Impaired Remyelination in a Mouse Model of Huntington Disease

Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease

(2019) Carola I. Radulescu et al.   NEUROBIOLOGY OF DISEASE

Myelin Plasticity and Nervous System Function

(2018) Michelle Monje   Annual Review of Neuroscience

Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease

(2018) H.D. Rosas et al.   NeuroImage-Clinical

Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease

(2018) Marta Garcia-Miralles et al.   MOLECULAR NEUROBIOLOGY

Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease: A cross-validation study in Q175 knock-in mice

(2017) Mahalakshmi Shankaran et al.   NEUROBIOLOGY OF DISEASE

Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function

(2017) Ian D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease

(2017) Baljit S. Khakh et al.   TRENDS IN NEUROSCIENCES

Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis

(2016) Ralph Andre et al.   CURRENT OPINION IN PHARMACOLOGY

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

(2016) Roy Tang Yi Teo et al.   HUMAN MOLECULAR GENETICS

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

(2016) Lin Xiao et al.   NATURE NEUROSCIENCE

Remodeling myelination: implications for mechanisms of neural plasticity

(2016) Kae-Jiun Chang et al.   NATURE NEUROSCIENCE

Major Superficial White Matter Abnormalities in Huntington's Disease

(2016) Owen R. Phillips et al.   Frontiers in Neuroscience

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

(2016) Marta Garcia-Miralles et al.   Scientific Reports

Cholesterol in myelin biogenesis and hypomyelinating disorders

(2015) Gesine Saher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice

(2015) M. Valenza et al.   EMBO Molecular Medicine

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

(2015) Jing Jin et al.   HUMAN MOLECULAR GENETICS

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study

(2015) Govinda R. Poudel et al.   NEUROBIOLOGY OF DISEASE

Mutant Huntingtin Downregulates Myelin Regulatory Factor-Mediated Myelin Gene Expression and Affects Mature Oligodendrocytes

(2015) Brenda Huang et al.   NEURON

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington’s disease

(2014) M Valenza et al.   CELL DEATH AND DIFFERENTIATION

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

White matter integrity in premanifest and early Huntington's disease is related to caudate loss and disease progression

(2013) Marianne J.U. Novak et al.   CORTEX

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

White matter plasticity in adulthood

(2013) S. Wang et al.   NEUROSCIENCE

Disconnected aging: Cerebral white matter integrity and age-related differences in cognition

(2013) I.J. Bennett et al.   NEUROSCIENCE

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

FluoroMyelin™ Red is a bright, photostable and non-toxic fluorescent stain for live imaging of myelin

(2012) Paula C. Monsma et al.   JOURNAL OF NEUROSCIENCE METHODS

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Peroxisome-Proliferator-Activated Receptor Gamma Coactivator 1   Contributes to Dysmyelination in Experimental Models of Huntington's Disease

(2011) Z. Xiang et al.   JOURNAL OF NEUROSCIENCE

Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease

(2011) Jeffrey B. Carroll et al.   NEUROBIOLOGY OF DISEASE

Emerging roles for cholesterol in Huntington's disease

(2011) Marta Valenza et al.   TRENDS IN NEUROSCIENCES

Striatal and white matter predictors of estimated diagnosis for Huntington disease

(2010) Jane S. Paulsen et al.   BRAIN RESEARCH BULLETIN

Axon-oligodendrocyte interactions during developmental myelination, demyelination and repair

(2010) Gabrièle Piaton et al.   JOURNAL OF NEUROCHEMISTRY

Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes

(2010) M. Valenza et al.   JOURNAL OF NEUROSCIENCE

Contrasting gray and white matter changes in preclinical Huntington disease: An MRI study

(2010) D. Stoffers et al.   NEUROLOGY

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

(2009) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

(2009) Gerardo A Morfini et al.   NATURE NEUROSCIENCE

Cerebral White Matter Integrity and Cognitive Aging: Contributions from Diffusion Tensor Imaging

(2009) David J. Madden et al.   NEUROPSYCHOLOGY REVIEW

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Specification of CNS glia from neural stem cells in the embryonic neuroepithelium

(2007) N. Kessaris et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES