional radiomics approaches, and two used deep learning radiomics. Radiomics is promising for the evaluation of TME and for the prediction of response to immunotherapy, but some limitations should be overcome.
Review
Medicine, General & Internal
Luca Filippi, Viviana Frantellizzi, Giuseppe De Vincentis, Orazio Schillaci, Laura Evangelista
Summary: The aim of this study was to provide a comprehensive overview of the clinical applications of PET with radiopharmaceuticals targeting TSPO in gliomas. Ten selected articles involving 314 glioma patients demonstrated the usefulness of TSPO PET in identifying anaplastic transformation and prognostic stratification. TSPO PET with [F-18]-GE-180 showed superior image quality compared to amino-acid PET, with larger and partially non-overlapping PET-based volumes.
Review
Biology
Marko Magdi Abdou Sidrak, Maria Silvia De Feo, Ferdinando Corica, Joana Gorica, Miriam Conte, Luca Filippi, Laura Evangelista, Giuseppe De Vincentis, Viviana Frantellizzi
Summary: This study evaluates the utility of exendin-4 imaging in insulinoma patients and finds that it is more sensitive than morphological imaging in detecting suspected benign insulinomas, especially in areas where endoscopic ultrasound cannot reach.
Review
Biology
Francesco Dondi, Achille Lazzarato, Joana Gorica, Priscilla Guglielmo, Francesca Borgia, Rossella Filice, Antonio Vento, Sara Pacella, Riccardo Camedda, Matteo Caracciolo, Maria Silvia De Feo, Paolo Mammucci, Viviana Frantellizzi, Naima Ortolan, Elisa Fiasconaro, Luca Urso, Laura Evangelista, Riccardo Laudicella, Giulia Santo
Summary: This review explores PET criteria developed for interpretation and treatment response assessment in non-FDG PET imaging in oncology, highlighting their potential role in predicting prognosis and their need for clinical trials to evaluate their impact on patient management.
Editorial Material
Oncology
Laura Evangelista, Stefano Fanti
Review
Medicine, General & Internal
Miriam Conte, Maria Silvia De Feo, Viviana Frantellizzi, Miriam Tomaciello, Francesco Marampon, Laura Evangelista, Luca Filippi, Giuseppe De Vincentis
Summary: Radio-guided surgery is a reliable approach for localizing lung nodules, ground-glass opacities, and metastatic lymph nodes. Using different tracers, it has been demonstrated to be a low-cost and low-morbidity alternative to existing approaches with low radiation exposure.
Review
Biology
Priscilla Guglielmo, Pierpaolo Alongi, Lucia Baratto, Elisabetta Abenavoli, Ambra Buschiazzo, Greta Celesti, Miriam Conte, Rossella Filice, Joana Gorica, Lorenzo Jonghi-Lavarini, Helena Lanzafame, Riccardo Laudicella, Maria Librando, Flavia Linguanti, Francesco Mattana, Alberto Miceli, Laura Olivari, Leandra Piscopo, Cinzia Romagnolo, Giulia Santo, Antonio Vento, Fabio Volpe, Laura Evangelista
Summary: FAPI-based radiopharmaceuticals, as a novel class of tracers, have shown significant advantages in imaging low-grade or well-differentiated tumors compared to [18F]FDG. Global studies have demonstrated promising results, particularly in detecting peritoneal carcinomatosis. However, more extensive population studies are needed to fully understand all the advantages of these new radiopharmaceuticals.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Rensi Marco, Decio Capobianco, Di Gregorio Fernando, Laura Evangelista
Summary: This case emphasizes the necessity of histopathological evaluation when significant uptake of labeled choline is observed in a single lung nodule.
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Luca Urso, Viviana Frantellizzi, Giuseppe De Vincentis, Orazio Schillaci, Luca Filippi, Laura Evangelista
Summary: This study provides a comprehensive overview of the current main applications of long axial field-of-view (LAFOV) PET/CT in oncology. Seventeen papers were selected, including retrospective and prospective studies, with a total of 877 included patients. Most studies employed [F-18]-FDG as the radiopharmaceutical agent. LAFOV PET/CT showed superior diagnostic performance compared to traditional SAFOV devices, allowing reduced activity/time and dynamic protocols.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Review
Medicine, General & Internal
Luca Urso, Luca Filippi, Angelo Castello, Maria Cristina Marzola, Mirco Bartolomei, Corrado Cittanti, Luigia Florimonte, Massimo Castellani, Paolo Zucali, Alessio Bruni, Roberto Sabbatini, Massimo Dominici, Stefano Panareo, Laura Evangelista
Summary: PSMA ligand PET has higher detection rates compared to conventional imaging in CRPC patients, reducing the number of M0 CRPC patients. However, its impact on patients' prognosis is still uncertain. Additionally, PSMA ligand PET has sensitivity and specificity limitations in CRPC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)