Journal
JOURNAL OF THERMAL BIOLOGY
Volume 82, Issue -, Pages 70-75Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtherbio.2019.03.012
Keywords
Heat stress; Liver; Oxidative stress; Inflammation; Resveratrol; Rats
Funding
- National Natural Science Foundation of China [31772634, 31802094, 31601948]
- National Key Research and Development Program of China [2018YFD0501101]
- Postdoctoral Research Foundation of China [2018M632320]
- Open Project of Shanghai Key Laboratory of Veterinary Biotechnology [klab201710]
Ask authors/readers for more resources
Heat stress jeopardizes humans and animals health, and results in enormous economic loss in public health care and livestock production. The aim of this study was to investigate the effects of resveratrol on hepatic oxidative stress and inflammation in heat-stressed rats. Male Sprague-Dawley rats were orally fed with 100 mg resveratrol/kg body weight/day prior to heat stress (40 degrees C per day for 1.5 h) exposure for 3 consecutive days. Serum and liver samples were collected for the analysis of hepatic injury, redox status and immune response. The results showed that the heat-stress-induced increased aspartate aminotransferase activities in the serum, aberrant hepatic histology, excessive hepatic malondialdehyde and tumor necrosis factor alpha concentrations, and up regulation of heat shock protein 70, superoxide dismutase 1, glutathione peroxidase 1, toll-like receptor 4 and interleukin 10 mRNA expression in the liver were mitigated by oral resveratrol treatment. Collectively, the beneficial effects of resveratrol on hepatic damage induced by heat stress were associated with the regulation of oxidative stress and inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available