Article
Polymer Science
Erhan Demirel, Yasemin Yuksel Durmaz
Summary: Combination therapy involving anticancer drugs and gene therapy agents has been proven effective in treating different types of cancer. In this study, a modified strategy was developed to enhance the use of reduced graphene oxide (rGO) as a carrier for delivering drugs and nucleotides. The newly designed copolymer allowed for the conjugation of a targeting peptide and the loading of hydrophobic drugs, resulting in a multifunctional nanoplatform with controlled drug release and high transfection efficiency. The experiments demonstrated the potential of this nanoplatform in selectively delivering different cargoes to tumor sites.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Shadi Rahimi, Daniel van Leeuwen, Fariba Roshanzamir, Santosh Pandit, Lei Shi, Nima Sasanian, Jens Nielsen, Elin K. Esbjoerner, Ivan Mijakovic
Summary: To enhance the delivery of doxorubicin (DOX) and minimize its side effects, researchers developed a pH-responsive delivery system based on graphene oxide (GO) that can release drugs specifically in acidic tumor environments.
Article
Chemistry, Physical
M. Saviz Baktash, Ali Zarrabi, Ehsan Avazverdi, Nuno Miguel Reis
Summary: A hybrid theranostic nano-system was designed with magnetic nanoparticles and chitosan-grafted graphene oxide to combine imaging and drug delivery capabilities for cancer treatment. Experimental evaluation showed high biocompatibility, optimal loading and release behavior, and improved therapeutic performance against cancer cells, suggesting potential for theranostic applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Pharmacology & Pharmacy
Niloufar Targhazeh, Masomeh Maleki, Forough Alemi, Bahman Yousefi
Summary: This study successfully linked DOX to the surface of pH-sensitive polyhydroxy glycerol-grafted graphene oxide nanoparticles, and assessed its loading capacity, release efficiency, and cytotoxicity using various molecular tests. The results showed that the nanocarrier had no significant toxic effect on healthy tissues, indicating its high potential for drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Malihe Pooresmaeil, Hassan Namazi
Summary: A new stimuli-responsive brushes copolymer modified magnetic graphene oxide surface was fabricated for targeted and stimuli-responsive drug delivery. DOX release followed the first-order kinetic model and Fickian mechanism. The MG-PB exhibited excellent cellular penetration and anticancer performance.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Engineering, Biomedical
Anandhavelu Sanmugam, S. Abbishek, S. Logesh Kumar, Ananda Babu Sairam, Vishnu Vardhan Palem, Raju Suresh Kumar, Abdulrahman I. Almansour, Natarajan Arumugam, Dhanasekaran Vikraman
Summary: The unique characteristics of chitosan, reduced graphene oxide (rGO), and cerium oxide (CeO2) based hybrid bionano-composites make them potential biomaterials for drug delivery and antimicrobial applications. The addition of biopolymers to rGO and CeO2 based nanocomposites has shown excellent performance in various applications such as biosensors, wound dressings, electrodes, microfluidic chips, drug delivery systems, and energy storage. The physiochemical characterization of the hybrid bionano-composites revealed their crystalline structure, interaction between chitosan and rGO-CeO2, and better thermal stability up to 550 degrees C. Additionally, the nanocomposites exhibited antibacterial properties and superior cell adhesion.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Suainibhe Kelly, Maria H. Byrne, Susan J. Quinn, Jeremy C. Simpson
Summary: The pre-clinical evaluation of nanomaterials as therapeutic delivery vehicles requires careful assessment of cellular toxicity, often necessitating advanced in vitro cell models. An automated high-content screening microscopy approach allows for quantifying nanoparticle-induced toxicity in a three-dimensional multicellular tumor spheroid cell model, revealing individual cell responses within the spheroid structure. Subcellular resolution using fluorescent reporters can provide detailed information on nanoparticle-induced toxicity at the cellular level.
Article
Chemistry, Multidisciplinary
D. Sahoo, T. Mitra, K. Chakraborty, P. Sarkar
Summary: This study developed a new electric field responsive graphene oxide nanoparticle system for on-demand drug delivery, showcasing remote control of dual drugs (aspirin and doxorubicin) release and observing their synergistic antitumor activity in breast cancer cells in vitro.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Polymer Science
M. Kurdtabar, S. Saif Heris, M. Dezfulian
Summary: Nanocomposite hydrogels are important biomaterials with unique characteristics, and can be used in drug delivery and tissue engineering applications. This study focused on the synthesis of graphene oxide and graphene oxide nanocomposite hydrogels. By adjusting reaction variables, the absorbency of the hydrogel was optimized. The structure and drug release behavior were analyzed using various techniques.
