Article
Chemistry, Multidisciplinary
Yang Luo, Alberto Martin-Jimenez, Rico Gutzler, Manish Garg, Klaus Kern
Summary: Tip-enhanced Raman spectroscopy (TERS) allows for the tracing of vibrational fingerprints of molecules and low-dimensional materials with subnanometer resolution. The localization of light in the plasmonic nanocavity of the STM enables high spatial resolution in STM-TERS. However, the temporal resolution is currently limited. In this study, stable TERS measurements were demonstrated from subphthalocyanine (SubPc) molecules excited by 500 fs long laser pulses in a low-temperature (LT) ultrahigh-vacuum (UHV) STM. The intensity of the TERS signal scales linearly with the increasing flux of the laser pulses and exponentially with the decreasing gap-size of the plasmonic nanocavity. Furthermore, the characteristic features of TERS excited with ultrashort pulses were compared with those excited with a continuous-wave (CW) laser.
Article
Chemistry, Physical
Shota Takahashi, Atsunori Sakurai, Tatsuto Mochizuki, Toshiki Sugimoto
Summary: In this study, we achieved significant enhancement of the nonlinear optical response in a tip-substrate plasmonic nanocavity. By focusing on the near-field second harmonics of a wavelength-tunable femtosecond laser, we demonstrated that the enhancement of nonlinear optical effects occurs over a broad wavelength range from visible to infrared. We also discovered that the sharpness of the tip apexes and the surface geometry of the tip shafts both affect the broadband nonlinear optical property.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Eric Boateng Osei, Liliia Paniushkina, Konrad Wilhelm, Juergen Popp, Irina Nazarenko, Christoph Krafft
Summary: Extracellular vesicles (EVs) ranging in size from 60 to 800 nm were isolated from plasma of control and prostate cancer patients using differential centrifugation and ultrafiltration techniques. Spontaneous Raman and surface-enhanced Raman spectroscopy (SERS) were employed to identify fractions that best discriminate between control and cancer patients, with results showing that EV12 and EV120 fractions provide the most effective separation.
Article
Chemistry, Multidisciplinary
Su-Bin Lee, Seung-Min Paek, Jae-Min Oh
Summary: The research proposed a method to immobilize AgNP on metal oxide for enhanced SERS activity. Characterization and SERS tests showed that the sample prepared at 600 degrees C exhibited the best performance.
Article
Multidisciplinary Sciences
Ryo Kato, Toki Moriyama, Takayuki Umakoshi, Taka-aki Yano, Prabhat Verma
Summary: In this study, long-duration TERS imaging of a micrometer-sized WS2 sample was achieved in a reproducible manner, enabling the detection of nanoscale defects and rare optical signals in large area 2D materials.
Article
Chemistry, Physical
Sergio L. L. M. Ramos, Marcos A. Pimenta, Ana Champi
Summary: The study investigates the double-resonance Raman process in rhombohedral graphite and compares it with Bernal graphite, revealing that rhombohedral graphite exhibits a richer DR Raman spectrum due to its larger Brillouin zone volume. The 2D band of rhombohedral graphite is broader and shows different dispersive behavior compared to Bernal graphite. Additionally, the intervalley TO-LA band of rhombohedral graphite is broader and richer in features.
Article
Biotechnology & Applied Microbiology
Matthew T. N. Yarnall, Eleonora I. Ioannidi, Cian Schmitt-Ulms, Rohan N. Krajeski, Justin Lim, Lukas Villiger, Wenyuan Zhou, Kaiyi Jiang, Sofya K. Garushyants, Nathaniel Roberts, Liyang Zhang, Christopher A. Vakulskas, John A. I. I. I. I. Walker, Anastasia P. Kadina, Adrianna E. Zepeda, Kevin Holden, Hong Ma, Jun Xie, Guangping Gao, Lander Foquet, Greg Bial, Sara K. Donnelly, Yoshinari Miyata, Daniel R. Radiloff, Jordana M. Henderson, Andrew Ujita, Omar O. Abudayyeh, Jonathan S. Gootenberg
Summary: The study presents a method called PASTE, which allows programmable integration of large and diverse DNA cargo into the genome. This method successfully integrated sequences up to 36 kilobases in length at multiple genomic loci, and demonstrated activity in non-dividing cells and in vivo.
NATURE BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Gary Sean Cooney, David Talaga, Vicky Ury-Thiery, Yann Fichou, Yuhan Huang, Sophie Lecomte, Sebastien Bonhommeau
Summary: In this study, TERS was used to visualize the spatial distribution of adenine, protein secondary structure, and amino acids in single polyadenosine-induced tau fibrils. The findings provide insights into the incorporation of the polyadenosine cofactor in the fibril structure and its interaction with amino acids. TERS proves to be a powerful technique for studying cofactors in individual tau fibrils and their mode of interaction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Multidisciplinary
Limei Liu, Pablo Martinez Pancorbo, Ting-Hui Xiao, Saya Noguchi, Machiko Marumi, Hiroki Segawa, Siddhant Karhadkar, Julia Gala de Pablo, Kotaro Hiramatsu, Yasutaka Kitahama, Tamitake Itoh, Junle Qu, Kuniharu Takei, Keisuke Goda
Summary: Over the past two decades, wearable sensor technology has experienced significant growth. One recent breakthrough is the development of wearable chemical sensors based on surface-enhanced Raman spectroscopy (SERS), which can universally and noninvasively detect molecular fingerprints. However, these sensors are not scalable due to their complex fabrication process and limited multifunctional sensing capabilities. A highly scalable, wearable SERS sensor based on a low-cost, ultrathin, flexible, stretchable, adhesive, and biointegratable gold nanomesh is demonstrated in this study. It can be worn on any surface and used for label-free, large-scale, in situ sensing of diverse analytes. To showcase its practical utility, the sensor is tested for the detection of sweat biomarkers, drugs of abuse, and microplastics. This wearable SERS sensor represents a significant step towards the generalizability and practicality of wearable sensing technology.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Shu Hu, Jingyu Wang, Yue-Jiao Zhang, Bao-Ying Wen, Si-Si Wu, Petar M. Radjenovic, Zhilin Yang, Bin Ren, Jian-Feng Li
Summary: In this study, the shell and structural effect of shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) were investigated. It was found that the field enhancement loss due to the shell could be overcome by optimizing the coupling geometry of the shell-isolated nanoparticles (SHINs), and signal enhancement could be further optimized by altering the aggregation geometries of the nanoparticles.
Article
Chemistry, Physical
Yumin Zhang, Ruoyu Chen, Fugang Liu, Peng Miao, Li Lin, Jian Ye
Summary: The detection of deep-seated lesions is challenging due to the strong photon absorption and scattering of biological tissues. In this work, the combination of ultra-bright SERS nanotags and TRS is used to achieve non-invasive and photosafe detection of phantom lesions hidden in biological tissues. The results demonstrate the potential of transmission Raman-guided identification and non-invasive imaging for clinically safe cancer diagnoses.
Review
Engineering, Environmental
Lifang Xie, Kedong Gong, Yangyang Liu, Liwu Zhang
Summary: Nanoplastics, at sizes smaller than 1000 nm, are found ubiquitously in various environmental media and pose a potential health risk due to their ability to easily enter cells. In this review, we summarize the prevalent analytical techniques for identifying nanoplastics, with a focus on the advantages and disadvantages of surface-enhanced Raman spectroscopy (SERS). We discuss the principles of SERS, advances in nanoplastic detection using SERS, and the application of SERS in real environmental samples. Furthermore, we highlight the importance of efficient SERS substrates and pretreatment methodologies to enable practical nanoplastic detection and identify future research needs in this field.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Chih-Feng Wang, Patrick Z. El-Khoury
Summary: The study reveals that nonlinear optical processes can be enhanced at plasmonic tip-sample nanojunctions, allowing for high-spatial-resolution chemical analysis through enhanced spectroscopies.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Analytical
Qingnan Zhao, Hai Wang, Wenji Jiang, Huimin Gao, Sisi Wen, Xin Feng, Qiong Wu, Chengyan He, Youliang Zhu, Lianghai Hu, Bing Zhao, Wei Song
Summary: Understanding the catalytic process in an acetic acid-sodium acetate buffer environment is crucial for designing efficient nanozymes. This study investigated the lattice restructuration of Au-LaNiO3-delta nanofibers after acidification and revealed the role of carboxyl group insertion in enhancing oxidase-like activity and protecting vacancies. The strategy offers potential for constructing an efficient nanozyme-linked immunosorbent assay system.
ANALYTICAL CHEMISTRY
(2022)
Article
Plant Sciences
Yu-chi Liu, Yue-Rong Tan, Chin-Wen Chang, Van C. Nguyen, Kazue Kanehara, Koichi Kobayashi, Yuki Nakamura
Summary: This study reveals major developmental defects in pale seedlings of the Arabidopsis pmt1 pmt3 double mutant, with impairments in xylem of the hypocotyl and reduced chloroplast development and photosynthetic activity in leaves. While both PMT1 and PMT3 are localized in the endoplasmic reticulum, they exhibit distinct tissue-specific expression patterns, and the function of PMT3 requires its characteristic N-terminal sequence in addition to the promoter.
