Article
Engineering, Biomedical
Yupeng Shi, Mengyang Zhou, Yong Zhang, Yifei Wang, Jingliang Cheng
Summary: Image-guided stimulus-responsive theranostics have been developed for enhanced tumor cell clearance through identification of malignant lesions and integration of multiple cell-killing mechanisms. In this study, an intelligent dual-responsive nanostructure (HSPMH-DOX) was designed for MRI-guided synergistic chemo-photothermal therapy and chemodynamic therapy. The nanoagent demonstrated both endogenous and external dual responses, allowing triggered drug release and localized overheating under specific tumor microenvironment and external near-infrared light irradiation. The prepared dual-response nanoagent exhibited excellent biocompatibility, targeting ability, and efficiency for MRI-guided combined therapy in vitro and in vivo. The combination of chemo-PTT and CDT achieved effective tumor eradication in animal models within a short period of time. This work holds great promise for future applications in stimulus-responsive synergistic theranostics.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Qing Bao, Ying Zhang, Xiangyu Liu, Tao Yang, Hui Yue, Mingying Yang, Chuanbin Mao
Summary: Due to the complexity and heterogeneity of cancer, there is a high demand for clear and accurate tumor imaging and image-guided multimodal synergistic therapy. In this work, bismuth-based mesoporous silica-coated nanoparticles (BMSNs) were successfully fabricated with a thin silica shell and modified with an MCF-7 breast cancer-targeting peptide. The resulting nanoparticles showed enhanced drug loading and aggregation in the tumor site, enabling enhanced computed tomography imaging and synergistic chemo-photothermal therapy.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Fenglin Li, Yi Lai, Jiayi Ye, Madiha Saeed, Yijing Dang, Zhifeng Zou, Fangmin Chen, Wen Zhang, Zhiai Xu
Summary: The study presents a dual-targeting nanotheranostic for precise photo-immunotherapy of glioblastoma (GBM). The nanotheranostic can deliver drugs to the tumor site and induce a photothermal effect, enhancing the therapeutic effect.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Botao Qu, Yahong Han, Juan Li, Qian Wang, Bingyu Zhao, Xiaoyang Peng, Ruiping Zhang
Summary: ZIF-8-IR820-MnPc-HA NPs have been demonstrated as a dual-modality imaging tool for visualization and localization of tumors, with potential applications in in vivo photodynamic therapy. Hyaluronic acid acts as a sponge in enhancing singlet oxygen generation and facilitating cellular therapeutic effects.
Article
Chemistry, Multidisciplinary
Cheng Yu, Zhuyuan Ding, Huan Liu, Yulu Ren, Minping Zhang, Qiuling Liao, Tao Luo, Lujing Gao, Shiyi Lyu, Huiwen Tan, Linan Hu, Zhu Chen, Pengfei Xu, Enhua Xiao
Summary: This study presents a novel multifunctional probe Gd-EB-ICG (GI) for FL/MR dual-modal imaging-guided PTT of cancer. GIAs formed by self-assembly with endogenous albumin exhibit excellent biocompatibility and can continuously accumulate in the tumor area. The MR contrast and photothermal efficacy of GIAs are significantly enhanced due to the prolonged rotational correlation time and constrained geometry.
FRONTIERS IN CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Lijun Zhu, Yu Li, Mou Jiang, Changsheng Ke, Hanxiong Long, Maosong Qiu, Lei Zhang, Chaohui Ye, Xin Zhou, Zhong-Xing Jiang, Shizhen Chen
Summary: This study developed a method to fluorinate bovine serum albumin with 34 cysteine residues, creating fluorine-19 magnetic resonance imaging (19F MRI)-traceable theranostics. The fluorinated albumin with a non-binding fluorocarbon and a long linker was found to avoid 19F signal splitting and line broadening. The self-assembled nanoparticles of paclitaxel and IR-780 showed high tumor accumulation and enabled 19F MRI-near infrared fluorescence imaging (NIR FLI)-guided synergistic chemotherapy, photothermal and photodynamic therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ning Chen, Wenhui Fu, Jie Zhou, Linqiang Mei, Jimin Yang, Yang Tian, Qiang Wang, Wenyan Yin
Summary: The study presents a novel inorganic-organic hybrid nanocomposite for precise cancer diagnosis and treatment, showing good biocompatibility and potential for multimodal imaging and chemo-photothermal combination therapy. This multifunctional platform exhibits enhanced cancer treatment efficacy in vivo due to the synergistic effect between photothermal therapy and chemotherapy.
