Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 11, Pages 20329-20341Publisher
WILEY
DOI: 10.1002/jcp.28633
Keywords
miR-218-5p; SFRP2; skin and hair follicle development; Wnt/beta-catenin signaling pathway
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Funding
- Modern Agricultural Industrial System Special Funding [CARS-43-A-1]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD 2014-134]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [XKYCX17_059]
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The hair follicle is a complex biological system involved in a dynamic process governed by gene regulation. MicroRNAs play a critical role in the regulation of gene expression. We demonstrated that the expression of miR-218-5p and SFRP2 showed the opposite relationship in catagen and telogen phases and that miR-218-5p promoted the growth of hair shafts. The luciferase reporter assays confirmed that SFRP2 is the direct target of miR-218-5p. The expression of miR-218-5p may decrease the expression of SFRP2, which activates the Wnt signaling pathway, including the regulation of downstream genes and beta-catenin/T-cell-specific factor transcriptional activity. Moreover, miR-218-5p enhanced apoptosis, but inhibition of miR-218-5p decreased apoptosis and inhibited RAB-9 cell proliferation. In this study, we show that miR-218-5p positively regulates the Wnt signaling pathway by targeting SFRP2 and acts as a dynamic governor during skin and hair follicle development.
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