Article
Engineering, Biomedical
Seho Kweon, Yoo-Seong Jeong, Seung Woo Chung, Hanul Lee, Ha Kyeong Lee, Seong Jin Park, Jeong Uk Choi, Jooho Park, Suk-Jae Chung, Youngro Byun
Summary: This study aims to identify the optimal metronomic chemotherapy (MCT) regimen of doxorubicin (DOX) by determining the concentration-response relationships of tumor suppression and cardiac toxicity. By utilizing an oral DOX formulation complexed with deoxycholic acid, a physiologically-based pharmacokinetic model was linked to toxicodynamic and pharmacodynamic models to generate drug profiles. The established mathematical model facilitates the calculation of adequate in vivo-relevant dosages and intervals, providing a useful guideline for the design and evaluation of oral DOX formulations.
Article
Oncology
Vikas Garg, Lalit Kumar
Summary: Translational research and targeted therapies have significantly impacted the treatment of epithelial ovarian cancer. Recurrent ovarian cancer remains a challenge and requires innovative strategies. Metronomic chemotherapy, which inhibits angiogenesis and activates the immune system, has emerged as a promising approach.
Review
Medicine, General & Internal
Piotr J. Wysocki, Maciej T. Lubas, Malgorzata L. Wysocka
Summary: This study investigated the actual effectiveness of metronomic chemotherapy in mCRPC patients who had failed all available standard therapies, and identified the optimal metronomic regimen for heavily pretreated mCRPC patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Daniel R. Schmidt, Rutulkumar Patel, David G. Kirsch, Caroline A. Lewis, Matthew G. Vander Heiden, Jason W. Locasale
Summary: Cancer has complex effects on cellular and systemic metabolism, with metabolomics playing a crucial role in providing insights for cancer diagnosis, monitoring, and therapy. Advances in technology have expanded the applications of metabolomics in clinical research, with the potential to further enhance cancer patient management in the future.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Immunology
Yongshuo Yin, Lina Cao, Meng Zhang, Yingjie Li, Chunhua Sun, Qinghua Ma, Zhaoyun Liu, Chao Li, Zhiyong Yu, Xiao Guan
Summary: This study applied label-free quantitative proteomics and non-targeted metabonomics to identify potential biomarkers for diagnosing CA-MRSA infection in breast abscess. The results showed differential expression of proteins and metabolites in CA-MRSA infection compared to MSSA. The identified biomarkers displayed good discriminative abilities in early identification of CA-MRSA infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Plant Sciences
Yaohan Li, Shengzhi Liu, Di Zhang, Amin Liu, Wei Zhu, Jianbin Zhang, Bingxian Yang
Summary: This study explored the regulation of flavonoid and lignin biosynthesis in Morus alba leaves under UV-B stress and Botrytis cinerea infection. The results showed that the abundance of proteins involved in these pathways increased under both stresses, which was confirmed by enzyme assays and metabolomics analysis. Additionally, the abundance of proteins involved in jasmonic acid synthesis increased after B. cinerea infection.
Review
Oncology
Marina Elena Cazzaniga, Nicoletta Cordani, Serena Capici, Viola Cogliati, Francesca Riva, Maria Grazia Cerrito
Summary: This article reviews the current state and underlying mechanisms of metronomic chemotherapy use, discussing new regimens, cancer types suitable for mCHT, and ongoing trials. It highlights that mCHT not only directly affects tumor cells, but also influences the cell microenvironment, making it a promising multi-target therapy.
Article
Immunology
Bing Wang, Heqiong Li, Zhen Li, Bo Wang, Han Zhang, Boyan Zhang, Hailing Luo
Summary: The beneficial effects of folic acid on lamb growth performance and immunity were observed, and the molecular mechanisms of folic acid in lambs were analyzed. The study found that folic acid was influenced by maternal and offspring diet, and it altered metabolites, genes, and pathways in blood, liver, and muscle. These findings provide a theoretical basis for the use of folic acid in animal health care.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Shruti Parshad, Amanjot K. Sidhu, Nabeeha Khan, Andrew Naoum, Urban Emmenegger
Summary: Low-dose metronomic chemotherapy (LDMC) is a safe and cost-effective treatment option for patients with advanced prostate cancer, providing superior tolerability and affordability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Guangsu Zhu, Min Guo, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: Alzheimer's disease is characterized by global metabolic alterations, leading to cognitive impairment. This study found that B. breve CCFM1025 intervention can restore the metabolic changes induced by Aβ injection, particularly in amino acid metabolism.
Review
Medicine, General & Internal
Marina Elena Cazzaniga, Serena Capici, Nicoletta Cordani, Viola Cogliati, Francesca Fulvia Pepe, Francesca Riva, Maria Grazia Cerrito
Summary: This review summarizes the advantages and challenges of metronomic chemotherapy (mCHT) in preclinical and clinical settings. In preclinical studies, mCHT has a significant effect on the tumor microenvironment, but the direct effects on tumor cells are less clear. Key issues that need to be addressed include the lack of definition of an optimal biological dose, administration method, and validation of predictive biomarkers. In the clinical context, low toxicity is the most recognized advantage of mCHT, but the type of study design, lack of randomized trials, and uncertainty in terms of doses and drugs are still challenges.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ji Hyung Hong, In Sook Woo
Summary: The use of immune checkpoint inhibitors (ICIs) in clinical practice for the treatment of metastatic colorectal cancer (mCRC) is currently limited to a small subset of patients. Combining ICIs with anti-angiogenic inhibitors has shown promising efficacy in early phase trials. Additionally, low-dose metronomic (LDM) chemotherapy has potential as a combination partner with ICIs for immunologically cold mCRC tumors.
Article
Immunology
Han She, Lei Tan, Yi Wang, Yuanlin Du, Yuanqun Zhou, Jun Zhang, Yunxia Du, Ningke Guo, Zhengbin Wu, Qinghui Li, Daiqin Bao, Qingxiang Mao, Yi Hu, Liangming Liu, Tao Li
Summary: Machine learning algorithms were used to identify key genes related to lipid metabolism, and it was found that these genes could be associated with immune dysfunction caused by lipid metabolism disorders in sepsis. The study revealed an immunosuppressive microenvironment in sepsis, and the role of these key genes in immune cells was confirmed. Further experiments showed significant changes in lipid metabolism-related signaling pathways in sepsis, which were associated with the MAPK14 gene. Lastly, inhibiting MAPK14 was found to reduce inflammatory cytokine levels and improve survival and myocardial injury in sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jijia Hu, Zongwei Zhang, Hongtu Hu, Keju Yang, Zijing Zhu, Qian Yang, Wei Liang
Summary: Alteration of metabolic phenotype in podocytes contributes to diabetic kidney disease (DKD). This study identified liver receptor homologue-1 (LRH-1) as a therapeutic target that improves podocyte injury in DKD. LRH-1 activation promoted glutaminolysis and mitochondrial function in diabetic podocytes. Targeting LRH-1 could restore podocytes from diabetes-induced disturbed glutaminolysis.
CELL PROLIFERATION
(2023)
Article
Multidisciplinary Sciences
Ryan S. Mote, Nicholas S. Hill, Joseph H. Skarlupka, Jessica M. Carpenter, Jeferson M. Lourenco, Todd R. Callaway, ViLinh T. Tran, Ken Liu, Mathew R. Smith, Dean P. Jones, Garret Suen, Nikolay M. Filipov
Summary: This study investigated the effects of bovine fescue toxicosis on the microbiota and metabolome of plants and animals using multi-omics approaches. The results showed that toxic tall fescue altered the microbiota and caused metabolic perturbations in both plants and animals. Unique metabolites and microbial taxa were identified, which could serve as potential biomarkers for the diagnosis and targeted therapy of bovine fescue toxicosis.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez
Summary: Intestinal PPAR alpha signaling modulates fatty acid uptake through regulating FABP1 expression, contributing to NASH progression. Targeting this pathway could be a potential therapeutic strategy for NASH treatment.
