Review
Engineering, Biomedical
Qingjin Cai, Wanshan Liao, Fangchao Xue, Xiaochen Wang, Weiming Zhou, Yanzhao Li, Wen Zeng
Summary: Selecting suitable types of endothelialization and seed cells can improve the long-term patency rate of tissue-engineered vascular grafts with different diameters and lengths.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Yuehao Xing, Yongquan Gu, Lianrui Guo, Jianming Guo, Zeqin Xu, Yonghao Xiao, Zhiping Fang, Cong Wang, Zeng-Guo Feng, Zhonggao Wang
Summary: Gelatin coating on the internal surface of PCL grafts is a simple and effective way to promote endothelialization. Heparinized gelatin-coated grafts showed more rapid and complete endothelialization, inhibiting intimal hyperplasia in the long-term, and promoting smooth muscle cells and extracellular matrix regeneration.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Engineering, Biomedical
Hongyan Kang, Guiqin Yan, Weichen Zhang, Junwei Xu, Jiaxin Guo, Jiali Yang, Xiao Liu, Anqiang Sun, Zengsheng Chen, Yubo Fan, Xiaoyan Deng
Summary: In this study, a hypercholesterolemia rat model was established and electrospun polycaprolactone vascular grafts were implanted into the rat abdominal aortas. The results showed that the grafts implanted in the hypercholesterolemia rats exhibited poor performance, which was associated with impaired proliferative, migratory, and adhesive abilities of endothelial cells.
ACTA BIOMATERIALIA
(2022)
Article
Biochemical Research Methods
Cynthia Hajal, Giovanni S. Offeddu, Yoojin Shin, Shun Zhang, Olga Morozova, Dean Hickman, Charles G. Knutson, Roger D. Kamm
Summary: This protocol describes an in vitro model of the human blood-brain barrier, self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes. The model features relevant cellular organization and morphological characteristics, and can be used to assess pathophysiological molecular transport mechanisms and design targeted therapies for neurological disorders.
Article
Engineering, Biomedical
Xue Chen, Nianguo Dong, Xu Xu, Ying Zhou, Jiawei Shi, Weihua Qiao, Hao Hong
Summary: Aptamer-immobilized DAVs can accelerate endothelialization and capture endothelial progenitor cells, promoting the re-endothelialization of scaffolds.
Article
Materials Science, Biomaterials
Dong Yeop Lee, Yongwoo Jang, Eunyoung Kim, Tao Li, Seon Jeong Kim
Summary: The tissue-engineered vascular graft (TEVG) is a promising alternative for small-diameter blood vessel replacement, and a bioresorbable polyglycolic acid (PGA) fiber-knitted tubular scaffold shows potential as a flexible and durable support for vascular cells. The PGA tubular knit serves as a porous three-dimensional matrix for cell attachment and growth, and it can withstand mechanical damage and maintain suturability.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Textiles
Gholamhosein Kazemzadeh, Nafiseh Jirofti, Hosein Kazemi Mehrjerdi, Masoud Rajabioun, Seyed Ali Alamdaran, Davod Mohebbi-Kalhori, Mahnaz Sadat Mirbagheri, Reza Taheri
Summary: This review article investigates the biocompatibility behavior of hybrid PCL-based scaffolds with collagen, gelatin, and chitosan in improving endothelialization for VTE applications. The high failure rate of small diameter vascular grafts due to adhesion and aggregation, over-proliferation of smooth muscle cells, and neointimal hyperplasia is a major challenge in vascular tissue engineering. Polycaprolactone (PCL) is a potential material, but its biocompatibility is a concern. Recent studies have proposed using natural polymers to modify PCL vascular grafts to speed up endothelial cell regeneration.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Biology
Hualong Bai, Peng Sun, Haoliang Wu, Shunbo Wei, Boao Xie, Wang Wang, Yachen Hou, Jing'an Li, Alan Dardik, Zhuo Li
Summary: The use of decellularized fish swim bladder coated with rapamycin as vascular patches or tubes showed reduced neointimal thickness and macrophages in rat models. This suggests that fish swim bladder could be a potential scaffold source for tissue-engineering vascular grafts.
