Article
Biochemistry & Molecular Biology
EunJin Bang, Cheol Park, Hyun Hwangbo, Jung-Hyun Shim, Sun-Hee Leem, Jin Won Hyun, Gi-Young Kim, Yung Hyun Choi
Summary: Diabetic retinopathy (DR) is a complex complication of diabetes characterized by vision loss, caused by the build-up of reactive oxygen species (ROS) due to hyperglycemia. In this study, spermidine, a natural polyamine with antioxidant effects, was investigated for its potential to inhibit high glucose-induced oxidative stress in human retinal pigment epithelial (RPE) cells. The results showed that spermidine effectively reduced cytotoxicity and apoptosis in high glucose-treated RPE cells by inhibiting mitochondrial ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xinyue Hu, Yingchun Shen, Yilin Zhao, Ji Wang, Xin Zhang, Wei Tu, William Kaufman, Juntao Feng, Peisong Gao
Summary: The study found that cockroach allergen induces overexpression of Muc5ac in human bronchial epithelial cells and asthma mouse model. Aryl hydrocarbon receptor (AhR) and mitochondrial ROS-NLRP3 inflammasome play important roles in regulating Muc5ac expression and airway inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Hyun Hwangbo, EunJin Bang, Su Hyun Hong, Kyoung Seob Song, Jeong Sook Noh, Do-Hyung Kim, Gi-Young Kim, Yung Hyun Choi
Summary: Diabetic retinopathy (DR) is a leading cause of vision loss and is commonly seen in diabetic patients. In this study, the researchers investigated the protective effects of beta-asarone, a compound extracted from Acori graminei Rhizoma, on human retinal pigment epithelial (RPE) ARPE-19 cells under high-glucose conditions. They found that beta-asarone significantly reduced oxidative damage in the cells by scavenging reactive oxygen species (ROS) and inhibiting the activation of the NF-kappa B/NLRP3 inflammasome pathway. These findings suggest that beta-asarone may have potential therapeutic applications in the treatment of diabetic retinopathy.
Article
Agriculture, Dairy & Animal Science
Liangli Song, Linnan Wang, Xiangchen Li, Longfei Xiao
Summary: Endometritis in dairy cows refers to a local inflammatory reaction in the endometrium caused by microbial invasion. This study investigated the therapeutic effect of ginsenoside Rg1 on endometritis-induced fibrosis and showed that ginsenoside Rg1 can alleviate the epithelial-mesenchymal transition process induced by lipopolysaccharides (LPS) by inhibiting reactive oxygen species accumulation. The study also demonstrated that ginsenoside Rg1 can relieve endometrial fibrosis in mice. These findings provide preclinical evidence for the potential use of ginsenoside Rg1 as an alternative treatment for endometrial fibrosis.
Article
Pharmacology & Pharmacy
Zhengzhu Sun, Chongfeng Fang, Shasha Xu, Bin Wang, Danlei Li, Xiaoman Liu, Yafei Mi, Hangyuan Guo, Jianjun Jiang
Summary: SIRT3 effectively attenuates DOX-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation and regulating autophagy. This finding provides a theoretical foundation for further exploration of cardiac toxicity.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenmin Dong, Chenglin Jia, Ji Li, Yi Zhou, Yun Luo, Jibo Liu, Zhiguo Zhao, Jiaqi Zhang, Shan Lin, Ying Chen
Summary: This study finds that fisetin can alleviate high glucose-induced podocyte injury and STZ-induced DN by restoring autophagy-mediated CDKN1B/P70S6K pathway and inhibiting NLRP3 inflammasome.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Jiexia Wen, Yumei Chang, Shanshan Huo, Wenyan Li, Heling Huang, Yunhuan Gao, Hongyu Lin, Jianlou Zhang, Yonghong Zhang, Yuzhu Zuo, Xuebin Cao, Fei Zhong
Summary: Tanshinone IIA has a strong anti-atherogenic function by inhibiting the activation of NLRP3 inflammasome, which plays a vital role in atherogenesis. The mechanism involves inhibiting NF-kappa B activation, downregulating pro-IL-1 beta and NLRP3 expression, and reducing oxLDL-induced cellular damage to prevent NLRP3 inflammasome assembly.
