Treatment with abatacept prevents experimental dermal fibrosis and induces regression of established inflammation-driven fibrosis

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

(2015) Jingang Huang et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of EGFR Tyrosine Kinase by Erlotinib Prevents Sclerodermatous Graft-Versus-Host Disease in a Mouse Model

(2015) Florence Morin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis

(2015) Nadira Ruzehaji et al.   ARTHRITIS RESEARCH & THERAPY

Abatacept induces clinical improvement in patients with severe systemic sclerosis

(2014) FV de Paoli et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis

(2014) Lucille Desallais et al.   ARTHRITIS RESEARCH & THERAPY

The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor β and Contributes to the Development of Experimental Dermal Fibrosis

(2014) Jérôme Avouac et al.   Arthritis & Rheumatology

CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients

(2013) Jennifer Pieper et al.   BMC IMMUNOLOGY

Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study

(2012) Muriel Elhai et al.   ANNALS OF THE RHEUMATIC DISEASES

Critical role of the adhesion receptor DNAX accessory molecule-1 (DNAM-1) in the development of inflammation-driven dermal fibrosis in a mouse model of systemic sclerosis

(2012) Jérôme Avouac et al.   ANNALS OF THE RHEUMATIC DISEASES

Abatacept modulates proinflammatory macrophage responses upon cytokine-activated T cell and Toll-like receptor ligand stimulation

(2011) M H Wenink et al.   ANNALS OF THE RHEUMATIC DISEASES

Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor β in the skin of mice with scleroderma-like features and prevents the development of the disease

(2011) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis

(2011) Jérôme Avouac et al.   ARTHRITIS AND RHEUMATISM

The effect of CTLA-4Ig, a CD28/B7 antagonist, on the lung inflammation and T cell subset profile during murine hypersensitivity pneumonitis

(2011) Luis Jiménez-Alvarez et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

CTLA-4Ig blocks the development and progression of citrullinated fibrinogen-induced arthritis in DR4-transgenic mice

(2010) David Yue et al.   ARTHRITIS AND RHEUMATISM

Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis

(2010) Jérôme Avouac et al.   ARTHRITIS AND RHEUMATISM

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

(2009) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

B7-1/2 (CD80/CD86) Direct Signaling to B Cells Enhances IgG Secretion

(2009) F. C. Rau et al.   JOURNAL OF IMMUNOLOGY

Transforming growth factor β as a therapeutic target in systemic sclerosis

(2009) John Varga et al.   Nature Reviews Rheumatology

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production

(2009) Maurizio Cutolo et al.   ARTHRITIS RESEARCH & THERAPY

Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study

(2008) M H Buch et al.   ANNALS OF THE RHEUMATIC DISEASES

Antitransforming growth factor-β therapy in fibrosis: recent progress and implications for systemic sclerosis

(2008) John Varga et al.   CURRENT OPINION IN RHEUMATOLOGY

The Immunobiology of Systemic Sclerosis

(2008) Y. Stephanie Gu et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM