Article
Chemistry, Multidisciplinary
Sobia Razzaq, Aisha Rauf, Abida Raza, Sohail Akhtar, Tanveer A. Tabish, Mansur Abdullah Sandhu, Muhammad Zaman, Ibrahim M. Ibrahim, Gul Shahnaz, Abbas Rahdar, Ana M. Diez-Pascual
Summary: This study focuses on overcoming multidrug resistance in cancer chemotherapy by delivering paclitaxel specifically to target sites with enhanced efficacy against solid tumors. The use of multifunctional polymeric micelles for loading and releasing paclitaxel has shown significant improvements in permeation, apoptosis induction, biodistribution, and toxicity reduction. By targeting the P-glycoprotein efflux pump, the mucopermeating PT-R-Ms demonstrated a promising approach to improve cancer therapy outcomes.
Article
Nanoscience & Nanotechnology
Junyan Chen, Wuyan Xu, Tianming Dai, Songsong Jiao, Xiang Xue, Jiayang Jiang, Siming Li, Qingqi Meng
Summary: In this study, HA-based cartilage-targeted nanomicelles were constructed to deliver pioglitazone in a sustained manner for the treatment of osteoarthritis (OA). The results showed that C-HA-DOs effectively inhibited cell death, restored cell function, and delayed the progression of OA by targeting cartilage.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Swati Sharma, Shrikant Sitaram Kirwale, Yash T. Katakia, Syamantak Majumder, Aniruddha Roy
Summary: In diabetic wounds, lack of angiogenesis limits healing. This study developed an in-situ forming scaffold loaded with simvastatin (SIM) to promote angiogenesis and collagen deposition at the wound site. The SIM-loaded scaffold demonstrated good mechanical stability and prolonged release of SIM, leading to faster wound closure, increased collagen deposition, and enhanced neovascularization in a diabetes-induced rat wound model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Han-yuan Zheng, Yu-dun Liu, Yu-lei Zhang, Qing-hua Shi, Xue-li Hou, Lin An
Summary: In this study, a supramolecular drug delivery system based on PDCA micelles has been developed to transport CPT to the therapeutic target. The CPT@PDCA micelles show high encapsulation efficiency and pH-responsive release behavior. CPT-loaded PDCA exhibits decreased toxicity to normal cells and comparable inhibitory effect on tumor proliferation compared with CPT alone.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Zemin Hou, Wencheng Zhou, Xi Guo, Rui Zhong, Ao Wang, Jiehua Li, Ying Cen, Chao You, Hong Tan, Meng Tian
Summary: This study investigates the drug delivery system of clinically relevant micelles composed of methoxypolyethylene glycol (MPEG) with identical chain length and poly(epsilon-caprolactone) (PCL) with tunable chain length. The results show that the micelles have negligible effects on blood components, phagocytosis, and biodistribution. The stability of the micelles plays an important role in biodistribution.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Youwu Liao, Haiqiao Wang, Shuang Li, Yuanyuan Xue, Yunqiu Chen, Michael Adu-Frimpong, Ying Xu, Jiangnan Yu, Ximing Xu, Hugh D. C. Smyth, Yuan Zhu
Summary: Astaxanthin-loaded composite micelles were successfully prepared via coaxial electrospray technology, showing enhanced drug solubility and release rate. The delivery system improved the absorption of AST in the gastrointestinal tract and significantly increased antioxidant capacity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Nanoscience & Nanotechnology
Wu Zhou, Ze Lin, Yuan Xiong, Hang Xue, Wen Song, Tao Yu, Lang Chen, Yiqiang Hu, Adriana C. Panayi, Yun Sun, Faqi Cao, Guodong Liu, Liangcong Hu, Chenchen Yan, Xudong Xie, Wenxiu Qiu, Bobin Mi, Guohui Liu
Summary: This study developed targeted nanoparticles loaded with BCL, which were magnetically delivered to the fracture site to induce M2 macrophage polarization and promote osteogenic differentiation, highlighting a potent therapeutic benefit with high biosafety.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Mohamad Mahani, Maral Bahmanpouri, Faeze Khakbaz, Faten Divsar
Summary: A pH-tunable on-off module polymeric micelles were synthesized for the delivery and controlled release of drug DOX. Nitrogen-doped carbon quantum dots were used to form micelles with robust fluorescence characteristics, and their properties were verified through various analyses. In vitro experiments showed that the developed nanocarrier exhibited good cytotoxicity against tumor cells, making it a promising approach for drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Nilesh Rarokar, Roshani Agrawal, Sakshi Yadav, Pramod Khedekar, C. Ravikumar, Darshan Telange, Shailendra Gurav
Summary: Targeting cancer cells can be achieved by surface functionalizing nanocarriers like polymeric micelles using block copolymers with conjugation moiety, increasing targeting ability and inhibiting drug efflux by inhibiting P-gp. This study develops FA-linked Pluronic (R) F68 (FA-PF68) micelles for DTX delivery to treat cancer progression associated with FR. The FA-PF68-DTX micelles demonstrate increased particle size, better physical stability, and higher entrapment efficiency. They also show sustained release of DTX and higher efficiency against MDA-MB-231 cells with lower toxicity on liver, kidney, and lung cells.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Ibrahim A. Komeil, Wessam M. El-Refaie, Mennatallah A. Gowayed, Samar O. El-Ganainy, Samar N. El Achy, Kristiina M. Huttunen, Ossama Y. Abdallah
