Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

(2018) Gannie Tzoneva et al.   NATURE

Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia

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Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

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Hypoxia/ischemia promotes CXCL10 expression in cardiac microvascular endothelial cells by NFkB activation

(2016) Jing-Bo Xia et al.   CYTOKINE

Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia

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The BIG Data Center: from deposition to integration to translation

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Making sense of hematopoietic stem cell niches

(2015) P. E. Boulais et al.   BLOOD

The hematopoietic stem cell niche in homeostasis and disease

(2015) L. M. Calvi et al.   BLOOD

DNA Damage-Induced NF-κB Activation in Human Glioblastoma Cells Promotes miR-181b Expression and Cell Proliferation

(2015) Rui-Xue Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Therapy-induced tumour secretomes promote resistance and tumour progression

(2015) Anna C. Obenauf et al.   NATURE

Negative feedback–defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL

(2015) Benshang Li et al.   NATURE MEDICINE

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(2015) Stephen P. Hunger et al.   NEW ENGLAND JOURNAL OF MEDICINE

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(2015) Meng Zhao et al.   Science China-Life Sciences

Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy

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(2014) Sean J. Morrison et al.   NATURE

Ionizing Radiation-Induced DNA Damage, Response, and Repair

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Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

(2013) Julia A Meyer et al.   NATURE GENETICS

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

(2013) Gannie Tzoneva et al.   NATURE MEDICINE

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(2013) Bryan A. Anthony et al.   TRENDS IN IMMUNOLOGY

The Role of the Tumor Microenvironment in Regulating Angiogenesis

(2013) R. S. Watnick   Cold Spring Harbor Perspectives in Medicine

Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma

(2012) J. Corre et al.   CANCER RESEARCH

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

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The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

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(2008) Domenico Ribatti et al.   Genes and Nutrition

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE