Article
Medicine, General & Internal
Kymberleigh A. Pagel, Hoyin Chu, Rashika Ramola, Rafael F. Guerrero, Judith H. Chung, Samuel Parry, Uma M. Reddy, Robert M. Silver, Jonathan G. Steller, Lynn M. Yee, Ronald J. Wapner, Matthew W. Hahn, Sriraam Natarajan, David M. Haas, Predrag Radivojac
Summary: This cohort study found that the addition of polygenic risk scores (PRS) was associated with the stratified risk of gestational diabetes (GD) diagnosis among high-risk patient subgroups, suggesting the benefits of targeted PRS ascertainment to encourage early intervention.
Article
Multidisciplinary Sciences
Qing-Xiang Zheng, Hai-Wei Wang, Xiu-Min Jiang, Yan Lin, Gui-Hua Liu, Mian Pan, Li Ge, Xiao-Qian Chen, Jing-Ling Wu, Xiao-Yun Zhang, Yu-Qing Pan, Hong-Gu He
Summary: This study aimed to determine the ranges of gestational weight gain (GWG) in Chinese women with gestational diabetes mellitus (GDM) and investigate the associations between prepregnancy body mass index (BMI), GWG, and maternal-infant adverse outcomes. The findings revealed that the ranges of GWG in Chinese women with GDM were different from the National Academy of Medicine's recommendation, and GDM women with high prepregnancy BMI and excessive GWG were associated with higher risks of adverse outcomes for both the mother and the infant.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Feng Fu, Ping Yan, Shuping You, Xinmin Mao, Tingting Qiao, Li Fu, Yanni Wang, Yali Dai, Palida Maimaiti
Summary: This study found that anxiety in GDM patients is common, and is positively correlated with vulnerable personality while negatively correlated with self-efficacy and social support. Factors such as education level, monthly income, abnormal pregnancy, cesarean section history, and first pregnancy are independent influencing factors for anxiety in GDM patients. Early care and interventions are crucial for these high-risk patients.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Medicine, General & Internal
Almudena Lara-Barea, Begona Sanchez-Lechuga, Alvaro Vidal-Suarez, Ana I. Arroba, Fernando Bugatto, Cristina Lopez-Tinoco
Summary: The alterations in ambulatory blood pressure monitoring have been associated with perinatal complications, especially in normotensive women with gestational diabetes mellitus and obesity. Nocturnal systolic blood pressure was found to be a predictor of hypertensive disorders of pregnancy in these patients. High blood pressure and a non-dipper pattern were observed in women who delivered preterm, indicating a potential association with poor obstetric and perinatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mariangela Gaudio, Nicoletta Dozio, Michael Feher, Marina Scavini, Amelia Caretto, Mark Joy, Jeremy Van Vlymer, William Hinton, Simon de Lusignan
Summary: The study aimed to describe trends in modifiable and non-modifiable unfavorable factors affecting pregnancy outcomes in women with diabetes of childbearing age from an English primary care perspective. Despite improvements in general diabetes care, the majority of women with Type 1 or Type 2 diabetes still have unfavorable, mostly modifiable factors for the start of pregnancy. Good diabetes care for women of childbearing age should consider the possibility of pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Jing Lin, Hua Jin, Lei Chen
Summary: This study found that IR in the second trimester significantly increased the risk of hypertensive disorders of pregnancy and large for gestational age in women with GDM, while other adverse pregnancy outcomes were not significantly increased. Additionally, factors such as FPG, HbA1c, TG in early pregnancy, pre-pregnant BMI, and weight gain before GDM diagnosis were all identified as independent risk factors for IR.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Biochemistry & Molecular Biology
Yuan Li, Xiaoqian Wang, Fengjuan Jiang, Wenqing Chen, Jie Li, Xiaotian Chen
Summary: This study found a correlation between gestational diabetes mellitus and abnormal lipid levels in pregnant women, suggesting that lipid control during the second trimester may reduce the incidence of GDM and improve clinical outcomes for high-risk women.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Obstetrics & Gynecology
R. Smith, M. Michalopoulou, H. Reid, S. Payne Riches, Y. N. Wango, Y. Kenworthy, C. Roman, M. Santos, J. E. Hirst, L. Mackillop
Summary: This study used the Behavior Change Wheel theoretical approach to design a smartphone application called Stay-Active, to support women attending an NHS GDM clinic in increasing and maintaining physical activity. The application incorporates four key intervention functions and delivers ten behavior change techniques, including goal setting, credible source, self-monitoring, and action planning.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Xizhenzi Fan, Lingli Wang, Ruifen Jiao, Wenhui Song, Yumeng Liu, Tianxiao Yu
Summary: This study aimed to explore the association between higher serum ferritin (SF) levels in mid-pregnancy and adverse pregnancy outcomes in gestational diabetes mellitus (GDM) pregnancies, and develop a predictive cut-off value for future clinical risk assessment. The results showed a significant association between SF levels in mid-pregnancy and GDM-related adverse pregnancy outcomes, and SF levels had moderate clinical value in predicting maternal preeclampsia, neonatal hypoglycemia, and respiratory distress.
