Article
Medical Laboratory Technology
Chris R. Bain, Paul S. Myles, Rachael Taylor, Hugh Trahair, Yin Peng Lee, Larry Croft, Philip J. Peyton, Thomas Painter, Matthew T. Chan, Sophie Wallace, Tomas Corcoran, Andrew D. Shaw, Eldho Paul, Mark Ziemann, Kiymet Bozaoglu
Summary: This study defines and validates a state of postoperative systemic inflammatory dysregulation (PSID) based on postoperative phenotypic extremes of plasma C-reactive protein concentration. PSID is associated with higher rates of sepsis, complications, longer hospital stays, and poorer short and long-term outcomes. Altered DNA methylation and differential gene expression in specific immune and metabolic pathways are identified during PSID, highlighting potential targets for early detection and treatment.
TRANSLATIONAL RESEARCH
(2022)
Review
Critical Care Medicine
Antonio Messina, Chiara Robba, Lorenzo Calabro, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi, Maurizio Cecconi
Summary: The choice between liberal or restrictive perioperative fluid management did not impact overall major postoperative complications or mortality in major abdominal elective surgery. However, a liberal approach was associated with lower renal major events compared to a restrictive approach.
Article
Surgery
Victor D. Plat, Daan M. Voeten, Freek Daams, Donald L. van der Peet, Jennifer Straatman
Summary: This study addressed the predictive value of routine assessment of C-reactive protein levels as an early marker for infectious complications after major abdominal surgery. It found that C-reactive protein levels can serve as an important indicator for predicting major infectious complications, with specific cut-off values calculated for each postoperative day. These cut-off values can be used as discharge criteria or to identify patients who may require further intervention due to infectious complications, facilitating clinical decision-making in surgical practice.
Article
Immunology
Silu Cao, Jinxuan Tang, Miaomiao Fei, Qi Jing, Fanbing Meng, Meixian Zhang, Qidong Liu, Hui Zhang, Cheng Li
Summary: This study identified hub genes associated with immune and metabolic alterations in patients with postoperative systemic inflammatory dysregulation (PSID) and hub genes that link these alterations. These findings provide novel insights into the mechanisms underlying immune and metabolic interactions and new targets for clinical treatment can be proposed on this basis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Anesthesiology
C. R. Bain, P. S. Myles, C. Martin, S. Wallace, M. A. Shulman, T. Corcoran, R. Bellomo, P. Peyton, D. A. Story, K. Leslie, A. Forbes, RELIEF Trial Investigators
Summary: Postoperative systemic inflammation is strongly associated with surgical outcomes and patient-centred outcomes. This study analysed data from a large cohort of high-risk abdominal surgery patients and found that greater postoperative inflammation was linked to increased risk of complications, poor quality of recovery, and persistent disability or death up to 90 days after surgery. These findings highlight the importance of detecting excessive inflammation and identifying factors associated with adverse patient-centred outcomes for the development of preventative treatment options.
Article
Multidisciplinary Sciences
Kenji Kuroda, Takahiro Toyokawa, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Hiroaki Tanaka, Shigeru Lee, Kazuya Muguruma, Masakazu Yashiro, Masaichi Ohira
Summary: This study investigated the correlation between systemic inflammatory response and long-term outcomes in gastric cancer patients and identified potential markers in stage II/III patients. The study found that maximum serum C-reactive protein (CRPmax) was an independent prognostic factor for overall survival and relapse-free survival, while maximum white blood cell count (WBCmax) and infectious complications were not. These findings suggest that CRPmax could be a promising prognostic indicator for stage II/III gastric cancer patients undergoing curative resection.
SCIENTIFIC REPORTS
(2022)
Review
Anesthesiology
C. R. Bain, P. S. Myles, T. Corcoran, J. M. Dieleman
Summary: Postoperative systemic inflammatory dysregulation, which progresses to a harmful state, increases the risk of complications and prolongs hospital stay in patients undergoing surgical injury. This review discusses the evolution, measurement, and prediction of this dysregulation, as well as the potential benefits and safety of corticosteroid supplementation in reducing major complications and death. It also emphasizes the importance of tailored corticosteroid regimes in patients at higher risk of peri-operative inflammatory complications.
Article
Surgery
Leerang Lim, Jihyuk Lee, So Yeong Hwang, Hannah Lee, Seung-Young Oh, Christine Kang, Ho Geol Ryu
Summary: This study retrospectively analyzed data from adult patients who underwent upper abdominal surgery at Seoul National University Hospital in 2021. The results showed no significant association between early postoperative fever and atelectasis. Fever was found to be associated with positive culture tests and prolonged use of antibiotics, but there was no difference in bacterial growth and postoperative pulmonary complications between the two groups.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Review
Oncology
Robert T. van Kooten, Renu R. Bahadoer, Koen C. M. J. Peeters, Jetty H. L. Hoeksema, Ewout W. Steyerberg, Henk H. Hartgrink, Cornelis J. H. van de Velde, Michel W. J. M. Wouters, Rob A. E. M. Tollenaar
Summary: Patients undergoing complex gastrointestinal surgery are at high risk of major postoperative complications, such as anastomotic leakage and sepsis. Identification of preoperative risk factors can help identify high-risk patients and design personalized perioperative care.
