Article
Surgery
Ayat Elsherif, Mary Freyvogel Ramirez, Edwina C. Moore, Jill R. Dietz, Chao Tu, Stephanie A. Valente
Summary: The risk of recurrence after mastectomy for DCIS is low and appears to be unrelated to margin status or the use of radiation therapy.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Marissa Howard-McNatt, Elisabeth Dupont, Theodore Tsangaris, Carlos Garcia-Cantu, Akiko Chiba, Adam C. Berger, Edward A. Levine, Jennifer S. Gass, David W. Ollila, Anees B. Chagpar
Summary: The study found that in patients with pure DCIS, cavity shave margins (CSM) can significantly reduce positive-margin rates, making it a practical solution for DCIS patients who tend to have a high rate of margin positivity. Size of DCIS remained an independent predictor of positive margins in the model.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Oncology
Laura E. G. Warren, Jennifer R. Bellon
Summary: The Oncology Grand Rounds series aims to help readers apply research results to clinical practice by presenting case studies, discussing diagnostic and management challenges, reviewing relevant literature, and summarizing suggested management approaches by the authors.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Trine Tramm, Peer Christiansen, Birgitte Vrou Offersen, Karen Berenth Madsen, Philip Poortmans, Orit Kaidar-Person
Summary: Skin-sparing and nipple-sparing mastectomies with immediate reconstruction for breast cancer are becoming more common. It is important to report on the superficial margin status in these procedures to understand its association with local recurrence risks.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Otorhinolaryngology
Kenric Tam, Shan Huang, Laith Mukdad, Yazeed Alhiyari, Jeffrey Krane, Ramesh Shori, Oscar Stafsudd, Maie St. John
Summary: Obtaining negative surgical cancer margins is crucial for long-term survival in oral cavity squamous cell carcinoma patients. The use of dynamic optical contrast imaging (DOCI) provides a real-time intraoperative tool that can quickly and accurately distinguish cancer from healthy tissues, improving surgical outcomes and overall survival.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Medicine, General & Internal
Jonathan Garnier, Jacques Ewald, Flora Poizat, Eddy Traversari, Ugo Marchese, Anais Palen, Jean Robert Delpero, Olivier Turrini
Summary: This study evaluated the resection margin status of patients with PDAC and DC using a standardized specimen protocol analysis. The R1 resection rate was comparable between the two groups, and venous groove was the most common type of resection margin. R1 resection margin did not influence patient survival in either group.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Otorhinolaryngology
James Fowler, Yael Campanile, Andrew Warner, Francisco Laxague, Naif Fnais, Kevin Fung, Adrian Mendez, Danielle MacNeil, John Yoo, David Palma, Anthony Nichols
Summary: The study found that in head and neck surgery, patients with margins greater than 1 mm had similar local recurrence and overall survival rates compared to patients with margins greater than 5 mm, while patients with margins less than 1 mm showed worse survival outcomes.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Oncology
Peijun Gong, Synn Lynn Chin, Wes M. Allen, Helen Ballal, James D. Anstie, Lixin Chin, Hina M. Ismail, Renate Zilkens, Devina D. Lakhiani, Matthew McCarthy, Qi Fang, Daniel Firth, Kyle Newman, Caleb Thomas, Jiayue Li, Rowan W. Sanderson, Ken Y. Foo, Chris Yeomans, Benjamin F. Dessauvagie, Bruce Latham, Christobel M. Saunders, Brendan F. Kennedy
Summary: This study investigated the application of a handheld QME probe to directly detect residual cancer in the breast cavity during breast-conserving surgery. The results showed that QME detected increased stiffness in four cancer cases, while 19 out of 21 benign cases exhibited low stiffness.
Review
Obstetrics & Gynecology
M. Fernandez-Pacheco, O. Ortmann, A. Ignatov, E. C. Inwald
Summary: Cavity shaving is a surgical technique that can reduce re-excision rates and margin positivity in breast conserving surgery for breast cancer. Although the results vary, most studies show that cavity shaving can be beneficial.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Surgery
Biqi Zhang, Grace C. Lee, Motaz Qadan, Zhi Ven Fong, Mari Mino-Kenudson, Vikram Desphande, Giuseppe Malleo, Laura Maggino, Giovanni Marchegiani, Roberto Salvia, Aldo Scarpa, Claudio Luchini, Lucia De Gregorio, Cristina R. Ferrone, Andrew L. Warshaw, Keith D. Lillemoe, Claudio Bassi, Carlos Fernandez-del Castillo
Summary: Complete, tumor-free resection at the pancreatic neck, achieved either en-bloc or non-en-bloc, is associated with improved survival in pancreatic ductal adenocarcinoma patients, without increased perioperative morbidity or mortality.
Article
Medicine, Research & Experimental
Emily M. Robinson, Austin S. Lam, Isaac Solomon, Jacob S. Brady, John Pang, Farhoud Faraji, Jeffrey J. Houlton, Neal D. Futran, Brittany R. Barber
Summary: The study aimed to evaluate trends in positive surgical margin incidence and factors associated with surgical margin status in cT1-T2 oral cavity squamous cell carcinoma. The results showed that the overall rate of positive surgical margins in cT1-T2 oral cavity squamous cell carcinoma is decreasing. Surgical subsite, disease staging, lymphovascular invasion, and histologic grade were identified as independent predictors of positive surgical margins.
Article
Oncology
Yong Zhang, Jie Wu, Wei Huang, Ying Wang, Lidys Rivera Galvis, Tiane Chen, Bing Han
Summary: Through a retrospective analysis of 409 patients who underwent lumpectomy for invasive breast cancer, it was found that larger tumor size, specified histologic type, higher tumor grade, multifocality, positive lymph node status, and lymphovascular invasion were significantly associated with positive margin. Identifying and comprehensively assessing these pathological predictors will be helpful for clinical management and intraoperative surgical decision-making to reduce the rate of re-excision.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2023)
Article
Otorhinolaryngology
Kavita Prasad, Michael C. Topf, Stephanie Clookey, Ramez Philips, Joseph Curry, Patrick Tassone
Summary: Positive surgical margins in oral cavity squamous cell carcinoma are associated with cost escalation, treatment intensification, and greater risk of recurrence and mortality. The positive margin rate has been decreasing for cT1-T2 oral cavity cancer over the past 2 decades.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Surgery
Yoshiko Iwai, Jake G. Prigoff, Luona Sun, Lisa Wiechmann, Bret Taback, Roshni Rao, Stacy K. Ugras
Summary: This study compared the use of cavity shaving margin (CSM) and specimen shave margin (SSM) techniques in breast cancer patients. The results showed that both techniques achieved similar re-excision rates and rates of final margin positivity. However, SSM resulted in larger volumes of shave specimens. For tumors larger than 2 cm, both techniques had similar outcomes.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Oncology
Gesche Schultek, Bernd Gerber, Toralf Reimer, Johannes Stubert, Steffi Hartmann, Annett Martin, Angrit Stachs
Summary: The study found that radiological underestimation is an independent risk factor for positive margins in BCT of DCIS associated with microcalcifications. A relevant radiological underestimation was observed in 37% of patients, and mammographic tumor size <= 20 mm was an independent risk factor associated with radiological underestimation.
Article
Surgery
Marguerite M. Rooney, Krislyn N. Miller, Jennifer K. Plichta
SURGICAL CLINICS OF NORTH AMERICA
(2023)
Article
Oncology
Jennifer K. K. Plichta, Mahsa Taskindoust, Rachel A. A. Greenup
Summary: The benefits of surgical resection of the primary tumor in individuals with metastatic breast cancer remain controversial, with conflicting findings from retrospective and prospective studies. While some retrospective studies suggest a potential survival benefit, recent randomized controlled trials challenge these findings. Prospective studies indicate that most patients with metastatic breast cancer are unlikely to experience a survival benefit from surgery.
