Article
Neurosciences
Charles N. S. Allen, Sterling P. Arjona, Maryline Santerre, Claudio De Lucia, Walter J. Koch, Bassel E. Sawaya
Summary: Patients infected with HIV-1 often suffer from HIV-associated neurocognitive disorders (HAND), such as spatial memory impairments. Research has shown that the HIV-1 protein, gp120, alters cellular metabolism and impairs memory function. By understanding the cellular processes and the proteins involved, potential treatments to prevent or reverse this memory impairment can be explored.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Sauradipta Banerjee
Summary: The study characterized MG-modified myoglobin in a time-dependent manner, with mass spectrometric studies indicating modifications at Lys-87 and Lys-133. Far-UV CD studies revealed alterations in protein structure and surface hydrophobicity as a result of MG modification. These findings suggest that MG-derived AGE adducts significantly impact the structure of Mb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha
Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Oncology
Hao Yu, Xueqing Hu, Yingru Zhang, Jiajia Wang, Zhongya Ni, Yan Wang, Huirong Zhu
Summary: Cancer metastasis is a major cause of death in cancer patients, and epithelial-mesenchymal transition (EMT) plays a crucial role in this process. Abnormal expression of Glycine Decarboxylase (GLDC) has been found in tumor progression, and GLDC is up-regulated in various types of cancers. However, the role of GLDC in colorectal cancer (CRC) metastasis is not well understood. This study aimed to investigate the role of GLDC in CRC metastasis and found that GLDC promotes EMT through the Hippo signaling pathway, providing a potential therapeutic target for CRC metastasis.
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Shams Tabrez, Majed S. Al-Okail, Gouse M. Shaik, Sheraz Ahmad Bhat, Tabish M. Rehman, Fohad Mabood Husain, Mohamed F. AlAjmi
Summary: Methylglyoxal (MG) is a potent glycating agent that leads to conformational changes in HSA and amyloid formation, which can be inhibited by quercetin. The study demonstrates that quercetin effectively reverses the adverse effects of MG by sterically inhibiting the interaction between HSA and MG.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Jinming Peng, Guiqiang Liang, Wenjun Wen, Zihui Qiu, Wenye Huang, Qin Wang, Gengsheng Xiao
Summary: This study prepared Penta-O-galloyl-beta-D-glucose (PGG) from tannic acid methanolysis products and investigated its protective effects and mechanism on glucose-induced glycation for the first time. PGG was found to have strong anti-AGEs effects in bovine serum albumin (BSA)-glucose (Glu) and BSA-methylglyoxal (MGO) glycation systems. It inhibits AGEs formation by blocking glycated intermediates, eliminating radicals, and chelating metal ions. Mechanism analysis showed that PGG prevents BSA from glycation by hindering amyloid fibril accumulation, stabilizing BSA secondary structures, and binding partial glycation sites. PGG also displays effective trapping capacities on MGO reactive intermediate. This research suggests PGG as a potential functional ingredient in food materials for preventing diabetic syndrome.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Leigh Donnellan, Clifford Young, Bradley S. Simpson, Mitchell Acland, Varinderpal S. Dhillon, Maurizio Costabile, Michael Fenech, Peter Hoffmann, Permal Deo
Summary: In this study, over 500 MGO modified proteins were identified through proteomic analysis, with a notable over-representation of modifications on glycolytic enzymes, ribosomal, and spliceosome proteins. Furthermore, MGO modifications were found on the active site residues of glycolytic enzymes, potentially affecting their activity. The modification of fructose bisphosphate aldolase was consistently observed in various cell lines and peripheral blood lymphocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Mingyeong Kim, Chiheung Cho, Changjun Lee, Bomi Ryu, Sera Kim, Jinyoung Hur, Sang-Hoon Lee
Summary: This study demonstrated that Ishige okamurae extract (IOE) possesses anti-glycation and renal protective properties by inhibiting formation of advanced glycation end-products (AGEs) in diabetic nephropathy. The bioactive compounds in IOE were found to suppress oxidative stress and apoptosis, suggesting its potential as a natural therapeutic agent for managing AGE-related nephropathy.
Article
Chemistry, Medicinal
Jae-Min Lim, Hee Joon Yoo, Kwang-Won Lee
Summary: High molecular weight fucoidan from brown seaweeds has been found to protect intestinal integrity and prevent dysfunction caused by methylglyoxal-derived hydroimidazolone-1. It reduces reactive oxygen species generation, improves monolayer integrity, inhibits tight junction marker expression, and prevents receptor for AGEs-mediated intestinal damage.
