Article
Dentistry, Oral Surgery & Medicine
Marco Mascitti, Lucrezia Togni, Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Lorenzo Lo Muzio, Corrado Rubini, Andrea Santarelli, Giuseppe Troiano
Summary: Tumor budding is found to be a reliable prognostic factor in oral tongue squamous cell carcinoma (OTSCC), but a standardized scoring system is lacking. This study aims to evaluate the prognostic role of tumor budding in 211 OTSCC patients. The results confirm the predictive value of tumor budding in disease-specific survival.
Article
Dentistry, Oral Surgery & Medicine
Jia Kang, Ming Su, Qiaoshi Xu, Chong Wang, Xiaohong Yuan, Zhengxue Han
Summary: The objective of this study was to evaluate the prognostic value of TSR and TB in OTSCC and establish a predictive model for the outcome of OTSCC patients. The results indicated that TSR was an independent risk factor for the prognosis of OTSCC patients and patients with stroma-rich had a worse long-term prognosis. The risk model combining TSR and TB showed valuable predictive power for the outcome of OTSCC patients.
Article
Dentistry, Oral Surgery & Medicine
Luiz Arthur Barbosa da Silva, Maria Luiza Diniz de Sousa Lopes, Melka Coelho Sa, Roseana de Almeida Freitas, Ricardo Della Coletta, Ericka Janine Dantas da Silveira, Marcia Cristina da Costa Miguel
Summary: This study compared the prognostic significance of four histopathologic grading systems in 80 cases of oral tongue squamous cell carcinoma (OTSCC). The results indicated that the BD model was the only histopathologic grading system associated with the outcome of patients with OTSCC.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Pathology
Inti Zlobec, Melanie Baechli, Francesca Galuppini, Martin D. Berger, Heather E. Dawson, Iris D. Nagtegaal, Alessandro Lugli
Summary: The study investigated the potential clinical relevance of a new category of zero tumor buds in colorectal cancer, which was found to provide important information on tumor behavior.
Article
Oncology
Parbatraj Regmi, Aliza Paudyal, Pranita Paudyal, Hai-Jie Hu, Fei Liu, Wen-Jie Ma, Yan-Wen Jin, Fu-Yu Li
Summary: Tumor budding is identified as a significant predictor of poor survival for biliary tract cancer (BTC), associated with poor histologic differentiation, lymphovascular invasion, and other factors. It has the potential to serve as a prognostic marker for BTC, pending the development of a standardized international consensus.
Review
Oncology
Lucrezia Togni, Vito Carlo Alberto Caponio, Nicoletta Zerman, Giuseppe Troiano, Khrystyna Zhurakivska, Lorenzo Lo Muzio, Andrea Balercia, Marco Mascitti, Andrea Santarelli
Summary: Tumor budding is an independent prognostic factor in various solid cancers, including oral squamous cell carcinoma. It can predict poor survival outcomes and has potential applications in daily pathological practice. However, further research and validation are needed due to the lack of standardized assessment methods.
Article
Oncology
Akira Yorozu, Shohei Sekiguchi, Akira Takasawa, Fumika Okazaki, Takeshi Niinuma, Hiroshi Kitajima, Eiichiro Yamamoto, Masahiro Kai, Mutsumi Toyota, Yui Hatanaka, Koyo Nishiyama, Kazuhiro Ogi, Hironari Dehari, Kazufumi Obata, Makoto Kurose, Atsushi Kondo, Makoto Osanai, Akihiro Miyazaki, Kenichi Takano, Hiromu Suzuki
Summary: The expression of CXCL12 in the tumor microenvironment of oral squamous cell carcinoma (OSCC) has both biological and clinical significance. CXCL12 is mainly expressed in stromal cells within the tumor tissue, and its expression level is negatively correlated with muscle structure disruption and overall survival. Furthermore, CXCL12 expression is associated with tumor infiltration and infiltration of CD8+ lymphocytes.
Article
Pathology
Bin Xu, Abeer M. Salama, Cristina Valero, Avery Yuan, Anjanie Khimraj, Maelle Saliba, Daniella K. Zanoni, Ian Ganly, Snehal G. Patel, Nora Katabi, Ronald Ghossein
Summary: Histologic grade is controversial in predicting prognosis of head and neck squamous cell carcinoma (HNSCC). In a study of early oral tongue squamous cell carcinoma (OTSCC), tumor budding and worst pattern of invasion (WPOI) were found to be more relevant prognostic factors compared to histologic grade, with tumor budding significantly predicting nodal metastasis. Consideration should be given to include WPOI and tumor budding in pathology reporting for OTSCC.
Article
Otorhinolaryngology
Yeoun Eun Sung, Min-Sik Kim, Youn Soo Lee
Summary: This study evaluated risk factors in oral squamous cell carcinoma using image analysis, with significant differences in prognosis found between low-, intermediate-, and high-risk groups. The high-risk groups were associated with poor survival even within different tumor-node-metastasis stages, suggesting a possible descriptive model for prognosis prediction based on pathological and imaging findings regardless of TNM stage.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Muyuan Liu, Litian Tong, Bin Liang, Xuhong Song, Lingzhu Xie, Hanwei Peng, Dongyang Huang
Summary: Our study successfully established a novel 15-mRNA prognostic model for predicting overall survival of non-distant metastatic OTSCC. The prediction ability of this 15-gene signature was independent of other clinicopathological factors and demonstrated excellent prediction accuracy. Additionally, an external validation using the GEO dataset confirmed the good prediction ability of the 15-gene model. The prognostic nomogram integrating the 15-gene signature and clinicopathological factors has the potential to be developed as a prognostic tool.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cheng Wang, Zhengxian Huang, Ming Zhang, Gan Xiong, Xiaohua Chen, Nan Xie
Summary: This study found that tertiary lymphoid structures (TLS) are frequently observed in oral tongue squamous cell carcinoma (OTSCC), and are associated with a favorable prognosis in early clinical stage OTSCC patients. TLS can serve as an independent prognostic factor for overall and disease-free survival, and may also be used to predict immunotherapy sensitivity.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Pathology
Lara Alessandrini, Elisabetta Zanoletti, Diego Cazzador, Marta Sbaraglia, Leonardo Franz, Giulia Tealdo, Anna Chiara Frigo, Stella Blandamura, Piero Nicolai, Antonio Mazzoni, Gino Marioni
Summary: This study highlights the significant role of tumor budding in the prognosis of TBSCC, showing associations with tumor invasion, lymph node metastasis, disease-free survival, and overall survival. Further research is needed to confirm these findings in larger prospective studies.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Shigeo Ishikawa, Masahiro Sugimoto, Tsuneo Konta, Kenichiro Kitabatake, Shohei Ueda, Kaoru Edamatsu, Naoki Okuyama, Kazuyuki Yusa, Mitsuyoshi Iino
Summary: This study identified salivary 3-methylhistidine as a prognostic factor for overall survival in patients with oral squamous cell carcinoma through comprehensive metabolomic analyses.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Vito Carlo Alberto Caponio, Giuseppe Troiano, Lucrezia Togni, Khrystyna Zhurakivska, Andrea Santarelli, Luigi Laino, Corrado Rubini, Lorenzo Lo Muzio, Marco Mascitti
Summary: The study investigated the clinic and prognostic value of perineural invasion (PNI) in oral tongue squamous cell carcinoma (OTSCC) patients. PNI was found in 40.5% of patients and tumors with positive PNI reported worse Disease-Specific Survival (DSS), with multifocal intra- and peritumoral PNI associated with the poorest DSS. By integrating PNI in the staging system, better prognostication and risk stratification were achieved.
Article
Pathology
Alhadi Almangush, Ibrahim O. Bello, Ilkka Heikkinen, Jaana Hagstrom, Caj Haglund, Luiz Paulo Kowalski, Pentti Nieminen, Ricardo D. Coletta, Antti A. Makitie, Tuula Salo, Ilmo Leivo
Summary: Categorizing the stroma of early OTSCC based on the amount of stroma and its infiltrating lymphocytes shows clinical relevance superior to categorization based on the maturity of stroma. This classification method has better predictive value in survival analyses.
