Article
Multidisciplinary Sciences
Yue Li, Siyuan Fan, Lingyao Kong, Zhenxuan Hao, Yanjun Zhou, Jiahong Shangguan, Lu Gao, Mingdan Wang, Yue Kang, Xiangrao Li, Kun Huang, Chao Zhang, Zhibo Liu
Summary: This study found that CD9 exacerbates pathological cardiac hypertrophy by regulating the GP130/STAT3 signaling pathway. The results provide important insights into the pathogenesis of heart diseases.
Article
Medicine, Research & Experimental
Na-Na Yang, Jing-Wen Yang, Yang Ye, Jin Huang, Lu Wang, Yu Wang, Xin-Tong Su, Ying Lin, Fang-Ting Yu, Si-Ming Ma, Ling-Yu Qi, Lu-Lu Lin, Li-Qiong Wang, Guang-Xia Shi, Hong-Ping Li, Cun-Zhi Liu
Summary: The study investigated how electroacupuncture stimulation at the hindlimb region ameliorates inflammation in postoperative ileus (POI). Results showed that electroacupuncture suppressed intestinal inflammation and promoted gastrointestinal motility by activating the alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR)-mediated JAK2/STAT3 signaling pathway in macrophages. Furthermore, hindlimb region stimulation inhibited the expression of GABA(A) receptor in dorsal motor nucleus of vagal (DMV) neurons, leading to suppression of inflammation via vagal efferent output.
Article
Gastroenterology & Hepatology
Alexandra Shingina, Nizar Mukhtar, Jamile Wakim-Fleming, Saleh Alqahtani, Robert J. Wong, Berkeley N. Limketkai, Anne M. Larson, Lafaine Grant
Summary: Acute liver failure (ALF) is a rare, potentially reversible condition that causes severe liver damage and rapid clinical deterioration in patients without preexisting liver disease. Due to limited studies, guidelines provided by the American College of Gastroenterology serve as the official practice recommendations for the identification, treatment, and management of ALF. The guidelines were developed through a process of reviewing scientific evidence and using expert opinions when robust evidence was lacking. Individualized care should be applied in specific clinical scenarios due to the varied clinical presentations of ALF.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, Research & Experimental
Shashi Bala, Yuan Zhuang, Prashanth Thevkar Nagesh, Donna Catalano, Adam Zivny, Yanbo Wang, Jun Xie, Guangping Gao, Gyongyi Szabo
Summary: This study investigated the therapeutic effect of miR-155 inhibition in liver fibrosis and found that miR-155 deficiency can significantly reduce liver fibrosis. The study also revealed that miR-155 regulates activation of hepatic stellate cells partly via STAT3 signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Environmental Sciences
Tingting Xia, Yijie Gu, Jiaqing Shen, Lu Zheng, Chunfang Xu
Summary: Research has shown that limonin has protective effects on acute pancreatitis by reducing the levels of inflammation initiators and modulating the JAK2/STAT3 signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell Biology
Yeping Yu, Ling Chang, Qingluan Hu, Jianjun Zhu, Jianjun Zhang, Qiang Xia, Jie Zhao
Summary: This study revealed that P2RX1 is involved in mitochondria dysfunction and immune-mediated inflammation in acetaminophen-induced liver injury (AILI). P2RX1 depletion offers protection against AILI by inhibiting cell death and promoting inflammation resolution. The blockade of P2RX1 shows promise as a therapeutic approach for AILI.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Changqing Deng, Jia Hu, Ling He, Laian Ge, Na Wu, Mingjun Xie, Xiaojuan Yang, Chuncheng Wu, Qin Liu
Summary: The combination of UCMSC-derived exosomes and daucosterol showed better efficacy in alleviating hepatic damage in mice with liver failure, compared to exosomes alone. This therapeutic strategy regulated the IL-6/STAT3 signaling pathway to achieve the desired effect.