Article
Chemistry, Applied
Yen-Tung Chen, You-Yu Lin, Min-Hsiung Pan, Chi-Tang Ho, Wei-Lun Hung
Summary: In thermally processed foods, heat-induced toxicants such as alpha-dicarbonyls and advanced glycation end products (AGEs) can be formed. The methylglyoxal (MGO)-trapping and antiglycative activities of herbal tea samples are strongly correlated with their phenolic and flavonoid contents. Rooibos tea exhibits the strongest MGO-trapping and antiglycative activities, reducing the levels of dicarbonyls and AGEs in cookies.
Article
Plant Sciences
Mariko Takenokuchi, Kinuyo Matsumoto, Yuko Nitta, Rumi Takasugi, Yukari Inoue, Michi Iwai, Keiichi Kadoyama, Kazutoshi Yoshida, Hiromi Takano-Ohmuro, Taizo Taniguchi
Summary: The study found that C. ruber extract effectively inhibited collagen glycation and formation of nonfluorescent AGEs, alleviating symptoms of diabetes in STZ-DM rats. Further research is necessary to determine the potential therapeutic benefits of C. ruber for various pathological conditions, including diabetes.
Article
Nutrition & Dietetics
Yantao Zhao, Yao Tang, Shengmin Sang
Summary: The study found that dietary quercetin significantly reduced MGO and AGEs concentrations in the plasma and tissues of mice, inhibiting AGE formation by trapping MGO and regulating the MGO detoxification systems.
JOURNAL OF NUTRITION
(2021)
Article
Psychiatry
Tomonori Hara, Manabu Toyoshima, Yasuko Hisano, Shabeesh Balan, Yoshimi Iwayama, Harumi Aono, Yushi Futamura, Hiroyuki Osada, Yuji Owada, Takeo Yoshikawa
Summary: Disruption of the GLO1 gene increases vulnerability to external carbonyl stress in human induced pluripotent stem cells, potentially leading to abnormal phenotypes resembling schizophrenia through mitochondrial dysfunction.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Marco Mouanness, Zaher Merhi
Summary: Advanced glycation end products (AGEs), formed by the reaction between protein and reducing sugars, can impact reproductive health and fertility through inducing inflammation and oxidative stress. This review summarizes the recent data on the pathogenesis of dietary AGEs and their potential impact on female reproductive health and offspring reproduction.
Article
Cell Biology
Cristian Arriagada-Petersen, Paula Fernandez, Maira Gomez, Natalia Ravello, Ivan Palomo, Eduardo Fuentes, Felipe Avila
Summary: This study suggests that AGEs formed with MG-Lys induce a higher activation and aggregation of platelets when compared to those formed from Gly-Lys. The effects of AGEs on platelet activation and aggregation vary depending on the concentrations and the type of AGEs generated.
Article
Cell & Tissue Engineering
Junghyun Park, Jung Han Lee, Byung Sun Yoon, Eun Kyoung Jun, Gilju Lee, In Yong Kim, Seungkwon You
STEM CELL RESEARCH & THERAPY
(2018)
Article
Cell & Tissue Engineering
Wonjin Yun, Wonjun Hong, Daryeon Son, Hui-Wen Liu, Seung-Soo Kim, Minji Park, In Yong Kim, Dae-Sung Kim, Gwonhwa Song, Seungkwon You
STEM CELLS AND DEVELOPMENT
(2019)
Article
Biochemistry & Molecular Biology
Junghyun Park, Eun Kyoung Jun, Daryeon Son, Wonjun Hong, Jihoon Jang, Wonjin Yun, Byung Sun Yoon, Gwonhwa Song, In Yong Kim, Seungkwon You
EXPERIMENTAL AND MOLECULAR MEDICINE
(2019)
Article
Cell Biology
Phil Jun Kang, Daryeon Son, Tae Hee Ko, Wonjun Hong, Wonjin Yun, Jihoon Jang, Jong-Il Choi, Gwonhwa Song, Jangbo Lee, In Yong Kim, Seungkwon You
Article
Cell & Tissue Engineering
Wonjin Yun, In Yong Kim, Gwonhwa Song, Seungkwon You
STEM CELLS TRANSLATIONAL MEDICINE
(2020)
Article
Cell & Tissue Engineering
Daryeon Son, Jie Zheng, In Yong Kim, Seungkwon You
Summary: Leigh syndrome is a progressive neurodegenerative disease caused by defects in mitochondrial genes, often starting in infancy or early childhood. A study successfully generated induced pluripotent stem cells from a patient with Leigh syndrome, showing pluripotency markers and differentiation potential.
