Article
Pharmacology & Pharmacy
Mahfoozur Rahman, Sarwar Beg, Khalid S. Alharbi, Nabil K. Alruwaili, Nasser Hadal Alotaibi, Abdulaziz I. Alzarea, Waleed H. Almalki, Sattam Khulaif Alenezi, Waleed M. Altowayan, Mohammed S. Alshammari, Muhammad Afzal, Shakir Saleem, Vikas Kumar
Summary: The study systematically developed GA-loaded solid lipid nanoparticles for the treatment of hepatocellular carcinoma. The optimized GA-SLNs showed promising results in terms of particle size, drug release, cytotoxicity, and in vivo anticancer activity, demonstrating superior efficacy compared to GA solution. Overall, GA-SLNs have shown great potential for the treatment of HCC.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2021)
Article
Nutrition & Dietetics
Woojae Hong, Jeon Hwang-Bo, Hyelin Jeon, Minsung Ko, Joongyeon Choi, Yong-Joon Jeong, Jae-Hyun Park, Inhye Kim, Tae-Woo Kim, Hyunggun Kim, Se-Chan Kang
Summary: The study investigated the hepatoprotective effect of Centella asiatica 50% ethanol extract (CA-HE50) in a lipopolysaccharide/galactosamine (LPS-D-Gal)-induced acute liver failure (ALF) animal model. The results showed that CA-HE50 had antioxidant and hepatoprotective effects comparable to silymarin, Lentinus edodes mycelia (LEM), ursodeoxycholic acid (UDCA), and dimethyl diphenyl bicarboxylate (DDB) in reducing liver injury indicators and potentially serving as a prophylactic and therapeutic agent for ALF.
Article
Biochemistry & Molecular Biology
Wenwen Mu, Qi Wang, Mingxia Jia, Sijia Dong, Sijie Li, Jie Yang, Guoyun Liu
Summary: This study prepared COP-22-loaded nanoparticles and demonstrated their significant hepatoprotective effects in the treatment of acute liver injury. These nanoparticles exert therapeutic effects through multiple pathways, such as inhibiting inflammation, oxidative stress, and apoptosis, and can passively accumulate in the liver through the retention effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Pengxiao Li, Xiaoyuan Guo, Ting Liu, Qing Liu, Jie Yang, Guoyun Liu
Summary: This study prepared PL 1-3-loaded bovine serum albumin nanoparticles, which improved the solubility of PL 1-3. The nanoparticles showed effective hepatoprotective effects on acute liver injury, similar to clinical liver injury. The treatment inhibited inflammation, oxidative stress, and apoptosis through various signaling pathways.
MOLECULAR PHARMACEUTICS
(2022)
Article
Instruments & Instrumentation
Md Meraj Anjum, Krishna Kumar Patel, Deepa Dehari, Nidhi Pandey, Ragini Tilak, Ashish Kumar Agrawal, Sanjay Singh
Summary: Biofilm mediated bacterial infections are key in infectious disease progression due to antimicrobial resistance evolution. Traditional antibiotics are inadequate due to increased resistance. Anacardic acid loaded solid lipid nanoparticles offer a promising alternative with enhanced efficacy against biofilm-mediated antimicrobial resistance.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yun Hee Jeong, Tae In Kim, You-Chang Oh, Jin Yeul Ma
Summary: The study demonstrated that Lysimachiae Herba ethanolic extract has potent anti-inflammatory and hepatoprotective effects in LPS-stimulated macrophages and the LPS/D-GalN-induced acute hepatitis mouse model. It inhibits the production of inflammatory mediators, activates antioxidant pathways, and suppresses inflammatory pathways, leading to a reduction in acute liver damage. Treatment with LHE could be a potential option for inflammation, hepatitis, and liver injury.
Article
Medicine, Research & Experimental
Aixa Aguilera-Garrido, Pablo Gravan, Saul A. Navarro-Marchal, Marta Medina-O'Donnell, Andres Parrah, Maria Jose Galvez-Ruiz, Juan Antonio Marchal, Francisco Galisteo-Gonzalez
Summary: Research has shown that solid lipid nanoparticles containing maslinic acid and curcumin can be prepared using Poloxamer 407 and Dicarboxylic acid-Poloxamer 407 as surfactants. These nanoparticles not only greatly improve the solubility of both substances, but also exhibit higher antitumor activity in human cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biophysics
Annita Katopodi, Kyriaki Safari, Alexandros Kalospyros, Konstantinos Politopoulos, Eleni Alexandratou, Anastasia Detsi
Summary: In this study, daphnetin and its synthetic analogue DHC were encapsulated in solid lipid nanoparticles (SLNs) and showed enhanced antioxidant and photodynamic therapy (PDT) efficacy compared to their free form. The study also found that the cellular uptake of the coumarin analogues was improved when loaded in SLNs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Plant Sciences
Paola Fincheira, Javier Espinoza, Joelis Vera, Daniela Berrios, Javiera Nahuelcura, Antonieta Ruiz, Andres Quiroz, Luis Bustamante, Pablo Cornejo, Gonzalo Tortella, Maria Cristina Diez, Adalberto Benavides-Mendoza, Olga Rubilar
Summary: It has been found that solid lipid nanoparticles (SLNs), as a nanocarrier, can modulate the growth and antioxidant system of L. sativa seedlings through the controlled release of 2-ketones. The effect depends on the dose of the released compound.
Article
Pharmacology & Pharmacy
Sonia Trombino, Rocco Malivindi, Giuseppe Barbarossa, Roberta Sole, Federica Curcio, Roberta Cassano
Summary: Classical melanoma therapy often has side effects, affecting the efficacy and patient compliance. Drug delivery systems, such as solid lipid nanoparticles (SLNs), can improve drug stability, release kinetics, and enhance therapy safety and efficacy. In this study, SLNs were prepared using hydroquinone esterified with stearic acid and characterized using FT-IR and H-1-NMR. The efficacy of SLNs on COLO-38 human melanoma cells were evaluated, and their potential effects on apoptotic mechanisms were analyzed. Safety tests, cytotoxicity evaluation, and antioxidant and anti-inflammatory activities were also conducted.
Article
Chemistry, Multidisciplinary
Mohammad Jammed Ansari, Mahfoozur Rahman, Khalid S. Alharbi, Waleed M. Altowayan, Ahmed Mahmoud Abdelhaleem Ali, Waleed H. Almalki, Md Abul Barkat, Tanuja Singh, Shehla Nasar, Md Habban Akhter, Sarwar Beg, Hani Choudhry
Summary: The present work demonstrates the development and characterization of liquid crystalline nanoparticles for the treatment of hepatocellular carcinoma. The optimized formulation (HP5) showed good stability, high bioavailability, and improved anticancer activity, making it a promising treatment option for liver cancer.
Article
Pharmacology & Pharmacy
Avni Nautiyal, Sarika Wairkar
Summary: This study aimed to develop azelaic acid-loaded solid lipid nanoparticles (AZA-loaded SLNs) that can achieve the desired effect at a lower dose and with fewer side effects. The optimized batch exhibited a particle size of 281 nm, an EE of 76.57%, and a sustained release pattern. In cell line studies, the 10% AZA-loaded SLNs showed potent tyrosinase enzyme inhibition and melanin content reduction compared to the 20% marketed cream. Additionally, it showed no dermal irritancy. Therefore, 10% AZA-loaded SLNs could be an effective and safer topical treatment option for chronic hyperpigmentation at a lower dose.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi-Chan Liu, Samwel Mchele Limbu, Jin-Gang Wang, Mai Wang, Li-Qiao Chen, Fang Qiao, Yuan Luo, Mei-Ling Zhang, Zhen-Yu Du
Summary: This study investigated the role of dietary docosahexaenoic acid (DHA) in improving liver health in Nile tilapia. The results showed that tilapia fed on DHA diets had lower lipid content in the liver and serum, as well as decreased triglyceride concentrations. Furthermore, DHA supplementation also downregulated the expression of genes related to liver damage.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Azadeh Emami, Hossein Ghafouri, Reyhaneh Sariri
Summary: This study developed and optimized a PD-loaded SLN formulation and evaluated its efficacy in breast cancer cell lines. Apoptosis was confirmed as the mechanism of cell death, and the PD-loaded SLN showed significant increase in apoptosis. In vivo studies on mice also supported this effect. PD-loaded SLN may be a promising breast cancer treatment without recognizable side effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Wei Xu, Zhaoyou Deng, Yifei Xiang, Dujuan Zhu, Dandan Yi, Yihao Mo, Yu Liu, Lanqian Qin, Ling Huang, Bingjie Wan, Liqin Wu, Xin Feng, Jiakang He
Summary: In this study, a tolfenamic acid solid lipid nanoparticle (TA-SLN) suspension was prepared to improve the sustained release and bioavailability of nonsteroidal anti-inflammatory drugs. The TA-SLN suspension showed improved sustained drug release in vitro and increased pharmacokinetic parameters in pigs compared with TA injection, indicating its potential as a promising new formulation.
Review
Biochemistry & Molecular Biology
Syeda Nashvia Adin, Isha Gupta, Bibhu Prasad Panda, Mohd Mujeeb
Summary: Monascus purpureus is a fungus that produces various beneficial secondary metabolites, including Monascus pigments, which are widely used as food additives, as a nitrite substitute in meat products, and as a colorant in the food industry. Monascus yellow pigments have shown potential in various activities, such as antidiabetic, antibacterial, anti-inflammatory, antidepressant, antibiotic, anticancer, and antiobesity effects. Additionally, it has potential as a dye in the cosmetic and textile industries.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Asad Ali, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Arshiya Parveen, Abdul Qadir, Mohd Humair Ali, Mohd Akhtar
Summary: The study aimed to prepare and optimize Embelin-loaded liposomes, resulting in the promising formulation EMB-NLop with enhanced antioxidant activity and permeation. Experimental data indicated that EMB-NLop is a promising and effective formulation for intranasal delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Shefali Madaan, Sanaa Ismael Abdul Jaber, Bibhu Prasad Panda
Summary: Through experiments and animal models, the antidiabetic effect of Pleurotus florida mycelia extract was evaluated. The extract exhibited antioxidant power, inhibition of alpha-amylase and alpha-glucosidase, and improved blood glucose control and insulin levels in diabetic animals. The extract also contained fatty acids that inhibited intestinal alpha-glucosidase and pancreatic alpha-amylase. The consumption of this mushroom can effectively control blood glucose levels.
Article
Engineering, Chemical
Muzaffar Iqbal, Mohammad Raish, Ajaz Ahmad, Essam A. Ali, Yousef A. Bin Jardan, Mushtaq A. Ansari, Mudassar Shahid, Abdul Ahad, Khalid M. Alkharfy, Fahad I. Al-Jenoobi
Summary: The study found that when Ibrutinib interacts with Sinapic acid, it may influence the pharmacokinetics of Ibrutinib and result in increased bioavailability. This may be due to the inhibition of IBR metabolism in the liver and intestines by SA.
Article
Food Science & Technology
Muneeb Ahmad Malik, Yasmeena Jan, Afrozul Haq, Jasmeet Kaur, Bibhu Prasad Panda
Summary: This study optimized parameters for enhancing vitamin D-2 formation in edible mushrooms using UV irradiation, resulting in significant increase in vitamin D-2 levels. The study also assessed vitamin D-2 stability during storage and cooking operations, providing valuable information for maximizing vitamin D-2 content in mushrooms.
NUTRITION & FOOD SCIENCE
(2022)
Article
Food Science & Technology
Yasmeena Jan, Lamya Ahmed Al-Keridis, Muneeb Malik, Afrozul Haq, Sayeed Ahmad, Jasmeet Kaur, Mohd Adnan, Nawaf Alshammari, Syed Amir Ashraf, Bibhu Prasad Panda
Summary: In this study, a low temperature aided sonication method was used to incorporate vitamin D3 into an oil-in-water emulsion. The optimized nanoemulsion exhibited small particle size, good stability, and high encapsulation efficiency, providing a potential solution for fortification of vitamin D in non-/low fat food matrices.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Md. Nurullah, Zakiya Usmani, Sheeraz Ahmad, Bibhu Prasad Panda, Saima Amin, Showkat Rasool Mir
Summary: This study aimed to develop a method for the separation of Taxol and 10-Deacetyl baccatin III from different matrices. The crude taxoid was prepared by extracting samples with methanol, partitioning with dichloromethane, and precipitating with hexane. Analytical high-performance liquid chromatography was used for quantification, and preparative high-performance liquid chromatography was performed for large-scale separation. The recovered compounds showed high purity, and the method can be used in biotransformation studies.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Medicinal
Abdul Ahad, Mohammad Raish, Ibrahim Abdelsalam Abdelrahman, Yousef A. Bin Jardan, Mohd Aftab Alam, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi
Summary: This study investigated the pharmacodynamics and pharmacokinetics interactions between losartan and Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive rats. Oral administration of CUR or LS showed significant antihypertensive activity and enhanced the blood pressure-lowering effects of losartan in hypertensive rats. Additionally, CUR and LS increased the plasma concentrations of losartan. These interactions suggest that dose adjustment and intermittent blood pressure monitoring are necessary when administering losartan with either CUR or LS in hypertensive patients.