Summary: This study aimed to improve the solubility of Genistein, protect it from metabolism, and increase its accumulation in hepatic cells using phytosomes. Results showed that GP and GPL effectively accumulated Gen aglycone in hepatic cells, increased intracellular accumulation of Gen in its complex form in HepG2 cells, and exhibited enhanced in vivo anti-tumor effects in an HCC mouse model. Genphytosomes represent a promising approach for liver cancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Baixue Xiao, Yuxuan Liu, Indika Chandrasiri, Emmanuela Adjei-Sowah, Jared Mereness, Ming Yan, Danielle S. W. Benoit
Summary: This study developed a bone-targeted nanoparticle drug delivery system that enhances fracture healing by modulating macrophage polarization. The experimental results showed that the system is predominantly uptaken by fracture-associated macrophages, resulting in increased M2/M1 ratio and expedited fracture healing, accompanied by upregulation of anti-inflammatory genes and downregulation of pro-inflammatory genes.
Article
Pharmacology & Pharmacy
Shery Adel, Rania Hassan Fahmy, Ibrahim Elsayed, Magdy Ibrahim Mohamed, Reem R. Ibrahim
Summary: Chronic inflammatory bowel diseases are often accompanied by opportunistic colonic fungal infections. ITZ-NMMs can enhance the solubility of ITZ and have improved antifungal and anticancer activities, making them suitable for the treatment of colon fungal infections and colon cancer therapy.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Shuanghu Wang, Xueying Tan, Quan Zhou, Peiwu Geng, Jinhui Wang, Ping Zou, Aiping Deng, Jingbo Hu
Summary: The study successfully constructed folate-targeted polymeric micellar carrier for co-delivery of doxorubicin (DOX) and SIS3 (FA/DOX/SIS3 micelles) to sensitize drug-resistant cancer cells, demonstrating superior anti-tumor activity and longer circulation time in blood, preferential accumulation in resistant tumor tissue. The FA/DOX/SIS3 micelles showed promising potential for synergistic treatment of drug-resistant tumors.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Engineering, Biomedical
Zhe Wang, Songsong Zhao, Wenxing Gu, Yangyang Dong, Fenghua Meng, Jiandong Yuan, Zhiyuan Zhong
Summary: A novel strategy combining A3-Ps and Vol for dual-targeted molecular therapy of OC showed significantly improved potency and reduced systemic toxicity in SKOV-3 tumor models. This approach presents a promising treatment modality for malignant PLK1-positive ovarian tumors.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
Yun Li, Zhi Cai, Yihua Yin, Ying Yi, Weiquan Cai, Shengxiang Tao, Mengting Du, Jingli Zhang, Ruyu Cao, Yijing Luo, Wenjin Xu
Summary: In this study, a photoactivated bactericide nanosystem was developed using hematoporphyrin as a photosensitizer and pectin as a carrier. The nanosystem showed good water solubility and demonstrated high photodynamic activity upon esterase stimulation. It exhibited potent antibacterial effects and good adherence to leaves with no apparent toxic effects on plants. This research provides a new strategy for obtaining a photoactivated bactericide nanosystem with high utilization rate, good photostability, and targeting ability.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Jeffery J. Nielsen, Stewart A. Low, Neal T. Ramseier, Rahul Hadap, Nicholas A. Young, Mingding Wang, Philip S. Low
Summary: The study aimed to improve bone fracture management by continuously applying bone anabolic agents to the fracture surface. Short oligopeptides of acidic amino acids were found to significantly increase localization of peptide payload to bone fractures, offering a promising strategy for enhancing fracture healing.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Endocrinology & Metabolism
Jeffery J. Nielsen, Stewart A. Low
CURRENT OSTEOPOROSIS REPORTS
(2020)
Article
Biochemical Research Methods
Xin Liu, Weichuan Luo, Boning Zhang, Yong Gu Lee, Imrul Shahriar, Madduri Srinivasarao, Philip S. Low
Summary: In this study, a modified influenza virus neuraminidase inhibitor, zanamivir, was utilized for diagnostic, imaging, and therapeutic purposes in influenza virus infections. Different conjugates like the zanamivir-conjugated rhodamine dye and zanamivir99 mTc radioimaging conjugate were designed for visual monitoring of virus-infected cells. Moreover, targeted cytotoxic drugs and CAR T cells were developed specifically for viral neuraminidase-expressing cells, showing potential for improved treatment of influenza virus infections.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sakkarapalayam M. Mahalingam, Karson S. Putt, Madduri Srinivasarao, Philip S. Low
Summary: The inadvertent severing of a ureter during colorectal surgeries is a common issue, leading to the development of new near-infrared dyes to help surgeons identify ureter location. The new PEGylated UreterGlow derivatives show promising optical and biodistribution characteristics, making them good candidates for translation into the clinic.