CHINESE CHEMICAL LETTERS
(2021)
Article
Engineering, Biomedical
Quazi T. H. Shubhra, Kai Guo, Yixuan Liu, Md Razzak, Md Serajum Manir, A. K. M. Moshiul Alam
Summary: This study describes the development of a smart drug delivery system for multimodal synergistic cancer therapy, utilizing chemo-photothermal-starvation approaches to improve drug release and cellular uptake as well as achieve a synergistic therapeutic effect for cancer treatment.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Geng Yang, Mengyue Li, Ting Song, Xiangyan Chen, Hanxi Zhang, Xiaodan Wei, Ningxi Li, Tingting Li, Xiang Qin, Shun Li, Fengming You, Chunhui Wu, Wei Zhang, Yiyao Liu, Hong Yang
Summary: This study proposes a multifunctional nanobeacon for sensitizing chemo-photothermal therapy through fluorescence detection and NIR-triggered drug release. The nanobeacon not only detects specific RNA in cells, but also reduces tumor cell resistance, thereby improving therapeutic efficacy. In vitro and in vivo experiments demonstrate that the nanobeacon effectively suppresses tumor proliferation and enhances apoptosis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Huai-An Chen, Yu-Jen Lu, Banendu Sunder Dash, Yin-Kai Chao, Jyh-Ping Chen
Summary: Combination chemo-photothermal therapy using HA/PMNPc nanoparticles can effectively treat cancer by reducing the dose of chemotherapeutic drugs and inducing cell death through heat generation. The nanoparticles exhibit targeted delivery, pH-sensitive drug release, and hyperthermia effects, resulting in higher cytotoxicity and apoptosis in cancer cells. In vivo studies demonstrate that the treatment modality inhibits tumor growth and increases survival time in mice.
Article
Chemistry, Multidisciplinary
Leihao Lu, Qing Bao, Yao Miao, Qichao Cheng, Yuyin Chen, Shuxu Yang, Chuanbin Mao, Mingying Yang
Summary: Thrombotic disease is a serious health threat that requires targeted therapy and precise thrombus localization. A nanoparticle called Mp-Bi@SiO2-GK has been developed to address the limitations of traditional drugs. It combines thrombus targeting, computed tomography (CT) imaging, photothermal therapy, and chemotherapy to enhance thrombolysis efficiency without harming tissues or affecting organ metabolism.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
De-Chao Yang, Lin-Feng Wen, Liyang Du, Cheng-Miao Luo, Zi-Yao Lu, Jian-Yong Liu, Zhonghui Lin
Summary: In this study, a multifunctional therapeutic BAC prodrug was designed and synthesized, which connected the chemotherapeutic drug and the fluorescent photothermal agent. The prodrug showed excellent biosafety and could perform chemotherapy in hypoxic cancer cells. Additionally, it could achieve irreversible cancer cell death through oxygen-independent photothermal therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Rajakar Selvam, Ashish Gandhi, Shih-Che Hung, Artashes V. Karmenyan, Elena Perevedentseva, Wang-Chi Yeh, Sheng-Yun Wu, Hsin-Hou Chang, Chia-Liang Cheng
Summary: The study utilized magnetic nanodiamond particles as an efficient drug delivery vehicle, conjugated with human serum albumin to improve dispersion in biological medium and facilitate controlled release of drugs. Results showed that when loaded with clinical drug, the particles exhibited significantly improved effectiveness against cancer cells when exposed to a magnetic field.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Rangrang Fan, Caili Chen, Huan Hou, Di Chuan, Min Mu, Zhiyong Liu, Ruichao Liang, Gang Guo, Jianguo Xu
Summary: The development of folic acid functionalized polydopamine nanoparticles for dual delivery of doxorubicin and epigallocatechin-3-gallate has shown promising results in enhancing cellular uptake and anti-tumor efficacy with the assistance of near-infrared light. In vivo studies demonstrate improved drug accumulation, penetration, and retention in tumors, leading to significant suppression of tumor growth and improved survival rates in breast cancer-bearing mice. These nanoparticles have the potential to serve as an effective nanoscale vector for enhanced cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Qingqing Pan, Xinyu Peng, Ju-E Cun, Junhua Li, Yuji Pu, Bin He
