SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy

Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury

(2018) Quan Hong et al.   KIDNEY INTERNATIONAL

The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress

(2017) Yunzhuo Ren et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes

(2017) Xueling Li et al.   Scientific Reports

The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue

(2016) Xiaole Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice

(2016) Bijaya K. Nayak et al.   DIABETES

Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis

(2016) Supriya R. Kulkarni et al.   HEPATOLOGY

miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy

(2016) Yan Sun et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3

(2016) Z Li et al.   ONCOGENE

SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes

(2015) Richard E. Gilbert et al.   DIABETOLOGIA

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Role of Transcription Factor Acetylation in Diabetic Kidney Disease

(2014) R. Liu et al.   DIABETES

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypoxia-induced Bmi1 promotes renal tubular epithelial cell–mesenchymal transition and renal fibrosis via PI3K/Akt signal

(2014) Rui Du et al.   MOLECULAR BIOLOGY OF THE CELL

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

(2013) L. Luu et al.   DIABETOLOGIA

SIRT1 attenuates neointima formation by inhibiting HIF-1α expression in neointimal lesion of a murine wire-injured femoral artery

(2013) Jin U. Bae et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury

(2013) Hong Fan et al.   KIDNEY INTERNATIONAL

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells

(2012) Yanggang Yuan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation

(2012) Hui Yao Lan   International Journal of Biological Sciences

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin

(2011) Yumi Takiyama et al.   DIABETES

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol Inhibits Renal Fibrosis in the Obstructed Kidney

(2010) Jinhua Li et al.   AMERICAN JOURNAL OF PATHOLOGY

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

(2010) Tsubasa Isoe et al.   KIDNEY INTERNATIONAL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

(2009) Kathryn Moynihan Ramsey et al.   AGING CELL

Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

(2009) Shiren Sun et al.   KIDNEY INTERNATIONAL

Mechanisms of Disease: the hypoxic tubular hypothesis of diabetic nephropathy

(2008) Dhruv K Singh et al.   Nature clinical practice. Nephrology

Adaptation to hypoxia in the diabetic rat kidney

(2007) C. Rosenberger et al.   KIDNEY INTERNATIONAL