An integrative view of mammalian seasonal neuroendocrinology

A brief history of circannual time

(2019) Gerald Lincoln   JOURNAL OF NEUROENDOCRINOLOGY

Functional Implications of RFRP-3 in the Central Control of Daily and Seasonal Rhythms in Reproduction

(2019) Eleni Angelopoulou et al.   Frontiers in Endocrinology

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

(2018) Vincent Prevot et al.   ENDOCRINE REVIEWS

Signaling pathways to and from the hypophysial pars tuberalis, an important center for the control of seasonal rhythms

(2018) Horst-Werner Korf   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The pars tuberalis: The site of the circannual clock in mammals?

(2018) Shona Wood et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Melatonin-independent Photoperiodic Entrainment of the Circannual TSH Rhythm in the Pars Tuberalis of the European Hamster

(2018) Cristina Sáenz de Miera et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Neuroendocrine correlates of the critical day length response in the Soay sheep

(2018) David Hazlerigg et al.   JOURNAL OF NEUROENDOCRINOLOGY

Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

(2018) Ludovic S. Mure et al.   SCIENCE

Epigenetic Regulation of Biological Rhythms: An Evolutionary Ancient Molecular Timer

(2018) Tyler J. Stevenson   TRENDS IN GENETICS

Pineal-dependent increase of hypothalamic neurogenesis contributes to the timing of seasonal reproduction in sheep

(2018) Martine Batailler et al.   Scientific Reports

How can a binary switch within the pars tuberalis control seasonal timing of reproduction?

(2018) Shona Hiedi Wood   JOURNAL OF ENDOCRINOLOGY

Photoperiod and thyroid hormone regulate expression of l -dopachrome tautomerase (Dct ), a melanocyte stem-cell marker, in tanycytes of the ovine hypothalamus

(2018) Hugues Dardente et al.   JOURNAL OF NEUROENDOCRINOLOGY

Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

(2018) Jian Qiu et al.   eLife

A Kiss to drive rhythms in reproduction

(2018) Valérie Simonneaux   EUROPEAN JOURNAL OF NEUROSCIENCE

Maternal photoperiodic programming enlightens the internal regulation of thyroid-hormone deiodinases in tanycytes

(2018) Cristina Sáenz de Miera   JOURNAL OF NEUROENDOCRINOLOGY

A unifying hypothesis for control of body weight and reproduction in seasonally breeding mammals

(2018) Gisela Helfer et al.   JOURNAL OF NEUROENDOCRINOLOGY

How to Contribute to the Progress of Neuroendocrinology: Discovery of GnIH and Progress of GnIH Research

(2018) Kazuyoshi Tsutsui et al.   Frontiers in Endocrinology

A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes

(2017) Heather Benford et al.   GLIA

Waiting for the Sun: the circannual programme of reindeer is delayed by the recurrence of rhythmical melatonin secretion after the arctic night

(2017) David Hazlerigg et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland

(2017) Cristina Sáenz de Miera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

(2017) Renchao Chen et al.   Cell Reports

Tanycytes As Regulators of Seasonal Cycles in Neuroendocrine Function

(2017) Jo E. Lewis et al.   Frontiers in Neurology

Amino acid sensing in hypothalamic tanycytes via umami taste receptors

(2017) Greta Lazutkaite et al.   Molecular Metabolism

Downregulation of Deiodinase 3 is the earliest event in photoperiodic and photorefractory activation of the gonadotropic axis in seasonal hamsters

(2017) Sébastien Milesi et al.   Scientific Reports

No Evidence That RFamide-Related Peptide 3 Directly Modulates LH Secretion in the Ewe

(2016) C. Decourt et al.   ENDOCRINOLOGY

Photoperiodic and Diurnal Regulation of WNT Signaling in the Arcuate Nucleus of the Female Djungarian Hamster,Phodopus sungorus

(2016) Alisa Boucsein et al.   ENDOCRINOLOGY

Comparative analysis reveals the underlying mechanism of vertebrate seasonal reproduction

(2016) Keisuke Ikegami et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Expression of regulatory neuropeptides in the hypothalamus of red deer (Cervus elaphus) reveals anomalous relationships in the seasonal control of appetite and reproduction

(2016) G.K. Barrell et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Coordinated seasonal regulation of metabolic and reproductive hypothalamic peptides in the desert jerboa