Article
Endocrinology & Metabolism
Wei Zheng, Jia Wang, Kexin Zhang, Cheng Liu, Li Zhang, Xin Liang, Lirui Zhang, Yuru Ma, Ruihua Yang, Xianxian Yuan, Guanghui Li
Summary: The study found that experiencing COVID-19 lockdown during pregnancy is associated with worse maternal metabolic status, but has no significant impact on neonatal outcomes or infant weight.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Caro Minschart, Astrid Lammertyn, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: The level of gestational weight gain (GWG) during pregnancy is associated with adverse pregnancy outcomes in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT). Low GWG below recommended levels frequently occurs in GDM women without increased risk for adverse outcomes. Excessive GWG is associated with increased risk for neonatal hypoglycemia and worse metabolic profile postpartum in GDM women, and with higher rates of instrumental delivery and larger infants in NGT women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jasmine Bahrami, George Tomlinson, Helen R. Murphy, Denice S. Feig
Summary: In pregnant women with type 1 diabetes, impaired awareness of hypoglycemia is associated with more maternal severe hypoglycemia episodes and increased fear of hypoglycemia. Having impaired awareness of hypoglycemia and/or fear of hypoglycemia should alert clinicians to the increased risk, but reassuringly, there was no increase in adverse neonatal outcomes.
Article
Medicine, General & Internal
Qiuhong Zhang, Chee Shin Lee, Lixia Zhang, Qi Wu, Yunyan Chen, Danqing Chen, Lu Qi, Zhaoxia Liang
Summary: Different factors, such as advanced age and high pre-pregnancy BMI, contribute to elevated HbA1c levels in pregnant women with GDM. Monitoring and controlling blood glucose levels have shown effectiveness in reducing adverse pregnancy outcomes, especially in cases of excessive GWG.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Jiawei Xu, Xuan Lin, Ying Fang, Jing Cui, Zhi Li, Fang Yu, Libin Tian, Hongyan Guo, Xinyan Lu, Jiahao Ding, Lu Ke, Jiahui Wu
Summary: This study found that lifestyle interventions, including dietary guidance, health education, and weight management, have positive effects on pregnancy outcomes in women at high risk of gestational diabetes mellitus (GDM). The risk of GDM was reduced by 46.9% and the risk of pregnancy induced hypertension (PIH) was reduced by 74.2% in the intervention group compared to the control group. This highlights the importance of early screening and intervention for high-risk pregnant women.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Sihui Luo, Xingwu Ran, Mei Zhang, Ji Hu, Daizhi Yang, Dalong Zhu, Jiajun Zhao, Xinhua Xiao, Xiaohui Guo, Tao Yang, Qin Huang, Fang Liu, Lu Jing, Jing Ma, Xinli Zhou, Fan Ping, Nan Gu, Wenwen Li, Yaling Yang, Chen Fang, Wei Bao, Xueying Zheng, Jinhua Yan, Zhiguang Zhou, Jianping Weng
Summary: Pregnancy outcomes of women with type 1 diabetes in China from 2004 to 2014 remained poor, showing higher rates of maternal mortality, pregnancy loss, preeclampsia, neonatal death, and congenital malformations compared to those without T1D. No significant improvement in outcomes was observed over this 11-year period.
