Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

First-in-human brain imaging of Alzheimer dementia patients and elderly controls with18F-MK-6240, a PET tracer targeting neurofibrillary tangle pathology

(2018) Talakad G Lohith et al.   JOURNAL OF NUCLEAR MEDICINE

In vivo characterization and quantification of neurofibrillary tau PET radioligand [18F]MK-6240 in humans from Alzheimer’s disease dementia to young controls

(2018) Tobey J Betthauser et al.   JOURNAL OF NUCLEAR MEDICINE

In vivo quantification of neurofibrillary tangles with [18F]MK-6240

(2018) Tharick A. Pascoal et al.   Alzheimers Research & Therapy

cGMP production of the radiopharmaceutical [18 F]MK-6240 for PET imaging of human neurofibrillary tangles

(2017) Thomas Lee Collier et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Clinical Amyloid Imaging

(2017) Atul Mallik et al.   SEMINARS IN NUCLEAR MEDICINE

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

(2017) Kok Pin Ng et al.   Alzheimers Research & Therapy

Editorial (Thematic Issue: From Current Diagnostic Tools and Therapeutics for Alzheimer's Disease Towards Earlier Diagnostic Markers and Treatment Targets)

(2016) Slavica Krantic   Current Alzheimer Research

Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

(2016) Abbas M. Walji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

(2016) E. D. Hostetler et al.   JOURNAL OF NUCLEAR MEDICINE

Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology

(2016) Jae Yong Choi et al.   MOLECULAR IMAGING AND BIOLOGY

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

(2015) Y. Kimura et al.   JOURNAL OF NUCLEAR MEDICINE

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

Amyloid PET imaging in Alzheimer’s disease: a comparison of three radiotracers

(2014) S. M. Landau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans

(2014) Aniket D. Joshi et al.   SYNAPSE

Suggested pathway to assess radiation safety of 18F-labeled PET tracers for first-in-human studies

(2013) Paolo Zanotti-Fregonara et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Whole-Body Biodistribution and Radiation Dosimetry of the Cannabinoid Type 2 Receptor Ligand [11C]-NE40 in Healthy Subjects

(2013) Rawaha Ahmad et al.   MOLECULAR IMAGING AND BIOLOGY

MIRD Pamphlet No. 21: A Generalized Schema for Radiopharmaceutical Dosimetry--Standardization of Nomenclature

(2009) W. E. Bolch et al.   JOURNAL OF NUCLEAR MEDICINE

Assessment of Human Biodistribution and Dosimetry of 4-Fluoro-11 -Methoxy-16 -18F-Fluoroestradiol Using Serial Whole-Body PET/CT

(2008) J.-M. Beauregard et al.   JOURNAL OF NUCLEAR MEDICINE

Cyclodextrins

(2008) Valentino J. Stella et al.   TOXICOLOGIC PATHOLOGY