(2016) Rajae Talbi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

(2016) Roman A Romanov et al.   NATURE NEUROSCIENCE

Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway

(2016) Zayna Chaker et al.   NEUROBIOLOGY OF AGING

Orchestration of gene expression across the seasons: Hypothalamic gene expression in natural photoperiod throughout the year in the Siberian hamster

(2016) Ines Petri et al.   Scientific Reports

Kisspeptin and RFRP-3 differentially regulate food intake and metabolic neuropeptides in the female desert jerboa

(2016) Rajae Talbi et al.   Scientific Reports

Somatostatin receptor activation is involved in the control of daily torpor in a seasonal mammal

(2015) Frank Scherbarth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Sensitivity to the photoperiod and potential migratory features of neuroblasts in the adult sheep hypothalamus

(2015) Martine Batailler et al.   Brain Structure & Function

Functional Divergence of Type 2 Deiodinase Paralogs in the Atlantic Salmon

(2015) Marlene Lorgen et al.   CURRENT BIOLOGY

Binary Switching of Calendar Cells in the Pituitary Defines the Phase of the Circannual Cycle in Mammals

(2015) Shona H. Wood et al.   CURRENT BIOLOGY

Neural mechanisms controlling seasonal reproduction: Principles derived from the sheep model and its comparison with hamsters

(2015) Peyton W. Weems et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Thyroid hormone and vitamin D regulate VGF expression and promoter activity

(2015) Jo E Lewis et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Evidence for Changes in Numbers of Synaptic Inputs onto KNDy and GnRH Neurones during the Preovulatory LH Surge in the Ewe

(2015) C. M. Merkley et al.   JOURNAL OF NEUROENDOCRINOLOGY

Somatostatin Agonist Pasireotide Promotes a Physiological State Resembling Short-Day Acclimation in the Photoperiodic Male Siberian Hamster (Phodopus sungorus)

(2015) R. A. Dumbell et al.   JOURNAL OF NEUROENDOCRINOLOGY

Hypothalamic tanycytes—masters and servants of metabolic, neuroendocrine, and neurogenic functions

(2015) Timothy Goodman et al.   Frontiers in Neuroscience

Hypothalamic Distribution, Adenohypophyseal Receptor Expression, and Ligand Functionality of RFamide-Related Peptide 3 in the Mare During the Breeding and Nonbreeding Seasons1

(2014) Jennifer F. Thorson et al.   BIOLOGY OF REPRODUCTION

A Circannual Clock Drives Expression of Genes Central for Seasonal Reproduction

(2014) Cristina Sáenz de Miera et al.   CURRENT BIOLOGY

Ezh2 represses the basal cell lineage during lung endoderm development

(2014) M. E. Snitow et al.   DEVELOPMENT

Physiological Roles of Gonadotropin-Inhibitory Hormone Signaling in the Control of Mammalian Reproductive Axis: Studies in the NPFF1 Receptor Null Mouse

(2014) Silvia León et al.   ENDOCRINOLOGY

Clocks for all seasons: unwinding the roles and mechanisms of circadian and interval timers in the hypothalamus and pituitary

(2014) Shona Wood et al.   JOURNAL OF ENDOCRINOLOGY

Efficient Gene Targeting in Golden Syrian Hamsters by the CRISPR/Cas9 System

(2014) Zhiqiang Fan et al.   PLoS One

A Thyroid Hormone Challenge in Hypothyroid Rats Identifies T3 Regulated Genes in the Hypothalamus and in Models with Altered Energy Balance and Glucose Homeostasis

(2014) Annika Herwig et al.   THYROID

Neuropeptide S receptor 1 (NPSR1) activates cancer-related pathways and is widely expressed in neuroendocrine tumors

(2014) V. Pulkkinen et al.   VIRCHOWS ARCHIV

Tissue-Specific Posttranslational Modification Allows Functional Targeting of Thyrotropin

(2014) Keisuke Ikegami et al.   Cell Reports

Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

(2014) Erik Södersten et al.   PLoS Genetics

Distinct and separable roles for EZH2 in neurogenic astroglia

(2014) William W Hwang et al.   eLife

Universality and diversity in the signal transduction pathway that regulates seasonal reproduction in vertebrates

