Journal
ANNALS OF ONCOLOGY
Volume 27, Issue 10, Pages 1922-1928Publisher
ELSEVIER
DOI: 10.1093/annonc/mdw280
Keywords
dynamic contrast-enhanced ultrasonography (DCE-US); imaging biomarker; early evaluation; bevacizumab; breast cancer; colon cancer
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Funding
- French National Cancer Institute
- Toshiba and Bracco
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Dynamic contrast-enhanced ultrasonography is a functional technique enabling quantitative assessment of solid tumor perfusion in metastatic patients treated with antiangiogenic therapies. In this study, we show that the mean transit time evaluated by DCE-US at day 7 may be used as a vascular normalization biomarker to predict the outcome of metastatic patients treated with bevacizumab.Dynamic contrast-enhanced ultrasonography (DCE-US) has been used for evaluation of tumor response to antiangiogenic treatments. The objective of this study was to assess the link between DCE-US data obtained during the first week of treatment and subsequent tumor progression. Patients treated with antiangiogenic therapies were included in a multicentric prospective study from 2007 to 2010. DCE-US examinations were available at baseline and at day 7. For each examination, a 3 min perfusion curve was recorded just after injection of a contrast agent. Each perfusion curve was modeled with seven parameters. We analyzed the correlation between criteria measured up to day 7 on freedom from progression (FFP). The impact was assessed globally, according to tumor localization and to type of treatment. The median follow-up was 20 months. The mean transit time (MTT) evaluated at day 7 was the only criterion significantly associated with FFP (P = 0.002). The cut-off point maximizing the difference between FFP curves was 12 s. Patients with at least a 12 s MTT had a better FFP. The results according to tumor type were significantly heterogeneous: the impact of MTT on FFP was more marked for breast cancer (P = 0.004) and for colon cancer (P = 0.025) than for other tumor types. Similarly, the differences in FFP according to MTT at day 7 were marked (P = 0.004) in patients receiving bevacizumab. The MTT evaluated with DCE-US at day 7 is significantly correlated to FFP of patients treated with bevacizumab. This criterion might be linked to vascular normalization. 2007-A00399-44.
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