JOURNAL OF DIABETES
(2022)
Article
Endocrinology & Metabolism
Lene Ringholm, Nicoline Callesen Do, Peter Damm, Elisabeth Reinhardt Mathiesen
Summary: This study evaluated pregnancy outcomes in pregnant women with type 1 diabetes using degludec, an ultra-long-acting insulin analog, compared to other long-acting insulin analogs. The results showed that degludec had similar pregnancy outcomes as other long-acting insulin analogs in a real-world setting, suggesting that degludec can be continued throughout pregnancy.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Nina Pappot, Nicoline Callesen Do, Marianne Vestgaard, Bjorg Asbjornsdottir, Javad Nouri Hajari, Henrik Lund-Andersen, Pernille Holmager, Peter Damm, Lene Ringholm, Elisabeth Reinhardt Mathiesen
Summary: This study evaluates the prevalence and severity of diabetic retinopathy in pregnant women with diabetes, and suggests that the frequency of retinal screening can be reduced for those with no retinopathy in early pregnancy and good glycemic control.
Article
Endocrinology & Metabolism
Marianne Vestgaard, Elaf Al-Saudi, Bjorg Asbjornsdottir, Lone N. Norgaard, Berit Woetman Pedersen, Charlotte Kvist Ekelund, Lene Ringholm, Lise Lotte T. Andersen, Dorte M. Jensen, Ann Tabor, Peter Damm, Elisabeth R. Mathiesen
Summary: Results of the study suggest that anti-hypertensive treatment for pregnancy-induced hypertension in pregnant women with pre-existing diabetes might not have a significant impact on foetal growth. The prevalence of small foetuses was higher before treatment initiation, but decreased after treatment. In a representative subgroup, the pulsatility index in the umbilical and middle cerebral artery remained stable after treatment initiation.
Review
Oncology
Pernille Holmager, Seppo W. Langer, Andreas Kjaer, Lene Ringholm, Rajendra Singh Garbyal, Hans-Christian Pommergaard, Carsten Falnaes Hansen, Birgitte Federspiel, Mikkel Andreassen, Ulrich Knigge
Summary: The 2019 WHO guidelines have changed the classification of gastro-entero-pancreatic neuroendocrine neoplasms (GEP NEN) to include both Ki-67 proliferation index and tumor differentiation. Current research suggests potential benefits of surgery for NEN G3 patients, while the effects of surgery for MiNEN patients remain uncertain due to limited studies.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Julie C. Soholm, Nicoline C. Do, Marianne Vestgaard, Bjorg Asbjornsdottir, Sidse K. Norgaard, Berit W. Pedersen, Lone Storgaard, Birgitte B. Nielsen, Pernille Holmager, Lene Ringholm, Peter Damm, Elisabeth R. Mathiesen
Summary: This study aimed to evaluate the prevalence of falling insulin requirements in pregnant women with preexisting diabetes delivering preterm and explore its relationship with fetal asphyxia and neonatal morbidity. The results showed that falling insulin requirements often preceded preterm delivery in women with diabetes, but were not associated with fetal asphyxia or neonatal morbidity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Nicoline Callesen Do, Marianne Vestgaard, Bjorg Asbjornsdottir, Lise Lotte Torvin Andersen, Dorte Moller Jensen, Lene Ringholm, Peter Damm, Elisabeth Reinhardt Mathiesen
Summary: In women with preexisting diabetes, both home blood pressure and office blood pressure are positively associated with the development of preeclampsia, and their predictive abilities are comparable. Home blood pressure is lower than office blood pressure in both early and late pregnancy, and the difference increases with increasing office blood pressure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Gernot Desoye, Lene Ringholm, Peter Damm, Elisabeth R. Mathiesen, Mireille N. M. van Poppel
Summary: Despite progress in blood glucose control, pregnancy in women with type 1 diabetes still poses risks for the fetus. Good glycemic control reduces the risk of fetal overgrowth, but hyperglycemia can still lead to fetal overnutrition and adiposity. Preventing fetal adiposity requires revised goal setting and continuous glucose monitoring.