CHINESE JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Fatemeh Yaghoubi, Seyed Morteza Naghib, Najmeh Sadat Hosseini Motlagh, Fateme Haghiralsadat, Hossein Zarei Jaliani, Davood Tofighi, Ali Moradi
Summary: Graphene oxide has attracted attention as a novel drug delivery system, with a biocompatible APT-GO-COOH synthesized for the co-delivery of chemotherapeutics and herbal drugs. The co-delivery system showed a thermo- and pH-sensitive drug release behavior, reducing the expression of certain genes and proteins while enhancing others, and effectively targeting gastric cancer cells.
NANOTECHNOLOGY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Heba K. Mohammed-Ahmed, Mustafa Nakipoglu, Aysen Tezcaner, Dilek Keskin, Zafer Evis
Summary: Graphene quantum dots (GQDs) have been widely used in biomedical applications, particularly in anticancer drug delivery. This study investigated the use of graphene oxide quantum dots conjugated with glucosamine and boric acid (GOQDs-GlcN-BA) for cancer therapy. The nanocomposite showed enhanced loading and release of the anticancer drug doxorubicin, as well as increased cytotoxicity against breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shabnam Kazemi, Mehrab Pourmadadi, Fatemeh Yazdian, Azam Ghadami
Summary: This study demonstrated the effective targeted delivery of curcumin anticancer drugs to MCF-7 breast cancer cells using CS-Fe3O4-RGO nanocomposites, showing superior performance of the nanocomposite material. The results suggest potential for the development of targeted drug delivery systems against various cancer cells in future research.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Zuhair M. Mohammedsaleh, Fayez M. Saleh
Summary: The usage of graphene oxide (GO) in drug delivery for cancer therapy has received significant attention. In this study, reduced graphene oxide (RGO) was synthesized for controlled delivery of the natural flavonoid rutin. The bactericidal effect of RGO nanoparticles was tested against S.aureus and E.coli bacteria, and enhanced activity was observed in E.coli. Additionally, rutin-loaded RGO nanomaterials showed dose-dependent cytotoxicity and induced apoptotic cell death in human breast cancer MM2 cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Immunology
Bahareh Vakili, Mahboubeh Karami-Darehnaranji, Esmaeil Mirzaei, Farnaz Hosseini, Navid Nezafat
Summary: Graphene, as a new type of vaccine adjuvant, has been found to enhance antigen immunogenicity and stimulate immune responses. However, its injection may lead to oxidative stress and inflammation, thereby requiring modifications to reduce adverse effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gioacchino Schifino, Claudio Gasparini, Simone Drudi, Marta Giannelli, Giovanna Sotgiu, Tamara Posati, Roberto Zamboni, Emanuele Treossi, Emanuele Maccaferri, Loris Giorgini, Raffaello Mazzarro, Vittorio Morandi, Vincenzo Palermo, Monica Bertoldo, Annalisa Aluigi
Summary: In this study, keratin/poly(lactic acid) blend nanofibers with different loadings of graphene-oxide were prepared and tested as drug delivery systems. The addition of graphene-oxide improved the performance of the nanofibers and slowed down the drug release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Biomaterials
Bakhshali Massoumi, Mojtaba Abbasian, Balal Khalilzadeh, Rana Jahanban-Esfahlan, Aram Rezaei, Hadi Samadian, Hossein Derakhshankhah, Mehdi Jaymand
Summary: Nanofibrous electrically conductive scaffolds based on gelatin, namely Gel-g-PTh and Gel-g-PTh/PCL, were successfully designed and fabricated using the electrospinning technique. The preliminary investigation showed that both types of scaffolds have potential for tissue engineering applications requiring electroactivity. Co-electrospinning Gel-g-PTh with a small amount of PCL was found to improve the uniformity and some biological characteristics of the nanofibrous scaffold.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2021)
Review
Engineering, Electrical & Electronic
Hossein Derakhshankhah, Rahim Mohammad-Rezaei, Bakhshali Massoumi, Mojtaba Abbasian, Aram Rezaei, Hadi Samadian, Mehdi Jaymand
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2020)
Article
Materials Science, Multidisciplinary
Anqiang Jia, Haiyan Liu, Nafiseh Sorkhishams, Bakhshali Massoumi, Raana Sarvari, Samira Agbolaghi
ORGANIC ELECTRONICS
(2020)
Article
Polymer Science
Bakhshali Massoumi, Nazila Taghavi, Aliyeh Ghamkhari
Summary: Magnetic nanocomposites are a promising drug delivery system with excellent chemical stability and biocompatibility, allowing for controlled drug release rates. Biocompatible carriers prepared using different polymerization techniques can be used for hydrophobic drug delivery, and studies show that the release rate of DTX can be efficiently controlled through pH.
