A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants

Opportunities and challenges for transcriptome-wide association studies

(2019) Michael Wainberg et al.   NATURE GENETICS

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

(2018) Fredrick R. Schumacher et al.   NATURE GENETICS

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

(2018) Yingchang Lu et al.   CANCER RESEARCH

A Powerful Framework for Integrating eQTL and GWAS Summary Data

(2017) Zhiyuan Xu et al.   GENETICS

Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction

(2017) Michelle R. Jones et al.   GYNECOLOGIC ONCOLOGY

Association analysis identifies 65 new breast cancer risk loci

(2017) Kyriaki Michailidou et al.   NATURE

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

(2017) Catherine M Phelan et al.   NATURE GENETICS

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

A Powerful Framework for Integrating eQTL and GWAS Summary Data

(2017) Zhiyuan Xu et al.   GENETICS

Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer

(2017) Kazutoshi Fujita et al.   Scientific Reports

Alternative splicing modulated by genetic variants demonstrates accelerated evolution regulated by highly conserved proteins

(2016) Yun-Hua Esther Hsiao et al.   GENOME RESEARCH

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

(2016) Kate Lawrenson et al.   Nature Communications

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

(2016) S. P. Kar et al.   Cancer Discovery

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

(2016) Helen Ross-Adams et al.   Oncotarget

Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues

(2016) Heather E. Wheeler et al.   PLoS Genetics

Incidental Nonuterine High-grade Serous Carcinomas Arise in the Fallopian Tube in Most Cases

(2015) C. Blake Gilks et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

PAX8 expression in ovarian surface epithelial cells

(2015) Emily Adler et al.   HUMAN PATHOLOGY

Targeting c-MYC in Platinum-Resistant Ovarian Cancer

(2015) J. M. Reyes-Gonzalez et al.   MOLECULAR CANCER THERAPEUTICS

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

(2015) Karoline B Kuchenbaecker et al.   NATURE GENETICS

Genome-wide significant risk associations for mucinous ovarian carcinoma

(2015) Linda E Kelemen et al.   NATURE GENETICS

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

Enhancer scanning to locate regulatory regions in genomic loci

(2015) Melissa Buckley et al.   Nature Protocols

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

(2015) Kate Lawrenson et al.   Nature Communications

Systematic pan-cancer analysis of tumour purity

(2015) Dvir Aran et al.   Nature Communications

Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility

(2015) Rebekah Baskin et al.   Scientific Reports

Open pipelines for integrated tumor genome profiles reveal differences between pancreatic cancer tumors and cell lines

(2015) Jeremy Goecks et al.   Cancer Medicine

Senescent Fibroblasts Promote Neoplastic Transformation of Partially Transformed Ovarian Epithelial Cells in a Three-dimensional Model of Early Stage Ovarian Cancer

(2015) Kate Lawrenson et al.   NEOPLASIA

Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types

(2014) Qiyuan Li et al.   HUMAN MOLECULAR GENETICS

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women

(2014) Kexin Chen et al.   Nature Communications

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers

(2013) Juliet D. French et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci

(2013) Qiyuan Li et al.   CELL

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

(2013) Paul D P Pharoah et al.   NATURE GENETICS

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

(2013) Stig E Bojesen et al.   NATURE GENETICS

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

(2013) Jennifer Permuth-Wey et al.   Nature Communications

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses

(2012) Oliver Stegle et al.   Nature Protocols

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Modeling high-grade serous ovarian carcinogenesis from the fallopian tube

(2011) A. M. Karst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

(2010) Ellen L Goode et al.   NATURE GENETICS

Common variants at 19p13 are associated with susceptibility to ovarian cancer

(2010) Kelly L Bolton et al.   NATURE GENETICS

In vitrothree-dimensional modelling of human ovarian surface epithelial cells

(2009) K. Lawrenson et al.   CELL PROLIFERATION

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

(2009) Honglin Song et al.   NATURE GENETICS