Summary: The study presents an in situ drug generation and controllable loading strategy to fabricate nanotheranostic agents for cancer treatment. The BSD nanoparticles demonstrated different photothermal effects at different S-2/DTC ratios, providing new insights into photoacoustic imaging-guided therapy and cancer treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Guihua Liu, Jinyuan Ma, Yang Li, Qi Li, Chunhua Tan, Hua Song, Shuhui Cai, Dengyue Chen, Zhenqing Hou, Qing Chen, Xuan Zhu
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Review
Plant Sciences
Qing Chen, Lichao Diao, Hua Song, Xuan Zhu
Article
Chemistry, Multidisciplinary
Yuxin Guo, Yang Zhang, Jinyuan Ma, Qi Li, Yang Li, Xinyi Zhou, Dan Zhao, Hua Song, Qing Chen, Xuan Zhu
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Biochemical Research Methods
Qing Chen, Hongjian Lin, Xiaoxue Wu, Hua Song, Xuan Zhu
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
(2018)
Article
Biochemistry & Molecular Biology
Jing Wang, Hua Song, Xiaoxue Wu, Shuyi Zhang, Xuemin Gao, Funan Li, Xuan Zhu, Qing Chen
Article
Biotechnology & Applied Microbiology
Dan Zhao, Qing Chen, Hua Song, Shuting Luo, Pingyun Ge, Yingjun Wang, Jinyuan Ma, Zhi Li, Xuemin Gao, Xuemei Zhao, Xiayiding Subinuer, Huayu Yang, Xiaojuan Jiang, Yanxin Chen, Xuan Zhu
Article
Medicine, Research & Experimental
Yu Zhou, Wushuang Yang, Zhiqun Li, Doudou Luo, Weijie Li, Yali Zhang, Xuan Wang, Meijuan Fang, Qing Chen, Xin Jin
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Biochemistry & Molecular Biology
Qing Chen, Xiaoxue Wu, Xuemin Gao, Hua Song, Xuan Zhu
Article
Biochemistry & Molecular Biology
Xiaoxue Wu, Xuemin Gao, Xinmei Liu, Shuyi Zhang, Huayu Yang, Xuan Zhu, Hua Song, Funan Li, Qing Chen
Article
Biochemistry & Molecular Biology
Xiaoxue Wu, Xuemin Gao, Xuan Zhu, Shuyi Zhang, Xinmei Liu, Huayu Yang, Hua Song, Qing Chen
Article
Nanoscience & Nanotechnology
Pingyun Ge, Yuqing Liu, Qing Chen, Zaiji Su, Yuting Du, Shuting Luo, Xuemei Zhao, Xiufeng Cao, Hua Song, Xuan Zhu
Summary: The designed nanocarriers Tf-5-ALA-PTX-NCs improve drug targeting ability, enabling synergistic chemotherapy and photodynamic therapy, with a controllable drug release switch.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Applied
Qing Chen, Xinmei Liu, Huayu Yang, Shuyi Zhang, Hua Song, Xuan Zhu
Summary: In this study, novel magnetic molecularly imprinted polymers (MMIPs) with specific tripterine recognition ability were successfully synthesized using molecular imprinting technology. The MMIPs showed good recognition of tripterine, with fast binding process and maximum adsorption capacity of 30.73 mg/g. The adsorption process of the polymers followed a pseudo-second-order kinetic model and the adsorption isotherm was well described by the Langmuir isotherm model.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Chemistry, Analytical
Huayu Yang, Hua Song, Ziqin Suo, Funan Li, Quanyi Jin, Xuan Zhu, Qing Chen
Summary: This study developed a molecular imprinted electrochemical sensor for the selective and sensitive detection of P-glycoprotein. The sensor exhibited excellent selectivity, specificity, storage stability, and reusability. Compared with the ELISA kit method, the sensor showed advantages of wider detection range, shorter detection time, higher accuracy, and lower cost.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Jingbo Zhang, Quancheng Chen, Xuemin Gao, Qian Lin, Ziqin Suo, Di Wu, Xijie Wu, Qing Chen
Summary: In this study, a label-free and antibody-free impedimetric biosensor based on molecularly imprinting technology was developed for quantifying exosomes derived from non-small-cell lung cancer (NSCLC) cells. The sensor showed high sensitivity and selectivity with an LOD of 2.03 x 10(3) and an LOQ of 4.10 x 10(4) particles/mL. It demonstrated great accuracy, precision, and retention of performance after multiple cycles of elution and re-adsorption. The sensor has potential clinical translational applications in improving the prognosis and survival of NSCLC patients.