The small molecule SI113 hinders epithelial‐to‐mesenchymal transition and subverts cytoskeletal organization in human cancer cells

Deregulation of SGK1 in Ulcerative Colitis: A Paradoxical Relationship Between Immune Cells and Colonic Epithelial Cells

(2018) Rocco Spagnuolo et al.   INFLAMMATORY BOWEL DISEASES

SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT

(2018) Weiwei Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Actin–microtubule crosstalk in cell biology

(2018) Marileen Dogterom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells

(2017) Domenico Conza et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme

(2017) Claudia Abbruzzese et al.   Oncotarget

SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation

(2017) Vincenzo Dattilo et al.   Scientific Reports

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

(2016) Pau Castel et al.   CANCER CELL

Interaction between the human papillomavirus 16 E7 oncoprotein and gelsolin ignites cancer cell motility and invasiveness

(2016) Paola Matarrese et al.   Oncotarget

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

(2016) Cristina Talarico et al.   Oncotarget

SI113, a Specific Inhibitor of the Sgk1 Kinase Activity that Counteracts Cancer Cell Proliferation

(2015) Lucia D''Antona et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy

(2015) Cristina Talarico et al.   Oncotarget

Evidence for the involvement of GD3 ganglioside in autophagosome formation and maturation

(2014) Paola Matarrese et al.   Autophagy

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

In Silico Identification and Biological Evaluation of Novel Selective Serum/Glucocorticoid-Inducible Kinase 1 Inhibitors Based on the Pyrazolo-Pyrimidine Scaffold

(2014) Francesco Ortuso et al.   Journal of Chemical Information and Modeling

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

(2014) Samantha J. Stehbens et al.   NATURE CELL BIOLOGY

Proteome-Wide Discovery and Characterizations of Nucleotide-Binding Proteins with Affinity-Labeled Chemical Probes

(2013) Yongsheng Xiao et al.   ANALYTICAL CHEMISTRY

Therapeutic potential of serum and glucocorticoid inducible kinase inhibition

(2013) Florian Lang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells

(2013) Jean-Cheng Kuo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chemical proteomic strategies for the discovery and development of anticancer drugs

(2013) Yuanzhen Liu et al.   PROTEOMICS

Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy

(2012) Eva Andres-Mateos et al.   EMBO Molecular Medicine

Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas

(2012) Claudia Abbruzzese et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells

(2012) R Amato et al.   ONCOGENE

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation

(2009) Rosario Amato et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors

(2008) C. Leonetti et al.   CLINICAL CANCER RESEARCH