COMMUNICATIONS BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ying Zhou, Ge Yan, Shuyu Wen, Wai Yen Yim, Zihao Wang, Xing Chen, Yin Xu, Xue Chen, Hong Cao, Peng Bai, Fei Li, Jiawei Shi, Jianglin Wang, Weihua Qiao, Nianguo Dong
Summary: This study constructs a dual-functional TEHV scaffold by modifying DHV with copper ions (Cu) and growth differentiation factor 11 (GDF11), which improves hemocompatibility and accelerates endothelialization. The newly-constructed scaffold successfully generates endogenous nitric oxide (NO) and possesses improved hemocompatibility. Furthermore, GDF11 immobilization significantly accelerates scaffold endothelialization.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Isabel Mayoral, Elisa Bevilacqua, Gorka Gomez, Abdelkrim Hmadcha, Ignacio Gonzalez-Loscertales, Esther Reina, Julio Sotelo, Antonia Dominguez, Pedro Perez-Alcantara, Younes Smani, Patricia Gonzalez-Puertas, Ana Mendez, Sergio Uribe, Tarik Smani, Antonio Ordonez, Israel Valverde
Summary: In this study, a patient-specific patch was designed using a hybrid 3D printing technique and VSMC differentiation. Through computational modeling and experimental evaluation, the patch demonstrated favorable hemodynamic characteristics, mechanical properties, cell infiltration, viability, and functionality. This innovative 3D biotechnology holds great potential for applications in regenerative medicine and heart disease prevention.
MATERIALS TODAY BIO
(2022)
Review
Engineering, Biomedical
Leanne de Silva, Paulina N. Bernal, A. J. W. Rosenberg, Jos Malda, Riccardo Levato, Debby Gawlitta
Summary: The development of tissue engineering strategies for treatment of large bone defects is crucial, and creating a vascular network is vital for tissue engineered bone constructs.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Hongyu Yan, Quhan Cheng, Jianghua Si, Songdi Wang, Ye Wan, Xin Kong, Ting Wang, Wenting Zheng, Muhammad Rafique, Xiaofeng Li, Ju He, Adam C. Midgley, Yi Zhu, Kai Wang, Deling Kong
Summary: Researchers have introduced highly efficient and biocompatible functional modifications to living cells within tissue-engineered constructs, improving the performance of vascular grafts and promoting vascular regeneration without the need for anticoagulant therapy.
BIOACTIVE MATERIALS
(2023)
Article
Polymer Science
Phillip R. Schmitt, Kiera D. Dwyer, Alicia J. Minor, Kareen L. K. Coulombe
Summary: Myocardial infarction is a leading cause of death globally, and cardiac tissue engineering using hiPSC-CMs aims to re-engineer the infarcted myocardium. The current challenges in this technology include maintaining tissue integrity and inducing cell function, while biodegradable PCL scaffolds offer a solution.
Review
Biochemistry & Molecular Biology
Clelia Dispenza, Daniela Giacomazza, Mats Jonsson
Summary: Bio-hybrid hydrogels utilize radiation technologies to enhance biological activity, control chemical reactions, and have potential sterilization functions. They can serve as delivery devices for therapeutic biomolecules and create hydrogel patterns on surfaces.
Article
Biotechnology & Applied Microbiology
Yalin Liu, Haoyong Yuan, Yuhong Liu, Chunyang Chen, Zhenjie Tang, Can Huang, Zuodong Ning, Ting Lu, Zhongshi Wu
Summary: A multifunctional nanoparticle-VEGF system consisting of chitosan, REDV peptide, heparin, and VEGF was developed to enhance anti-thrombosis and promote rapid endothelialization of small-diameter tissue-engineered vascular grafts. The results showed improved patency rates and endothelialization in a rabbit model.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)