Article
Microbiology
S. Nagal, A. Raja, I. Gupta, S. N. Adin, B. P. Panda
Summary: Beta-carotene production was achieved through the treatment of mutated P. rhodozyma cells with different concentrations of beta-ionone. The optimized conditions resulted in a maximum production of 750μg/g.
Article
Biochemistry & Molecular Biology
Mohammad Raish, Ajaz Ahmad, Mudassar Shahid, Yousef A. Bin Jardan, Abdul Ahad, Mohd Abul Kalam, Mushtaq Ahmad Ansari, Muzaffar Iqbal, Naushad Ali, Khalid M. M. Alkharfy, Fahad I. I. Al-Jenoobi
Summary: Dasatinib is a drug used to treat chronic myelogenous leukemia and Ph-positive acute lymphocytic leukemia. Apigenin is a common ingredient used in food, herbs, and traditional medicine. The concomitant use of apigenin and dasatinib may result in potential herb-drug interactions.
Review
Immunology
Muzamil Y. Want, Zeenat Bashir, Rauf A. Najar
Summary: T cell-based immunotherapy plays a critical role in destroying cancer cells by recognizing cancer-specific antigens. However, limited specificity, longevity, and toxicity have hindered its success rates. This review provides an overview of T cells as a therapeutic tool for cancer, discussing the challenges associated with identifying T cells and their corresponding antigens and proposing future strategies to improve clinical outcomes.
Article
Chemistry, Analytical
Yan-Hong Wang, Goutam Mondal, Washim Khan, Bill J. Gurley, Charles R. Yates
Summary: Pomegranate extracts rich in ellagitannins and ellagic acid have pharmacological activity through gut microbiota-derived urolithin metabolites. This study developed a UHPLC-MS/MS assay to investigate the pharmacokinetics of ellagic acid and urolithins in humans after oral administration of pomegranate extract.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Yousef A. Bin Jardan, Abdul Ahad, Mohammad Raish, Fahad I. Al-Jenoobi
Summary: Sinapic acid (SA) is a bioactive phenolic acid with diverse properties such as anti-inflammatory, antioxidant, anticancer, and antibacterial activities. This study aimed to enhance the water solubility of SA through the formulation of SA-transethosomes and evaluate their efficacy. The optimized formulation showed high entrapment efficacy, appropriate vesicle size, and smooth surface morphology, as well as enhanced antioxidant activity and penetration ability.
Article
Chemistry, Medicinal
Rama Tyagi, Ayesha Waheed, Neeraj Kumar, Abdul Ahad, Yousef A. Bin Jardan, Mohd. Mujeeb, Ashok Kumar, Tanveer Naved, Swati Madan
Summary: This study aims to develop plumbagin-enclosed niosomes using the QbD strategy for effective diabetes treatment. The optimized plumbagin-loaded niosomes demonstrated controlled release and showed antioxidant activity and inhibition of alpha-amylase and alpha-glucosidase enzymes.
Article
Chemistry, Analytical
Ibrahim Abdelsalam Abdelrahman, Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan, Mohd Aftab Alam, Fahad I. Al-Jenoobi
Summary: The study aimed to investigate the influence of cumin and green tea on the pharmacodynamics and pharmacokinetics of amlodipine in hypertensive rats. The results showed that both cumin and green tea significantly decreased blood pressure, with green tea having a more prominent effect on the pharmacodynamics of amlodipine. Co-administration of green tea and cumin increased the peak concentration and half-life of amlodipine.
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)