CANCER BIOLOGY & THERAPY
(2023)
Article
Cell Biology
Jiacheng Lin, Qihua Ling, Liang Yan, Bowu Chen, Fang Wang, Yihan Qian, Yueqiu Gao, Qian Wang, Hailong Wu, Xuehua Sun, Yanjun Shi, Xiaoni Kong
Summary: The study found that MaHuang-LianQiao-ChiXiaoDou decoction (MHLQD) has therapeutic effects on acute liver failure (ALF) and acute-on-chronic liver failure (ACLF), possibly by protecting hepatocytes from death via inhibition of the VWF/RAP1B/ITGB3 signaling pathway.
Article
Medicine, Research & Experimental
Jun Weng, Xu Han, Fanhong Zeng, Yue Zhang, Lei Feng, Lei Cai, Kangyan Liang, Shusong Liu, Shao Li, Gongbo Fu, Min Zeng, Yi Gao
Summary: The study utilized a fiber scaffold bioreactor for high-density, 3D culture of porcine hepatocytes to construct a bioartificial liver and evaluated its protective effects in an ALF porcine model. The bioartificial liver treatment enhanced liver regeneration, alleviated systemic inflammatory response, and reduced extrahepatic organ injury, leading to prolonged survival in the ALF model.
Article
Plant Sciences
Ya-yue Yang, Li-xia Du, Jian-yu Zhu, Ting Yi, Ya-chen Yang, Zheng Qiao, Qi-liang Maoying, Yu-xia Chu, Yan-qing Wang, Wen-li Mi
Summary: This study found that geraniol, a compound found in essential oils, has significant anti-itch effects by modulating the spinal GABA/GRPR signaling. These findings suggest that geraniol could be a promising therapeutic option for managing itch, particularly in cases of severe pruritus.
Article
Pharmacology & Pharmacy
Mengting Zhang, Wanhong Wu, Caoxin Huang, Teng Cai, Nengjiang Zhao, Suhuan Liu, Shuyu Yang
Summary: This study investigated the effects and mechanisms of the traditional Chinese medicine formula SX-1 in treating chronic stress-induced depression and liver injury. The results showed that SX-1 effectively ameliorated depression-like behaviors and hepatic injuries caused by chronic stress, possibly through the blockade of hepatic IL-6/JAK2/STAT3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Yulin He, Xingrong Guo, Tingyu Lan, Jianbo Xia, Jinsong Wang, Bei Li, Chunyan Peng, Yue Chen, Xiang Hu, Zhongji Meng
Summary: The transplantation of hUC-MSCs can improve liver function, degree of fibrosis, and liver damage in rats with ACLI or ACLF, likely mediated by inhibiting Notch signaling and reversing the imbalance of the Stat1/Stat3 pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Gastroenterology & Hepatology
Seonghwan Hwang, Amy Hicks, Chai Zhen Hoo, Yong Seong Kwon, Ye Eun Cho, Joanna Moore, Bin Gao
Summary: Acute liver failure (ALF) is a life-threatening condition characterized by rapidly progressing liver dysfunction, while acute-on-chronic liver failure (ACLF) occurs in patients with existing chronic liver disease. Both conditions are associated with multiple organ failure and high short-term mortality. This review discusses the causes, pathogenesis, and current treatment options for ALF and ACLF, and explores the potential therapeutic use of interleukin-22 (IL-22), a cytokine that has shown promise in protecting against organ damage and reducing bacterial infection.
