Journal
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
Volume 65, Issue 2, Pages 202-204Publisher
CENTER ACADEMIC PUBL JAPAN
DOI: 10.3177/jnsv.65.202
Keywords
rubiscolin-6; tail suspension test; depression; delta-opioid receptor; acute restraint stress
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Funding
- Specific Research Foundation of Hokuriku University [250100]
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Rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) is produced by a pepsin digest of spinach D-ribulose- 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and known to act as an agonist on delta-opioid receptor. Here, we showed that administration of rubiscolin-6 reduced immobility time in the tail suspension test in restraint-stressed mice without effect on locomotor activity. The antidepressant-like effect of rubiscolin-6 was blocked by a delta-opioid receptor antagonist, naltrindole. These results indicate that rubiscolin-6 exerts antidepressant-like effect through activation of delta-opioid receptor.
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