Chromatin looping as a target for altering erythroid gene expression

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

(2015) S. Cui et al.   BLOOD

Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/ -globin looping

(2015) I. Krivega et al.   BLOOD

Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin

(2015) Daniel E Bauer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping

(2014) Wulan Deng et al.   CELL

Role of LDB1 in the transition from chromatin looping to transcription activation

(2014) I. Krivega et al.   GENES & DEVELOPMENT

Enhancer Function: Mechanistic and Genome-Wide Insights Come Together

(2014) Jennifer L. Plank et al.   MOLECULAR CELL

Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation

(2013) L. Li et al.   BLOOD

Fetal hemoglobin in sickle cell anemia: a glass half full?

(2013) M. H. Steinberg et al.   BLOOD

Genome organization and long-range regulation of gene expression by enhancers

(2013) Andrea Smallwood et al.   CURRENT OPINION IN CELL BIOLOGY

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

(2013) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor

(2012) Wulan Deng et al.   CELL

G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment

(2012) X. Chen et al.   GENES & DEVELOPMENT

Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development

(2012) Stefan Bonn et al.   NATURE GENETICS

Distinct Ldb1/NLI complexes orchestrate  -globin repression and reactivation through ETO2 in human adult erythroid cells

(2011) C. M. Kiefer et al.   BLOOD

Functional and Mechanistic Diversity of Distal Transcription Enhancers

(2011) Michael Bulger et al.   CELL

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

(2011) Masoud Vedadi et al.   Nature Chemical Biology

Multiple functions of Ldb1 required for  -globin activation during erythroid differentiation

(2010) S.-H. Song et al.   BLOOD

Advances in the understanding of haemoglobin switching

(2010) Vijay G. Sankaran et al.   BRITISH JOURNAL OF HAEMATOLOGY

The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

(2010) E. Soler et al.   GENES & DEVELOPMENT

LIM Domain Binding Proteins 1 and 2 Have Different Oligomeric States

(2010) Arwen J. Cross et al.   JOURNAL OF MOLECULAR BIOLOGY

Genomics tools for unraveling chromosome architecture

(2010) Bas van Steensel et al.   NATURE BIOTECHNOLOGY

Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells

(2010) LiQi Li et al.   NATURE IMMUNOLOGY

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

(2010) James E. Bradner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual role for the methyltransferase G9a in the maintenance of  -globin gene transcription in adult erythroid cells

(2009) C.-P. Chaturvedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA