Article
Clinical Neurology
Pablo Rodriguez de Vera Gomez, Mariola Mendez Muros, Alberto Torres Cuadro, Francisco Javier Toyos Saenz de Miera, Rocio Lopez Ruiz, Raquel Guerrero Vazquez, Juan Jesus Garcia Gonzalez, Antonio Manuel Garrido Hermosilla, Tomas Martin Hernandez
Summary: This study describes the clinical and biochemical characteristics of GD-ALZ and the clinical course of GO-ALZ cases in patients treated with Alemtuzumab for RRMS. GD-ALZ was observed in 32.6% of the cases, mainly affecting women with an average age of 41.9 years. Having first-degree relatives with hypothyroidism was identified as a risk factor. GO-ALZ was diagnosed in 13.6% of the cases, with 3 cases requiring anti-IL-6 treatment.
JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Nicole Kashani, Eve E. Kelland, Borna Vajdi, Lauren M. Anderson, Wendy Gilmore, Brett T. Lund
Summary: This study revealed that patients treated with alemtuzumab for multiple sclerosis showed an increase in the number and function of regulatory B cells after treatment, which were positively correlated with regulatory T cells. Additionally, an anti-inflammatory bias in monocytes was observed after the second annual course of treatment. These findings highlight the importance of further studies on all regulatory cell types following alemtuzumab treatment to understand the mechanisms of drug action and identify key predictors of durable clinical efficacy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yahiya Y. Syed
Summary: Alemtuzumab is an effective treatment option for patients with highly active RRMS, with maintained treatment benefits over up to 9 years. It has an acceptable tolerability profile and convenient treatment regimen.
Article
Clinical Neurology
Jordi Rio, Alex Rovira, Claudio Gasperini, Mar Tintore, Luca Prosperini, Susana Otero-Romero, Manuel Comabella, Angela Vidal-Jordana, Ingrid Galan, Luciana Midaglia, Breogan Rodriguez-Acevedo, Ana Zabalza, Joaquim Castillo, Georgina Arrambide, Carlos Nos, Alvaro Cobo, Carmen Tur, Cristina Auger, Jaume Sastre-Garriga, Xavier Montalban
Summary: Different treatment response scoring systems have acceptable prognostic value in predicting long-term disability in RRMS patients treated with self-injectable DMTs. Among these systems, the RoS score has the best sensitivity, the MRS score has the best specificity, and the RS score has the best accuracy in predicting long-term disability.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Sofia Sandgren, Lenka Novakova, Markus Axelsson, Firoozeh Amirbeagi, Ingrid Kockum, Tomas Olsson, Clas Malmestrom, Jan Lycke
Summary: A study in Sweden found that monitoring autoimmune antibodies, particularly thyroid autoantibodies, can predict the risk of secondary autoimmune diseases caused by Alemtuzumab treatment. The presence of thyroid autoantibodies increased the risk of developing autoimmune thyroid disease (AITD) by 50%.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Emanuele D'Amico, Aurora Zanghi, Nunziatina Laura Parrinello, Alessandra Romano, Giuseppe Alberto Palumbo, Clara Grazia Chisari, Simona Toscano, Francesco Di Raimondo, Mario Zappia, Francesco Patti
Summary: This study characterized the immune cell phenotypes of patients recently diagnosed with relapsing-remitting multiple sclerosis who had not received disease-modifying therapies. The results revealed differences in myeloid, B, and T cells between these patients and healthy controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Chiara Zilli, Pietro Scribani Rossi, Arianna Di Stadio, Mariangela Fratino, Giada Giuliani, Rosanna Annecca, Gaetano Russo, Vittorio Di Piero, Marta Altieri
Summary: The objective of this study was to identify clinical, demographic, and treatment approach characteristics that affect the maintenance of NEDA-3 and the occurrence of clinical relapses. The results showed that early use of second-line treatment had a protective effect on achieving NEDA-3, preventing clinical relapse, and reducing the number of relapses.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Tamara Castillo-Trivino, Rocio Gomez-Ballesteros, Monica Borges, Jesus Martin-Martinez, Javier Sotoca, Ana Alonso, Ana B. Caminero, Laura Borrega, Jose L. Sanchez-Menoyo, Francisco J. Barrero-Hernandez, Carmen Calles, Luis Brieva, Maria R. Blasco-Quilez, Julio Dotor Garcia-Soto, Maria del Campo-Amigo, Laura Navarro-Canto, Eduardo Aguera, Moises Garces-Redondo, Olga Carmona, Laura Gabaldon-Torres, Lucia Forero, Mariona Hervas, Jorge Maurino, Susana Sainz de la Maza
Summary: This study aimed to describe patients' preferences and identify factors associated with long-term prognosis communication preferences in early-stage relapsing-remitting multiple sclerosis (RRMS) patients. The results showed that most patients wanted to know their long-term prognosis shortly after diagnosis, and male gender and lower cognitive function score were predictors of long-term prognosis information preferences.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Letter
Clinical Neurology
Harald Kropshofer, Dieter A. Haering, Ludwig Kappos, David Leppert, Jens Kuhle
Summary: The results of this study contradict with earlier large phase 3 studies, suggesting that high baseline serum neurofilament light chain levels are associated with increased risk of disability progression in MS. The authors hypothesize that this discrepancy may be due to the anti-inflammatory effects of natalizumab, which suppresses inflammatory activity and renders sNfL unrelated to disability progression.
Article
Clinical Neurology
Masoud Etemadifar, Amir Parsa Abhari, Hosein Nouri, Mehri Salari, Shiva Maleki, Alireza Amin, Nahad Sedaghat
Summary: This study aimed to detect possible changes in clinical disease activity of MS after COVID-19. The results showed a significant reduction in probable disability progression rate, but no significant change in relapse rate, among RRMS patients post-COVID-19.
Article
Clinical Neurology
Zhizheng Zhuo, Yongmei Li, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Jinli Ding, Decai Tian, Xinli Wang, Jinhui Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Xuemei Han, Sven Haller, Frederik Barkhof, Fudong Shi, Yaou Liu
Summary: Three MRI subtypes of RRMS were identified with distinct clinical and imaging features and different prognoses. The subtypes showed variations in cognitive impairment and conversion rate to SPMS.
JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Insha Zahoor, Hamid Suhail, Indrani Datta, Mohammad Ejaz Ahmed, Laila M. Poisson, Jeffrey Waters, Faraz Rashid, Rui Bin, Jaspreet Singh, Mirela Cerghet, Ashok Kumar, Md Nasrul Hoda, Ramandeep Rattan, Ashutosh K. Mangalam, Shailendra Giri
Summary: Metabolic aberrations were found to impact the pathogenesis of relapsing-remitting multiple sclerosis, with changes in multiple metabolic pathways identified in patient samples. Enhanced glycolysis in immune cells of MS patients was observed, and treatment with a glycolytic inhibitor showed promising effects in ameliorating disease progression by promoting an antiinflammatory phenotype. This study highlights the potential of blood-based metabolomic approaches in identifying therapeutic targets for developing new treatment strategies for multiple sclerosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Zoe Y. G. J. van Lierop, Samantha Noteboom, Martijn D. Steenwijk, Maureen van Dam, Alyssa A. Toorop, Zoe L. E. van Kempen, Bastiaan Moraal, Frederik Barkhof, Bernard M. J. Uitdehaag, Menno M. Schoonheim, Charlotte E. Teunissen, Joep Killestein
Summary: This study found that the Year 1 sNfL level can predict long-term brain atrophy in patients treated with natalizumab for RRMS, while the sCNTN1 level did not show a clear predictive value.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Gregor Brecl Jakob, Barbara Barun, Sarah Gomezelj, Tereza Gabelic, Sasa Sega Jazbec, Ivan Adamec, Alenka Horvat Ledinek, Uros Rot, Magdalena Krbot Skoric, Mario Habek
Summary: A retrospective chart review of 71 patients with relapsing-remitting MS treated with ALM in two MS centers in Slovenia and Croatia found that the efficacy of ALM remains high in real-world clinical practice. Despite 84.1% of participants experiencing adverse events, no new safety signals were identified.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Karolina Kania, Wojciech Ambrosius, Wojciech Kozubski, Alicja Kalinowska
Summary: Balo's concentric sclerosis (BCS) is a rare demyelinating disorder with a debated connection to classic multiple sclerosis. Our report presents a case of a patient who developed a symptomatic Balo-like lesion following years of treatment for relapsing-remitting multiple sclerosis with dimethyl fumarate.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Anna Camos-Carreras, Salut Alba-Arbalat, Marina Dotti-Boada, Alba Parrado-Carrillo, Carolina Bernal-Morales, Albert Saiz, Bernardo Sanchez-Dalmau
Summary: Macular oedema is a rare complication of fingolimod treatment, usually presenting within a few months but occasionally occurring later. In some cases, macular oedema can resolve without discontinuing the treatment.
NEURO-OPHTHALMOLOGY
(2021)
Article
Clinical Neurology
Rocco Capuano, Irati Zubizarreta, Salut Alba-Arbalat, Maria Sepulveda, Nuria Sola-Valls, Irene Pulido-Valdeolivas, Magi Andorra, Eloy Martinez-Heras, Elisabeth Solana, Elisabet Lopez-Soley, Carmen Montejo, Yolanda Blanco, Jose Ignacio Fernandez-Velasco, Antonio Gallo, Alvino Bisecco, Pablo Villoslada, Albert Saiz, Sara Llufriu, Luisa M. Villar, Elena H. Martinez-Lapiscina
Summary: This study investigated the role of cerebrospinal fluid (CSF) markers in predicting long-term multiple sclerosis outcomes, with the presence of oligoclonal IgM bands (OCMB) associated with unfavorable long-term outcomes. These findings suggest that OCMB should be determined in relapsing MS patients to inform long-term prognosis.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Clinical Neurology
Louise Rath, Minh Viet Bui, Julian Ellis, John Carey, Josephine Baker, Lisa Taylor, Hasini Fernando, Nicola Taylor, Poppy Savage, Janene Richards, Michael Zhong, Tomas Kalincik, Olga Skibina, Robb Wesselingh, Ai-Lan Nguyen, Mastura Monif, Helmut Butzkueven, Anneke van der Walt
Summary: This study analyzed the rapid infusions of natalizumab and ocrelizumab during the COVID-19 pandemic, finding that there was no increase in the frequency or severity of infusion related reactions. Patient experience with rapid infusions was positive.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Nabil Seery, Sifat Sharmin, Vivien Li, Ai-Lan Nguyen, Claire Meaton, Roberts Atvars, Nicola Taylor, Kelsey Tunnell, John Carey, Mark P. Marriott, Katherine A. Buzzard, Izanne Roos, Chris Dwyer, Josephine Baker, Lisa Taylor, Kymble Spriggs, Trevor J. Kilpatrick, Tomas Kalincik, Mastura Monif
Summary: This study found that older age, higher serum IgA and IgG levels were associated with reduced odds of infection in MS patients receiving ocrelizumab, while longer disease duration and higher EDSS score were associated with increased odds of antimicrobial use. This highlights the importance of monitoring immunoglobulin levels in patients on ocrelizumab therapy.
Article
Clinical Neurology
Vivien Li, Izanne Roos, Mastura Monif, Charles Malpas, Stefanie Roberts, Mark Marriott, Katherine Buzzard, Ai-Lan Nguyen, Nabil Seery, Lisa Taylor, Tomas Kalincik, Trevor Kilpatrick
Summary: This study assessed the impact of telehealth on MS outpatient care during the COVID-19 pandemic. The findings showed a high usage of telehealth and patient satisfaction, but a preference for in-person consultations. Telehealth was effective in identifying patients with disability worsening, but face-to-face consultations recorded more increases in scores for patients with lower baseline disability. Further studies are needed to examine the long-term impact of telehealth on clinical outcomes.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Neurosciences
Jordi Casas-Roma, Eloy Martinez-Heras, Albert Sole-Ribalta, Elisabeth Solana, Elisabet Lopez-Soley, Francesc Vivo, Marcos Diaz-Hurtado, Salut Alba-Arbalat, Maria Sepulveda, Yolanda Blanco, Albert Saiz, Javier Borge-Holthoefer, Sara Llufriu, Ferran Prados
Summary: This study presents a framework that merges multiple brain connectivity networks and validates its effectiveness. The framework was applied to a cohort of multiple sclerosis patients and successfully identified regions with connectivity deterioration.
NETWORK NEUROSCIENCE
(2022)
Article
Clinical Neurology
Sam Harding-Forrester, Izanne Roos, Ai-Lan Nguyen, Charles B. Malpas, Ibrahima Diouf, Nahid Moradi, Sifat Sharmin, Guillermo Izquierdo, Sara Eichau, Francesco Patti, Dana Horakova, Eva Kubala Havrdova, Alexandre Prat, Marc Girard, Pierre Duquette, Francois Grand Maison, Marco Onofrj, Alessandra Lugaresi, Pierre Grammond, Serkan Ozakbas, Maria Pia Amato, Oliver Gerlach, Patrizia Sola, Diana Ferraro, Katherine Buzzard, Olga Skibina, Jeannette Lechner-Scott, Raed Alroughani, Cavit Boz, Vincent Van Pesch, Elisabetta Cartechini, Murat Terzi, Davide Maimone, Cristina Ramo-Tello, Bassem Yamout, Samia Joseph Khoury, Daniele La Spitaleri, Maria Jose Sa, Yolanda Blanco, Franco Granella, Mark Slee, Ernest Butler, Youssef Sidhom, Riadh Gouider, Roberto Bergamaschi, Rana Karabudak, Radek Ampapa, Jose Luis Sanchez-Menoyo, Julie Prevost, Tamara Castillo-Trivino, Pamela A. McCombe, Richard Macdonell, Guy Laureys, Liesbeth Van Hijfte, Jiwon Oh, Ayse Altintas, Koen de Gans, Recai Turkoglu, Anneke van der Walt, Helmut Butzkueven, Steve Vucic, Michael Barnett, Edgardo Cristiano, Suzanne Hodgkinson, Gerardo Iuliano, Ludwig Kappos, Jens Kuhle, Vahid Shaygannejad, Aysun Soysal, Bianca Weinstock-Guttman, Bart Van Wijmeersch, Tomas Kalincik
Summary: This study compared primary and secondary progressive multiple sclerosis (PPMS, SPMS), and found that SPMS has later onset of the progressive phase and slower disability accrual, but higher baseline disability.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
E. Lopez-Soley, E. Martinez-Heras, E. Solana, A. Solanes, J. Radua, F. Vivo, F. Prados, M. Sepulveda, J. M. Cabrera-Maqueda, E. Fonseca, Y. Blanco, S. Alba-Arbalat, E. H. Martinez-Lapiscina, P. Villoslada, A. Saiz, S. Llufriu
Summary: This study investigated the relationship between brain diffusion microstructural changes and disability in multiple sclerosis (MS). The results demonstrate the predictive value of microstructural properties in white and grey matter for mid-term disability. Motor performance was associated with white matter, while cognitive performance was related to grey matter diffusion metrics.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Clinical Neurology