LIVER INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Xiangmin He, Kai Kang, Dan Pan, Yue Sun, Bing Chang
Summary: This study found that Fingolimod (FTY720) has a protective effect on acetaminophen (APAP)-induced liver injury (AILI). FTY720 regulates the JAK2/STAT3 signaling pathway to reduce immune cell recruitment and inflammation, inhibit cell apoptosis and oxidative stress, and attenuate liver tissue damage.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Shaopeng Zhang, Xinzheng Dai, Yong Shi, Xiaowen Zhu, Yongjiu Dai, Xiaofeng Qian, Jian Gu
Summary: The research demonstrated that serum CHI3L1 levels were negatively correlated with ALT and AST levels in ALI patients, indicating a potential protective role of CHI3L1 against liver injury. The experiment on mouse models showed that CHI3L1 could reduce liver tissue injury and promote Treg cell differentiation, while inhibiting IFN-gamma+ Th1 cell differentiation. These findings suggest that CHI3L1 may be a promising therapeutic strategy for ALI.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
M. Mohamed, L. Kang, C. Zhang, B. Edenfield, J. Sykes, T. Brown, J. L. Johnson, F. Rehman, J. H. Nguyen
TRANSPLANTATION PROCEEDINGS
(2019)
Article
Surgery
Yuanxin Chen, Toshiyuki Hata, Fatima Rehman, Lu Kang, Liu Yang, Betty Y. S. Kim, Justin H. Nguyen
JOURNAL OF SURGICAL RESEARCH
(2019)
Article
Oncology
Sok-Hyong Lee, Fatima Khwaja Rehman, Kari C. Tyler, Bing Yu, Zhaobin Zhang, Satoru Osuka, Abdessamad Zerrouqi, Milota Kaluzova, Costas G. Hadjipanayis, Richard D. Cummings, Jeffrey J. Olson, Narra S. Devi, Erwin G. Van Meir
CLINICAL CANCER RESEARCH
(2020)
Letter
Gastroenterology & Hepatology
Justin H. Nguyen, Liuyan (Jennifer) Jiang, Lu Kang, Sunita Malik, Christopher Orlando, Abba Zubair, Fatima Khwaja Rehman
LIVER TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Mollie A. Brekker, Tala Sartawi, Tina M. Sawatzky, Corey P. Causey, Fatima Khwaja Rehman, Bryan Knuckley
Summary: Protein arginine methyltransferases (PRMTs) are enzymes that transfer a methyl group to arginine residues within proteins. Different types of methylated products can lead to increased or decreased transcription of cancer-related genes in certain cancers, suggesting that PRMT family members may be potential therapeutic targets. Peptide-based compounds, traditionally used to target PRMTs, suffer from poor stability and short half-lives. On the other hand, peptoids, peptide-mimetics composed of N-substituted glycine monomers, have improved stability and longer half-lives. This study reports the development of a bioavailable, peptoid-based PRMT1 inhibitor that induces cell death in specific cancer cell lines without significant impact on normal cells, suggesting it has less toxicity as a cytostatic agent.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Arooj Shafiq, January Moore, Aliya Suleman, Sabeen Faiz, Omar Farooq, Adnan Arshad, Mohammad Tehseen, Ammarah Zafar, Syed Haider Ali, Nasir Ud Din, Asif Loya, Neelam Siddiqui, Fatima K. Rehman
INTERNATIONAL JOURNAL OF BREAST CANCER
(2020)
Article
Biochemical Research Methods
Fatima W. Khwaja, Matthew S. Reed, Jeffrey J. Olson, Brian J. Schmotzer, G. Yancey Gillespie, Abhijit Guha, Morris D. Groves, Santosh Kesari, Jan Pohl, Erwin G. Van Meir
JOURNAL OF PROTEOME RESEARCH
(2007)
Article
Biochemical Research Methods
Fatima W. Khwaja, John David Larkin Nolen, Savaas E. Mendrinos, Melinda M. Lewis, Jeffrey J. Olson, Jan Pohl, Erwin G. Van Meir, James C. Ritchie, Daniel J. Brat
Article
Oncology
Fatima W. Khwaja, Jonathan S. Duke-Cohan, Daniel J. Brat, Erwin G. Van Meir
CLINICAL CANCER RESEARCH
(2006)
Article
Immunology
A Bunin, FW Khwaja, GJ Kersh
JOURNAL OF IMMUNOLOGY
(2005)
Review
Oncology
B Kaur, FW Khwaja, EA Severson, SL Matheny, DJ Brat, EG Van Meir
Article
Oncology
C Tan, RG de Noronha, AJ Roecker, B Pyrzynska, F Khwaja, ZB Zhang, HC Zhang, Q Teng, AC Nicholson, P Giannakakou, W Zhou, JJ Olson, MM Pereira, KN Nicolaou, EG Van Meir
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)