Article
Polymer Science
Farnaz Fazlalizadeh, Bakhshali Massoumi, Alireza Banaei, Mehdi Jaymand
POLYMER SCIENCE SERIES B
(2020)
Article
Polymer Science
Ziba Jahanbakhsh, Hossein Hosseinzadeh, Bakhshali Massoumi
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2020)
Article
Chemistry, Medicinal
Bakhshali Massoumi, Amir Farnudiyan-Habibi, Hossein Derakhshankhah, Hadi Samadian, Rana Jahanban-Esfahlan, Mehdi Jaymand
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2020)
Article
Polymer Science
Sanaz Motamedi, Bakhshali Massoumi, Mehdi Jaymand, Hamed Hamishehkar
JOURNAL OF POLYMER RESEARCH
(2020)
Article
Materials Science, Textiles
Bakhshali Massoumi, Mojtaba Abbasian, Balal Khalilzadeh, Rana Jahanban-Esfahlan, Hadi Samadian, Hossein Derakhshankhah, Mehdi Jaymand
Summary: Two novel electrically conductive nanofibrous scaffolds based on chitosan-grafted polythiophene (CS-g-PTh) and chitosan-grafted polythiophene/poly(epsilon-caprolactone) (CS-g-PTh/PCL) were fabricated using electrospinning technique, showing good biological compatibility, conductivity, and cell proliferation. The CS-g-PTh/PCL scaffold exhibited slightly higher cell proliferation than the CS-g-PTh scaffold within 7 days.
FIBERS AND POLYMERS
(2021)
Article
Materials Science, Biomaterials
Sanaz Motamedi, Bakhshali Massoumi, Mehdi Jaymand, Hossein Derakhshankhah, Effat Alizadeh
Summary: Novel shell crosslinked micelles with pH- and reduction-responsive properties were developed for drug delivery, showing slow and stimuli-triggered drug release behavior.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Shahram Astani, Roya Salehi, Bakhshali Massoumi, Abdolhossein Massoudi
Summary: A novel pH-responsive magnetic nanocomposite based on reduced graphene oxide was developed for combined delivery of Dox and Cis to MCF-7 cells, displaying high cytotoxicity. The nanocomposite's unique structure allowed for simultaneous encapsulation of Dox and Cis, leading to apoptosis in the cells.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Polymer Science
Hossein Derakhshankhah, Rana Jahanban-Esfahlan, Somayeh Vandghanooni, Sattar Akbari-Nakhjavani, Bakhshali Massoumi, Babak Haghshenas, Aram Rezaei, Amir Farnudiyan-Habibi, Hadi Samadian, Mehdi Jaymand
Summary: In this study, gelatin-based pH- and thermal-responsive magnetic hydrogels were developed as novel drug delivery systems for cancer chemo/hyperthermia therapy. By loading anticancer drugs and investigating their performance in both chemo- and chemo/hyperthermia-therapies, the hydrogels showed acceptable drug release behaviors and high drug loading capacities. The combination of hyperthermia therapy and chemotherapy demonstrated synergic effects on the anticancer activities of the developed drug delivery systems.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Rana Jahanban-Esfahlan, Khadijeh Soleimani, Hossein Derakhshankhah, Babak Haghshenas, Aram Rezaei, Bakhshali Massoumi, Amir Farnudiyan-Habibi, Hadi Samadian, Mehdi Jaymand
Summary: A novel magnetic pH- and redox-responsive drug delivery system was developed using natural Tragacanth gum, with magnetic nanoparticles synthesized and incorporated for targeted cancer therapy. The system showed higher anti-cancer activity due to its smart drug release behavior and synergistic effect of hyperthermia therapy.
JOURNAL OF MATERIALS RESEARCH
(2021)
Article
Polymer Science
Nazila Taghavi, Bakhshali Massoumi, Mehdi Jaymand
Summary: A novel pH-responsive magnetic nanosystem was developed for cancer therapy, demonstrating efficient control over drug release in response to pH stimuli. Through a combination of polymerization and chemical methods, the system successfully loaded and released the anticancer drug doxorubicin hydrochloride.
POLYMER SCIENCE SERIES B
(2021)
Article
Chemistry, Medicinal
Bakhshali Massoumi, Rogayeh Mossavi, Sanaz Motamedi, Hossein Derakhshankhah, Somayeh Vandghanooni, Mehdi Jaymand
Summary: A dual stimuli-responsive magnetic nanohydrogel was developed as a potent drug delivery system for 'smart' cancer treatment using chemo/hyperthermia approach. The fabricated nanohydrogel exhibited high drug loading efficiency and proper drug release behavior in the abnormal micro-environment of cancerous tumors, showing promising anticancer activity.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)