Article
Clinical Neurology
Zahra Aghelan, Saeed Karima, Habibolah Khazaie, Seyed Hosein Abtahi, Ali Reza Farokhi, Masoumeh Rostampour, Fariborz Bahrehmand, Reza Khodarahmi
Summary: This study found increased activation of NLRP1 and NLRP3 inflammasomes in blood cells, abnormal levels of cytokines, and a correlation between cytokine levels and the severity of insomnia in individuals with chronic insomnia disorder. Additionally, MRI scans showed structural differences in the brains of individuals with chronic insomnia disorder.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
Shinji Hirano, Akira Higashimori, Yasuaki Nagami, Yuji Nadatani, Tetsuya Tanigawa, Masaki Ominami, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara
Summary: This study found that the NLRP3 inflammasome promotes esophageal stricture formation following ulcer healing, and pirfenidone (PFD) has the potential to prevent stricture formation by inhibiting the NLRP3/IL-1 beta/TGF-beta 1 axis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
David M. Calcagno, Angela Chu, Susanne Gaul, Nika Taghdiri, Avinash Toomu, Aleksandra Leszczynska, Benedikt Kaufmann, Bettina Papouchado, Alexander Wree, Lukas Geisler, Hal M. Hoffman, Ariel E. Feldstein, Kevin R. King
Summary: Activation of NLRP3 causes chronic extramedullary myelopoiesis in the liver, leading to inflammation and fibrosis. This activation also down-regulates metabolic pathways in hepatocytes and shifts hepatic stellate cells towards an activated profibrotic state.
Article
Gastroenterology & Hepatology
Akira Higashimori, Toshio Watanabe, Yuji Nadatani, Akinobu Nakata, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Koichi Taira, Yasuaki Nagami, Tetsuya Tanigawa, Yasuhiro Fujiwara
Summary: The study revealed that NLRP3 inflammasome-derived IL-1 beta plays a protective role in stress-induced gastric injury through activation of the COX-2/PGE(2) axis. Toll-like receptor 4 signaling and gastric acid may be involved in NLRP3 inflammasome activation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Li Jiang, Yixin Zhang, Feng Jing, Ting Long, Guangcheng Qin, Dunke Zhang, Lixue Chen, Jiying Zhou
Summary: This study revealed dysfunction of the autophagic process in chronic migraine, and suggested that activated autophagy may have a preventive effect on migraine chronification. P2X7R contributes to central sensitization through mediating autophagy regulation, making it a potential therapeutic target for chronic migraine.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Ines Schmidt-Morgenroth, Philippe Michaud, Fabrizio Gasparini, Alexandre Avrameas
Summary: Mild cognitive impairment (MCI) is characterized by a decline in cognitive function and is an underlying condition of Alzheimer's disease (AD). Neuroinflammation has been investigated as a mechanism contributing to the progression of MCI to AD. Understanding this mechanism could help in the diagnosis and treatment of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yanhong Chen, Xiuhui Chen, Shuli Liang, Yitao Ou, Geng Lin, Lei Hua, Xinyi Wu, Yinghua Zhou, Zhuorong Liu, Haowei Cai, Zhongjin Yang, Wenhui Hu, Ping Sun
Summary: Psoriasis is a chronic autoimmune skin disease associated with inflammation, and the antimicrobial agent chlorquinaldol (CQD) has been found to inhibit the activation of inflammasomes and reduce the severity of psoriatic response.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Chemistry, Multidisciplinary
Juan Jin, Tao-jie Zhou, Gui-ling Ren, Liang Cai, Xiao-ming Meng
Summary: NLRs, a major subfamily of pattern recognition receptors, have gained considerable attention due to their involvement in mediating the immune response and inflammatory pathways. This review summarises recent progress on the functions and mechanisms of NLRs in different types of renal diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Clinical Neurology
Qi Pan, Yunfeng Wang, Ruimin Tian, Qianwen Wen, Guangcheng Qin, Dunke Zhang, Lixue Chen, Yixin Zhang, Jiying Zhou
Summary: The study reveals that inhibiting S1PR1 signal can alleviate central sensitization and inhibit microglia activity in chronic migraine through the STAT3 signal pathway.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Immunology
Ya-Qin Song, Wei-Ji Lin, Hong-Jie Hu, Shu-hui Wu, Liang Jing, Qing Lu, Wei Zhu
Summary: The study found that STS protected against sepsis-associated brain injury and neuroinflammatory response by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway and reducing the secretion of proinflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Qianwen Wen, Yunfeng Wang, Qi Pan, Ruimin Tian, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lixue Chen
Summary: The study found that the upregulation of miR-155-5p in patients with chronic migraine, and inhibiting miR-155-5p can alleviate neuroinflammation by activating SIRT1 in the TNC.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Xiaolin Xu, Xianli Wu, Gengyu Yue, Qimin An, Jun Lou, Xiaoxu Yang, Zhe Jin, Jianhong Ding, Yanxia Hu, Qian Du, Jingyu Xu, Rui Xie
Summary: This article summarizes the activation mechanisms of inflammasomes and their relationship with diseases, and provides an overview of the effects of intracellular and extracellular ion activities and ion channels on inflammasome activation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Xiaoxu Zeng, Jia Mai, Hongjian Xie, Ling Yang, Xiaojuan Liu
Summary: This study found that the activation of CB1R alleviates central sensitization in CM rats by regulating the HCN2-pNR2B signaling pathway. This suggests that CB1R activation may have a positive effect on the prevention of CM by mitigating central sensitization.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Medicine, Research & Experimental
Daisuke Watanabe, Yijie Guo, Nobuhiko Kamada
Summary: The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death by detecting microbial and endogenous stimuli, leading to the release of pro-inflammatory cytokines or cell death. Interactions between gut microbiota and the inflammasome have significant impacts on gastrointestinal homeostasis and disease progression.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Yineng Han, Pengfei Gao, Qiaolin Yang, Yiping Huang, Lingfei Jia, Yunfei Zheng, Weiran Li
Summary: This study reveals the involvement of NLRP3 inflammasome and Pasteurella multocida toxin (PMT) in periodontitis. PMT promotes NLRP3 expression and activates NLRP3 inflammasome, exacerbating periodontal bone loss and inflammation. NLRP3 may serve as an effective target for periodontitis treatment, and MCC950 could be a potential drug against this disease.
