Article
Cell Biology
Qi Peng, Huihui Liu, Zhisheng Luo, Haiyan Zhao, Xinming Wang, Xiuru Guan
Summary: In the progression of atherosclerotic plaque, the death of foam cells accelerates plaque development. While Nrf2 has been considered a major regulator of antioxidants, recent studies have shown that insufficient autophagy can deactivate Nrf2-mediated defense, leading to ferroptosis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Hematology
Jie Lin, Qian Ren, Fanjie Zhang, Jing Gui, Xin Xiang, Qin Wan
Summary: This study investigated the role and mechanism of beta-hydroxybutyrate dehydrogenase 1 (Bdh1) in regulating macrophage oxidative stress in diabetes-induced atherosclerosis (AS). The results showed that Bdh1 expression was decreased in patients with diabetes-induced AS, HG-treated macrophages, and diabetic Apoe(-/-) mice. AAV-mediated Bdh1 overexpression attenuated aortic plaque formation in diabetic Apoe(-/-) mice, while silencing of Bdh1 increased reactive oxygen species (ROS) production and an inflammatory response in macrophages.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Suvi Linna-Kuosmanen, Vanesa Tomas Bosch, Pierre R. Moreau, Maria Bouvy-Liivrand, Henri Niskanen, Emilia Kansanen, Annukka Kivela, Juha Hartikainen, Mikko Hippelainen, Hannu Kokki, Pasi Tavi, Anna-Liisa Levonen, Minna U. Kaikkonen
Summary: This study investigated the genome-wide effects of oxidized phospholipids on transcriptional gene regulation in endothelial cells, focusing on the role of miRNAs and NRF2 transcription factor. The results showed that NRF2 plays a key role in up-regulated transcripts and transcriptional initiation in response to oxidized phospholipids. Furthermore, NRF2 was identified as a novel regulator of over 100 endothelial pri-miRNAs, with miR-21-5p and miR-100-5p demonstrating opposing roles in gene expressions and potential correlation with the severity of coronary artery disease.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ying Lv, Shan Zhang, Xiuzhu Weng, Jianxin Huang, Honggang Zhao, Xinyu Dai, Xiaoxuan Bai, Xiaoyi Bao, Chen Zhao, Ming Zeng, Yunshu Bai, Sining Hu, Ji Li, Haibo Jia, Bo Yu
Summary: Oxidative stress and lipid metabolism disorder caused by estrogen deficiency contribute to postmenopausal atherosclerosis. This study used ovariectomized female ApoE(-/-) mice fed with a high-fat diet to simulate postmenopausal atherosclerosis. The progression of atherosclerosis was accelerated in these mice, accompanied by increased indicators of ferroptosis. Estradiol and a ferroptosis inhibitor showed protective effects against atherosclerosis and inhibited lipid peroxidation and iron deposition in endothelial cells. Additionally, estradiol exhibited anti-ferroptosis effects by improving mitochondrial dysfunction and upregulating GPX4 expression. NRF2 inhibition attenuated the protective effects of estradiol against ferroptosis. This research highlights the role of endothelial cell ferroptosis in postmenopausal atherosclerosis and the protective effects of NRF2/GPX4 pathway activation by estradiol.
Article
Oncology
Fen Xu, Jiamin Zhang, Xiaoyan Zhou, Hua Hao
Summary: Excessive oxidative stress and decreased antioxidant capacity of macrophages are key factors in the transformation of macrophages to foam cells, a crucial event in the progression of atherosclerosis. The analog of lipoxin A(4), BML-111, can attenuate HF diet-induced atherosclerosis by activating Nrf2, independent of a specific LXA(4) receptor. In addition, BML-111 can inhibit the promotion of MDA level, increase HDL level, and decrease levels of IL-1, MCP-1, IL-6, VCAM, ICAM, and TNF-alpha in the aorta. In vitro experiments also showed that LXA(4) can inhibit the transformation of THP-1 cells to foam cells through the Nrf2 pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Immunology
Katarzyna Sarad, Monika Stefanska, Izabela Kraszewska, Krzysztof Szade, Judith C. Sluimer, Przemyslaw Blyszczuk, Jozef Dulak, Agnieszka Jazwa-Kusior
Summary: This study analyzed the transcriptome of different Nrf2-deficient macrophage subpopulations from murine atherosclerotic aortas. The results showed that Nrf2 deficiency led to subtype-specific transcriptomic changes associated with inflammation, iron homeostasis, and cell injury or death pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Mengling Zhang, Hongmei Qiu, Lejiao Mao, Bin Wang, Na Li, Yinzhen Fan, Ping Weng, Siyao Hu, Xiaomei Dong, Xia Qin, Chengzhi Chen, Zhen Zou, Chao Yu, Jun Zhang
Summary: In this study, we discovered that ammonium tetrathiomolybdate (TTM) is a novel NRF2 activator and demonstrated that autophagy contributes to TTM-induced NRF2 activation. We also found that TTM protects cells from oxidative damage through autophagy.
CELL DEATH & DISEASE
(2022)
Article
Engineering, Environmental
Na Liu, Ying Liang, Tingting Wei, Lingyue Zou, Xiaoquan Huang, Lu Kong, Meng Tang, Ting Zhang
Summary: Cadmium telluride quantum dots (CdTe QDs) trigger inflammatory responses and activate macrophages in mice, and the mechanism behind the activation of macrophages to overexpress IL-1 beta and IL-6 is explored. The study reveals that CdTe QDs induce ferroptosis in macrophages. Activation of ferritinophagy through a decrease in NRF2 and phosphorylation of ERK1/2 plays a key role in initiating ferroptosis in macrophages.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Ayaka Sano, Toko Maehara, Ko Fujimori
Summary: This study demonstrates that PGF(2 alpha) can enhance the expression of antioxidant genes through the FP receptor-ERK-Nrf2 signaling pathway, thereby suppressing 6-OHDA-induced neuronal cell death. The findings suggest that the FP receptor may be a potential therapeutic target for ROS-mediated neurodegeneration.
Article
Biochemistry & Molecular Biology
Chuan Wei, Xiaoling Chen, Daiwen Chen, Bing Yu, Ping Zheng, Jun He, Hong Chen, Hui Yan, Yuheng Luo, Zhiqing Huang
Summary: This study found that dihydromyricetin (DHM) enhances the intestinal antioxidant capacity of growing-finishing pigs by activating the ERK/Nrf2/HO-1 signaling pathway.
Article
Biochemistry & Molecular Biology
Elisabetta Profumo, Elisa Maggi, Marzia Arese, Claudio Di Cristofano, Bruno Salvati, Luciano Saso, Rita Businaro, Brigitta Buttari
Summary: This study reveals that neuropeptide Y (NPY) can modulate the phenotype and functions of human macrophages, promoting their transition to a reparative phenotype that has therapeutic effects on atherosclerosis. NPY reduces lipid droplet accumulation and enhances autophagosome formation in macrophages. Additionally, NPY increases the activation of the antioxidant signaling pathway in macrophages, protecting cells from further damage in the inflammatory pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Shitian Guo, Yu Zhou, Xiaojie Xie
Summary: Atherosclerosis is a pathologic basis of cardiovascular diseases, and its treatment is challenging. Resveratrol can inhibit the development of atherosclerosis by modulating the TGF/ERK signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Jie Zeng, Zhihui Deng, Yixin Zou, Chang Liu, Hongjuan Fu, Yi Gu, Hui Chang
Summary: The study demonstrated that TF can decrease serum lipid levels, increase the activity of antioxidant enzymes, and inhibit atherosclerotic plaque formation in mice. In vitro, TF was shown to protect endothelial cells from oxidative damage.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Doudou Dong, Yun Zhang, Hui He, Yuan Zhu, Hailong Ou
Summary: Alpinetin can inhibit macrophage infiltration and alleviate atherosclerosis by improving the redox homeostasis.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