Article
Pharmacology & Pharmacy
Jiajia Shen, Huimin Guo, Shijia Liu, Wei Jin, Zhi-Wei Zhang, Yong Zhang, Keanqi Liu, Shuying Mao, Zhihao Zhou, Lin Xie, Guangji Wang, Haiping Hao, Yan Liang
Summary: This study identifies the crucial role of intestinal flora and microbiota metabolites in the occurrence and treatment of ischaemic stroke. The accumulation of branched-chain amino acids is closely associated with gut microflora dysbiosis and neuroinflammation. Lactobacillus helveticus and Lactobacillus brevis colonization exhibit neuroprotective activity and alleviate the accumulation of branched-chain amino acids.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuang Cui, Huijian Hu, An Chen, Ming Cui, Xiaojie Pan, Pengfei Zhang, Guangji Wang, Hong Wang, Haiping Hao
Summary: The acetylation of FXR regulates its nucleocytoplasmic shuttling and degradation under conditions of liver injury, which limits the clinical benefits of FXR agonists. SIRT1 activators can reduce FXR acetylation and prevent its cytosolic degradation, and combining SIRT1 activators with FXR agonists shows promise in treating liver diseases.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Medicine, Research & Experimental
Mi Bai, Mengqiu Wu, Mingzhu Jiang, Jia He, Xu Deng, Shuang Xu, Jiaojiao Fan, Mengqiu Miao, Ting Wang, Yuting Li, Xiaowen Yu, Lin Wang, Yue Zhang, Songming Huang, Li Yang, Zhanjun Jia, Aihua Zhang
Summary: Mitochondria are the central metabolic hub of cells and their imbalance plays a pathogenic role in chronic kidney disease (CKD). This study found that Lon protease 1 (LONP1) expression was decreased in CKD patients and mice, and its overexpression mitigated renal injury and mitochondrial dysfunction. Mechanistically, LONP1 downregulation caused mitochondrial accumulation of HMGCS2, leading to disrupted mitochondrial function and CKD progression. A novel LONP1 activator was also identified, which attenuated renal fibrosis and mitochondrial dysfunction. These findings suggest that LONP1 is a promising therapeutic target for CKD.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jiaojiao Fan, Xinyue Xu, Yuting Li, Lingge Zhang, Mengqiu Miao, Yujia Niu, Yue Zhang, Aihua Zhang, Zhanjun Jia, Mengqiu Wu
Summary: A novel compound, 84-B10, was found to protect against cisplatin-induced acute kidney injury by restoring mitochondrial homeostasis and inhibiting mtROS-induced ferroptosis. This suggests the potential use of 84-B10 in preventing and treating cisplatin nephrotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Correction
Biochemistry & Molecular Biology
Jiaojiao Fan, Xinyue Xu, Yuting Li, Lingge Zhang, Mengqiu Miao, Yujia Niu, Yue Zhang, Aihua Zhang, Zhanjun Jia, Mengqiu Wu
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemical Research Methods
Huanhuan Li, Langlang Lv, Shuo Tang, Yiqi Zang, Tianyan Wan, Dexiang Wang, Lingchao Cai, Hui Ye, Renxiang Tan, Nanxi Wang
Summary: Researchers have developed an oxidation-induced protein cross-linking strategy that involves introducing a vinyl thioether group into proteins in both bacteria and mammalian cells. This strategy allows for selective induction of the vinyl thioether group by oxidants, reactive oxygen species, or photocatalysts, leading to fluorescence labeling and protein cross-linking.
ACS SYNTHETIC BIOLOGY
(2023)
Review
Urology & Nephrology
Lingge Zhang, Mengqiu Miao, Xinyue Xu, Mi Bai, Mengqiu Wu, Aihua Zhang
Summary: Renal diseases have become a growing public health concern, and mitochondria play a critical role in their pathogenesis. Under conditions of acute kidney injury and chronic kidney disease, disruption of mitochondrial energy metabolism and dynamics lead to increased oxidative stress and impaired cellular functions. Mitochondria-targeted strategies are emerging as important therapeutic approaches for attenuating renal diseases.
Article
Urology & Nephrology
Yuting Li, Jiaojiao Fan, Wenping Zhu, Yujia Niu, Mengqiu Wu, Aihua Zhang
Summary: Podocyte injury is the primary cause of focal segmental glomerulosclerosis (FSGS) with clinical manifestations of proteinuria or nephrotic syndrome, and mitochondrial dysfunction plays a key role in this process. This review summarized recent advances in the study of mitochondrial homeostatic imbalance and dysfunction in FSGS and discussed the potential of mitochondria-targeted therapeutics in improving FSGS and retarding its progression to end-stage renal disease (ESRD).