CELLULAR MICROBIOLOGY
(2022)
Article
Clinical Neurology
Li Jiang, Dong Li Yuan, Maolin Li, Chaoyang Liu, Qing Liu, Yixin Zhang, Ge Tan
ACTA NEUROLOGICA SCANDINAVICA
(2019)
Review
Clinical Neurology
Wei He, Yixin Zhang, Ting Long, Qi Pan, Shanshan Zhang, Jiying Zhou
Article
Clinical Neurology
Yixin Zhang, Qi Pan, Huahua Jiang, Gang Yang, Lixue Chen, Guangcheng Qin, Jiying Zhou
Article
Cell Biology
Yixin Zhang, Ningbo Xu, Yan Ding, Desislava Met Doycheva, Yiting Zhang, Qian Li, Jerry Flores, Mina Haghighiabyaneh, Jiping Tang, John H. Zhang
CELL DEATH & DISEASE
(2019)
Review
Clinical Neurology
Shanshan Zhang, Dongli Yuan, Ge Tan
FRONTIERS IN NEUROLOGY
(2019)
Article
Clinical Neurology
Qi Pan, Yixin Zhang, Shanshan Zhang, Weiheng Wang, Huahua Jiang, Yulan Fan, Jiying Zhou
ACTA NEUROLOGICA SCANDINAVICA
(2020)
Article
Clinical Neurology
Ting Long, Wei He, Qi Pan, Shanshan Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen, Jiying Zhou
JOURNAL OF HEADACHE AND PAIN
(2020)
Editorial Material
Clinical Neurology
Qi Pan, Yixin Zhang, Shanshan Zhang, Weiheng Wang, Huahua Jiang, Yulan Fan, Jiying Zhou
ACTA NEUROLOGICA SCANDINAVICA
(2020)
Article
Clinical Neurology
Dongli Yuan, Yixin Zhang, Qin Li, Yuhua Lv, Xuelian Li, Yichuan Yu, Wangwen Li, Ge Tan
FRONTIERS IN NEUROLOGY
(2020)
Article
Neurosciences
Li Liu, Xiaofei Hu, Yixin Zhang, Qi Pan, Qunling Zhan, Ge Tan, Kuiyun Wang, Jiying Zhou
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Clinical Neurology
Yun Zhang, Yixin Zhang, Ke Tian, Yunfeng Wang, Xiaoping Fan, Qi Pan, Guangcheng Qin, Dunke Zhang, Lixue Chen, Jiying Zhou
JOURNAL OF HEADACHE AND PAIN
(2020)
Article
Immunology
Li Jiang, Yixin Zhang, Feng Jing, Ting Long, Guangcheng Qin, Dunke Zhang, Lixue Chen, Jiying Zhou
Summary: This study revealed dysfunction of the autophagic process in chronic migraine, and suggested that activated autophagy may have a preventive effect on migraine chronification. P2X7R contributes to central sensitization through mediating autophagy regulation, making it a potential therapeutic target for chronic migraine.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Emergency Medicine
Weiheng Wang, Yixin Zhang, Qi Pan, Juan Liu, Yinglin Zhu, Ge Tan, Qunling Zhan, Jiying Zhou
Summary: The combination of HINTS and ABCD(2) score can effectively differentiate cerebrovascular causes of dizziness, especially when accompanied by skew deviation and ABCD(2) score of 4 or higher. The presence of central pattern of nystagmus and an ABCD(2) score of 4 or higher are practical for identifying cerebrovascular causes in patients with dizziness.
ACADEMIC EMERGENCY MEDICINE
(2021)