CURRENT BREAST CANCER REPORTS
(2023)
Editorial Material
Oncology
Sydney M. Record, Jennifer K. Plichta
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Krislyn N. N. Miller, Samantha M. M. Thomas, Sydney M. M. Record, Laura H. H. Rosenberger, Maggie L. L. DiNome, Gayle DiLalla, Jeremy M. M. Force, E. Shelley Hwang, Jennifer K. K. Plichta
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Amanda L. Nash, Diane L. Bloom, Brittany M. Chapman, Stephanie B. Wheeler, Kandace P. McGuire, Clara N. Lee, Kevin Weinfurt, Donald L. Rosenstein, Jennifer K. Plichta, Julie C. Jacobson Vann, E. Shelley Hwang
Summary: This study explored the experiences of the partners of women who undergo CPM. Most partners hoped their wives would choose a bilateral mastectomy, but the final decision was up to the women. The male partners had difficulty understanding the physical and emotional changes of mastectomy, making communication about sexuality and intimacy challenging.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Sydney M. Record, Samantha M. Thomas, Tori A. Chanenchuk, Jay J. Baker, Lars K. Grimm, Jennifer Plichta
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Krislyn N. Miller, Samantha M. Thomas, Sydney M. Record, Laura H. Rosenberger, Maggie L. DiNome, Gayle DiLalla, Jeremy M. Force, E. Shelley Hwang, Jennifer K. Plichta
Summary: This study examines the impact of age on pathologic complete response (pCR) rates and overall survival (OS) in women with estrogen receptor-positive (ER+) breast cancer after neoadjuvant therapy. The results indicate that older women have lower rates of pCR in the breast or lymph nodes after neoadjuvant chemotherapy, but age has less impact on pCR rates after neoadjuvant endocrine therapy. Importantly, achieving pCR after endocrine therapy is associated with improved OS in older women.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Laura H. Rosenberger, Samantha M. Thomas, Tina J. Hieken, Kristalyn K. Gallagher, Heather B. Neuman, Anna C. Weiss, Tari A. King, Jasmine Wong, Barry S. Tong, Amanda L. Nash, Carolyn S. Menendez, Shelley Hwang, James W. Jakub, Jennifer K. Plichta
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Astrid M. Botty van den Bruele, Yi Ren, Samantha M. Thomas, Marguerite Rooney, Carolyn S. Menendez, Akiko Chiba, Lars Grimm, Jennifer K. Plichta
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Hannah E. Woriax, Samantha M. Thomas, Jennifer K. Plichta, Laura H. Rosenberger, Astrid Botty van den Bruele, Akiko Chiba, Kendra J. Modell Parrish, Gayle D. DiLalla, Carolyn S. Menendez, Shelley Hwang, Maggie L. DiNome
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Astrid Botty van den Bruele, Morgan Paul, Samantha M. Thomas, Sarah L. Sammons, Maggie L. DiNome, Jennifer K. Plichta, Akiko Chiba, Laura H. Rosenberger, E. Shelley Hwang
Meeting Abstract
Oncology
Hannah E. Woriax, Samantha M. Thomas, Jennifer K. Plichta, Laura H. Rosenberger, Astrid Botty van de Bruele, Akiko Chiba, Gayle DiLalla, Carolyn Menendez, E. Shelley Hwang, Maggie L. DiNome
Meeting Abstract
Oncology
Amanda Nash, Diane Bloom, Stephanie Wheeler, Kandace McGuire, Clara Lee, Kevin Weinfurt, Donald Rosenstein, Jennifer Plichta, Julie Jacobson Vann, E. Shelley Hwang
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Kendra Modell Parrish, Samantha Thomas, Astrid Botty van den Bruele, Gayle DiLalla, Maggie DiNome, Carolyn Menendez, Jeremy Force, Laura Rosenberger, Hannah Woriax, E. Shelley Hwang, Jennifer Plichta, Akiko Chiba
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Kendra Modell Parrish, Samantha Thomas, Astrid Botty van den Bruele, Gayle DiLalla, Maggie DiNome, Carolyn Menendez, Laura Rosenberger, E. Shelley Hwang, Jennifer Plichta, Akiko Chiba, Hannah Woriax
ANNALS OF SURGICAL ONCOLOGY
(2023)