Article
Chemistry, Multidisciplinary
John Victor Napoleon, Boning Zhang, Qian Luo, Madduri Srinivasarao, Philip S. Low
Summary: Administering a CAR-targeted TLR7 agonist can reverse CAR T cell exhaustion and successfully treat solid tumors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Qian Luo, John Napoleon, Xin Liu, Boning Zhang, Suilan Zheng, Philip S. Low
Summary: This study describes a strategy to reverse CAR T-cell exhaustion by using a universal anti-fluorescein CAR that engages multiple cancer cell clones and acts as a drug-internalizing receptor. By attaching a Toll-like receptor 7 agonist to the anti-fluorescein CAR, they downregulate exhaustion markers and reactivate exhausted CAR-T cells, leading to regression of solid tumors.
MOLECULAR CANCER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Stewart A. Low, Jeffery J. Nielsen, Cheyanne M. Coakley, Mini Thomas, Ephraim U. Mbachu, Christopher L. Chen, Yava Jones-Hall, Madeleine I. Tremblay, Jonathan R. Hicks, Philip S. Low
Summary: Targeted drug delivery is a process of delivering therapeutic drugs to specific parts of the body, increasing their concentration at desired sites. A fracture-targeted peptide has been designed, which accumulates specifically at fracture sites and reduces healing time while improving bone strength. This peptide shows no toxicity to healthy tissues.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Yun Chang, Gyuhyung Jin, Weichuan Luo, Qian Luo, Juhyung Jung, Sydney N. Hummel, Sandra Torregrosa-Allen, Bennett D. Elzey, Philip S. Low, Xiaojun Lance Lian, Xiaoping Bao
Summary: Adoptive CAR-engineered NK cells have potential for cancer treatment, but limited immunological memory and donor cell availability hinder their applications. We evaluated different CAR constructs to enhance NK cell proliferation and anti-tumor cytotoxicity. We genetically engineered hPSCs with optimized CARs and differentiated them into dual CAR-NK cells. The memory-like hPSC-NK cells showed enhanced anti-tumor activity through antigen-dependent activation of signaling pathways. Our modular hPSC CAR-NK engineering platform is a realistic strategy for off-the-shelf CAR-NK cells with immunological memory-like phenotype for targeted immunotherapy.
BIOACTIVE MATERIALS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Stewart Low, Jeffery Nielsen, Xinlan Li, Ephraim Mbachu, Arden Shen, Mini Thomas, Mary Niedrauer
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Jeffery Nielsen, Stewart Low, Ephraim Mbachu, Lina Trigg, Christopher Chen, Madeleine Tremblay, Philip Low
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Immunology
Huynh Dinh Chien, Antonella Pantaleo, Kristina R. Kesely, Panae Noomuna, Karson S. Putt, Tran Anh Tuan, Philip S. Low, Francesco M. Turrini
Summary: The coadministration of imatinib with standard of care (SOC) in uncomplicated P. falciparum malaria patients led to a faster decline in parasite density and fever, without any delayed parasite clearance. The improvements were most significant in patients with the highest parasite density, where serious complications and death are most common.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Xin Liu, Boning Zhang, Yingcai Wang, Hanan S. Haymour, Fenghua Zhang, Le-cun Xu, Madduri Srinivasarao, Philip S. Low
NATURE COMMUNICATIONS
(2020)
Meeting Abstract
Endocrinology & Metabolism
Stewart Low, Jeffery Nielsen, Philip Low
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Meeting Abstract
Endocrinology & Metabolism
Jeffery Nielsen, Stewart Low, Philip Low, Chris Chen, Ephriam Mbachu
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)