Editorial Material
Endocrinology & Metabolism
Mireille N. M. van Poppel, Peter Damm, Elisabeth R. R. Mathiesen, Lene Ringholm, Cuilin Zhang, Gernot Desoye
Summary: In pregnancies of women with obesity or diabetes, neonates are often overgrown. This article focuses on possible growth deviations earlier in pregnancy and their potential contribution to neonatal overgrowth, suggesting that early-pregnancy growth reduction followed by in utero catch-up growth may confer a higher risk of obesity in later life.
Review
Endocrinology & Metabolism
Katrien Benhalima, Kaat Beunen, Sarah E. Siegelaar, Rebecca Painter, Helen R. Murphy, Denice S. Feig, Lois E. Donovan, Sarit Polsky, Elizabeth Buschur, Carol J. Levy, Yogish C. Kudva, Tadej Battelino, Lene Ringholm, Elisabeth R. Mathiesen, Chantal Mathieu
Summary: Maintaining glucose concentrations within target, appropriate gestational weight gain, lifestyle management, and using antihypertensive treatment and low-dose aspirin if necessary can reduce the risk of complications in pregnancies complicated by type 1 diabetes. Hybrid closed-loop insulin delivery systems show promise as a treatment option during pregnancy.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sidse K. Norgaard, Julie C. Soholm, Elisabeth R. Mathiesen, Kirsten Norgaard, Tine D. Clausen, Pernille Holmager, Nicoline C. Do, Peter Damm, Lene Ringholm
Summary: The study found that using faster aspart compared to insulin aspart in pregnant women with diabetes did not pose additional safety issues, and resulted in similar effects on fetal growth and maternal indicators.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Nicoline Callesen Do, Marianne Vestgaard, Sidse Kjaerhus Norgaard, Peter Damm, Elisabeth R. Mathiesen, Lene Ringholm
Summary: Women with type 1 or type 2 diabetes are more likely to develop preeclampsia. Blood pressure monitoring, physical activity, and prophylactic aspirin may help decrease the prevalence of preeclampsia in women with preexisting diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Cathrine Munk Scheuer, Dorte Moller Jensen, H. David McIntyre, Lene Ringholm, Elisabeth Reinhardt Mathiesen, Celina Pforr Korsgard Nielsen, Runa Louise Mortansdottir Nolsoe, Julie Milbak, Thore Hillig, Peter Damm, Martin Overgaard, Tine Dalsgaard Clausen
Summary: This study aims to compare the prevalence of gestational diabetes mellitus (GDM) in a Danish cohort using the current Danish criteria and the WHO2013 criteria, and evaluate the adverse pregnancy outcomes among untreated women who fall between the diagnostic thresholds. The results showed a significantly higher GDM prevalence when using the WHO2013 criteria compared to the Danish criteria, and untreated GDM in the gap between the two criteria resulted in higher risks of adverse pregnancy outcomes.
ACTA DIABETOLOGICA
(2023)
Meeting Abstract
Endocrinology & Metabolism
S. Norgaard, J. Soholm, E. Mathiesen, K. Norgaard, T. Clausen, P. Holmager, N. Do, P. Damm, L. Ringholm
Meeting Abstract
Endocrinology & Metabolism
J. C. Soholm, S. K. Norgaard, N. C. Do, K. Norgaard, T. D. Clausen, P. Damm, E. R. Mathiesen, L. Ringholm
Letter
Endocrinology & Metabolism
Lene Ringholm, Nicoline Callesen Do, Peter Damm, Elisabeth Reinhardt Mathiesen
ACTA DIABETOLOGICA
(2023)