Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 377, Issue -, Pages 214-219Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2019.03.050
Keywords
BODIPY; Fluorescent probes; Poly(ethylene glycol); Water-soluble; Bioimaging agents
Categories
Funding
- Chosun University
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A series of poly(ethylene glycol) (PEG)-modified water-soluble boron dipyrromethene (BODIPY) dyes (EtBOD-PEG and BOD-PEG) were synthesized and their photophysical properties in various solutions were investigated. The presence of ethyl groups at the 2,6-positions of the BODIPY core in EtBOD-PEG resulted in bathochromic shifts in both the absorption and emission spectra relative to those of the unsubstituted BOD-PEG. Importantly, bulky di-branched PEG chains were introduced at the meso position of the BODIPY core, leading to enhanced solubilities and high fluorescence quantum yields in aqueous solutions. The water-soluble BODIPY dyes were explored for their applicability in fluorescent bio-imaging using MCF-7 human breast cancer cells. The dyes were cell-permeable and were concentrated in cellular cytoplasm area, suggesting that they have potential applications as bio-imaging agents.
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