M. Monif, V. T. F. Voo, V. B. Minh, A. Hsu, A. Nguyen, K. Fazzolari, V. E. Maltby, R. Wesselingh, J. Richards, M. Marriott, C. Nesbitt, L. Taylor, L. Rath, T. Kalincik, A. van der Walt, T. O'Brien, J. Lechner-Scott, H. Butkueven
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
M. G. Panisset, L. E. Cofre Lizama, T. Kalincik, L. Taylor, A. L. Nguyen, M. P. Marriott, T. Kilpatrick, C. Dwyer, M. Monif, I. Roos, K. A. Buzzard, F. Khan, M. P. Galea
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
N. Seery, S. Sharmin, V. Li, A. Nguyen, C. Meaton, R. Atvars, N. Taylor, K. Tunnell, J. Carey, M. P. Marriott, K. A. Buzzard, I. Roos, C. Dwyer, J. Baker, L. Taylor, K. Spriggs, T. J. Kilpatrick, T. Kalincik, M. Monif
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
F. Bridge, J. Brotherton, J. Stankovich, P. Sanfilippo, O. Skibina, T. Kalincik, K. Buzzard, A. L. Nguyen, M. Monif, D. Wrede, L. Rath, L. Taylor, H. Butzkueven, V. Jokubaitis, A. Van der Walt
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
V. G. Jokubaitis, C. Zhu, P. Sanfilippo, K. Vodehnalova, H. Butzkueven, O. Skibina, J. Lechner-Scott, A. -L. Nguyen, T. Kalincik, K. Buzzard, R. Alroughani, B. Taylor, J. MacIntyre, L. -A. Hall, M. Slee, R. Macdonell, P. A. McCombe, A. Van der Walt
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
Sam Harding-Forrester, Izanne Roos, Sifat Sharmin, Ibrahima Diouf, Charles Malpas, Ai-Lan Nguyen, Nahid Moradi, Dana Horakova, Eva Kubala Havrdova, Francesco Patti, Guillermo Izquierdo Ayuso, Sara Eichau Madueno, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Francois Grand'Maison, Bianca Weinstock-Guttman, Maria Pia Amato, Pierre Grammond, Oliver Gerlach, Serkan Ozakbas, Patrizia Sola, Diana Ferraro, Helmut Butzkueven, Jeannette Lechner-Scott, Cavit Boz, Raed Alroughani, Vincent Van Pesch, Elisabetta Cartechini, Murat Terzi, Davide Maimone, Cristina Ramo-Tello, Daniele Litterio A. Spitaleri, Ludwig Kappos, Bassem Yamout, Maria Jose Sa, Mark Slee, Yolanda Blanco Morgado, Roberto Bergamaschi, Ernest Butler, Gerardo Iuliano, Franco Granella, Youssef Sidhom, Riadh Gouider, Radek Ampapa, Bart Van Wijmeersch, Rana Karabudak, Julie Prevost, Jose Luis Sanchez-Menoyo, Koen De Gans, Pamela McCombe, Tamara Castillo-Trivino, Richard Macdonell, Ayse Altintas, Guy Laureys, Liesbeth Van Hijfte, Anneke Van der Walt, Steve Vucic, Recai Turkoglu, Michael Barnett, Edgardo Cristiano, Magd Zakaria, Vahid Shaygannejad, Suzanne Hodgkinson, Aysun Soysal, Katherine Buzzard, Olga Skibina, Tomas Kalincik
Article
Ophthalmology
Salut Alba-Arbalat, Magi Andorra, Bernardo Sanchez-Dalmau, Anna Camos-Carreras, Marina Dotti-Boada, Irene Pulido-Valdeolivas, Sara Llufriu, Yolanda Blanco, Maria Sepulveda, Albert Saiz, Oscar Batet, Iker Bilbao, Iratxe Torre, Ivan Amat-Roldan, Elena H. Martinez-Lapiscina, Pablo Villoslada
Summary: Raman spectroscopy was used to quantify molecular changes in the retina of multiple sclerosis (MS) patients. Significant metabolic alterations were observed in the retina of MS patients, with changes in specific molecules associated with axonal degeneration and neuroinflammation. These dynamic changes over time suggest progressive neurodegeneration in MS patients.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)