Functional and structural characterisation of common cytochrome P450 2D6 allelic variants—roles of Pro34 and Thr107 in catalysis and inhibition

Molecular Dynamics Simulations Reveal Structural Differences among Allelic Variants of Membrane-Anchored Cytochrome P450 2D6

(2018) André Fischer et al.   Journal of Chemical Information and Modeling

Microsecond MD simulations of human CYP2D6 wild-type and five allelic variants reveal mechanistic insights on the function

(2018) Charleen G. Don et al.   PLoS One

Effect of CYP2D6 genetic polymorphism on the metabolism of citalopram in vitro

(2016) Xiao-xia Hu et al.   Drug Metabolism and Pharmacokinetics

Molecular Dynamics Simulations to Investigate the Influences of Amino Acid Mutations on Protein Three-Dimensional Structures of Cytochrome P450 2D6.1, 2, 10, 14A, 51, and 62

(2016) Shuichi Fukuyoshi et al.   PLoS One

In VitroFunctional Assessment of 22 Newly Identified CYP2D6 Allelic Variants in the Chinese Population

(2015) Da-Peng Dai et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Effect of CYP2D6 variants on venlafaxine metabolism in vitro

(2015) Yun-Yun Zhan et al.   XENOBIOTICA

Molecular Dynamics of CYP2D6 Polymorphisms in the Absence and Presence of a Mechanism-Based Inactivator Reveals Changes in Local Flexibility and Dominant Substrate Access Channels

(2014) Parker W. de Waal et al.   PLoS One

In Silieo Study on the Inhibitory Interaction of Drugs with Wild-type CYP2D6.1 and the Natural Variant CYP2D6.17

(2013) Koichi Handa et al.   Drug Metabolism and Pharmacokinetics

Behavior of Human Cytochromes P450 on Lipid Membranes

(2013) Karel Berka et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacophore, QSAR, and Binding Mode Studies of Substrates of Human Cytochrome P450 2D6 (CYP2D6) Using Molecular Docking and Virtual Mutations and an Application to Chinese Herbal Medicine Screening

(2012) Sui-Lin Mo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound

(2012) An Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of the Inhibitory Profiles of Itraconazole and Cimetidine in Cytochrome P450 3A4 Genetic Variants

(2011) T. Akiyoshi et al.   DRUG METABOLISM AND DISPOSITION

Genetic Variation in Metabolizing Enzyme and Transporter Genes: Comprehensive Assessment in 3 Major East Asian Subpopulations With Comparison to Caucasians and Africans

(2010) Michael Man et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Genetic Polymorphism and Toxicology—With Emphasis on Cytochrome P450

(2010) Inger Johansson et al.   TOXICOLOGICAL SCIENCES

New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme

(2009) Bo Wang et al.   DRUG METABOLISM REVIEWS

Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase

(2009) Kirk E. Hevener et al.   Journal of Chemical Information and Modeling

Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese

(2009) Q Zhou et al.   PHARMACOGENOMICS JOURNAL

Functional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57)

(2008) K. Sakuyama et al.   DRUG METABOLISM AND DISPOSITION