Hypoxia-inducible gene 2 promotes the immune escape of hepatocellular carcinoma from nature killer cells through the interleukin-10-STAT3 signaling pathway

VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

(2018) Ming Zhang et al.   BMC CANCER

A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine

(2018) Michael Herfs et al.   BRITISH JOURNAL OF CANCER

Chronic liver injury promotes hepatocarcinoma cell seeding and growth, associated with infiltration by macrophages

(2018) Bénédicte Delire et al.   CANCER SCIENCE

Hepatitis C virus treatment by direct-acting antivirals in successfully treated hepatocellular carcinoma and possible mutual impact

(2018) Mohamed Hassany et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism

(2018) Vanessa Zaiatz-Bittencourt et al.   JOURNAL OF IMMUNOLOGY

Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages

(2018) Djeneba Dabitao et al.   JOURNAL OF IMMUNOLOGY

Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells

(2018) Huimin Wang et al.   MOLECULAR CARCINOGENESIS

Inhibition of IL-6-JAK/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1/NKG2D ligand levels

(2018) LiJun Xu et al.   Molecular Oncology

Prognostic Factors Associated with Postprogression Survival in Advanced Hepatocellular Carcinoma Patients Treated with Sorafenib Not Eligible for Second-Line Regorafenib Treatment

(2018) Teiji Kuzuya et al.   ONCOLOGY

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity

(2018) Lucas Ferrari de Andrade et al.   SCIENCE

Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC

(2018) Jie Ji et al.   Cell Death & Disease

HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway

(2018) Lu Chen et al.   Cell Death & Disease

Novel therapeutic features of disulfiram against hepatocellular carcinoma cells with inhibitory effects on a disintegrin and metalloproteinase 10

(2018) Kaku Goto et al.   Oncotarget

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

(2018) Matthew Knight et al.   PLoS Pathogens

Innate Immune Memory: Time for Adopting a Correct Terminology

(2018) Diana Boraschi et al.   Frontiers in Immunology

Tribody [(HER2)2xCD16] Is More Effective Than Trastuzumab in Enhancing γδ T Cell and Natural Killer Cell Cytotoxicity Against HER2-Expressing Cancer Cells

(2018) Hans H. Oberg et al.   Frontiers in Immunology

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma

(2018) A. Asgarova et al.   OncoImmunology

CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity

(2018) Amelia Roman Aguilera et al.   OncoImmunology

Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs

(2018) Kawaljit Kaur et al.   OncoImmunology

Hypoxia-Inducible Lipid Droplet–Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue

(2017) Wieneke Dijk et al.   ENDOCRINOLOGY

Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E–deficient mice

(2017) Anja Maier et al.   FASEB JOURNAL

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

(2017) Xiaodong Zhang et al.   eLife

Effective induction of cytotoxic T cells recognizing an epitope peptide derived from hypoxia-inducible protein 2 (HIG2) in patients with metastatic renal cell carcinoma

(2016) Wataru Obara et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma

(2016) Venera Kuci et al.   LEUKEMIA & LYMPHOMA

Type conversion of secretomes in a 3D TAM2 and HCC cell co-culture system and functional importance of CXCL2 in HCC

(2016) Yu Lu et al.   Scientific Reports

The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis

(2015) Marina T. DiStefano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-15-induced IL-10 increases the cytolytic activity of human natural killer cells

(2011) Ju Yeong Park et al.   MOLECULES AND CELLS