Article
Biochemistry & Molecular Biology
Hongsong Li, Rong Li, Lijun Wang, Dingying Liao, Wenyi Zhang, Jianming Wang
Summary: PACs can prevent retinal pigment epithelial cells from high glucose-induced injury by inhibiting the generation of ROS and activation of the NLRP3 inflammasome.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Immunology
Junjun Guo, Meijuan Zhou, Man Zhao, Shuxian Li, Zhenya Fang, Anna Li, Meihua Zhang
Summary: Through the study, it was found that TIGAR is up-regulated under high glucose conditions in vivo and in vitro, and loss of TIGAR increases ROS levels in trophoblast cells, leading to phenotypic changes and inhibition of migration, invasion, and tube formation. This switch is caused by the activation of the NLRP3-ASC-caspase-1 signaling pathway, resulting in pyroptosis. These findings can be reversed by antioxidant treatment and receptor blockage. In conclusion, trophoblast pyroptosis is an upstream event of TIGAR deficiency-induced inflammation, which is promoted by ROS accumulation through NLRP3-ASC inflammasome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
You Zhou, Yongjun Chen, Xiaowu Zhong, Hongtao Xia, Mingcai Zhao, Mengyuan Zhao, Lei Xu, Xiaolan Guo, Chong-Ge You
Summary: The findings suggest that Lipoxin A4 (LXA4) can inhibit the activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals, thereby exerting anti-inflammatory effects and reducing joint inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Hongxia Li, Lin Xiao, Hui He, Hongmei Zeng, Jingjing Liu, Chunjie Jiang, Guibin Mei, Jiasheng Yu, Hao Chen, Ping Yao, Yuhan Tang
Summary: This study investigates the anti-atherosclerotic properties of quercetin by modulating the Gal-3-NLRP3 pathway, showing promising effects in reducing atherosclerotic lesions. The findings suggest a potential strategy for the prevention and treatment of atherosclerosis using naturally-occurring quercetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Plant Sciences
Xuejiao Jiang, Chongyang Ma, Yanbin Gao, Hehe Cui, Yalin Zheng, JinXia Li, Wenjing Zong, Qiuyun Zhang
Summary: This study investigated the influence of Tongxinluo (TXL) on endothelial cell pyroptosis in atherosclerosis (AS) and its underlying mechanism. The results showed that TXL could inhibit endothelial cell pyroptosis and reduce the release of inflammatory cytokines. Additionally, TXL decreased the accumulation of reactive oxygen species (ROS), which further reduced endothelial cell pyroptotic damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Zongqi You, Xinying Huang, Yaoxian Xiang, Junxi Dai, Lei Xu, Junjian Jiang, Jianguang Xu
Summary: This study investigated the role of NLRP3 inflammasome activation in denervated muscle and found that its activation leads to pyroptosis, proteolysis, and apoptosis, resulting in muscle atrophy. Inhibition of NLRP3 activation can effectively alleviate muscle atrophy, suggesting the potential involvement of NLRP3 inflammasome in the pathogenesis of neuromuscular diseases.
Article
Immunology
Yifan Wang, Wen Zhu, Dandan Lu, Chuzhao Zhang, Yue Wang
Summary: The study found that tetrahydropalmatine (THP) can alleviate MSU-induced gouty arthritis by suppressing NLRP3 inflammasome activation and reducing ROS generation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Hao Wu, Yu Wang, Jingjian Huang, Yaolei Li, Zhijian Lin, Bing Zhang
Summary: Gout is a metabolic disease caused by the deposition of monosodium urate (MSU) and is associated with hyperuricemia. The effectiveness and safety of current anti-gout drugs are limited. This study investigates the protective effects of rutin, a natural flavonoid, on gout. The results show that rutin reduces gout symptoms, inflammatory expression, XOD activity, ROS production, and NLRP3 inflammasome activation in quails. The study also establishes a useful animal model for gout drug research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)