Article
Sport Sciences
Rebecca A. G. Christensen, Julia A. Knight, Rinku Sutradhar, Jennifer D. Brooks
Summary: This study aims to examine the association between cardiorespiratory fitness (CRF) and the risk of breast cancer in postmenopausal women. The findings suggest that higher CRF may be a protective factor against breast cancer, but only for women with elevated body fat.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jari A. Laukkanen, Sudhir Kurl, Hassan Khan, Setor K. Kunutsor
Summary: The study found a dose-response relationship between age-predicted cardiorespiratory fitness and risk of sudden cardiac death. An increase in percentage of age-predicted CRF was associated with a decreased risk of SCD, independent of other factors. Comparison of extreme quartiles showed consistent results in relation to SCD risk.
Article
Pediatrics
Ruben Lopez-Bueno, Joaquin Calatayud, Lars Louis Andersen, Jose Casana, Yasmin Ezzatvar, Jose Antonio Casajus, Guillermo Felipe Lopez-Sanchez, Lee Smith
Summary: The study found that COVID-19 confinement has a negative impact on the development of VO2 max in adolescents, especially in the subgroups of 14-year-old girls and 12-year-old boys. Measures are needed to address this concerning decline.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Robert A. A. Sloan, Youngdeok Kim, Jonathan Kenyon, Marco Visentini-Scarzanella, Susumu S. S. Sawada, Xuemei Sui, I-Min Lee, Jonathan N. N. Myers, Carl J. J. Lavie
Summary: This study used a new estimated cardiorespiratory fitness algorithm to predict abnormal blood glucose incidence based on routinely documented information in electronic health care records. The results showed that higher estimated cardiorespiratory fitness was associated with a lower risk of abnormal glucose.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Alex Di Florio, Chiara Fusi, Francesca Anselmi, Luna Cavigli, Marta Focardi, Matteo Cameli, Andrea Felici, Massimo Capitani, Serafina Valente, Marco Bonifazi, Alessandro Zorzi, Domenico Corrado, Sergio Mondillo, Flavio D'Ascenzi
Summary: The most common morphologies of premature ventricular beats (PVBs) observed in athletes are infundibular and fascicular PVBs. The diagnosis of cardiac disease correlates with uncommon PVBs morphology and arrhythmia complexity. Athletes with cardiac disease had lower number of PVBs/24-h compared to those with normal heart, and athletes with PVBs and negative investigation showed a good prognosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Setor K. Kunutsor, Sae Young Jae, Timo H. Makikallio, Jari A. Laukkanen
Summary: The study found that higher cardiorespiratory fitness (CRF) can moderately attenuate the increased risk of chronic obstructive pulmonary disease (COPD) due to smoking.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Medicine, General & Internal
Setor K. Kunutsor, Ari Voutilainen, Jari A. Laukkanen
Summary: The study examined the association between cardiorespiratory fitness (CRF) and prostate cancer risk in 2204 middle-aged men over a median follow-up of 24.9 years. The findings suggest that elevated CRF is not associated with a reduced risk of prostate cancer, with consistent results even after adjusting for various risk factors. Previous studies that reported associations between high CRF and prostate cancer risk may be influenced by increased screening and detection, as well as reverse causation bias.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jari A. Laukkanen, Setor K. Kunutsor
Summary: The study found a linear, inverse, and independent association between percentage of age-predicted cardiorespiratory fitness and the risk of developing hypertension (HTN). For every 1% increase in percentage of age-predicted cardiorespiratory fitness, the risk of HTN decreased. The study concludes that percentage of age-predicted cardiorespiratory fitness is a comparable risk indicator to absolute cardiorespiratory fitness for HTN in middle-aged men.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2022)
Article
Multidisciplinary Sciences
Rebecca A. G. Christensen, Jasleen Arneja, Kate St. Cyr, Shelby L. Sturrock, Jennifer D. Brooks
Summary: While there was no significant association between cardiorespiratory fitness and testing positive for COVID-19, individuals with moderate and high fitness levels had a significantly lower risk of dying from COVID-19 compared to those with low fitness levels. This suggests that improving cardiorespiratory fitness could potentially provide protection against severe outcomes of COVID-19.
