Article
Behavioral Sciences
Sara Pereira Braga, Eslen Delanogare, Adriano Emanuel Machado, Rui Daniel Prediger, Eduardo Luiz Gasnhar Moreira
Summary: This study observed a progressive deleterious effect of high-fat diet (HFD) in metabolic and behavioral parameters in mice, but after switching from HFD to a standard diet (SD), improvements in metabolic and behavioral parameters were observed.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Changming Chen, Meiling Wen, Caixia Wang, Zhongwen Yuan, Ya Jin
Summary: In this study, a proteomic analysis of brain proteins in hyperlipidemic mice was conducted. The results showed significant changes in the expression of proteins related to lipid metabolism, neurological disorders, synaptic events, and nervous system development. Additionally, different expression patterns were observed in the two hemispheres of the brain, suggesting an asymmetric effect of hyperlipidemia on brain proteins.
Article
Nutrition & Dietetics
Mengyu Wang, Hui Han, Fan Wan, Ruqing Zhong, Yoon Jung Do, Sang-Ik Oh, Xuemeng Lu, Lei Liu, Bao Yi, Hongfu Zhang
Summary: This study found that DHQ improved lipid dysmetabolism in the body, especially in the liver, and was associated with altered gut flora.
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xianan Sun, Yi Zu, Xiang Li, Shulei Zhao, Xiao Sun, Lu Li, Xinjing Zhang, Wei Wang, Yuezhu Liang, Wenyao Wang, Xuankai Liang, Mingqi Gao, Chi Sun, Xue Guan, Man Tang
Summary: The study found that decreased extracellular 5-HT, increased 5-HT reuptake efficiency, and absence of 5-HT response to CORT injections may be signature features in the depressive state. Fluoxetine (FLX) was able to reverse these changes, but in FLX nonresponsive mice, these features persisted and worsened.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Candice M. Roux, Marianne Leger, Thomas Freret
Summary: The hippocampus plays a crucial role in memory disorders, with 5-HT(4)Rs receptors emerging as potential new therapeutic targets. Activation of 5-HT(4)Rs may help in restoring or limiting hippocampal alterations associated with neurological diseases, though further research is needed to fully understand the mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Edward Ofori, Edem K. Onyameh, Uma M. Gonela, Chandrashekhar Voshavar, Barbara Bricker, Tracy L. Swanson, Amy J. Eshleman, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: We have conducted a study to explore the potential of dual 5-HT1AR and 5-HT7R ligands, resulting in the identification of a new compound with high affinity for these receptors. This compound, designated as 21, shows promising functional characteristics as a potential antidepressant agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Sowmya Shree Gopal, Shinde Vijay Sukhdeo, Baskaran Vallikannan, Ganesan Ponesakki
Summary: Lutein has antiobesity effects in a high-fat diet-induced obese mouse model, reducing adipose tissue weight, serum cholesterol, triglycerides, and blood glucose levels, as well as downregulating genes and proteins associated with obesity.
PHYTOTHERAPY RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Canye Li, Qiming Cai, Zuanjun Su, Zhicong Chen, Jinming Cao, Feng Xu
Summary: This review aimed to investigate the relationship between peripheral 5-HT levels and depression, and found inconsistent results among different studies, suggesting that peripheral 5-HT levels cannot be used as a biomarker for depression diagnosis or evaluation of antidepressant efficacy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Drake Z. Ao, Yihua Xu, Xueting Sun, Weibo Zhang, Ye Yuan
Summary: The study aimed to investigate the effect of alternating-day diet regimens on high-fat diet-induced metabolic disorders in mice. The results showed that alternating an HFD with a normal diet effectively controlled weight and prevented metabolic disorders, possibly by affecting fat absorption and intestinal immunity.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Nazia Begum, Kandavalli Manipriya, B. Veeresh
Summary: This study developed a new animal model by combining a high-fat diet with letrozole to better simulate polycystic ovary syndrome (PCOS). Compared to the letrozole-only model, this new model can better demonstrate metabolic anomalies observed in PCOS.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Carmem Peres Valgas Da Silva, Vikram K. Shettigar, Lisa A. Baer, Eaman Abay, Kelsey M. Pinckard, Jorge Vinales, Sarah L. Sturgill, Pablo Vidal, Mark T. Ziolo, Kristin I. Stanford
Summary: This study demonstrates that aerobic exercise can significantly improve survival after myocardial infarction (MI), independent of its effects on cardiac function. However, exercise does not have an impact on obesity and glucose intolerance induced by a high-fat diet (HFD). This highlights the importance of considering environmental interventions, including diet, in the cardiac rehabilitation of obese patients.
Article
Nutrition & Dietetics
Elena Yorgidis, Lisa Beiner, Nicola Blazynski, Katja Schneider-Momm, Hans-Willi Clement, Reinhold Rauh, Eberhard Schulz, Christina Clement, Christian Fleischhaker
Summary: The study revealed the impact of eliminating certain food components on ADHD symptoms, identifying 27 food sensitivity reactions, with most participants being sensitive to multiple foods, indicating that the combination of Oligoantigenic Diet and subsequent food challenge is an effective method to identify individual food sensitivity in ADHD.
Article
Environmental Sciences
Analu Bender dos Santos, Lilian Correa Costa-Beber, Eloisa Gabriela de Pelegrin Basso, Yohanna Hannah Donato, Maicon Machado Sulzbacher, Lucas Machado Sulzbacher, Mirna Stela Ludwig, Thiago Gomes Heck
Summary: Obesity and exposure to fine particulate matter (PM2.5) are risk factors for insulin resistance. This study demonstrates that moderate aerobic training can alleviate metabolic and oxidative impairment caused by a high-fat diet and PM2.5 exposure, even in a polluted environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Organic
Vandana Cherkadu, Praveen Kumar Kalavagunta, Mallesha Ningegowda, Nanjunda Swamy Shivananju, Mahendra Madegowda, Babu Shubha Priya
Article
Chemistry, Organic
Vandana Cherkadu, Praveen Kumar Kalavagunta, Narender Ravirala, Nanjunda Swamy Shivananju, Babu Shubha Priya
Article
Dermatology
Sha Liao, Jinpeng Lv, Jia Zhou, Praveen Kumar Kalavagunta, Jing Shang
EXPERIMENTAL DERMATOLOGY
(2017)
Article
Endocrinology & Metabolism
Huali Wu, Qiongzhen Liu, Praveen Kumar Kalavagunta, Qiaoling Huang, Wenting Lv, Xiaohong An, Haijuan Chen, Tao Wang, Rakotomalala Manda Heriniaina, Tong Qiao, Jing Shang
METABOLIC BRAIN DISEASE
(2018)
Article
Medicine, Research & Experimental
Ji Ma, Maoru Li, Praveen Kumar Kalavagunta, Jiajing Li, Qiangqiang He, Yifan Zhang, Owais Ahmad, Hongli Yin, Tao Wang, Jing Shang
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Chemistry, Medicinal
Praveen Kumar Kalavagunta, Pankaj K. Bagul, Anvesh Jallapally, Srinivas Kantevari, Sanjay K. Banerjee, Narender Ravirala
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Agriculture, Multidisciplinary
Praveen Kumar Kalavagunta, Rajasekharreddy Pala, Usha Rani Pathipati, Narender Ravirala
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2014)
Article
Chemistry, Organic
P. Lakshmi Reddy, K. Praveen Kumar, S. Satyanarayana, R. Narender, B. V. Subba Reddy
TETRAHEDRON LETTERS
(2012)
Article
Chemistry, Organic
S. Satyanarayana, K. Praveen Kumar, P. Lakshmi Reddy, R. Narender, G. Narasimhulu, B. V. Subba Reddy
TETRAHEDRON LETTERS
(2013)
Article
Clinical Neurology
Huali Wu, Wenting Lv, Qi Pan, Praveen Kumar Kalavaguntaa, Qiongzhen Liu, Guohong Qin, Minxuan Cai, Liangliang Zhou, Tao Wang, Zhenjiang Xia, Jing Shang
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Microbiology
Ziwei Song, Yuanyuan Cai, Xingzhen Lao, Xue Wang, Xiaoxuan Lin, Yingyun Cui, Praveen Kumar Kalavagunta, Jun Liao, Liang Jin, Jing Shang, Jing Li
Article
Biochemistry & Molecular Biology
Qiangqiang He, Ji Ma, Praveen Kumar Kalavagunta, Liangliang Zhou, Junyi Zhu, Jing Dong, Owais Ahmad, Yuzhi Du, Lixin Wei, Jing Shang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Owais Ahmed, Vandana Cherkadu, Praveen Kumar Kalavagunta, Jing Shang
Article
Integrative & Complementary Medicine
Rakotomalala Manda Heriniaina, Dong Jing, Praveen Kumar Kalavagunta, Wu Hua-Li, Yan Dong-Sheng, Shang Jing
CHINESE JOURNAL OF NATURAL MEDICINES
(2018)