Senescent glia spell trouble in Alzheimer’s disease

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Oligodendrocyte Development and Plasticity

(2015) Dwight E. Bergles et al.   Cold Spring Harbor Perspectives in Biology

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

(2012) Gwendolyn Behrendt et al.   GLIA

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING