Review
Pharmacology & Pharmacy
Yanhui Liu, Haobo Kong, Heping Cai, Guanru Chen, Huiying Chen, Wenyi Ruan
Summary: This paper reviews the association between the PI3K/Akt pathway and COPD, aiming to identify new therapeutic targets for clinical intervention in this disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockiam
Summary: Hepatocellular carcinoma (HCC) is the third leading malignancy worldwide, causing high mortality in adults and children. This study explored the expression and function of the miR-221/AEG-1 axis in HCC. The silencing of the miR-221/AEG-1 axis induced apoptosis and G2/M phase arrest, inhibited cellular proliferation and angiogenesis in HCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Lin Lin, Yunan Gao, Xiaochen Hu, Jiabao Ouyang, Chunbo Liu
Summary: Pentamidine inhibits proliferation, migration, and invasion of endometrial cancer cells through the suppression of the PI3K/AKT signaling pathway. These findings suggest that Pentamidine may be a potential candidate for treating endometrial cancer.
Article
Pharmacology & Pharmacy
Wenbin Luo, Yu Tao, Shengnan Chen, Hao Luo, Xiaoping Li, Shuang Qu, Ken Chen, Chunyu Zeng
Summary: This study found that rosmarinic acid (RA) can effectively protect against pulmonary ischemia/reperfusion (IR) injury by activating the PI3K/Akt signaling pathway for antioxidation and anti-apoptosis, suggesting its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wanyun Zuo, Na Liu, Yunhong Zeng, Zhenghui Xiao, Keke Wu, Fan Yang, Biao Li, Qingqing Song, Yunbin Xiao, Qiming Liu
Summary: In this study, luteolin was found to have a beneficial effect on pulmonary arterial hypertension, possibly through inhibiting the HIPPO-YAP/PI3K/AKT signaling pathway. Therefore, luteolin may become a promising candidate for the treatment of PAH.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Reproductive Biology
Jia Liu, Chong Wang
Summary: This study demonstrates that increased LPA activates the PI3K-Akt-mTOR pathway through LPAR1 in granulosa cells, suppressing apoptosis by enhancing autophagy, which might play a role in oocyte maturation in vivo.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Aiping Xu, Xiuli Xia, Ting Xu, Ruxia Liu
Summary: This study investigated the effects of TIGAR on lung ischemia/reperfusion injury (LIRI) and its mechanism of action. The results showed that overexpression of TIGAR exerts protective roles in LIRI rats through activation of the PI3K/Akt signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pharmacology & Pharmacy
Xingxing Hu, Menglin Zou, Lan Ni, Mingyang Zhang, Weishuai Zheng, Bing Liu, Zhenshun Cheng
Summary: DEC1 plays a significant role in pulmonary fibrosis by promoting epithelial-mesenchymal transition (EMT) through the PI3K/AKT/GSK-3 beta/beta-catenin integrated signaling pathway, leading to the accumulation of fibroblasts and myofibroblasts and excessive collagen deposition. Targeting DEC1 may be a potential novel therapeutic approach for idiopathic pulmonary fibrosis (IPF).
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jincheng Wang, Kaili Hu, Xuanyan Cai, Bo Yang, Qiaojun He, Jiajia Wang, Qinjie Weng
Summary: This article discusses the progress made in understanding the complex interpretation of the cause of IPF, emphasizing the importance of the PI3K/AKT signaling pathway in IPF development, and explores the potential benefits of PI3K/AKT inhibitors in IPF treatment.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Medicine, Research & Experimental
Wei Wang, Da Liu, Liyun Yang, Lixia Chen, Mengdan Miao, Yongsheng Liu, Yajuan Yin, Mei Wei, Gang Liu, Yonghui An, Mingqi Zheng
Summary: This study aimed to investigate whether Compound Kushen injection (CKI) alleviates heart failure (HF) by attenuating cardiomyocyte apoptosis via the inhibition of the PI3K/Akt pathway. The results showed that CKI promoted healthy cardiac function, reduced myocardial structural damage, and attenuated the rate of cardiomyocyte apoptosis. CKI significantly suppressed the expression of apoptosis-related proteins in the PI3K/Akt pathway. In conclusion, CKI reduces cardiomyocyte apoptosis, improves cardiac function, and attenuates Ang II-mediated HF, possibly through the inhibition of the PI3K/Akt pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Oncology
Amin Huang, Peiting Zeng, Yinguang Li, Wenhua Lu, Yaoming Lai
Summary: This study discusses the resistance of AML patients with FLT3-ITD mutation to sorafenib, potentially due to the loss of the FLT3 target protein and sustained activation of the PI3K/Akt signaling pathway. The PI3K inhibitor, LY294002, can block this pathway and inhibit glycolysis, disrupting ATP production and inducing cell apoptosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hualin Chen, Lin Ma, Wenjie Yang, Yingjie Li, Zhigang Ji
Summary: POLR3G is highly expressed in bladder cancer and is associated with poor prognosis. Its deficiency inhibits migration and invasion of bladder cancer cells and reduces the expression of EMT-related markers. Mechanistically, POLR3G can promote EMT in bladder cancer by activating the PI3K/AKT signaling pathway.
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Respiratory System
Yang Hu, Liu-Sheng Wang, Yue-Ping Jin, Shan-Shan Du, Yu-Kui Du, Xian He, Dong Weng, Ying Zhou, Qiu-Hong Li, Li Shen, Fen Zhang, Yi-Liang Su, Xiao-Li Sun, Jing-Jing Ding, Wen-Hui Zhang, Hou-Rong Cai, Hua-Ping Dai, Jing-Hong Dai, Hui-Ping Li
CLINICAL RESPIRATORY JOURNAL
(2017)
Article
Respiratory System
Yingwei Zhang, Lintao Bi, Yuying Qiu, Yang Wang, Jingjing Ding, Yi Zhuang, Yaqiong Tian, Hourong Cai
Article
Medicine, General & Internal
Jingjing Ding, Jinghong Dai, Hourong Cai, Qian Gao, Yanting Wen
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2017)
Article
Medicine, General & Internal
Yanting Wen, Jingjing Ding, Bin Zhang, Qian Gao
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2018)
Review
Oncology
Yingwei Zhang, Lintao Bi, Yuying Qiu, Tingting Zhao, Mengshu Cao, Jingjing Ding, Fanqing Meng, Hourong Cai
Article
Immunology
Bin Zhang, Fan Zhao, Huimin Mao, Wenyan Ma, Yang Zhang, Xinyu Zhang, Jingjing Ding, Qian Gao, Yanting Wen
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Article
Immunology
Xianhua Gui, Xiaohua Qiu, Yaqiong Tian, Miaomiao Xie, Hui Li, Yujuan Gao, Yi Zhuang, Mengshu Cao, Hui Ding, Jingjing Ding, Yingwei Zhang, Hourong Cai
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Respiratory System
Xianhua Gui, Jingjing Ding, Yan Li, Min Yu, Tingting Chen, Mei Huang, Yonglong Xiao
BMC PULMONARY MEDICINE
(2020)
Article
Rheumatology
Xianhua Gui, Miao Ma, Jingjing Ding, ShenYun Shi, Xiaoyan Xin, Xiaohua Qiu, Yingwei Zhang, Yuying Qiu, Min Cao, Mei Huang, Mengshu Cao, Jinghong Dai, Hourong Cai, Yonglong Xiao
Summary: The study aimed to evaluate the clinical significance of CYFRA21-1 in MDA5-DM-ILD patients and found that it could be a useful serum indicator associated with the occurrence of A/SIP in MDA5-DM-ILD. Additionally, it was associated with a poor survival in MDA5-DM-ILD patients.
Article
Rheumatology
Xianhua Gui, Shi Shenyun, Hui Ding, Rujia Wang, Jingzhi Tong, Min Yu, Tingting Zhao, Miao Ma, Jingjing Ding, Xiaoyan Xin, Yuying Qiu, Xiaohua Qiu, Yingwei Zhang, Min Cao, Mei Huang, Mengshu Cao, Jinghong Dai, Hourong Cai, Yonglong Xiao
Summary: The prevalence of anti-Ro52 antibodies is high in patients with idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD), especially in those with anti-MDA5 and anti-Jo1 antibodies. Patients with anti-Ro52 antibodies are more likely to exhibit Gottron sign and have a poorer prognosis, especially in the anti-MDA5 antibody subgroup.
Article
Immunology
Kaifang Meng, Bin Zhang, Chengxing Ma, Qianqian Dai, Xianhua Gui, Xiaoqin Liu, Qi Zhao, Qian Gao, Yanting Wen, Jingjing Ding
Summary: Sarcoidosis is a disease characterized by inflammation and the imbalance of Th17 and Treg cells. In this study, it was found that serum amyloid A (SAA) can promote the expression of chemokine ligand 20 (CCL20) and interleukin-17A (IL-17A), exacerbating the migration and polarization of T cells in pulmonary sarcoidosis. However, blocking CCL20 can partially reverse these effects and show potential as a therapeutic approach.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Kaifang Meng, Mi Tian, Xianhua Gui, Miaomiao Xie, Yujuan Gao, Shenyun Shi, Tingting Zhao, Yonglong Xiao, Hourong Cai, Jingjing Ding
Summary: This study found that the expression of HE4 in both serum and lung specimens was significantly elevated in CTD-ILD patients with UIP pattern. Serum HE4 levels were correlated with disease severity and prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shenyun Shi, Xianhua Gui, Jingjing Ding, Shangwen Yang, Xiaoyan Xin, Kaifeng Xu, Yonglong Xiao
Summary: This prospective observational study evaluated the safety and efficacy of oral statin therapy for pulmonary alveolar proteinosis (PAP) patients without hypercholesterolemia. The results demonstrated that statin therapy improved arterial blood gas measurement, pulmonary function, and radiographic assessment.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Respiratory System
Ying Zhou, Lei Wang, Mei Huang, Jingjing Ding, Hanyi Jiang, Kefeng Zhou, Fanqing Meng, Yonglong Xiao, Hourong Cai, Jinghong Dai
CHRONIC RESPIRATORY DISEASE
(2019)