STEM CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wei-Wei Gao, Jie Zheng, Wonjin Yun, Phil-Jun Kang, Gyuman Park, Gwonhwa Song, In-Yong Kim, Seungkwon You
Summary: A novel method has been developed to generate expandable iNPCs from human urine-derived cells, holding broad applicability potential for patient-specific treatment of kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Wonjin Yun, Kyung-Ah Choi, Insik Hwang, Jie Zheng, Minji Park, Wonjun Hong, Ah-Young Jang, Jeong Hee Kim, Wonji Choi, Dae-Sung Kim, In Yong Kim, Yong Jun Kim, Ying Liu, Byung Sun Yoon, Gyuman Park, Gwonhwa Song, Sunghoi Hong, Seungkwon You
Summary: This study successfully reprogrammed human somatic cells into expandable induced OPCs (iOPCs) using OCT4 and a small molecule cocktail. The generated iOPCs are capable of differentiating into mature oligodendrocytes and have the potential to remyelinate damaged brains. This research has significant implications for the development of therapeutic approaches for neurological disorders.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Cell & Tissue Engineering
Sureerat Khunmanee, So Young Chun, Yun-Sok Ha, Jun Nyung Lee, Bum Soo Kim, Wei-Wei Gao, In Yong Kim, Dong Keun Han, Seungkwon You, Tae Gyun Kwon, Hansoo Park
Summary: This study demonstrated the potential of using a hyaluronic acid/gelatin hydrogel as a cell carrier for therapeutic kidney regeneration in IgA nephropathy. The hydrogel showed promising mechanical properties and biocompatibility, and when combined with renal progenitor cells, it led to a reduction in blood urea nitrogen and serum creatinine levels, as well as improved kidney structure and decreased expression of pro-inflammatory and pro-fibrotic molecules.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Entomology
In-Yong Kim, Benjamin Lew, Youfu Zhao, Schuyler S. Korban, Hyungsoo Choi, Kyekyoon Kim
Summary: This study demonstrates the effectiveness of encapsulated bacterial antagonist Pantoea agglomerans strain E325 (E325) in alginate microcapsules (AMCs) in suppressing the growth of Erwinia amylovora strain Ea153 (Ea153) under different relative humidity (RH) conditions, especially at the main infection site. It suggests that microcapsule-mediated delivery of biocontrol agents could be a viable strategy for managing fire blight in apples.
Article
Biochemistry & Molecular Biology
Wei-Wei Gao, So Young Chun, Bum Soo Kim, Yun-Sok Ha, Jun Nyung Lee, Eun Hye Lee, In Yong Kim, Seungkwon You, Tae Gyun Kwon
Summary: Chronic Kidney Disease (CKD) is a global public health issue, and diabetic nephropathy (DN) is a leading cause of CKD. A study shows that induced nephron progenitor cells (iNPCs) derived from human urine have therapeutic potential in a DN animal model, reducing renal damage and promoting renal regeneration and repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Dae-Won Lee, Sungho Shin, Jeong-Ho Kim, Cheolju Lee, In Yong Kim, Il-Hoan Oh
Summary: The inhibition of let-7 miRNAs enhances the therapeutic potential of MSCs by promoting cell proliferation, migration, and regenerative processes. It does not alter the fate of MSCs but instead induces functional changes accompanied by changes in proteomics. In addition, let-7-inhibited MSCs promote self-renewal of hematopoietic progenitor cells and enhance capillary formation in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Junghyun Park, Daryeon Son, Wonjun Hong, Jihoon Jang, Geum Joon Cho, Gwonhwa Song, In Yong Kim, Seungkwon You
OBSTETRICS & GYNECOLOGY SCIENCE
(2020)
Article
Cell Biology
Jie Zheng, Wonjin Yun, Junghyun Park, Phil Jun Kang, Gilju Lee, Gwonhwa Song, In Yong Kim, Seungkwon You
JOURNAL OF BIOMEDICAL SCIENCE
(2020)
Article
Biotechnology & Applied Microbiology
Nicolas Huber, Edgar Alberto Alcala-Orozco, Thomas Rexer, Udo Reichl, Steffen Klamt
Summary: Cell-free production systems are commonly used for synthesizing industrial chemicals and biopharmaceuticals. This study presents a model-based optimization framework for cell-free enzyme cascades, taking into account parameter uncertainties. The approach was exemplified using the synthesis of GDP-fucose, resulting in significant improvements in the process.
METABOLIC ENGINEERING
(2024)