(2014) Yusuke Nakane et al.   Frontiers in Neuroscience

Thyroid Hormone and Seasonal Rhythmicity

(2014) Hugues Dardente et al.   Frontiers in Endocrinology

Photoperiodic Variation in CD45-Positive Cells and Cell Proliferation in the Mediobasal Hypothalamus of the Soay Sheep

(2013) D. G. Hazlerigg et al.   CHRONOBIOLOGY INTERNATIONAL

2-Arachidonoyl glycerol sensitizes the pars distalis and enhances forskolin-stimulated prolactin secretion in Syrian hamsters

(2013) Shinobu Yasuo et al.   CHRONOBIOLOGY INTERNATIONAL

Induction of the Metabolic Regulator Txnip in Fasting-Induced and Natural Torpor

(2013) Laura E. Hand et al.   ENDOCRINOLOGY

TSH restores a summer phenotype in photoinhibited mammals via the RF-amides RFRP3 and kisspeptin

(2013) Paul Klosen et al.   FASEB JOURNAL

Photoperiod Can Entrain Circannual Rhythms in Pinealectomized European Hamsters

(2013) Stefanie Monecke et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Exogenous T3 Elicits Long Day–Like Alterations in Testis Size and the RFamides Kisspeptin and Gonadotropin-Inhibitory Hormone in Short-Day Siberian Hamsters

(2013) Jerad R. Henson et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Neuromedin U Partly Mimics Thyroid-Stimulating Hormone and Triggers Wnt/β-Catenin Signalling in the Photoperiodic Response of F344 Rats

(2013) G. Helfer et al.   JOURNAL OF NEUROENDOCRINOLOGY

Circannual Variation in Thyroid Hormone Deiodinases in a Short-Day Breeder

(2013) C. Sáenz de Miera et al.   JOURNAL OF NEUROENDOCRINOLOGY

Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus

(2013) N. Haan et al.   JOURNAL OF NEUROSCIENCE

Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin

(2013) Massimiliano Beltramo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Npas4Is Activated by Melatonin, and Drives the Clock GeneCry1in the Ovine Pars Tuberalis

(2013) A. West et al.   MOLECULAR ENDOCRINOLOGY

Hypothalamic Ventricular Ependymal Thyroid Hormone Deiodinases Are an Important Element of Circannual Timing in the Siberian Hamster (Phodopus sungorus)

(2013) Annika Herwig et al.   PLoS One

Reversible DNA methylation regulates seasonal photoperiodic time measurement

(2013) T. J. Stevenson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

(2013) Matei Bolborea et al.   TRENDS IN NEUROSCIENCES

α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors

(2013) S.C. Robins et al.   Nature Communications

The saccus vasculosus of fish is a sensor of seasonal changes in day length

(2013) Yusuke Nakane et al.   Nature Communications

Development, Sex Steroid Regulation, and Phenotypic Characterization of RFamide-Related Peptide (Rfrp) Gene Expression and RFamide Receptors in the Mouse Hypothalamus

(2012) Matthew C. Poling et al.   ENDOCRINOLOGY

Stimulatory Effect of RFRP-3 on the Gonadotrophic Axis in the Male Syrian Hamster: The Exception Proves the Rule

(2012) Caroline Ancel et al.   ENDOCRINOLOGY

Conservation of the photoperiodic neuroendocrine axis among vertebrates: Evidence from the teleost fish, Gasterosteus aculeatus

(2012) Conor S. O’Brien et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Hypothesis

(2012) David G. Hazlerigg et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Seasonal Changes in Cell Proliferation in the Adult Sheep Brain and Pars Tuberalis

(2012) Martine Migaud et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

(2012) Daniel A Lee et al.   NATURE NEUROSCIENCE

Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding

(2012) Iain J. Clarke et al.   NEUROENDOCRINOLOGY

A vitamin for the brain

(2012) Kirsty D. Shearer et al.   TRENDS IN NEUROSCIENCES

Melatonin Controls Photoperiodic Changes in Tanycyte Vimentin and Neural Cell Adhesion Molecule Expression in the Djungarian Hamster (Phodopus sungorus)

(2011) Matei Bolborea et al.   ENDOCRINOLOGY

Photoperiod Regulates Vitamin A and Wnt/β-Catenin Signaling in F344 Rats

(2011) Gisela Helfer et al.   ENDOCRINOLOGY

Identification, Expression, and Physiological Functions of Siberian Hamster Gonadotropin-Inhibitory Hormone