Article
Chemistry, Analytical
Xiaoqing Wang, XiaoLong Liu, XiaoTong Wang, YunPeng Wang, Yanlong Xiao, Zhu Zhuo, Yang Li
Summary: In this work, a new surface-enhanced Raman spectroscopy method was developed for label-free and accurate fingerprint determination of nonaromatic amino acids. By using a reducing agent and an aggregator, the detection of amino acid molecules on the surface of silver nano-substrates was successfully achieved.
Article
Chemistry, Physical
Xiaoyue Li, Xiaotong Wang, Jiaxin Liu, Miaomiao Dai, Qianjun Zhang, Yang Li, Jian-An Huang
Summary: The study addresses challenges in reliable SERS detection of organic molecules and in situ monitoring of organic reactions by introducing calcium ions to aggregate silver nanoparticles and acetone to promote uniform distribution of organic molecules on the nanoparticle surface. The method demonstrates stable SERS detection of up to 6 types of organic molecules and real-time monitoring of 3 kinds of organic reactions, showing potential for applications in biomedical analysis, environmental analysis, and organic catalysis research.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Biophysics
Dan Li, Zhe Zhang, Xiaotong Wang, Yunpeng Wang, Xin Gao, Yang Li
Summary: In this study, the aggregation of silver nanoparticles (AgNPs) was optimized using dichloromethane (DCM) and CaCl2, enabling sensitive and reproducible surface enhanced Raman spectroscopy (SERS) detection of unlabeled proteins while maintaining their native structure. The method showed good repeatability and a high quality in the analysis of protein samples. Furthermore, the technique allowed for protein quantification in mixtures and serum, and demonstrated promise for applications in food testing and clinical diagnosis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Hematology
Qinglian Wang, Jiangong Lin, Hui Han, Dongfeng Wu, Yan Zhou, Bing Zhao
Summary: This study found that preoperative cardiac index is associated with the maturation and patency of radiocephalic arteriovenous fistula. A decreased cardiac index may be a predictor of an increased risk of failed maturation and a shorter primary patency time.
BLOOD PURIFICATION
(2022)
Article
Engineering, Environmental
Jing Jin, Wei Song, Jiaqi Wang, Linjia Li, Yu Tian, Shoujun Zhu, Yuping Zhang, Shuping Xu, Bai Yang, Bing Zhao
Summary: A uniform and small-sized core-shell Ag/oxidized graphene quantum dots (o-GQDs) nanohybrid with enhanced SERS sensitivity and biocompatibility was prepared for intracellular SERS analysis and potential cancer cell therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Yanan Wang, Jing Jin, Hao Ma, Meng Zhang, Qianwen Li, He Wang, Bing Zhao, Weidong Ruan, Guan Yan
Summary: This study investigates the importance of enhancing charge transfer in the AZO/MPy/Ag sandwich structure, and identifies a significant CT route from the CB of AZO to the LUMO of the MPy molecule, which can effectively improve the degree of CT. This discovery is expected to play a crucial role in enhancing SERS.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Spectroscopy
Yan Ma, Qianwen Li, Siyu Wang, Yanan Wang, Hongye Liu, Xu Wang, Bing Zhao, Ziping Jiang, Weidong Ruan
Summary: The application of surface enhanced infrared absorption (SEIRA) is limited by the use of expensive noble metal substrates. This study introduces a new semiconductor SEIRA substrate, indium tin oxide (ITO) nanoparticles, and demonstrates their SEIRA property. Furthermore, the results show that the doping ratio of tin heteroatoms in ITO nanoparticles affects the enhancement factor.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Engineering, Environmental
Yunpeng Wang, Cuiwei Yu, Haoyu Ji, Zhehan Liu, Xiaotong Wang, Yinghe Ji, Xiaomeng Sun, Yue Zhao, Xiaohong Qiu, Ting Zhang, Jing Li, Xin Liu, Xinpeng Lv, Benzhi Cai, Yingqi Zhao, Jian-An Huang, Yang Li
Summary: This article reports a 3-step method to prepare a SERS system of silver nanoparticle clusters to overcome the interference of complex constituents of serum and achieve quantitative SERS analysis of drugs in serum. The method involves removing proteins from serum, enhancing drug adsorption on the nanoparticles, and suppressing background by using an internal standard in nanoparticle aggregation. The method shows great potential for clinical application in therapeutic drug monitoring and personalized medicine.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Xiaotong Wang, Yunpeng Wang, Yingying He, Ling Liu, Xiaoqing Wang, Shen Jiang, Ni Yang, Na Shi, Yang Li
