Journal
NEUROIMAGING CLINICS OF NORTH AMERICA
Volume 29, Issue 2, Pages 261-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nic.2019.01.006
Keywords
Migraine headache; Patent foramen ovale; Right-to-left shunt
Funding
- NHLBI NIH HHS [T32 HL007895] Funding Source: Medline
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Observational studies have identified a relationship between patent foramen ovale (PFO) and migraine headache. In people who have migraine with aura, 40% to 60% have a PFO, compared with 20% to 30% in the general adult population. It is hypothesized that migraine, especially migraine with aura, may be triggered by hypoxemia or vasoactive chemicals (eg, serotonin), which are ordinarily metabolized during passage through the lungs. Although PFO closure is currently not a FDA-approved therapy for migraines, randomized trials suggest that this intervention may benefit a subgroup of migraineurs.
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