(2011) Takayoshi Ubuka et al.   ENDOCRINOLOGY

Effects of Manipulating Hypothalamic Triiodothyronine Concentrations on Seasonal Body Weight and Torpor Cycles in Siberian Hamsters

(2011) Michelle Murphy et al.   ENDOCRINOLOGY

Anatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry

(2011) Stewart D. Clark et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Melatonin-Dependent Timing of Seasonal Reproduction by the Pars Tuberalis: Pivotal Roles for Long Daylengths and Thyroid Hormones

(2011) Hugues Dardente   JOURNAL OF NEUROENDOCRINOLOGY

Thyroid Hormone Signalling Genes Are Regulated by Photoperiod in the Hypothalamus of F344 Rats

(2011) Alexander W. Ross et al.   PLoS One

Identification of Eya3 and TAC1 as Long-Day Signals in the Sheep Pituitary

(2010) Sandrine M. Dupré et al.   CURRENT BIOLOGY

Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism

(2010) Koh-hei Masumoto et al.   CURRENT BIOLOGY

Adaptive Divergence in the Thyroid Hormone Signaling Pathway in the Stickleback Radiation

(2010) Jun Kitano et al.   CURRENT BIOLOGY

A Molecular Switch for Photoperiod Responsiveness in Mammals

(2010) Hugues Dardente et al.   CURRENT BIOLOGY

Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function

(2010) Kazuyoshi Tsutsui et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The hypophysial pars tuberalis transduces photoperiodic signals via multiple pathways and messenger molecules

(2010) Shinobu Yasuo et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Differential Regulation of Kiss1 Expression by Melatonin and Gonadal Hormones in Male and Female Syrian Hamsters

(2010) L. Ansel et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Photoperiodic Regulation of Prolactin Gene Expression in the Syrian Hamster by a Pars Tuberalis-Derived Factor

(2010) J. A. Stirland et al.   JOURNAL OF NEUROENDOCRINOLOGY

Characterization of Kiss1 neurons using transgenic mouse models

(2010) R.M. Cravo et al.   NEUROSCIENCE

Seasonal regulation of reproduction: altered role of melatonin under naturalistic conditions in hamsters

(2010) M. P. Butler et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Impact of Melatonin and Molecular Clockwork Components on the Expression of Thyrotropin β-Chain (Tshb) and theTshReceptor in the Mouse Pars Tuberalis

(2009) Claudia Unfried et al.   ENDOCRINOLOGY

Photoperiodic regulation of retinoic acid signaling in the hypothalamus

(2009) Kirsty D. Shearer et al.   JOURNAL OF NEUROCHEMISTRY

New Insights into Ancient Seasonal Life Timers

(2008) David Hazlerigg et al.   CURRENT BIOLOGY

Ancestral TSH Mechanism Signals Summer in a Photoperiodic Mammal

(2008) Elodie A. Hanon et al.   CURRENT BIOLOGY

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control

(2008) Sandrine M. Dupré et al.   ENDOCRINOLOGY

Potent Action of RFamide-Related Peptide-3 on Pituitary Gonadotropes Indicative of a Hypophysiotropic Role in the Negative Regulation of Gonadotropin Secretion

(2008) Iain J. Clarke et al.   ENDOCRINOLOGY

Egr1 involvement in evening gene regulation by melatonin

(2008) J. M. Fustin et al.   FASEB JOURNAL

The Regulation of Seasonal Changes in Food Intake and Body Weight

(2008) F. J. P. Ebling et al.   JOURNAL OF NEUROENDOCRINOLOGY

Thyrotrophin in the pars tuberalis triggers photoperiodic response

(2008) Nobuhiro Nakao et al.   NATURE

Involvement of thyrotropin in photoperiodic signal transduction in mice

(2008) H. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RFamide-Related Peptide Gene Is a Melatonin-Driven Photoperiodic Gene

(2007) Florent G. Revel et al.   ENDOCRINOLOGY

Keeping track of time under ice and snow in a sub-arctic lake: plasma melatonin rhythms in Arctic charr overwintering under natural conditions

(2007) Jo Espen Tau Strand et al.   JOURNAL OF PINEAL RESEARCH