Article
Multidisciplinary Sciences
Hu Hua, Mengqiu Wu, Tong Wu, Yong Ji, Lv Jin, Yang Du, Yue Zhang, Songming Huang, Aihua Zhang, Guixia Ding, Qianqi Liu, Zhanjun Jia
Summary: Artemisinin derivatives have recently been found to have anti-obesity effects, but the precise mechanism remains controversial. This study showed that long-term DHA treatment reduced body weight and improved glucose metabolism in obese mice. Moreover, it was found that DHA inhibited adipocyte differentiation by reducing NOX4 expression, thereby reducing fat accumulation. Overall, DHA can effectively reduce fat mass and improve glucose metabolism in obese mice by targeting NOX4 expression.
Article
Biochemical Research Methods
Wenxin Wu, Min Ma, Angel Erbey Ibarra, Gaoyuan Lu, Vaishali P. P. Bakshi, Lingjun Li
Summary: Traumatic stress triggers or exacerbates multiple psychiatric illnesses, including post-traumatic stress disorder (PTSD). Neuropeptides play a crucial role in the neurophysiological mechanisms underlying stress-induced pathology; however, their specific involvement remains unclear. In this study, mass spectrometry was used to identify and analyze neuropeptides in the brains of rats exposed to trauma-like stress. The results indicate brain-region-specific alterations in various neuropeptide families, providing insights into the molecular mechanisms of stress-induced psychopathology and potential therapeutic strategies for PTSD.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Review
Chemistry, Medicinal
Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang
Summary: Nonalcoholic fatty liver disease is a common liver disease without approved pharmacotherapy. Farnesoid X receptor (FXR) is considered a promising therapeutic target, but currently developed drugs have shown limited efficacy in clinical trials. This review summarizes the development of the FXR agonist obeticholic acid and discusses its limitations in depth.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Mengqiu Wu, Qianqian Jin, Xinyue Xu, Jiaojiao Fan, Weiyi Chen, Mengqiu Miao, Ran Gu, Shengnan Zhang, Yan Guo, Songming Huang, Yue Zhang, Aihua Zhang, Zhanjun Jia
Summary: Renal fibrosis is a common feature of chronic kidney diseases, and its severity is determined by the injury to renal tubular epithelial cells and activation of fibroblasts. This study explores the role of TP53RK in renal fibrosis and its underlying mechanisms. TP53RK is upregulated in fibrotic kidneys and its deletion in mice mitigates renal fibrosis. Mechanistic studies reveal that TP53RK phosphorylates Birc5 and enhances its profibrotic effect through PI3K/Akt and MAPK pathways. Furthermore, pharmacological inhibition of TP53RK and Birc5 using fusidic acid and YM-155 respectively ameliorates kidney fibrosis. These findings suggest that targeting TP53RK/Birc5 signaling may be a potential strategy for treating chronic kidney diseases.
Article
Psychology, Multidisciplinary
Haiping Hao, Xiaobao Li, Xi Shen, Hong Jiang, Haoyue Xiao, Houchao Lyu
Summary: This study examined the reciprocal relationship between future time perspective and self-control among adolescents. The results showed that future-negative and future-confusional were negatively related to self-control, while future-positive, future-perspicuity, future-perseverant, and future-planning were positively related to self-control. The study also found reciprocal relationships between future-confusional, future-planning, and self-control.
CURRENT PSYCHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Gongyu Li, Chae Kyung Jeon, Min Ma, Yifei Jia, Zhen Zheng, Daniel G. Delafield, Gaoyuan Lu, Elena V. Romanova, Jonathan V. Sweedler, Brandon T. Ruotolo, Lingjun Li
Summary: Growing evidence supports the association between distinct amyloid beta (A beta) isoforms and Alzheimer's Disease (AD) pathogenesis. Investigating the translational factors contributing to A beta toxicity is of great value. In this study, we assess the stereochemistry of full-length A beta 42, focusing on the naturally-occurring isomerization of Asp and Ser residues. We demonstrate that co-d-epimerization at these residues effectively reduces cytotoxicity by compacting and remodeling A beta 42 secondary structure.