Journal
JOURNAL OF GLAUCOMA
Volume 28, Issue 7, Pages 588-592Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IJG.0000000000001268
Keywords
glaucoma; biomechanics; cornea; intraocular pressure; Scheimpflug photography
Categories
Funding
- Carl Zeiss Meditec
- Genentech
- Heidelberg Engineering
- Konan
- Optovue
- Tomey
- Topcon
- Allergan
- Bausch Lomb
- ForSight
- Unity
- National Eye Institute [R01EY029058]
- Research to Prevent Blindness (New York, NY)
Ask authors/readers for more resources
Purpose: To evaluate the relationship between biomechanical parameters measured with a dynamic Scheimpflug analyzer and glaucoma. Patients and Methods: Cross-sectional observational data of 47 eyes of 47 consecutive subjects with medically controlled primary open-angle glaucoma and 75 eyes of 75 healthy subjects examined with a dynamic Scheimpflug analyzer (Corvis ST) were retrospectively investigated. Eight biomechanical parameters were compared between eyes with and without glaucoma using multivariable models adjusting for intraocular pressure (IOP), central corneal thickness, age, and axial length. Results: In multivariable models, glaucoma was negatively correlated with A1 time (P<0.001, coefficient=-0.5535), A2 time (P=0.008, coefficient=-0.1509), radius (P=0.011, coefficient=-0.4034), and whole eye movement (P<0.001, coefficient=-0.0622). Negative correlation between glaucoma and 3 parameters (A1 time, A2 time, and radius) consistently indicate larger deformability of the cornea and negative correlation between glaucoma and whole eye movement indicate smaller eye movement, in glaucoma eyes. There were significant correlations of many biomechanical parameters with other baseline factors (8 parameters with IOP, 2 with central corneal thickness, 4 with age, and 7 with axial length). Conclusions: Eyes with medically controlled glaucoma were more deformable than healthy eyes, which may increase the risk of optic nerve damage through an underestimation of IOP and biomechanical vulnerability of the globe. Many parameters showed a significant correlation with baseline factors, suggesting the importance of adjustment for these confounding factors when evaluating the correlation between biomechanical parameters and ocular diseases. These results suggest the relevance of measuring biomechanical properties of glaucoma eyes for accurate IOP measurement and risk assessment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available