Article
Medicine, General & Internal
Vanja Persic, Alexander Jerman, Marija Malgaj Vrecko, Jernej Berden, Vojka Gorjup, Adela Stecher, Milica Lukic, Matjaz Jereb, Gordana Taleska Stupica, Jakob Gubensek
Summary: Hemoadsorption in shocked patients with SIRS leads to a rapid decrease in IL-6 and improvement in hemodynamics, resulting in better observed survival rates compared to predicted rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Adrien Picod, Louis Morisson, Charles de Roquetaillade, Malha Sadoune, Alexandre Mebazaa, Etienne Gayat, Beth A. Davison, Gad Cotter, Benjamin Glenn Chousterman
Summary: This study assessed the relationship between IL-6 and CRP levels and mortality, organ dysfunction, and the need for organ support in critically ill patients. The results showed that high levels of IL-6 or CRP were associated with worse 90-day survival and increased risk of requiring organ support.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Paul M. Ridker, Matt Devalaraja, Florian M. M. Baeres, Mads D. M. Engelmann, G. Kees Hovingh, Milana Ivkovic, Larry Lo, Douglas Kling, Pablo Pergola, Dominic Raj, Peter Libby, Michael Davidson
Summary: This study investigated the safety and efficacy of IL-6 inhibition treatment in high cardiovascular risk individuals. Results showed that ziltivekimab effectively reduced biomarkers of inflammation and thrombosis, with promising effects observed in patients with chronic kidney disease.
Article
Nutrition & Dietetics
Alba Fernandez-Candela, Alicia Calero, Luis Sanchez-Guillen, Javier Escrig-Sos, Jose A. Barreras, Francisco Lopez-Rodriguez-Arias, Laura Armananzas, Ana Murcia, Antonio Arroyo, Francisco Javier Lacueva
Summary: The study assessed the impact of preoperative immunonutrition intake on postoperative major complications in patients undergoing cytoreductive surgery, showing that immunonutrition intake was associated with a decreased risk of postoperative complications.
Article
Endocrinology & Metabolism
Maria Krajewska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Anna Stelmaszczyk-Emmel, Maria Sobol, Anna Majcher, Beata Pyrzak
Summary: The study found that vitamin D supplementation had beneficial effects in overweight and obese children, reducing inflammation levels and stabilizing anti-inflammatory cytokines.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Athanasios Chalkias, Eleni Laou, Konstantina Kolonia, Dimitrios Ragias, Zacharoula Angelopoulou, Eleni Mitsiouli, Thomas Kallemose, Lars Smith-Hansen, Jesper Eugen-Olsen, Eleni Arnaoutoglou
Summary: This study investigated the use of preoperative soluble urokinase plasminogen activator receptor as a predictive marker for postoperative complications in white patients undergoing major noncardiac surgery. The results showed that soluble urokinase plasminogen activator receptor had strong independent predictive value, and could be used to assess the risk of postoperative complications in these patients.
Article
Anesthesiology
P. G. Noordzij, O. van Geffen, I. M. Dijkstra, D. Boerma, A. J. Meinders, T. C. D. Rettig, F. D. Eefting, D. van Loon, E. M. W. van de Garde, E. P. A. van Dongen
BRITISH JOURNAL OF ANAESTHESIA
(2015)
Article
Anesthesiology
Thijs C. D. Rettig, Sander Rigter, Vincent J. Nijenhuis, Jan-Peter van Kuijk, Jurrien M. ten Berg, Robin H. Heijmen, Ewoudt M. W. van de Garde, Peter G. Noordzij
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2015)
Letter
Anesthesiology
P. G. Noordzij, T. C. D. Rettig, E. M. W. van de Garde, E. P. A. van Dongen
BRITISH JOURNAL OF ANAESTHESIA
(2016)
Letter
Anesthesiology
Thijs C. D. Rettig, Erik Vermeulen, Ineke M. Dijkstra, Wilton A. van Klei, Ewoudt M. W. van de Garde, Linda M. Peelen, Peter G. Noordzij
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2017)
Article
Anesthesiology
Thijs C. D. Rettig, Linda M. Peelen, Guillaume S. C. Geuzebroek, Wilton A. van Klei, Christa Boer, Jan Willem van der Veer, Jan Hofland, Ewoudt M. W. van de Garde, Peter G. Noordzij
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2017)
Letter
Surgery
Thijs C. D. Rettig, Lisa Verwijmeren, Ewoudt M. W. van de Garde, Djamilla Boerma, Peter G. Noordzij
Article
Orthopedics
Mark P. Arts, Thijs C. D. Rettig, Jessica de Vries, Jasper F. C. Wolfs, Bas A. in't Veld
BMC MUSCULOSKELETAL DISORDERS
(2013)
Article
Cardiac & Cardiovascular Systems
T. C. D. Rettig, B. J. Bouma, R. B. A. van den Brink
NETHERLANDS HEART JOURNAL
(2009)
Article
Cardiac & Cardiovascular Systems
N. L. Hartholt, T. C. D. Rettig, M. Schijffelen, W. J. Morshuis, E. M. W. van de Garde, P. G. Noordzij
NETHERLANDS HEART JOURNAL
(2014)
Article
Clinical Neurology
M. Nassif, M. E. Annink, H. Yang, T. C. D. Rettig, Y. B. W. E. M. Roos, R. B. A. van den Brink, J. G. P. Tijssen, B. J. M. Mulder, R. J. de Winter, B. J. Bouma
Summary: The study found a relatively high incidence of recurrent stroke/TIA during long-term follow-up of young ESUS patients, while the incidence of new-onset clinical AF was relatively low and may not play a significant role in the pathophysiology of first-ever and recurrent stroke/TIA in these patients.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Anesthesiology
Mandy Langstraat, Carla M. Megens-Bastiaanse, Thijs C. D. Rettig, Thierry V. Scohy, Bas M. Gerritse
Summary: This study described the outcome of Jehovah's Witnesses undergoing cardiac surgery at a specific center. The results showed that cardiac surgery in Jehovah's Witnesses is safe when a strict perioperative patient blood management protocol is followed.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Letter
Surgery
Thijs C. D. Rettig, Lisa Verwijmeren, Ewoudt M. W. Van de Garde, Djamilla Boerma, Peter G. Noordzij