Article
Cardiac & Cardiovascular Systems
Luc Souilla, Martina Avesani, Aymeric Boisson, Anne Requirand, Stefan Matecki, Marie Vincenti, Oscar Werner, Gregoire de la Villeon, Victor Pommier, Jean-Luc Pasquie, Sophie Guillaumont, Pascal Amedro
Summary: In children with congenital long QT syndrome, finding a balance between exercise restrictions and promotion of physical activity is challenging due to the increased risk of arrhythmic events during exercise. However, there is limited research on cardiorespiratory fitness, muscle fitness, and physical activity in these children. Therefore, assessing and providing rehabilitation for these children is of great importance.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Ryoko Kawakami, Susumu S. Sawada, Kiminori Kato, Yuko Gando, Haruki Momma, Hideaki Oike, Motohiko Miyachi, I-Min Lee, Steven N. Blair, Minoru Tashiro, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Kazuya Fujihara, Hirohito Sone
Summary: The study demonstrates a correlation between higher muscular and performance fitness levels and a lower incidence of hearing loss, with vertical jump height and single-leg balance showing the strongest association.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Geriatrics & Gerontology
Setor K. Kunutsor, Nzechukwu M. Isiozor, Jonathan Myers, Samuel Seidu, Kamlesh Khunti, Jari A. Laukkanen
Summary: Chronic kidney disease (CKD) is a preventable global public health burden. High levels of cardiorespiratory fitness (CRF) are associated with a decreased risk of CKD, but the dose-response relationship and long-term relevance of CRF levels to CKD have not been fully addressed.
Article
Public, Environmental & Occupational Health
Alexander Wilhelm Gorny, Jonathan Yap, Jia Wei Neo, Wei En Chow, Khung Keong Yeo, Chuen Seng Tan, Falk Mueller-Riemenschneider
Summary: This study investigated the association between cardiorespiratory fitness, body mass index (BMI), incidence of major acute cardiovascular events (MACE), and all-cause mortality (ACM). The study included 212,631 healthy young men aged 16 to 25 years who had undergone medical examination and fitness testing. Lower cardiorespiratory fitness and higher BMI were associated with increased hazards of MACE and ACM.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Nixiao Zhang, Chuangshi Wang, Alessio Gasperetti, Yanyan Song, Hongxia Niu, Min Gu, Firat Duru, Liang Chen, Shu Zhang, Wei Hua
Summary: The study validated the good fitness of the novel risk-prediction model in predicting arrhythmic risk in Asian ARVC patients for primary prevention, and for secondary prevention patients after recalibration of the baseline risk. The performance of the prediction model in secondary prevention patients was improved after recalibration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Chenjie Xu, Yabing Hou, Keyi Si, Zhi Cao
Summary: There is an interaction between cardiorespiratory fitness and genetic susceptibility and inflammation in relation to the risk of type 2 diabetes. Improving cardiorespiratory fitness can reduce the risk of type 2 diabetes caused by genetic susceptibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Nutrition & Dietetics
Setor K. Kunutsor, Jari A. Laukkanen, Jyrki K. Virtanen
Summary: Egg or cholesterol intake is not associated with future risk of venous thromboembolism (VTE) in middle-aged and older Finnish men.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Peripheral Vascular Disease
Sae Young Jae, Hyun Jeong Kim, Sudhir Kurl, Setor K. Kunutsor, Jari A. Laukkanen
Summary: A study of 1,481 men showed that an exaggerated systolic blood pressure (ESBP) during exercise is associated with an increased risk of cardiovascular disease (CVD) mortality. However, high levels of cardiorespiratory fitness (CRF) do not attenuate this risk.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Review
Orthopedics
Ifrah Omar, Setor K. Kunutsor, Wendy Bertram, Andrew J. Moore, Ashley W. Blom, Erik Lenguerrand, Michael R. Whitehouse, Vikki Wylde
Summary: This study aimed to understand the current provision of rehabilitation for revision total knee replacement (TKR) in England and evaluate the existing evidence. The study involved an online national survey of education and rehabilitation provision for patients receiving revision TKR in 22 hospitals across England, as well as a systematic review of studies evaluating rehabilitation programs for revision joint replacement. The study identified the need for future research on tailored rehabilitation to optimize patient outcomes following revision TKR.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Letter
Medicine, General & Internal
Setor K. Kunutsor, Jari A. Laukkanen
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Public, Environmental & Occupational Health
Samuel Seidu, Mohammad Abdool, Abdullah Almaqhawi, Thomas J. Wilkinson, Setor K. Kunutsor, Kamlesh Khunti, Tom Yates
Summary: Regular physical activity is associated with a reduced risk of chronic kidney disease (CKD) in the general population, according to a systematic review and meta-analysis of observational cohort studies. However, the quality of the evidence is low.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Orthopedics
Richard L. Donovan, Harvey Johnson, Sherwin Fernando, Michael Foxall-Smith, Michael R. Whitehouse, Ashley W. Blom, Setor K. Kunutsor
Summary: This study compared the use of constrained acetabular components and dual mobility implants in revision total hip arthroplasty (rTHA) and found that dual mobility implants had lower rates of dislocation, re-revision for dislocation, and re-revision for any cause compared to constrained acetabular components. Surgeons should consider these findings when choosing implants for the treatment of instability.
JOURNAL OF ARTHROPLASTY
(2023)
Letter
Cardiac & Cardiovascular Systems
Setor K. K. Kunutsor, Sae Young Jae, Sudhir Kurl, Jari A. Laukkanen
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Geriatrics & Gerontology
Setor K. Kunutsor, Nzechukwu M. Isiozor, Jonathan Myers, Samuel Seidu, Kamlesh Khunti, Jari A. Laukkanen
Summary: Chronic kidney disease (CKD) is a preventable global public health burden. High levels of cardiorespiratory fitness (CRF) are associated with a decreased risk of CKD, but the dose-response relationship and long-term relevance of CRF levels to CKD have not been fully addressed.
Article
Cell Biology
Sira Karvinen, Tia-Marje Korhonen, Tero Sievanen, Jari E. Karppinen, Hanna-Kaarina Juppi, Veera Jakoaho, Urho M. Kujala, Jari A. Laukkanen, Maarit Lehti, Eija K. Laakkonen
Summary: Decreased systemic oestrogen levels have an impact on metabolic health, and the mechanisms behind this process are not fully understood. Both oestrogens and exercise have been shown to improve metabolic health, potentially through circulating microRNA signalling. Extracellular vesicles (EV) have gained attention in the field of tissue crosstalk, but the co-isolation of high-density lipoprotein (HDL) particles with EVs has been overlooked in many studies, which may influence the results.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Cardiac & Cardiovascular Systems
Nzechukwu M. Isiozor, Setor K. Kunutsor, Ari Voutilainen, Ifeanyichukwu Isiozor, Bamba Gaye, Jussi Kauhanen, Jari A. Laukkanen
Summary: This study aimed to examine the association between cardiovascular health (CVH) metrics and the risk of heart failure (HF) in a Finnish population. The study found that individuals with optimal CVH scores had a lower risk of heart failure compared to those with inadequate CVH scores.
Article
Cardiac & Cardiovascular Systems
Jari A. Laukkanen, Nzechukwu M. Isiozor, Peter Willeit, Setor K. Kunutsor
Summary: The study examines the association between hemodynamic gain index (HGI) and cardiovascular disease (CVD) mortality risk. The results show an inverse relationship between HGI and CVD mortality risk, which is partly dependent on cardiorespiratory fitness (CRF) levels.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Letter
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Sudhir Kurl, Jari A. Laukkanen
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hassan Khan, Setor K. Kunutsor
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Samuel Seidu, Harini Willis, Setor K. Kunutsor, Kamlesh Khunti
Summary: This study assessed and compared the benefits and harms of intensive versus standard blood pressure control in older people with or without diabetes. Analysis of six randomized controlled trials involving 20,985 patients showed that intensive blood pressure control reduces the risk of cardiovascular events in the general population, but its effectiveness in patients with diabetes is uncertain.
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jari A. Laukkanen, Carl J. Lavie, Setor K. Kunutsor
Summary: Elevated levels of serum testosterone in middle-aged and older men are associated with an increased risk of aortic stenosis (AS).
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)