Summary: A double-enhanced Raman scattering (DERS) detection platform was developed in this study based on silver nanoparticles, enabling the successful identification of various types of biomolecules. This technique has great application prospects in the fields of biomarker detection and medical diagnosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Yunpeng Wang, Na Shi, Yingying He, Yang Li, Qingchuan Zheng
Summary: In this study, a new method combining surface-enhanced Raman spectroscopy (SERS) and molecular dynamics simulations was proposed to analyze the interactions between DNA and its ligands. The changes of SERS fingerprint peaks of hydrogen bonds and bases were successfully detected, which were consistent with the predicted results of molecular dynamics simulations. This SERS technology combined with the molecular dynamics simulation detection platform provides a general analysis tool for rapid drug screening.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Analytical
Yuan Zhang, De-Sheng Zhan, Xiao-Ying Xu, Zhe Zhang, Mahmoud Elsayed Hafez, Yue He, Yang Li, Da-Wei Li
Summary: This study developed a SERS platform for detecting DNA methylation by modifying silver nanoparticles with zirconium ions. The use of zirconium ions enabled the opening of folded DNA molecules, allowing for the identification of subtle differences between normal and methylated DNA with single base-level sensitivity.
Article
Chemistry, Analytical
Ling Liu, Ting Zhang, Zheng Wu, Fenghai Zhang, Yunpeng Wang, Xiaotong Wang, Zhe Zhang, Chengming Li, Xinpeng Lv, Deqiang Chen, Songyan Jiao, Jing Wu, Yang Li
Summary: We developed a universal label-free biomolecule detection method using sulfhydryl-modified gold nanoparticles as the substrate for surface-enhanced Raman spectroscopy (SERS). Through a two-step enhancement method, we were able to obtain fingerprints of DNA, RNA, amino acids, peptides, proteins, viruses, bacteria, and lipid molecules. This low-toxic, highly sensitive, and widely applicable technique has potential applications in biomedical research, clinical testing, and disease diagnosis, laying a foundation for SERS technology in various fields.
ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Zhe Zhang, Heng Jiang, Shen Jiang, Tuo Dong, Xiaotong Wang, Yunpeng Wang, Yang Li
Summary: Conventional detection methods are inadequate for early and rapid detection of monkeypox virus (MPXV) infection due to their complex pretreatment, time consumption, and complex operation. This study proposes a method based on surface-enhanced Raman spectroscopy (SERS) to capture the characteristic fingerprints of MPXV genome and antigenic proteins without the need for specific probes. The detection limit of the method is 100 copies/mL, with good reproducibility and signal-to-noise ratio. Principal component analysis (PCA) can identify SERS spectra of four different MPXV proteins in serum. Therefore, this rapid detection method has significant application prospects for controlling the current monkeypox outbreak and responding to future outbreaks.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Spectroscopy
Xinpeng Lv, Zhe Zhang, Yue Zhao, Xiaomeng Sun, Heng Jiang, Shuwen Zhang, Xianqi Sun, Xiaohong Qiu, Yang Li
Summary: This study develops a suitable virus detection hotspot using surface-enhanced Raman scattering (SERS) by reducing sodium borohydride and aggregating silver nanoparticles. Monkeypox virus and human papillomavirus fingerprints were successfully obtained and identified in serum and artificial vaginal discharge, respectively, using the principal component analysis method. The method has a low detection limit of 100 copies/mL, good reproducibility, and signal-to-noise ratio, and can solve the SERS signal interference problem in complex biological samples, showing potential for clinical application.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Xinyu Yao, Jingyi Lin, Qiang Zhou, Yingli Song, Tingting Sun, Xiaohong Qiu, Bo Cao, Yang Li
Summary: To effectively detect pollutants in environmental water, a detection platform based on surface-enhanced Raman spectroscopy was developed. This platform could amplify the Raman signal of target molecules and obtain SERS signals of different types of pollutants. It has a sensitivity of 0.1 pg mL(-1) and can accurately identify and quantify environmental contaminants under realistic conditions, providing an efficient, accurate, and low-cost method for environmental pollutant monitoring.
ENVIRONMENTAL SCIENCE-NANO
(2023)
